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| Number | Title | Issue Date |
| 8183354 | Virus coat protein/receptor chimeras and methods of use The invention relates to chimeric molecules comprising a virus coat sequence and a receptor sequence that can inter-act with each other to form a complex that is capable of binding a co-receptor. Such chimeric molecules therefore exhibit functional properties charac... | 05/22/2012 |
| 8182878 | Metal-enhanced fluorescence from plastic substrates The present invention relates to methods for functionally modifying a polymeric surface for subsequent deposition of metallic particles and/or films, wherein the polymeric surface is modified by increasing hydroxyl and/or amine functional groups thereby providing an... | 05/22/2012 |
| 8143366 | Aryl carbamate oligomers for hydrolyzable prodrugs and prodrugs comprising same The present invention provides a compound having a formula: where R1 is selected from the group consisting of alkyl, CH2(OC2H4)OCH3, and —(OC2H4)OCH3; n is 0-4; Olig is an olig... | 03/27/2012 |
| 8114598 | High-sensitivity assays for pathogen detection using metal enhanced fluorescence The present invention relates to an assay including a surface having silver colloids or islands attached thereto. Attached to the surface and/or silver colloids/islands are polynucleotides which are complimentary to a target polynucleotide sequence. The assay is per... | 02/14/2012 |
| 8101424 | Bioassays using plasmonic scattering from noble metal nanostructures The present invention relates to detecting and/or measuring scattering effects due to the aggregating metallic nanostructures or the interaction of plasmonic emissions from approaching metallic nanoparticles. The scattering effects may be measured at different angle... | 01/24/2012 |
| 8097245 | Delivery vehicle for probiotic bacteria comprising a dry matrix of polysaccharides, saccharides and polyols in a glass form and methods of making same The disclosure relates to a solid glass matrix of polysaccharide, saccharides and polyols as delivery vehicle for preservation and post gastric administration of a probiotic. The delivery vehicle is capable of releasing the probiotic at their site of action. The pre... | 01/17/2012 |
| 8075956 | Metal-enhanced fluorescence from plastic substrates The present invention relates to methods for functionally modifying a polymeric surface for subsequent deposition of metallic particles and/or films, wherein the polymeric surface is modified by increasing hydroxyl and/or amine functional groups thereby providing an... | 12/13/2011 |
| 8048924 | Methods and compositions employing 4-aminophenylacetic acid compounds The invention provides compositions comprising 4-APAA compounds and methods for treating disorders involving inflammation of the intestinal system, such as inflammatory bowel disease. The methods and compositions of the invention also include combinations of 4-APAA ... | 11/01/2011 |
| 8048875 | Topical pharmaceutical composition comprising a cholinergic agent or a calcium channel blocker Bethanechol, diltiazem, or a combination thereof is administered locally to the anus for the treatment of benign anal disorders, in particular anal fissures and hemorrhoids. The agents induce a reduction in the mean and resting pressure, thereby assisting in the hea... | 11/01/2011 |
| 8034633 | Microwave accelerated assays The present invention provides for increasing fluorescence detection in surface assay systems while increasing kinetics of a bioreaction therein by providing low-power microwaves to irradiate metallic materials within the system in an amount sufficient to increase h... | 10/11/2011 |
| 8030269 | Calcitonin drug-oligomer conjugates, and uses thereof Calcitonin drug-oligomer conjugates that include a calcitonin drug coupled to an oligomer including a single polyalkylene glycol moiety consisting of between 4 and 10 polyalkylene glycol subunits are disclosed. Pharmaceutical compositions including such conjugates a... | 10/04/2011 |
| 8008067 | Microwave trigger metal-enhanced chemiluminescence (MT MEC) and spatial and temporal control of same The present invention relates to a method of imaging structures and features using plasmonic emissions from metallic surfaces caused by chemiluminescence based chemical and biological reactions wherein imaging of the reactions is enhanced by the use of microwave ene... | 08/30/2011 |
| 7998502 | Encapsulated vaccines for the oral vaccination and boostering of fish and other animals The invention relates to a composition comprising a pharmaceutically active agent and a bioadhesive delivery system that provides for the oral delivery of a vaccine to animals, particularly aquatic animals. ... | 08/16/2011 |
| 7973148 | Crustacean expression vector Methods and constructs for genetic manipulation of one or more of shrimp, shellfish, mollusks, and fish are disclosed. The nucleic acid construct includes a promoter and an internal ribosome entry site of an insect picomavirus, such as a cricket paralysis-like picom... | 07/05/2011 |
| 7939333 | Metal enhanced fluorescence-based sensing methods The present invention relates to metallic-surface detection systems for determining target substances including free bilirubin in neonatal serum in the presence of a predominantly high background of bilirubin bound Human Serum Albumin (HSA) or sensing and isolating ... | 05/10/2011 |
| 7932366 | Synthesis of azo bonded immunoregulatory compounds Methods are disclosed for preparing compounds of Formula I: where R1, R3, and R4 are independently hydrogen or C1 to C4 alkyl, and R2 is: where R5 is selected from the group consisting of h... | 04/26/2011 |
| 7932056 | Crustaceans as production systems for therapeutic proteins A crustacean or rotifer is infected with a recombinant infectious virus that expresses a protein exogenous to the virus. The genome of the crustacean or rotifer itself remains unaltered. Crustacean, rotifer, insect, or viral promoters drive the transcription of a ge... | 04/26/2011 |
| 7910801 | Plants with reduced expression of phosphatase type 2C gene for enhanced pathogen resistance The present invention relates to a method for down regulating an Arabidopsis protein phosphatase type 2C gene, referred to as “defense-associated protein phosphatase type 2C one” (DAPP1) that functions as a negative regulator of a plant defense pathway by... | 03/22/2011 |
| 7875700 | Cation complexes of insulin compound conjugates, formulation and uses thereof The invention provides a complex including a cation and an insulin compound conjugate. The insulin compound conjugate includes insulin compound, such as human insulin or an analog thereof, conjugated to a modifying moiety, such as a polyethylene glycol moiety. The i... | 01/25/2011 |
| 7872095 | Insulin-oligomer conjugates, formulations and uses thereof An insulin compound coupled to a modifying moiety having a formula: —X—R1—Y-PAG-Z—R (Formula VI) where, X, Y and Z are independently selected linking groups and each is optionally ... | 01/18/2011 |
| 7863242 | Compositions for down-regulation of CCR5 expression and methods of use thereof The present invention relates to the downregulation of surface receptor CCR5 expression through manipulation of the cell cycle in activated lymphocytes by administering a composition that arrests the G1 phase of the cell cycle, thereby reducing receptor sites for en... | 01/04/2011 |
| 7807405 | Glycoprotein synthesis and remodeling by enzymatic transglycosylation A chemoenzymatic method for the preparation of a homogeneous glycoprotein or glycopeptide, including (a) providing an acceptor selected from the group consisting of GlcNAc-protein and GlcNAc-peptide; and (b) reacting the acceptor with a donor substrate including an ... | 10/05/2010 |
| 7807186 | Tumor cells from immune privileged sites as base cells for cell-based cancer vaccines The present invention relates to tumor cell-based vaccines and methods of using same, wherein the vaccines are based on naturally immune privileged tumor cells that have been genetically modified to express MHC-II restricted peptides derived from endogenously encode... | 10/05/2010 |
| 7732215 | Cyanide sensing compounds and uses thereof The present invention relates to a cyanide detection method using fluorescence and cyanide sensitive boronic acid containing fluorophores, wherein a change in a measured fluorescent property correlates to the concentration of the cyanide compound in a biological or ... | 06/08/2010 |
| 7728106 | HIV-1 glycopeptides and derivatives; preparation and applications thereof A method of making a synthetic glycopeptide, by addition of a synthetic oligosaccharide oxazoline to a GlcNAc-containing peptide precursor in the presence of an enzyme selected from among Endo-A and Endo-M. In a specific implementation, the method is utilized to syn... | 06/01/2010 |
| 7718804 | Quaternary nitrogen heterocyclic compounds for detecting aqueous monosaccharides in physiological fluids Quaternary nitrogen heterocyclic boronic acid-containing compounds are described, which are sensitive to glucose and fructose, as well as a variety of other physiologically important analytes, such as aqueous chloride and iodide, and a method of using the compounds.... | 05/18/2010 |
| 7713932 | Calcitonin drug-oligomer conjugates, and uses thereof Calcitonin drug-oligomer conjugates that include a calcitonin drug coupled to an oligomer including a single polyalkylene glycol moiety consisting of between 4 and 10 polyalkylene glycol subunits are disclosed. Pharmaceutical compositions including such conjugates a... | 05/11/2010 |
| 7708983 | Directional induction of immune response by co-administration of antigens with chemokines The present invention relates to compositions and methods of using same to direct an immune response thereby enhancing the efficacy of an antigen containing vaccine by combining a chemokine in conjunction with the vaccine, wherein the choice of the chemokine directs... | 05/04/2010 |
| 7673551 | Aerial-supported procedure for the detection of landmines The present invention refers to an aerial-supported procedure for the detection of landmines, duds or similar explosive bodies using a fluorescence procedure, including aerial-supported geo-referencing of the detected locations by means of a digital terrain model. | 03/09/2010 |
| 7662773 | Natriuretic compounds, conjugates, and uses thereof Modified natriuretic compounds and conjugates thereof are disclosed in the present invention. In particular, conjugated forms of hBNP are provided that include at least one modifying moiety attached thereto. The modified natriuretic compound conjugates retain activi... | 02/16/2010 |
| 7648962 | Natriuretic compounds, conjugates, and uses thereof Modified natriuretic compounds and conjugates thereof are disclosed in the present invention. In particular, conjugated forms of hBNP are provided that include at least one modifying moiety attached thereto. The modified natriuretic compound conjugates retain activi... | 01/19/2010 |
| 7635675 | Micro-particle fatty acid salt solid dosage formulations for therapeutic agents Fatty acid salt particles having a size distribution wherein the particles are from about 1 to about 1,000 microns in diameter, use of the particles in pharmaceutical compositions, as well as methods of making and using the particles and compositions. ... | 12/22/2009 |
| 7625995 | Aryl carbamate oligomers for hydrolyzable prodrugs and prodrugs comprising same The present invention provides a compound having a formula: where R1 is selected from the group consisting of alkyl, CH2(OC2H4)OCH3, and —(OC2H4)OCH3; n is 0-4; Olig is an olig... | 12/01/2009 |
| 7611864 | Proinsulin polypeptide-oligomer conjugates Methods for synthesizing proinsulin polypeptides are described that include a contacting a proinsulin polypeptide including an insulin polypeptide coupled to one or more peptides by peptide bond(s) capable of being cleaved to yield the insulin polypeptide with an ol... | 11/03/2009 |
| 7608584 | Calcitonin drug-oligomer conjugates, and uses thereof Calcitonin drug-oligomer conjugates that include a calcitonin drug coupled to an oligomer including a single polyalkylene glycol moiety consisting of between 4 and 10 polyalkylene glycol subunits are disclosed. Pharmaceutical compositions including such conjugates a... | 10/27/2009 |
| 7605123 | Fatty acid formulations for oral delivery of proteins and peptides, and uses thereof Fatty acid compositions for administration of of pharmaceutical agents, such as proteins and peptides, protein and peptide conjugates, and/or cation-polypeptide conjugate complexes. In particular, the invention provides a solid pharmaceutical composition formulated ... | 10/20/2009 |
| 7604804 | Enhancing anti-HIV efficiency through multivalent inhibitors targeting oligomeric gp120 The present invention relates to multivalent HIV inhibitors that bind to multiple sites on a trimeric gp120 complex thereby blocking the CD4 binding site on the trimeric gp120 complex and inhibiting the attachment and entry of HIV through gp120-CD4 interactions.... | 10/20/2009 |
| 7601688 | Methods of reducing hypoglycemic episodes in the treatment of diabetes mellitus The present invention provides compositions and methods for reducing hypoglycemic episodes experienced by a subject in need of treatment for diabetes mellitus, said method comprising orally administering an amount of an insulin polypeptide-oligomer conjugate to the ... | 10/13/2009 |
| 7556806 | Carbohydrate-based synthetic vaccines for HIV The present invention relates to a constructed oligosaccharide cluster, optionally bonded to an immunogenic protein, that can be administered to a subject to induce an immune response for increasing production of 2G12 and/or used in assays as reactive sites for dete... | 07/07/2009 |
| 7550647 | Transfected shrimp as production systems for therapeutic proteins A crustacean or rotifer is infected with a recombinant infectious virus that expresses a protein exogenous to the virus. The genome of the crustacean or rotifer itself remains unaltered. Crustacean, rotifer, insect, or viral promoters drive the transcription of a ge... | 06/23/2009 |
