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| Number | Title | Issue Date |
| 8153440 | Methods for altering surface characteristics of microspheres Various methods for altering surface characteristics of a microsphere are provided. One method includes coupling an enolic acid to the microsphere to modify the surface characteristics of the microsphere. The surface characteristics may include charge density and/or... | 04/10/2012 |
| 8148171 | Multiplexed analysis of clinical specimens apparatus and methods A method for the multiplexed diagnostic and genetic analysis of enzymes, DNA fragments, antibodies, and other biomolecules comprises the steps of constructing an appropriately labeled beadset, exposing the beadset to a clinical sample, and analyzing the combined sam... | 04/03/2012 |
| 8147805 | Conjugates for dual imaging and radiochemotherapy: composition, manufacturing, and applications Compositions and methods for dual imaging and for dual chemotherapy and radiotherapy are disclosed. More particularly, the invention concerns compounds comprising the structure X1—Y—X2, wherein Y comprises two or more carbohydrate residues ... | 04/03/2012 |
| 8138311 | Modified proteins, designer toxins, and methods of making thereof The present invention concerns methods of reducing the antigenicity of a proteinaceous compound while maintaining the compounds biological activity, as well as proteinaceous compositions with biological activity but reduced antigenicity. These methods and compositio... | 03/20/2012 |
| 8137922 | Method for diagnosing the metabolic syndrome (MS) The present invention discloses a method for diagnosing the metabolic syndrome by determination of the afamin content in a sample of a body fluid or a tissue sample, wherein the metabolic syndrome is diagnosed if the afamin content in the sample is increased compare... | 03/20/2012 |
| 8136613 | Vehicle control systems and methods Systems for controlling the speed and direction of vehicles such as tractors, including vehicles that have low to zero turning radius capability. Systems include steering and speed coordination systems that control the direction and speed of rotation of vehicle driv... | 03/20/2012 |
| 8129370 | Use of oxicam compounds The invention relates to the use of lornoxicam or analogues thereof which inhibit cyclo-oxygenase 1 and cyclo-oxygenase 2 (COX 1 and COX 2), cannot penetrate the blood-brain barrier under physiological conditions, and reduce the prostaglandin E2-induced induction of... | 03/06/2012 |
| 8129135 | Method for diagnosing cardiovascular diseases Method for diagnosing a cardiovascular disease in an individual comprising the steps of: providing a sample of an individual; determining the amount of cytokeratin-18 (CK-18) or fragments thereof and/or interleukin-1β precursor (IL-1β precursor) in the sample; com... | 03/06/2012 |
| 8129129 | Method for diagnosing tumors The present invention describes a method for diagnosing tumors of the reproductive organs which is characterized by determination of the afamin content in a sample of a body fluid or in a tissue sample, wherein a tumor is diagnosed if the afamin content in the sampl... | 03/06/2012 |
| 8124230 | Non-aggregating nanoparticles and the use thereof The present invention relates generally to non-aggregating nanoparticles, including ligand capped metal oxide nanoparticles. Methods for their synthesis and methods for their use, for example, for improved immersion lithography processes, are also disclosed. ... | 02/28/2012 |
| 8124067 | Method for immunotherapy of tumors A method for making dendritic cells reactive to an antigen comprises obtaining a sample of dendritic cells and contacting the cells with the antigen and at least one Toll-like receptor stimulant. Dendritic cells activated by this method provide a means for treating ... | 02/28/2012 |
| 8111582 | Projectile-detection collars and methods User-wearable sensor arrays for use with projectile-detection systems, and methods of detecting a projectile with user-wearable sensor arrays. ... | 02/07/2012 |
| 8097468 | Using plasma proteomic pattern for diagnosis, classification, prediction of response to therapy and clinical behavior, stratification of therapy, and monitoring disease in hematologic malignancies The present invention demonstrates that the diagnosis and prediction of clinical behavior in patients with hematologic malignancies, such as leukemia, can be accomplished by analysis of proteins present in a plasma sample. Thus, in particular embodiments the present... | 01/17/2012 |
| 8088629 | Methods for forming dyed microspheres and populations of microspheres Various methods for forming dyed microspheres are provided. One method includes attaching a hydrophilic dye to chemical groups to form a bubble. The bubble includes the chemical groups surrounding the hydrophilic dye and an aqueous solution. The chemical groups are ... | 01/03/2012 |
| 8077960 | Methods for altering one or more parameters of a measurement system Methods for altering one or more parameters of a measurement system are provided. One method includes analyzing a sample using the system to generate values from classification channels of the system for a population of particles in the sample. The method also inclu... | 12/13/2011 |
| 8076470 | VMP-like sequences of pathogenic species and strains The present invention relates to DNA sequences encoding Vmp-like polypeptides of pathogenic Borrelia, the use of the DNA sequences in recombinant vectors to express polypeptides, the encoded amino acid sequences, application of the DNA and amino acid sequence... | 12/13/2011 |
| 8076283 | Methods for treating congestive heart failure The invention features methods of treating or preventing congestive heart failure by administering a polypeptide containing an epidermal growth factor-like domain encoded by a neuregulin gene. ... | 12/13/2011 |
| 8071632 | Antioxidant inflammation modulators: novel derivatives of oleanolic acid Disclosed herein are novel oleanolic acid derivatives. Methods of preparing these compounds are also disclosed. The oleanolic acid derivatives of this invention may be used for the treatment and prevention of many diseases, including cancer, neurological disorders, ... | 12/06/2011 |
| 8071109 | VMP-like sequences of pathogenic The present invention relates to DNA sequences encoding Vmp-like polypeptides of pathogenic Borreliae, the use of the DNA sequences in recombinant vectors to express polypeptides, the encoded amino acid sequences, application of the DNA and amino acid sequenc... | 12/06/2011 |
| 8067465 | Tricyclic-bis-enone derivatives and methods of use thereof Novel tricyclic-bis-enone derivatives (TBEs) as well as the process for the preparation of such TBEs are provided. Also provided are methods for prevention and/or treatment of cancer, Alzheimer's disease, Parkinson's disease, multiple sclerosis, amyotropic lateral s... | 11/29/2011 |
| 8067394 | Synthesis and biological activities of new tricyclic--enones (TBEs) This invention describes novel tricyclic-bis-enone derivatives (TBEs), such as TBE-31, TBE-34, TBE-45 and water-soluble TBEs. The methods of preparing these compounds are also disclosed. The inventors demonstrate the ability of these new TBEs to inhibit proliferatio... | 11/29/2011 |
| 8062609 | Flow cytometer and fluidic line assembly with multiple injection needles A flow cytometer is provided which includes an interrogation flow cell and a plurality of assay fluidic lines extending into the interrogation flow cell. A method of operating such a flow cytometer includes priming the interrogation flow cell with a sheath fluid and... | 11/22/2011 |
| 8060316 | Methods, data structures, and systems for classifying microparticles Methods, data structures, and systems for classifying particles are provided. In particular, the methods and systems are configured to acquire a first set of data corresponding to measurable parameters of a microparticle and identify a location of a look-up table to... | 11/15/2011 |
| 8048979 | Process for synthesis of telechelic urethane acrylate UV curable pre-polymeric materials The present invention involves the design of a radiation curable organic pre polymer resin material based on urethane acrylic linkage synthesized from the natural renewable resource cardanol or a derivative thereof, for coating application. These new molecules have ... | 11/01/2011 |
| 8043094 | Model and method for simulating water treatment A portable model and methods for simulating water treatment processes are presented. Included are a body of untreated drinking water, simulated sources of wastewater, and simulated drinking and wastewater treatment plants. In the simulated drinking water treatment p... | 10/25/2011 |
| 8039008 | Identification of residues critical for the function of the vibrio cholerae virulence regulator ToxT by scanning alanine mutagenesis Disclosed are Vibrio cholerae comprising a mutated transcriptional regulatory protein (ToxT) amino acid sequence, wherein the mutation results in a reduction in the expression of cholera toxin by the Vibrio cholerae. Also disclosed are Vibrio choler... | 10/18/2011 |
| 8038734 | Methods for forming dyed microspheres and populations of dyed microspheres Various methods for forming dyed microspheres are provided. One method includes activating a chemical structure coupled to a dye using heat or light to form a reaction intermediate in the presence of a microsphere. The reaction intermediate covalently attaches to a ... | 10/18/2011 |
| 8034955 | Therapeutic compounds and methods of use Compounds and methods useful for chemopreventative treatment of diseases such as cancer, Alzheimer's disease, Parkinson's disease, inflammatory bowel diseases, and multiple sclerosis. ... | 10/11/2011 |
| 8034778 | Neuroprotective compounds and uses thereof The present invention relates to a neuroprotective compound consisting of the amino acid sequence DLHW. ... | 10/11/2011 |
| 8031918 | Methods and systems for image data processing Methods, storage mediums, and systems for image data processing are provided. Embodiments for the methods, storage mediums, and systems include configurations to perform one or more of the following steps: background signal measurement, particle identification using... | 10/04/2011 |
| 8021831 | Taxane chemosensitivity prediction test The present invention provides a method for determining the chemosensitivity of a cancer cell to a taxane comprising assessing the effect of the taxane on the expression level or activity of one or more cell cycle molecules in a cancer cell. Such a method makes use ... | 09/20/2011 |
| 8008460 | Polynucleotide fragments of an infectious human endogenous retrovirus Nucleotide sequences and fragments which code for a human endogenous retrovirus which is infectious. “Fragments” according to the present invention relate also to specific fragments of the sequences inserted into the vector pCR4-Topo and deposited as MERV-env, M... | 08/30/2011 |
| 8008019 | Use of dual-tags for the evaluation of genomic variable repeat regions The methods and compositions of the present invention allow for the evaluation of a nucleotide expansion, contraction or deletion. In one embodiment, the present invention provides a method for detecting a nucleotide expansion, contraction or deletion comprising amp... | 08/30/2011 |
| 8003813 | Process for separating saturated and unsaturated fatty acids A process for separating a blend of saturated and unsaturated fatty acids or saturated and unsaturated fatty acid alky esters into a first fraction enriched with the saturated fatty acids or saturated fatty acid alkyl esters and a second fraction enriched with unsat... | 08/23/2011 |
| 8003343 | Method for determining diamine oxidase Disclosed is a method for determining histaminase (DAO; EC 1.4.3.6) activity in a sample. Said method comprises the following steps: an aqueous solution is supplied which contains a predefined amount of a diamine; the aqueous solution is mixed and incubated with the... | 08/23/2011 |
| 7989619 | Nanotextured surfaces The invention describes novel compositions that include a cross linking compound, a polymer and a 1 nm to about a 25 micron sized particle optionally with an oxide layer. In particular, the particle is a silica and one which has been pretreated with a silane. ... | 08/02/2011 |
| 7985435 | Triterpene compositions and methods for use thereof The invention provides saponin mixtures and compounds which are isolated from the species Acacia victoriae and methods for their use. These compounds may contain a triterpene moiety, such as acacic or oleanolic acid, to which oligosaccharides and monoterpenoi... | 07/26/2011 |
| 7981878 | Tumor treatment with gliotoxin derivatives The present invention describes the use of Notch2 inhibitors for producing a medicament for the treatment of tumours, which tumours are characterized by ligand-independent Notch2 fragments. ... | 07/19/2011 |
| 7964352 | 3′-OH unblocked nucleotides and nucleosides, base modified with labels and photocleavable, terminating groups and methods for their use in DNA sequencing Provided are novel nucleotides, nucleoside, and their derivatives described herein, that can be used in DNA sequencing technology and other types of DNA analysis. In one embodiment, the nucleotide or nucleoside with an unprotected 3′-OH group is derivatized at the... | 06/21/2011 |
| 7961922 | Systems and methods for processing medical image data to facilitate comparisons among groups of subjects Systems and methods for processing medical image data with increased sensitivity to facilitate comparisons among groups of subjects are disclosed herein. In one embodiment, a method comprises receiving a first three-dimensional image comprising a plurality of voxels... | 06/14/2011 |
