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| Number | Title | Issue Date |
| 8178082 | Methods for up-regulating PAP1 in animals suffering from pancreatic disorders The present invention is directed to interleukin-22 polypeptides and nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptid... | 05/15/2012 |
| 8147830 | Antibody fragment-polymer conjugates and uses of same Described are conjugates formed by an antibody fragment covalently attached to a non-proteinaceous polymer, wherein the apparent size of the conjugate is at least about 500 kD. The conjugates exhibit substantially improved half-life, mean residence time, and/or clea... | 04/03/2012 |
| 8107693 | Artificial intelligence system for genetic analysis The present invention provides a complete artificial intelligence system for the acquisition and analysis of nucleic acid array hybridization information. The system includes a central data processing facility and one or more user facilities, linked by encrypted con... | 01/31/2012 |
| 8101571 | Treatment methods using NGF variants NGF variants which have trkC-binding activity and trkC-signal inducing activity are provided. The variants optionally have trkA or trkB binding and signal induction activity. The NGF variants of the present invention are useful in the treatment of neuronal disorders... | 01/24/2012 |
| 8097587 | IGF-I protein variants for treating IGFBP-1-related disorders IGF-I variants having an alanine, glycine, or serine amino acid residue at position 16, 25, 49 or at positions 3 and 49 of native-sequence IGF-I are provided that are useful to treat a disorder characterized by dysregulation of the GH/IGF axis in a mammal, such as a... | 01/17/2012 |
| 8068990 | Diagnosis of intra-uterine infection by proteomic analysis of cervical-vaginal fluids The invention concerns the identification of proteomes of biological fluids and their use in determining the state of maternal/fetal conditions, including maternal conditions of fetal origin, chromosomal aneuploidies, and fetal diseases associated with fetal growth ... | 11/29/2011 |
| 8067664 | PRO224 gene disruptions, and methods related thereto The present invention relates to transgenic animals, as well as compositions and methods relating to the characterization of gene function. Specifically, the present invention provides transgenic mice comprising disruptions in PRO224, PRO9783, PRO1108, PRO34000, PRO... | 11/29/2011 |
| 7956237 | Gene disruptions, compositions and methods relating thereto The present invention relates to transgenic animals, as well as compositions and methods relating to the characterization of gene function. Specifically, the present invention provides transgenic mice comprising disruptions in PRO196, PRO217, PRO231, PRO236, PRO245,... | 06/07/2011 |
| 7951546 | Compositions and methods for the diagnosis and treatment of tumor The present invention is directed to compositions of matter useful for the diagnosis and treatment of tumor in mammals and to methods of using those compositions of matter for the same. ... | 05/31/2011 |
| 7939268 | Compositions and methods for the diagnosis and treatment of tumor The present invention is directed to compositions of matter useful for the diagnosis and treatment of tumor in mammals and to methods of using those compositions of matter for the same. ... | 05/10/2011 |
| 7935671 | Pantropic neurotrophic factors Pantropic neurotrophic factors which have multiple neurotrophic specificities are provided. The pantropic neurotrophic factors of the present invention are useful in the treatment of neuronal disorders. Nucleic acids and expression vectors encoding the pantropic neu... | 05/03/2011 |
| 7919254 | Tissue analysis and kits therefor This invention relates to methods of analyzing a tissue sample from a subject. In particular, the invention combines morphological staining and/or immunohistochemistry (IHC) with fluorescence in situ hybridization (FISH) within the same section of a tissue sample. T... | 04/05/2011 |
| 7879334 | Fusion molecules and treatment of IgE-mediated allergic diseases The invention concerns bifunctional fusion molecules for the treatment of IgE-mediated allergic conditions and FcεRI-mediated autoimmune conditions. The invention provides a new therapeutic approach for the treatment of both acute and late-phase allergic responses ... | 02/01/2011 |
| 7879324 | Fusion molecules and methods for treatment of immune diseases The invention concerns bifunctional fusion molecules, and novel, safer and more efficacious methods for the treatment of immune disorders resulting from excessive or unwanted immune responses. The invention provides methods for the suppression of type I hypersensiti... | 02/01/2011 |
| 7842789 | Antibody fragment-polymer conjugates and uses of same Described are conjugates formed by an antibody fragment covalently attached to a non-proteinaceous polymer, wherein the apparent size of the conjugate is at least about 500 kD. The conjugates exhibit substantially improved half-life, mean residence time, and/or clea... | 11/30/2010 |
| 7803915 | Antibody compositions for the diagnosis and treatment of tumor The present invention is directed to compositions of matter useful for the diagnosis and treatment of tumor in mammals and to methods of using those compositions of matter for the same. ... | 09/28/2010 |
| 7795412 | Nucleic acids encoding PRO6308 polypeptides and related vectors and host cells The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of ... | 09/14/2010 |
| 7785588 | Anti-neurturin receptor-A antibody compositions comprising cytokines or neurotrophic factors NTNRα, NTNRα extracellular domain (ECD), NTNRα variants, chimeric NTNRα (e.g., NTNRα immunoadhesion), and antibodies which bind thereto (including agonist and neutralizing antibodies) are disclosed. Various uses for these molecules are described, including meth... | 08/31/2010 |
| 7727527 | Anti-NGF antibodies for the therapeutic treatments The present invention relates generally to methods of using anti-NGF antibodies in the treatment of various NGF-related disorders, including asthma, arthritis and psoriasis. The methods are effective in treating these disorders in a patient without having a signific... | 06/01/2010 |
| 7704498 | ErbB4 antagonists The present invention concerns methods and means for controlling excessive proliferation and/or migration of smooth muscle cells, and in particular for treating stenosis, by using antagonists of a native ErbB4 receptor. The invention further concerns a method for th... | 04/27/2010 |
| 7691973 | GFRα3 polypeptides The present invention relates to nucleotide sequences, including expressed sequence tags (ESTs), oligonucleotide probes, polypeptides, vectors and host cells expressing, and immunoadhesions and antibodies to mammalian GFRα3, a novel α-subunit receptor of the GDNF ... | 04/06/2010 |
| 7691606 | Polynucleotides encoding GDNFRα GDNFRα, GDNFRα extracellular domain (ECD), GDNFRα variants, chimeric GDNFRα (e.g., GDNFRα immunoadhesin), and antibodies which bind thereto (including agonist and neutralizing antibodies) are disclosed. Various uses for these molecules are described, including ... | 04/06/2010 |
| 7674589 | Methods for tissue analysis This invention relates to methods of analyzing a tissue sample from a subject. In particular the invention combines morphological staining and/or immunohistochemistry (IHC) with fluorescence in situ hybridization (FISH) within the same section of a tissue sample. Th... | 03/09/2010 |
| 7655230 | Co-administration of a tissue plasminogen activator, anti-CD11b antibody and anti-CD18 antibody in stroke A method for improving clinical outcome in focal ischemic stroke in a mammal by increasing cerebral blood flow and/or reducing infarct size is described which involves administering an effective amount of an anti-CD18 antibody to the mammal, in the absence of remova... | 02/02/2010 |
| 7615383 | Methods for treating neuropathy by agonist anti-trk-C monoclonal antibodies The invention concerns agonist anti-trkC monoclonal antibodies which mimic certain biological activities of NT-3, the native ligand of trkC. The invention further concerns the use of such antibodies in the prevention and/or treatment of cellular degeneration, includ... | 11/10/2009 |
| 7596455 | Crystallization of IGF-1 Crystalline IGF-1 is provided along with a method for production thereof. Crystallizing IGF-1 comprises the steps of mixing an aqueous solution comprising IGF-1 with a reservoir solution comprising a precipitant to form a mixture; and crystallizing the mixture, opti... | 09/29/2009 |
| 7589172 | PRO256 polypeptides The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of ... | 09/15/2009 |
| 7582293 | Anti-PRO6308 antibodies The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of ... | 09/01/2009 |
| 7575748 | Methods of treatment using anti-ErbB antibody-maytansinoid conjugates The application concerns methods of treatment using anti-ErbB receptor antibody-maytansinoid conjugates, and articles of manufacture suitable for use in such methods. In particular, the invention concerns ErbB receptor-directed cancer therapies, using anti-ErbB rece... | 08/18/2009 |
| 7552930 | Snow sled A snow sled for use by a seated rider includes a body section, a seat section having an underside for engaging the snow and a top side for receiving the seated rider, the seat section attached to the body section, a foot section having an underside for engaging the ... | 06/30/2009 |
| 7544659 | Promotion of axonal regeneration The present invention concerns a method of promoting axonal regeneration. In particular, the invention concerns a method of promoting the growth or regeneration of neurons, and treating disease or conditions associated with the loss, loss of function or dysfunction ... | 06/09/2009 |
| 7534440 | Fusion molecules and methods for treatment of immune diseases The invention concerns bifunctional fusion molecules, and novel, safer and more efficacious methods for the treatment of immune disorders resulting from excessive or unwanted immune responses. The invention provides methods for the suppression of type I hypersensiti... | 05/19/2009 |
| 7528233 | Pantropic neurothrophic factors Pantropic neurotrophic factors which have multiple neurotrophic specificities are provided. The pantropic neurotrophic factors of the present invention are useful in the treatment of neuronal disorders. Nucleic acids and expression vectors encoding the pantropic neu... | 05/05/2009 |
| 7507405 | Antibody fragment-polymer conjugates and uses of same Described are conjugates formed by an antibody fragment covalently attached to a non-proteinaceous polymer, wherein the apparent size of the conjugate is at least about 500 kD. The conjugates exhibit substantially improved half-life, mean residence time, and/or clea... | 03/24/2009 |
| 7384632 | Agonist anti-trk-C monoclonal antibodies The invention concerns agonist anti-trkC monoclonal antoibodies which mimic certain biological activities of NT-3, the native ligand of trkC. The invention further concerns the use of such antibodies in the prevention and/or treatment of cellular degeneration, inclu... | 06/10/2008 |
| 7504480 | PRO10275 polypeptides The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of ... | 03/17/2009 |
| 7503568 | Sled board with tracking bottom The invention features a soft foam sled board for use by a sitting or kneeling rider to slide over a snow or ice covered surface. The sled is prepared from a shaped polyethylene foam core, and at least the bottom surface of the core is covered by a slick, polyethyle... | 03/17/2009 |
| 7491797 | PRO6308 polypeptide The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of ... | 02/17/2009 |
| 7488804 | Modified fusion molecules for treatment of allergic disease The present invention comprises a fusion molecule comprising a Fcε fragment sequence including functionally active CH2, CH3 and CH4 domains of the constant region of an IgE heavy chain (CHε2-CHε3-CHε4 sequence) linked at its C-terminus to the N-terminus of a sec... | 02/10/2009 |
| 7468252 | Methods for tissue analysis This invention relates to methods of analyzing a tissue sample from a subject. In particular, the invention combines morphological staining and/or immunohistochemistry (IHC) with fluorescence in situ hybridization (FISH) within the same section of a tissue sample. T... | 12/23/2008 |
