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| Number | Title | Issue Date |
| 7834063 | Benzonitryl and nitrobenzyl derivatives that modulate androgen receptors This invention relates to benzonitryl and nitrobenzyl derivatives that are modulators of androgen, glucocorticoid, mineralocorticoid, and progesterone receptors, and also to the methods for the making and use of such compounds. These compounds are useful, for exampl... | 11/16/2010 |
| 7785853 | Polypeptides having cellobiohydrolase I activity and polynucleotides encoding same The present invention relates to polypeptides having cellobiohydrolase I activity and polynucleotides having a nucleotide sequence which encodes for the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the nucle... | 08/31/2010 |
| 7731851 | Waste water treatment The present invention relates to wastewater treatment in general and to methods of controlling odors and degrading compounds contained in wastewater in particular. ... | 06/08/2010 |
| 7723385 | Aniline derivatives as selective androgen receptor modulators This invention relates to non-steroidal compounds that are modulators of androgen, glucocorticoid, mineralocorticoid, and progesterone receptors, and also to the methods for the making and use of such compounds. ... | 05/25/2010 |
| 7641928 | Dewatering whole stillage The present invention relates to a method of dewatering whole stillage comprising subjecting whole stillage to one or more enzymes capable of degrading a whole stillage component and separating the material obtained in step i) into a solid fraction and a liquid frac... | 01/05/2010 |
| 7582458 | Fermentation processes and compositions The present invention provides improved fermentation processes, including for use in an ethanol production process. The improved fermentation processes include applying at least one fatty acid oxidizing enzyme (especially a lipoxygenase) in a fermentation process. T... | 09/01/2009 |
| 7572820 | Chemical compounds This invention relates to non-steroidal compounds that are modulators of androgen receptor, and also to the methods for the making and use of such compounds. ... | 08/11/2009 |
| 7514470 | Aniline derivatives as selective androgen receptor modulators This invention relates to non-steroidal compounds that are modulators of androgen, glucocorticoid, mineralocorticoid, and progesterone receptors, and also to the methods for the making and use of such compounds. ... | 04/07/2009 |
| 7338960 | Phenylalkanoic acid and phenyloxyalkanoic acid derivatives as hPPAR activators A compound of formula (I) or a pharmaceutically acceptable salt, solvate, or hydrolysable ester thereof, wherein: ... | 03/04/2008 |
| 7338959 | Diamino-pyrimidines and their use as angiogenesis inhibitors Benzimidazole derivatives, which are useful as TIE-2 and/or VEGFR-2 inhibitors are described herein. The described invention also includes methods of making such benzimidazole derivatives as well as methods of using the same in the treatment of hyperproliferative di... | 03/04/2008 |
| 7329685 | 1-Phenyl-2-oxo-3-sulfonylamino-pyrrolidine derivatives and related compounds as factor Xa inhibitors for the treatment of acute vascular diseases The invention relates to compounds of formula (I): wherein substituents are as defined. ... | 02/12/2008 |
| 7326785 | Pyrrolidine derivatives as factor XA inhibitors The invention relates to compounds of formula (I) processes for their preparation, pharmaceutical compositions containing them and to their use in medicine, particularly use in the amelioration of a clinical cond... | 02/05/2008 |
| 7319104 | hPPARs activators Compounds of formula (1) or a pharmaceutically acceptable salt, solvate, acid isostere, or hydrolyzable ester thereof, are disclosed. Methods of making and using the compounds are also disclosed. In particular methods for treating diseases or conditions associated w... | 01/15/2008 |
| 7282497 | Pyrrolidin-2-one derivatives as inhibitors of factor xa The invention relates to compounds of formula (Ic) processes for their preparation, pharmaceutical compositions containing them and to their use in medicine, particularly use in the amelioration of a clinical con... | 10/16/2007 |
| 7262203 | Pyrimidineamines as angiogenesis modulators Pyrimidine derivatives, which are useful as VEGFR2 inhibitors are described herein. The described invention also includes methods of making such pyrimidine derivatives as well as methods of using the same in the treatment of hyperproliferative diseases. ... | 08/28/2007 |
| 7244849 | Process for preparing a thiazole PPAR-ligand and polymorphs thereof A method of preparing a compound of formula (I), and pharmaceutically acceptable salts and solvates thereof. Polymorphs of this compound and their use as PPAR ligands are also disclosed ... | 07/17/2007 |
| 7241793 | Phenyloxyalkanonic acid derivatives as hPPAR activators A compound of formula (I) or a pharmaceutically acceptable salt, solvate, or hydrolysable ester thereof, wherein: ... | 07/10/2007 |
| 7238813 | Chemical compounds Benzimidazole derivatives, which are useful as TIE-2 and/or VEGFR2 inhibitors are described herein. The described invention also includes methods of making such benzimidazole derivatives as well as methods of using the same in the treatment of hyperproliferative dis... | 07/03/2007 |
| 7235544 | 3-sulfonylamino-pyrrolidine-2-one derivatives as inhibitors of factor Xa The invention relates to compounds of formula (I): wherein substituents are as defined. ... | 06/26/2007 |
| 7229998 | Thiazole and oxazole derivatives as activators of human peroxisome proliferator activated receptors The present invention provides a compound of formula (I): wherein R1–R5, R25, R26, Y and X2 are as defined herein. The compounds a... | 06/12/2007 |
| 7226929 | Pyrrolidin-2-one derivatives as inhibitors of factor xa The invention relates to compounds of formula (Ic) processes for their preparation, pharmaceutical compositions containing them and to their use in medicine, particularly use in the amelioration of a clinical con... | 06/05/2007 |
| 7199239 | Chemical compounds A compound of formula (I) or a pharmaceutically acceptable salt, solvate, or hydrolysable ester thereof, Wherein: R1 and R2 are independently hydrogen or C... | 04/03/2007 |
| 7196107 | Thia-and oxazoles and their use as ppars activators A compound of formula (I) or pharmaceutically acceptable salts and solvates thereof. R1 and R2 are independently H or C1-3alkyl, m is 0–3; X1 is NH, NCH3, O, S; R3, R4 and R5 a... | 03/27/2007 |
| 7189712 | 1,3-Oxazole compounds for the treatment of cancer Oxazole derivatives, which are useful as VEGFR2, CDK2, and CDK4 inhibitors are described herein. The described invention also includes methods of making such oxazole derivatives as well as methods of using the same in the treatment of hyperproliferative diseases. | 03/13/2007 |
| 7157479 | Oxazol/thiazol-derivatives activators of the hPPAR-alpha receptor A compound of formula (I) and pharmaceutically acceptable salts, solvates and hydrolysable esters thereof Wherein X1 represents O or S; R1 and R2 are ind... | 01/02/2007 |
| 7141591 | 1,2,4-oxadiazole derivatives as hPPAR alpha agonists A compound of formula (I) and pharmaceutically acceptable salts, solvates and hydrolysable esters thereof wherein: X1 is O or S; X2 is O or S; n is 1–3, One of Y and Z is N, and the other is O; R1 and R2 are independentl... | 11/28/2006 |
| 7129253 | Compounds Compounds of formula (I) wherein R1, R2, R3, R4, R5, R6, R7, R8, A, D, X, Y and Z have the meaning as defined in the claims exhibit protein tyrosine kinase and protein serin/threonine kinase inhibitory activity. ... | 10/31/2006 |
| 7105551 | Thiazole derivatives for treating PPAR related disorders The present invention provides compounds of formula (I). These compounds are used for the treatment of PPAR related diseases ... | 09/12/2006 |
| 7105530 | Pyrimidineamines as angiogenesis modulators Pyrimidine derivatives, which are useful as VEGFR2 inhibitors are described herein. The described invention also Includes methods of making such pyrimidine derivatives as well as methods of using the same in the treatment of hyperproliferative diseases. ... | 09/12/2006 |
| 7105529 | Substituted oxindole derivatives as protein tyrosine and as protein serine/threonine kinase inhibitors and compositions and methods of treating chemotherapy and radiation therapy side effects Compounds of formula (I): wherein X is N, CH, CCF3, or C(C1-12 aliphatic); R4 is sulfonic acid, C1-12 aliphatic-sulfonyl, sulfonyl-C1-12 aliphatic, C1-12 aliphatic-sulfonyl-C1-6 aliphatic, ... | 09/12/2006 |
| 7091225 | Substituted oxazoles and thiazoles as hPPAR alpha agonists Compounds of formula (I) and pharmaceutically acceptable salts, solvates and hydrolysable esters thereof wherein X is O or S X1 is O or S; X is S or O; R1 and R2 are independently H, methyl, or halogen; R4 and R5 are independently H or C1-3 alkyl or R4 and R5 may, t... | 08/15/2006 |
| 7091237 | Furan and thiophene derivatives that activate human peroxisome proliferator activated receptors A compound of formula (I) or pharmaceutically acceptable salts and solvates thereof, for the treatment of a hPPAR mediated disease or condition ... | 08/15/2006 |
| 7084161 | Method for treating inflammatory diseases or conditions A method of treating inflammatory diseases comprising administering 2-[2-methyl-4-[[[4-methyl-2-[4-(trifluoromethyl)phenyl]-1,3-thiazol-5-yl]methyl]sulfanyl]phenoxy]acetic acid is disclosed. ... | 08/01/2006 |
| 6958352 | Compounds for inhibiting insulin secretion and methods related thereto Compounds, compositions and methods for altering insulin secretion, particularly in the context of treatment of subjects having, or suspected of being at risk for having, diabetes mellitus. The compounds have the following structure (I): | 10/25/2005 |
| 6911455 | Methods for preparing pharmaceutical formulations The invention relates to pharmaceutical formulations and methods for preparing pharmaceutical formulations of histamine releasers. The present invention provides methods for determining the concentration of physiologically acceptable excipients for use in the formul... | 06/28/2005 |
