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Attorney: Frommer Lawrence & Haug LLp, Kowalski; Thomas J.


Number of patents: 32
Last date: January 04, 2000

NumberTitleIssue Date
6541248Anti-viral vectors
A viral vector production system is provided which system comprises: (i) a viral genome comprising at least one first nucleotide sequence encoding a gene product capable of binding to and effecting the cleavage, directly or indirectly, of a second nucleotide s...
04/01/2003
6384193Agents for the regulation of oestrogen synthesis
A system comprising a IL-6-IL-6sR complex and an agent that can block the interaction of the complex with gp130 to regulate oestrogen synthesis....
05/07/2002
6379635Process for preparing a nanocrystalline material
A process for preparing a nanocrystalline material comprising at least a first ion and at least a second ion different from the first ion, and wherein at least the first ion is a metal ion, is described. The process comprises contacting a metal complex co...
04/30/2002
6377637Sub-band exponential smoothing noise canceling system
A noise canceling method and apparatus for canceling noise by time domain processing sub-bands of a digital input signal. The input signal is divided into a number of frequency-limited time-domain sub-bands. Each sub-band is then individually processed to...
04/23/2002
6368816Regulation of intracellular glucocorticoid concentrations
The interconversion of inactive 11-keto steroids with their active 11ଲ-hydroxy equivalents can be controlled by the use of inhibitors of the 11ଲ-reductase enzyme, such as carbenoxolone (3ଲ-(3-carboxypropionyloxy)-11-oxo-olean-2-en30-oic ...
04/09/2002
6332028Dual-processing interference cancelling system and method
A dual-processing interference cancelling system and method for processing a broadband input in a computationally efficient manner. Dual processing divides the input into higher and lower frequency bands and applies adaptive filter processing to the lower...
12/18/2001
6300101Methods and compositions including a 13kD B. burgdorferi protein
All Borrelia burgdorferi sensu lato isolates characterized to date have one or a combination of several major outer surface proteins (Osp). Mutants of B. burgdorferi lacking Osp proteins were selected with polyclonal or monoclonal antibodies at a frequenc...
10/09/2001
6296910Film or coating deposition on a substrate
A method of depositing a material onto a substrate, comprising the steps of: feeding a material solution to an outlet to provide a stream of droplets of the material solution; applying a potential difference between the outlet and a substrate to electrost...
10/02/2001
6271004Method for improved reverse transcription at high temperatures
The invention relates to a method for enzyme stabilization. A method for improved reverse transcription at high temperatures is provided, wherein a thermostable heat shock protein (HSPs) stabilizes a reverse transcriptase, as well as reduces the RNase H a...
08/07/2001
6271368Recombinant mistletoe lectin (rML)
The invention relates to nucleic acid molecules encoding preproproteins having after maturation the biological activity of the mistletoe lectin dimer, to vectors comprising these nucleic acid molecules, to hosts transformed with said vectors and to polype...
08/07/2001
6232122Inhibition of gene expression
A method of inhibiting gene expression in is described. The method, which affects enzymatic activity in a plant, involves expressing in a plant, or a cell, cell line, tissue, or an organ thereof, a nucleotide sequence wherein the nucleotide sequence codes...
05/15/2001
6224882Insect cells or fractions as adjuvant for antigens
Disclosed and claimed is an adjuvant for immunogenic, immunological, antigenic or vaccine compositions. The adjuvant is composed of insect cells or fractions thereof. Disclosed and claimed are also methods for preparing and using the adjuvant and composit...
05/01/2001
6187766Steroid sulphatase inhibitors
A method of inhibiting steroid sulphatase activity in a subject in need of same as described. The method comprises administering to said subject a steroid sulphatase inhibiting amount of a ring system compound; which ring system compound comprises a ring ...
02/13/2001
6184510Cakeboard and methods of manufacturing and use
A cakeboard useful for direct transfer of a cake from the oven, for finishing and serving, without the need for a cooling rack. The cakeboard can have a first layer of corrugated cardboard and a second layer of PET. The first layer can have its top liner ...
02/06/2001
6159960Steroid sulphatase inhibitors
A method of inhibiting steroid sulphatase activity in a subject in need of same is described. The method comprises administering to said subject a steroid sulphatase inhibiting amount of a ring system compound; which ring system compound comprises a ring ...
12/12/2000
6147279Inhibition of gene expression
A method of inhibiting gene expression is described. The method, which affects enzymatic activity in a plant. The method includes expressing in a plant, or a cell, a tissue or an organ thereof, a nucleotide sequence wherein the nucleotide sequence codes, ...
11/14/2000
6108415Noise cancelling acoustical improvement to a communications device
A cellular telephone for reducing background noise comprising a housing having a receiver portion and a speaker portion; the receiver portion having a voice port and a noise port; a microphone isolator located within the receiver portion; at least one noi...
08/22/2000
6103526Spodoptera frugiperda single cell suspension cell line in serum-free media, methods of producing and using
Disclosed and claimed is a new insect cell line, Sf900+, ATCC CRL-12579. The insect cell line was established from Lepidoptera, Noctuidae, Spodoptera frugiperda Sf-9 (ATCC CRL-1771) through multiple rounds of limiting dilution and selection in a serum-fre...
08/15/2000
6090625Method of increasing the relative number of CD34+ cells in a cell population
A method of increasing the relative number of CD34+ cells in a cell population is described. The method comprises contacting the cell population with an agent that causes the relative number of CD34+ cells to increase....
07/18/2000
6083978Compounds with a sulfamate group
A sulphamate compound suitable for use as an inhibitor of both oestrone sulphatase activity and aromatase activity. The compound can have the general formula (II) wherein F represents a phenolic ring structure (the first ring structure), J represents the ...
07/04/2000
6049607Interference canceling method and apparatus
Interference canceling is provided for canceling, from a target signal generated from a target source, an interference signal generated by an interference source. The beam splitter beam-splits the target signal into a plurality of band-limited target sign...
04/11/2000
6028184Pax6 and Pax4 nucleic acid mixtures
The present invention relates to a novel method for testing the developmel status in pancreatic cells of a mammal. The present invention further relates to applications in the medical field that directly arise from the method of the invention. Additional...
02/22/2000
6017904Steroid sulphatase inhibitors
Phosphate esters of formula: ##STR1## for use in the inhibition of steroid sulfatase enzyme, wherein R is as defined in the specification and the -O-polycycle represents a residue of a sterol....
01/25/2000
6013451Bacillus stearothermophilus DNA Polymerase I (klenow) clones including those with reduced 3'- to -5' exonuclease activity
Disclosed and claimed are isolated nucleic acid molecules encoding Bacillus stearothermophilus DNA polymerase (DNApolI), including the structural gene for DNApolI, such as DNApolI genes having insertions, deletions, inactivation, or mutations at the 5' en...
01/11/2000
6011024Steroid sulphatase inhibitors
A method of inhibiting steroid sulphatase activity in a subject in need of same is described. The method comprises administering to said subject a steroid sulphatase inhibiting amount of a ring system compound; which ring system compound comprises a ring ...
01/04/2000
6009519Method and apparatus for providing audio utility software for use in windows applications
A method is provided for allowing a WINDOWS computer user to effectively utilize audio applications in a WINDOWS 95 or WINDOWS NT operating system by individually setting the controls of the computer sound card by an improved dialog-based tabbed menu syst...
12/28/1999
5976552Virus vaccines
Improved mammalian virus vaccines are combinations that contain an immunogenic amount of inactivated virus, such as influenza virus, Herpes varicella virus, measles virus, Epstein Barr virus, respiratory syncytial virus, parainfluenza 3, Herpes simplex ty...
11/02/1999
5908655Shortening system, products therewith, and methods for making and using the same
Disclosed and claimed are shortening systems and methods for making and using the shortening system The shortening system can contain vegetable oil and a stearine fraction obtainable from the glycerolysis of a saturated fat or oil, such as a stearine frac...
06/01/1999
5909495Noise canceling improvement to stethoscope
A stethoscope for reducing background noise comprising a housing having a receiver portion and an audio output means; the receiver portion having a plurality of noise ports; a microphone isolator located within the receiver portion; a noise canceling micr...
06/01/1999
5906746Method for the control of biodegradation
A novel method for control of biodegradation is disclosed, said biodegradation being performed by mixed cultures of microorganisms. Measurements and adjustment (preferably on-line) of process parameters which relate to metabolic activity of the microorgan...
05/25/1999
5891620Steroid sulfatase assay
An assay comprising determining the absence or presence of steroid sulphatase activity is described. In a preferred embodiment, the assay uses white blood cells. The assay can be used to determine if an agent is an in vitro and/or in vivo steroid sulphata...
04/06/1999
5858368Vaccine comprising a baculovirus produced influenza hemagglutinin protein fused to a second protein
A method of preparing a recombinant influenza vaccine using DNA technology is provided. The resulting vaccine is a multivalent, preferably trivalent, influenza vaccine based on a mixture of recombinant hemagglutinin antigens cloned from influenza viruses ...
01/12/1999
 
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