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| Number | Title | Issue Date |
| 6254885 | Oral cyclosphorin formulations Improved oral cyclosporin formulations which have high bioavailability and are capable of admiration in hard capsules are provided. In the subject formations, cyclosporin is delivered in an orally acceptable vehicle comprising at least one alkanol solvent... | 07/03/2001 |
| 6074853 | Sequence alterations using homologous recombination The invention relates to methods for targeting an exogenous polynucleotide or exogenous complementary polynucleotide pair to a predetermined endogenous DNA target sequence in a target cell by homologous pairing, particularly for altering an endogenous DNA... | 06/13/2000 |
| 6033660 | Method of treating a nervous system injury with cultured schwann cells A method for enhancing the survival and/or proliferation of Schwann cells (especially human Schwann cells) in cell culture is disclosed which involves culturing the cells in serum free culture medium comprising gas6 and other mitogenic agents, such as her... | 03/07/2000 |
| 6022529 | Photoresponsive sunscreen compositions The disclosure provides sunscreen compositions comprising a carrier for topical administration and photoresponsive first sunscreen agents which are capable of undergoing intramolecular photorearrangements to form second sunscreen agents. The second sunscr... | 02/08/2000 |
| 6004513 | Automatic device for nucleic acid sequence detection employing amplification probes Methods and compositions are provided for detecting nucleic acid sequences. In particular, pairs of probes are employed, where the pair defines a substantially contiguous sequence on a target nucleic acid. Each of the pairs has a side chain which forms a ... | 12/21/1999 |
| 5876929 | Representational approach to DNA analysis Methodology is provided for developing probes for identifying sequence differences between two related DNA populations, sets of DNA fragments or collections of restriction-endonuclease-cleaved DNA or CODA. The method employs an initial stage to obtain a r... | 03/02/1999 |
| 5824868 | Plants having modified response to ethylene The invention includes transformed plants having at least one cell transformed with a modified ETR nucleic acid. Such plants have a phenotype characterized by a decrease in the response of at least one transformed plant cell to ethylene as compared to a p... | 10/20/1998 |
| 5788833 | Sensors for detecting analytes in fluids Chemical sensors for detecting analytes in fluids comprise first and second conductive elements (e.g., electrical leads) electrically coupled to and separated by a chemically sensitive resistor which provides an electrical path between the conductive elem... | 08/04/1998 |
| 5770719 | Membrane-associated immunogens of mycobacteria Nucleic acid encoding four novel immunodeterminant protein antigens of M. bovis BCG, which is a vaccine strain for tuberculosis, have been isolated. These genes were isolated as immunoreactive recombinant clones from a genomic library of M. bovis BCG DNA,... | 06/23/1998 |
| 5766629 | Oral cyclosporin formulations Improved oral cyclosporin formulations which have high bioavailability and are capable of administration in hard capsules are provided. In the subject formulations, cyclosporin is delivered in an orally acceptable vehicle comprising at least one alkanol s... | 06/16/1998 |
| 5767259 | Oligonucleotides containing base-free linking groups with photoactivatable side chains Methods and compositions are provided for detecting nucleic acid sequences. In particular, pairs of probes are employed, where the pair defines a substantially contiguous sequence on a target nucleic acid. Each of the pairs has a side chain which forms a ... | 06/16/1998 |
| 5750015 | Method and device for moving molecules by the application of a plurality of electrical fields Devices and methods are disclosed for moving charged molecules through a medium by the application of a plurality of electrical fields of sufficient strength and applied for sufficient amounts of time so as to move the charged molecules through the medium... | 05/12/1998 |
| 5744693 | Plants having altered floral development The invention includes plants having at least one cell transformed with a vector comprising at least a portion of an agamous nucleic acid. Such plants have a phenotype characterized by altered floral development such as an AG or AP2 phenotype. The inventi... | 04/28/1998 |
| 5736136 | Immunoglobulin infusion in xenotransplantation Intravascular introduction of pooled immunoglobulin is employed prior to xenotransplantation to extend the effective lifetime of the donor organ. In particular, intravenous administration of concentrated immunoglobulin for intravenous use (IVIg) by itself... | 04/07/1998 |
| 5736512 | Serine protease variants having peptide ligase activity The invention relates to serine protease variants derived from precursor serine proteases via recombinant and/or chemical methods to form protease variants having improved peptide ligase activity. The invention also includes novel ligation substrates whic... | 04/07/1998 |
| 5714332 | Anti -gal screening technique Compounds and libraries are labeled with a galactosyl epitope amd then screened in accordance with an assay involving cells having a characteristic of interest. Conveniently, the screening may embody target cells, where the compounds are brought in contac... | 02/03/1998 |
| 5698089 | Sensor arrays for detecting analytes in fluids Chemical sensors for detecting analytes in fluids comprise first and second conductive elements (e.g. electrical leads) electrically coupled to and separated by a chemically sensitive resistor which provides an electrical path between the conductive eleme... | 12/16/1997 |
