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| Number | Title | Issue Date |
| 7709607 | Adiponectin variants An adiponectin variant with one or more amino acid modifications relative to a corresponding parent adiponectin, wherein the solubility of the variant is improved by at least 3-fold relative to residues 110-244 of human adiponectin. ... | 05/04/2010 |
| 7687461 | Treatment of TNF-α related disorders with TNF-α variant proteins The invention relates to novel proteins with TNF-alpha antagonist activity and nucleic acids encoding these proteins. The invention further relates to the use of the novel proteins in the treatment of TNF-alpha related disorders. ... | 03/30/2010 |
| 7678886 | Pharmaceutical compositions of adiponectin variants and methods of storage A composition comprising an adiponectin variant at a concentration of at least 2.0 mg/mL, and a pharmaceutically acceptable carrier, wherein less than 20% of said adiponectin variant would aggregate after storage at 4° C. for one week in 10 mM PO4, 150 m... | 03/16/2010 |
| 7662925 | Optimized Fc variants and methods for their generation The present invention relates to optimized Fc variants, methods for their generation, and antibodies and Fc fusions comprising optimized Fc variants. ... | 02/16/2010 |
| 7662367 | Pharmaceutical compositions for the treatment of TNF-α related disorders The invention relates to a pharmaceutical composition comprising a variant TNF-α protein that inhibits the activity of soluble TNF-α while substantially maintaining the activity of transmembrane TNF-α a buffer and a tonicity agent wherein said composition has a p... | 02/16/2010 |
| 7657380 | Methods of generating variant antibodies with increased host string content The present invention relates to novel methods for generating variant proteins with increased host string content by comparing a parent protein sequence with two or more natural protein sequences from a host species, analyzing one or more amino acid strings of the p... | 02/02/2010 |
| 7642340 | PEGylated TNF-α variant proteins The present invention relates to the use of simulation technology to rationally optimize the locations and sizes of attached polymeric moieties for modification of therapeutic proteins and the proteins generated from this method. ... | 01/05/2010 |
| 7610156 | Methods for rational pegylation of proteins The present invention relates to the use of simulation technology to rationally optimize the locations and sizes of attached polymeric moieties for modification of therapeutic proteins and the proteins generated from this method. ... | 10/27/2009 |
| 7553930 | BAFF variants and methods thereof The invention relates to novel proteins with BAFF dominant negative antagonist, receptor antagonist activity and agonist activity and nucleic acids encoding these proteins. The invention further relates to the use of the novel proteins in the treatment of BAFF or AP... | 06/30/2009 |
| 7446174 | Protein based TNF-α variants for the treatment of TNF-α related disorders The invention relates to novel proteins with TNF-α antagonist activity and nucleic acids encoding these proteins. The invention further relates to the use of the novel proteins in the treatment of TNF-α related disorders. ... | 11/04/2008 |
| 6890764 | Encoding and decoding of array sensors utilizing nanocrystals Described herein are assays and components for encoding and decoding microspheres. Each assay or component described utilizes at least one nanocrystal. ... | 05/10/2005 |
