Did You Know...
...that two musicians were responsible for the invention of color print film? Fascinated by photography, Leopold Godowsky and Leopold Mannes worked together to produce an easy-to-use, practical color film. They worked full time as music teachers and gave concerts while experimenting during their off hours in Mannes' kitchen. Their success earned them full-time, well-paying jobs at Kodak and their efforts resulted in Kodachrome film, which was introduced in 1935.
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| Number | Title | Issue Date |
| 8173849 | Therapeutic compounds A (−)-stereoisomer of formula (I): (formula I), wherein X is H or F; or a pharmaceutically acceptable salt or prodrug thereof, is useful as an anesthetic. ... | 05/08/2012 |
| 8168756 | Levetiracetam immunoassays Methods, compositions and kits are disclosed directed at levetiracetam derivatives, immunogens, signal generating moieties, antibodies that bind levetiracetam and immunoassays for detection of levetiracetam. ... | 05/01/2012 |
| 8163701 | Prodrugs of active agents Disclosed herein are prodrugs of active agents which contain at least one amine, phenol, carboxylic acid, or thiol functionality. Also disclosed herein are methods of making prodrugs of active agents, pharmaceutical compositions of prodrugs of active agents and meth... | 04/24/2012 |
| 8148335 | De-N-acetyl sialic acid antigens, antibodies thereto, and methods of use in cancer therapy The present invention generally provides compositions methods and composition relating to the diagnosis and/or treatment of cancers having a cell surface de-N-acetylated sialic acid antigen, e.g., an at least partially de-N-acetylated ganglioside and/or a de-N-acety... | 04/03/2012 |
| 8143295 | Compounds having activity in correcting mutant-CFTR processing and uses thereof The invention provides compositions, pharmaceutical preparations and methods for correcting cellular processing (e.g., folding, trafficking, or post-translational modification) of a mutant-cystic fibrosis transmembrane conductance regulator protein (e.g., ΔF508 CFT... | 03/27/2012 |
| 8143031 | Production of N-acylated sulphur-containing amino acids with microorganisms having enhanced N-acyltransferase enzymatic activity The present invention claims an isolated polypeptide having L-amino-acid-N-acyl transferase enzymatic activity and a modified microorganism in which this enzyme is overexpressed. Substrates of said enzyme include mainly methionine and their derivatives or analogs. O... | 03/27/2012 |
| 8138155 | Compounds for intracellular delivery of therapeutic moieties to nerve cells A compound for delivering a non-cytotoxic therapeutic moiety into nerve cells, the compound having the general formula: B-L-TM where: B is a binding agent capable of selectively binding to a nerve cell surface r... | 03/20/2012 |
| 8129365 | Water-soluble, fluorescent compounds for detection of potassium ions The invention provides chromoionophore compounds comprising a triazacryptand (TAC) K+ ionophore conjugated to at least a first chromophoric moiety (e.g., xanthylium dyes and derivatives thereof). In related embodiments, the chromoionophore compounds furth... | 03/06/2012 |
| 8105789 | Diagnosis and treatment of infectious diseases through indel-differentiated proteins A compound capable of specifically binding to pathogen EF-1α but not host EF-1α, wherein the compound binds to any part of an amino acid sequence having at least 70% sequence identity to amino acids 240-230 of SEQ ID NO:22. ... | 01/31/2012 |
| 8105607 | Porin B (PorB) as a therapeutic target for prevention and treatment of infection by The present invention features the use of PorB polypeptide as a therapeutic agent. In specific embodiment the invention features a chlamydial vaccine based on a PorB polypeptide, as well as methods for induction of a protective immune response against infecti... | 01/31/2012 |
| 8105570 | Methods and compositions for controlled release of drugs This invention provides a method and compositions for the controlled release of drugs that have been attached by means of a covalent bond to a polymer or other moiety that blocks activity of the drug until it has been released. A two-stage process is provided in whi... | 01/31/2012 |
| 8101174 | Pharmaceutical compositions for treating arthritis and inflammatory disease The biological effects of the cytokine TNF are mediated by binding to receptors on the surface of cells. This disclosure describes new proteins and polynucleotides that promote enzymatic cleavage and release of TNF receptors. Also provided are methods for identifyin... | 01/24/2012 |
| 8097701 | Aldehyde tags, uses thereof in site-specific protein modification The invention features compositions and methods for site-specific modification of proteins by incorporation of an aldehyde tag. Enzymatic modification at a sulfatase motif of the aldehyde tag through action of a formylglycine generating enzyme (FGE) generates a form... | 01/17/2012 |
| 8097591 | Polysialic acid derivatives, methods of production, and uses in enhancing cancer antigen production and targeting The present invention relates to compositions and methods of their production and use, including use in increasing de-N-acetyl sialic acid antigen of a mammalian cell and methods that exploit the increase in deNAc sialic acid antigen on such cells. ... | 01/17/2012 |
| RE43096 | Tagged extendable primers and extension products This invention provides a duplex comprising an oligonucleotide primer and a template, wherein the primer is coupled chemically to a chromophore or fluorophore so as to allow chain extension by a polymerase. In one embodiment, the primer is extended by a polymerase t... | 01/10/2012 |
| 8084209 | HMGCR isoforms in prediction of efficacy and identification of cholesterol-modulating compounds The present invention provides methods for assessing a subject's responsiveness to a HMGCR inhibitor therapy, and selection of a HMGCR inhibitor therapy based upon such methods. The invention further provides methods for identifying agents that modulate HMGCR activi... | 12/27/2011 |
| 8076103 | Eukaryotic expression system for the incorporation of stable isotopes into proteins Methods for producing stable isotope-labeled recombinant protein are provided. The methods include isolating a stable isotope-labeled recombinant protein from a Trichoplusia ni larva expressing a recombinant protein, which Trichoplusia ni larva has ing... | 12/13/2011 |
| 8071839 | Transgenic mouse comprising a polynucleotide encoding human or humanized C5aR and methods of production and use The present invention relates to transgenic non-human mammals comprising a polynucleotide encoding a human or humanized C5aR. The invention also relates to use of the transgenic non-human mammals in methods of screening for agonists, inverse agonists and antagonists... | 12/06/2011 |
| 8071818 | Therapeutic compounds A (−)-stereoisomer of formula (I): [insert formula (I) wherein X is H or F; or a pharmaceutically acceptable salt or prodrug thereof, useful as an anesthetic. ... | 12/06/2011 |
| 8071286 | Gene expression profiling in biopsied tumor tissues The invention concerns sensitive methods to measure mRNA levels in biopsied tumor tissues, including archived paraffin-embedded biopsy material. The invention also concerns breast cancer gene sets important in the diagnosis and treatment of breast cancer, and method... | 12/06/2011 |
| 8071096 | Anti-C5aR antibodies and uses thereof The present invention relates to antibodies which bind to C5aR and which are useful in diagnostic and therapeutic methods. The antibodies of the present invention are reactive with an extracellular loop of C5aR other than the N-terminal domain and are ... | 12/06/2011 |
| 8071054 | Microfluidic magnetophoretic device and methods for using the same A microfluidic device may employ one or more sorting stations for separating target species from other species in a sample. The separation is driven by magnetophoresis. A sorting station generally includes separate buffer and sample streams. A magnetic field gradien... | 12/06/2011 |
| 8067178 | Gene expression markers for prediction of patient response to chemotherapy The present invention relates to gene sets useful in assessing prognosis and/or predicting the response of cancer, e.g. colorectal cancer to chemotherapy. In addition, the invention relates to a clinically validated cancer test, e.g. colorectal test, for assessment ... | 11/29/2011 |
| 8066987 | Bacterial delivery of biologically active polypeptides The present invention relates to methods for the delivery of biologically active polypeptides to a subject by colonizing non-pathogenic Gram negative bacteria. Also provided by this invention are methods of treating or preventing diseases by administering colonizing... | 11/29/2011 |
| 8058023 | Assessment of cardiac health and thrombotic risk in a patient The invention features methods and compositions for assessing risk, particularly immediate risk, of thrombotic events in patients with suspected or known vascular disease, and more particularly to assessing risk of thrombotic events in patients with coronary artery ... | 11/15/2011 |
| 8032347 | Methods and apparatus for protein sequence analysis Apparatus, methods, media, signals and data structures for protein sequence analysis are disclosed. A method includes identifying, from among a first group of aligned protein sequences having at least a threshold degree of alignment with a first protein sequence, a ... | 10/04/2011 |
| 8032346 | System and method for high-content oncology assay The present invention provides an apparatus, system, method and computer program and computer program product for analyzing cellular samples. One embodiment of the apparatus and method provides a multiparameter assay that provides information with respect to cell pr... | 10/04/2011 |
| 8030095 | Gel microdrop composition and method of using the same A gel microdrop composition is provided. In certain embodiments, the gel microdrop composition contains a polymer matrix, an effector particle that releases an effector molecule into the polymer matrix, a first reporter particle that emits a first optically detectab... | 10/04/2011 |
| 8029826 | Chlorite in the treatment of neurodegenerative disease The invention features methods of treating a macrophage-associated neurodegenerative disease such as amyotrophic lateral sclerosis (ALS), Alzheimer's disease (AD), or multiple sclerosis (MS) in a subject by administering chlorite in an amount effective to decrease b... | 10/04/2011 |
| 8017313 | Human G protein-coupled receptor and modulators thereof for the treatment of cardiovascular disorders The present invention relates to methods of identifying whether a candidate compound is a modulator of a G protein-coupled receptor (GPCR). In some embodiments, the GPCR is mammalian, preferably human. In some embodiments, the GPCR is expressed endogenously by cardi... | 09/13/2011 |
| 8008353 | Methods for modulating macrophage proliferation using polyamine analogs Methods for modulating macrophage proliferation in an individual afflicted with or at risk for a macrophage-associated disease are provided. The methods employ a polyamine analog, or salt or protected derivative thereof. Macrophage proliferation has been implicated ... | 08/30/2011 |
| 7999079 | Therapeutic monoclonal antibodies that neutralize botulinum neurotoxins This invention provides antibodies that specifically bind to and neutralize botulinum neurotoxin type A (BoNT/A) and the epitopes bound by those antibodies. The antibodies and derivatives thereof and/or other antibodies that specifically bind to the neutralizing epi... | 08/16/2011 |
| 7998685 | Methods of identifying candidate compounds of the human G protein-coupled receptor, GPR50, as modulators of body mass or adiposity The present invention relates to methods of using a G protein-coupled receptor (GPCR) to screen one or more candidate compounds as a modulator of body mass or of adiposity or of percentage body fat in a subject or as a pharmaceutical agent for obesity and conditions... | 08/16/2011 |
| 7985783 | Aldehyde tags, uses thereof in site-specific protein modification The invention features compositions and methods for site-specific modification of proteins by incorporation of an aldehyde tag. Enzymatic modification at a sulfatase motif of the aldehyde tag through action of a formylglycine generating enzyme (FGE) generates a form... | 07/26/2011 |
| 7970549 | System and method for high-content oncology assay The present invention provides an apparatus, system, method and computer program and computer program product for analyzing cellular samples. One embodiment of the apparatus and method provides a multiparameter assay that provides information with respect to cell pr... | 06/28/2011 |
| 7968339 | Method of inducing genome reorganization via intracellular activation of thermostable multifrequency DNA-cleaving enzyme The present invention relates to a method for increasing genetic recombination frequency in a genomic DNA and a method for inducing genome rearrangement. Specifically, according to the present invention there are provided: the method for increasing genetic recombina... | 06/28/2011 |
| 7964200 | Methods and compositions for immunizing against infection The present invention relates, in part, to methods and compositions for immunizing against infection by Chlamydia trachomatis. The methods and compositions rely, in part, on administering an immunogenic composition comprising one or more peptides derived from... | 06/21/2011 |
| 7959923 | Method for treating cancer using anti-Wnt2 monoclonal antibodies and siRNA This invention relates to methods of inhibiting the growth of cells, in particular cancer cells, that overexpress Wnt2. The methods comprise contacting the cell with an agent that binds to Wnt2 mRNA or Wnt2 protein, interferes with Wnt2 signaling or inhibits binding... | 06/14/2011 |
| 7955277 | Method and apparatus for physiological testing A device and method to test the level of physical effort of an individual is disclosed. The device has a moveable member which may be a shaft, a sensor for measuring force applied to the shaft; and a resistance means to vary the resistance to movement of the moveabl... | 06/07/2011 |
| 7939626 | Chemoselective ligation The present invention features a chemoselective ligation reaction that can be carried out under physiological conditions. In general, the invention involves condensation of a specifically engineered phosphine, which can provide for formation of an amide bond between... | 05/10/2011 |
