Franks; Robert A. - US Patent Attorneys and Agents

Attorney: Franks; Robert A.

Number of patents: 161
Last date: March 13, 2012

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Number	Title	Issue Date
8134008	Preparation of amorphous hydrous esomeprazole magnesium A hydrate of esomeprazole magnesium in the form of an amorphous solid is provided. Methods of preparation and use of, as well as formulation containing the hydrate of esomeprazole magnesium in the form of an amorphous solid are also provided. ...	03/13/2012
8133994	Preparation of aprepitant A process for preparing aprepitant. ...	03/13/2012
8080668	Thiazoles derivatives as AMPK activator The present application provides novel thiazole derivatives that are useful as activators of Adenosine 5′-Monophosphate-Activated Protein Kinase and pharmaceutical compositions containing such compounds. ...	12/20/2011
8080559	5(S)-(2′-hydroxyethoxy)-20(S)-camptothecin and its preparation and use for the treatment of cancer A 5(S)-(2′-hydroxyethoxy)-20(S)-camptothecin diasterisomer is described which is a better inhibitor of topoisomerase I than either the diastereoisomeric mixture 5(RS)-(2′-hydroxyethoxy)-20(S)-camptothecin, or the 5(R)-(2′-hydroxyethoxy)-20(S)-camptothecin dias...	12/20/2011
8063214	Polymorphic forms of tadalafil A process for preparing crystalline Form A of tadalafil (I), comprising crystallization from a solution of tadalafil in a solvent comprising a C3-C7 ester, a ketone, dimethylformamide, dimethylsulfoxide, ethanol, acetonitrile, a chlorinated hyd...	11/22/2011
8063074	Polymorphic forms of esomeprazole sodium Polymorphic crystalline Forms J, K, L, M, and N of esomeprazole sodium. ...	11/22/2011
8058438	Eszopiclone process Eszopiclone is prepared by reacting zopiclone with an enatiomerically pure di-p-toluoyl tartaric acid, recovering a solid salt, and reacting a solid salt with a base. Zopiclone is prepared by reacting 6-(5-chloropyrid-2-yl)-5-hydroxy-7-oxo-5,6-dihydropyrrolo[3,4-b]-...	11/15/2011
8053000	Compositions for drug delivery Substantially non-porous polymeric microparticles comprising a hydrophobic polymer and a plasticizer, and containing therein a bioactive or bioinactive agent. ...	11/08/2011
8049021	Process for the preparation of fluorotetraene There is provided a process for preparing 21-acetyloxy-6-alpha-fluoro-pregna-1,4,9(11),16-tetraene-3,20-dione compound of Formula I, which comprises reacting 21-acetyloxy-pregna-1,3,5,9(11),16-pentaene-3-oxo acetate with a fluorinating agent. ...	11/01/2011
8039619	Process for preparing (2R,3S/2S,3R)-2-(2,4-difluorophenyl)-3-(5-fluoropyrimidin-4-yl)-1-(1H-1,2,4-triazol-1-yl)butan-2-ol Voriconazole is prepared by a process comprising condensing 1-(2,4-difluorophenyl)-2-(1H-1,2,4-triazole-1-yl)ethanone with 4-chloro-6-ethyl-5-fluoropyrimidine, in a ketone, ether, aliphatic hydrocarbon, or aromatic hydrocarbon solvent, to give (2R,3S/2S,3R)-3-(4-chl...	10/18/2011
8013181	Preparation of rivastigmine and its salts There are provided processes for making rivastigmine. In one embodiment, the process includes reacting S-(−)-[1-(3-hydroxyphenyl)ethyl]dimethylamine with N-ethyl-N-methyl carbamoyl chloride in the presence of an organic base to obtain a free base of rivastigmine.	09/06/2011
8008328	Methods for the treatment of diabetes-associated dyslipdemia Methods for the treatment of insulin resistance, diabetes, and/or diabetes associated dyslipidemia by administering niacin and meloxicam are disclosed. ...	08/30/2011
8003820	Process for preparing bisphosphonic acids A process for preparing a bisphosphonate compound comprises reacting a carboxylic acid with a phosphonating agent, in a cresol solvent. ...	08/23/2011
7989463	Biccyclic compounds as GATA modulators Novel bicyclic compounds of the formula (I), stereoisomers, and/or pharmaceutically acceptable salts of the novel bicyclic compounds, and/or pharmaceutically acceptable salts of the stereoisomers of the novel bicyclic compounds are provided. Additionally, methods of...	08/02/2011
7977478	Polymorphic forms of vardenafil Crystalline polymorphic forms of vardenafil and vardenafil hydrochloride, and processes for preparing them. ...	07/12/2011
7943781	Process for preparing telmisartan A process comprising cyclizing 3-amino-4-butyramido-5-methylbenzoic acid to form 2-n-propyl-4-methyl-benzimidazole-6-carboxylic acid. ...	05/17/2011
7939513	Tetracycline derivatives as antibacterial agents In accordance with one aspect, the present invention provides a compound of general formula (I), its stereoisomers thereof and/or its pharmaceutically acceptable salts thereof, which have antibacterial activity; with methods of treating infectious diseases in warm b...	05/10/2011
7935841	Bisphospholanes for use as catalysts in asymmetric reactions The invention concerns an enantiomerically enriched compound of formula (1) or the opposite enantiomer thereof wherein each of Ar1—Ar4 represent the same or different aromatic groups of up to 20 carb...	05/03/2011
7919633	Process for preparation of celecoxib There is provided a process for preparation of celecoxib by reacting 4,4,4-trifluoro-1-[4-(methyl)phenyl]butane-1,3-dione with 4-sulphonamidophenylhydrazine or its salt in a solvent medium that contains an alkyl ester. There is also provided a process for the purifi...	04/05/2011
7824919	Method for analyzing activated polyethylene glycol compounds A chemical analysis method for the determination of RO(CH2CH2O)nH, RO(C2H4O)nA, and AO(C2H4O)nA in a mixture thereof, wherein R is an alkyl group, A is a functional gr...	11/02/2010
7816484	Method for making polyethylene glycol carbonates A method for preparing a polyalkylene glycol carbonate is disclosed comprising reacting a hydroxyl functional polyalkylene glycol and a reagent selected from carbonates and chloroformates in the presence of an aromatic solvent and an amine. ...	10/19/2010
7790886	Polymorphic forms of ziprasidone and its hydrochloride salt and process for preparation thereof The present invention is related to crystalline forms of ziprasidone and its hydrochloride salt and an amorphous form of ziprasidone hydrochloride and the process for the preparation thereof. The crystalline forms and amorphous form of the invention are suitable for...	09/07/2010
7777037	Ziprasidone process A process for preparing ziprasidone having low levels of keto ziprasidone and hydroxy ziprasidone impurities. ...	08/17/2010
7772398	Process for making crystalline form I of clopidogrel hydrogen sulphate A process for preparation of crystalline Form I of clopidogrel hydrogen sulphate, that include separating the crystalline Form I of clopidogrel hydrogen sulphate from a solution of clopidogrel freebase in a solvent, which is 2-propanol or 2-butanol is provided. ...	08/10/2010
7700779	Crystalline forms of fexofenadine and its hydrochloride The present invention is related to novel polymorph of Fexofenadine and Fexofenadine hydrochloride of formula 1 and process of preparation thereof. The present invention is also directed to provide pure novel polymorphs of Fexofenadine and its hydrochloride by a sim...	04/20/2010
7659406	Process for preparing valsartan A process for preparing valsartan. ...	02/09/2010
7612098	Amorphous hydrous esomeprazole magnesium A hydrate of esomeprazole magnesium in the form of an amorphous solid is provided. Methods of preparation and use of, as well as formulation containing the hydrate of esomeprazole magnesium in the form of an amorphous solid are also provided. ...	11/03/2009
7547785	Process for preparing topotecan A process for preparing topotecan. ...	06/16/2009
7531673	Preparation of amino acid amides A process for making amino acid amides, comprising reacting an amino acid, or acid salt of an amino acid, with a halogenating agent, or with a substance that reacts with carboxylic acids to form a leaving group, to form an intermediate, then reacting the intermediat...	05/12/2009
7501515	Polymorphic form of 17-β-(N-ter. butyl carbamoyl)-4-aza-5-α-androst-1-en-3-one The present invention relates to a novel polymorphic form of 17-β-(N-ter.butyl carbamoyl)-4-aza-5-α-androst-1-en-3-one (Finasteride) of the Formula (I) and processes for preparing the form. ...	03/10/2009
7488729	Polymorphic forms of ziprasidone and its hydrochloride salt and process for preparation thereof The present invention is related to crystalline forms of ziprasidone and its hydrochloride salt and an amorphous form of ziprasidone hydrochloride and the process for the preparation thereof. The crystalline forms and amorphous form of the invention are suitable for...	02/10/2009
7476737	Eszopiclone process Eszopiclone is prepared by reacting zopiclone with an enatiomerically pure di-p-toluoyl tartaric acid, recovering a solid salt, and reacting a solid salt with a base. Zopiclone is prepared by reacting 6-(5-chloropyrid-2-yl)-5-hydroxy-7-oxo-5,6-dihydropyrrolo[3,4-b]-...	01/13/2009
7365064	Benzoxazine and benzothiazine derivatives and pharmaceutical compositions containing them The present invention relates to novel antidiabetic, hypolipidemic, antiobesity and hypocholesterolemic compounds of formula (I) their derivatives, their analogs, their tautomeric forms, their stereoisomers, their polymorphs, their pharmaceutically acceptable salts,...	04/29/2008
7355077	Process for preparing tolterodine A process for preparing tolterodine with high purity. ...	04/08/2008
7241895	Polymorphic forms of 5-[4-[2-[n-methyl-n-(2-pyridyl)amino[ethoxy]benzyl] thiazolidine-2,4-dione maleate and process for their preparation This invention relates to novel polymorphic/pseudopolymorphic forms of 5-[4-[2[N-methyl-N-(2-pyridyl)amino]ethoxy]benzyl]thiazolidine-2,4-dione maleate having formula (I). The invention also relates to a pharmaceutical composition comprising the novel polymorphic fo...	07/10/2007
7238692	Medical devices employing triazine compounds and compositions thereof The present invention relates to methods and compositions comprising compounds that treat pathophysiological conditions arising from inflammatory responses. In particular, the present invention is directed to compounds that inhibit or block glycated protein produced...	07/03/2007
7230006	Crystalline form III of anhydrous moxifloxacin hydrochloride and a process for preparation thereof A new crystalline Form III of moxifloxacin monohydrochloride and processes for making the crystalline form as well as compositions, pharmaceutical compositions, and methods utilizing the crystalline form are described. ...	06/12/2007
7230129	Process for the preparation of optically pure isomers of 2-(4-hydroxy phenoxy)-2-methyl-butyric acid methyl ester The invention provides a process for preparing R-(+)-2-(4-hydroxyphenoxy)-2-methyl-butyric acid methyl ester of the formula (I): Various embodiments and variants are provided. The invention also provides ...	06/12/2007
7202254	Antibacterial compounds: process for their preparation and pharmaceutical compositions containing them The present invention relates to novel triazole compounds of formula (I), their derivatives, their analogs, their tautomeric forms, their regioisomers, their rotamers, their stereoisomers, their polymorphs, their pharmaceutically acceptable salts, their pharmaceutic...	04/10/2007
7189853	Process for the preparation of [R-(E)-1-[[[1-[3-[2-[7-chloro-2-quinolinyl]ethenyl]phenyl]-3-[2-(1-hydroxy-1-methylethyl)phenyl]propyl]thio]methyl]cyclopropaneacetic acid (Montelukast) and its pharmaceutically acceptable salts The present invention is related to a process for preparing montelukast involving the compound of formula (VI): wherein X═CN or CONH2. ...	03/13/2007

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Attorney: Franks; Robert A.