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| Number | Title | Issue Date |
| 8182995 | Real time gene expression profiling The invention relates to methods of monitoring the amplification of one or more nucleic acid sequences of interest. More particularly, the invention relates to methods of monitoring the amplification of sequences of interest in real time. The methods disclosed herei... | 05/22/2012 |
| 8182809 | Methods for treating cancer by inhibiting MIC shedding Described herein are compositions and methods for treating cancer, comprising administering to an individual having cancer an agent to prevent MIC shedding (initiated at the alpha-3 ectodomain of MIC) by a tumor cell. Also provided herein are screening assays for id... | 05/22/2012 |
| 8178091 | Compositions and methods for the treatment of respiratory disorders Methods and compositions are provided for the treatment of acute lung injury and pulmonary fibrosis by administering inhibitors of IGF-1R signaling activity. ... | 05/15/2012 |
| 8158355 | Method to generate or determine nucleic acid tags corresponding to the terminal ends of DNA molecules using sequences analysis of gene expression (terminal SAGE) A method of providing an indication of an instance of expression of a gene is described herein, the method which may comprise the steps of: (a) providing a complementary deoxyribonucleic acid (cDNA) having a terminus comprising a terminal transcribed sequence of a g... | 04/17/2012 |
| 8101176 | Compositions and methods related to TIM-3, a TH1-specific cell surface molecule The present invention provides compositions and methods useful for promoting or reducing T-cell trafficking to a target tissue. Also provided are compositions and methods useful for promoting or inhibiting antigen-presenting cell (APC) activation. The invention is r... | 01/24/2012 |
| 7998701 | Molecule We describe an Fve polypeptide being a fragment, homologue, variant or derivative of Fve protein, which comprises at least one biological activity of Fve protein. Uses of such a polypeptide, etc, and nucleic acids encoding these, in the treatment and prevention of a... | 08/16/2011 |
| 7985581 | Multiple RNA polymerase III promoter expression constructs Expression constructs comprising at least two different RNA polymerase III promoters, wherein each promoter is operably linked to a nucleic acid sequence encoding an RNA effector molecule, are disclosed herein. Further provided are expression constructs comprising m... | 07/26/2011 |
| 7972856 | Targeted gene modification by parvoviral vectors This invention provides methods for obtaining targeted gene modification in vertebrate cells using parvoviral vectors, including adeno-associated virus (AAV). The parvoviral vectors used in the methods of the invention are capable of targeting a specific genetic mod... | 07/05/2011 |
| 7674582 | Methods for amplification monitoring and gene expression profiling, involving real time amplification reaction sampling The invention relates to methods of monitoring the amplification of one or more nucleic acid sequences of interest. More particularly, the invention relates to methods of monitoring the amplification of sequences of interest in real time. The methods disclosed herei... | 03/09/2010 |
| 7550266 | Methods and systems for dynamic gene expression profiling The invention provides compositions, methods and systems for dynamic transcription profiling of two or more samples. The method of the invention comprises the uses of sample-specific primers for cDNA synthesis and for subsequent amplification of the synthesized cDNA... | 06/23/2009 |
| 7445893 | Sampling method for amplification reaction analysis The invention provides sampling methods that permit the quantitative analysis of nucleic acid amplification reactions. The methods disclosed permit quantitative expression analysis of multiple genes or transcription units, both in the same amplification reaction and... | 11/04/2008 |
| 7368246 | Quantitative gene expression profiling Described herein are approaches to the measurement of gene expression for chosen genes in a biological sample. The methods permit the quantitation of target nucleic acids, e.g., DNAs or RNAs in a nucleic acid sample, both singly and in a multiplex format that permit... | 05/06/2008 |
| 7257562 | High throughput method for discovery of gene clusters A method for identifying gene cluster is disclosed. The method may be used for identifying gene clusters involved in the biosynthesis of natural products. A small insert library of DNA fragments of genomic DNA and a large insert library of DNA fragments of genomic D... | 08/14/2007 |
| 7214509 | Methods and compositions for degradation of nitroaromatic and nitramine pollutants The invention relates to novel Methylobacterium species that are capable of degrading nitroaromatic and nitramine compounds. Compositions, kits and methods of using the Methylobacterium species for the degradation of nitroaromatic and nitramine polluta... | 05/08/2007 |
| 7186713 | Farnesyl dibenzodiazepinones and methods of treating cancer using same This invention relates to methods of inhibiting growth of a cancer cell and methods of treating cancer using a novel farnesylated dibenzodiazepinone. ... | 03/06/2007 |
| 7166612 | Methods for reducing platelet activation platelet aggregaton or thrombosis The invention provides methods and compositions for reducing platelet activation, platelet aggregation and thrombosis. The invention further provides compositions and methods for treating or preventing diseases or disorders in which the pathology of the disease or d... | 01/23/2007 |
| 7148339 | Temperature sensitive mutant of bacteriophage T4 endonuclease VII The subject invention provides for a method of selectively cloning homoduplex nucleic acid molecules, in particular, by using a strain of host cells that contains a conditionally expressed and/or conditionally active mismatch-recognizing enzyme, e.g., a temperature ... | 12/12/2006 |
| 7138233 | IN vitro sorting method The invention describes a method for isolating one or more genetic elements encoding a gene product having a desired activity, comprising of the steps of: (a) compartmentalising genetic elements into microcapsules; (b) expressing the genetic elements to produce thei... | 11/21/2006 |
| 7109178 | Method for ligating nucleic acids and molecular cloning The invention provides methods of covalently joining nucleic acid molecules and methods of molecular cloning. The methods provide either sequential or simultaneous ligation of flanking or vector nucleic acid molecules to nucleic acid insert molecules by topoisomeras... | 09/19/2006 |
| 7101872 | Farnesyl dibenzodiazepinone, and processes for its production This invention relates to a novel farnesylated dibenzodiazepinone, named ECO-04601, its pharmaceutically acceptable salts and derivatives, and to methods for obtaining such compounds. One method of obtaining the ECO-04601 compound is by cultivation of a novel strain... | 09/05/2006 |
| 7081339 | Methods for variation detection The invention relates to methods of monitoring the amplification of one or more nucleic acid sequences of interest. More particularly, the invention relates to methods of monitoring the amplification of sequences of interest in real time. The methods disclosed herei... | 07/25/2006 |
| 7060506 | Compositions and methods for monitoring the modification of modification dependent binding partner polypeptides The invention provides methods and compositions for monitoring enzymatic activity as a function of the interaction of modification dependant binding partner polypeptides. Association or dissociation of the binding partner polypeptides is dependant upon the addition ... | 06/13/2006 |
| 6996477 | Computational subtraction method The invention provides a method and system for performing computational subtraction to detect microbes within a host organism. In some aspects, the microbes are pathogens and the system is used to identify sequences belonging to these pathogens which can then be use... | 02/07/2006 |
| 6972198 | Methods and compositions using protein binding partners The invention relates to a method for determining the conformational state of a protein, comprising the steps of: a) providing a first binding partner which is capable of binding to the protein in a manner dependent on the conformational state of the protein and whi... | 12/06/2005 |
| 6936428 | Dimeric flourescent polypeptides The invention relates to proteins or polypeptides that comprise intramolecular dimers of fluorescent protein monomers. More specifically, the invention relates to recombinant polypeptides comprising a monomer of a fluorescent polypeptide, a linker peptide, and a sec... | 08/30/2005 |
| 6706879 | Fluorescent dye The invention relates to fluorescent dyes. More particularly, the invention relates to fluorescent cyanine dyes, and especially to water soluble fluorescent cyanine dyes that contain additional sites for attachment to biomolecules. The invention provides a group of ... | 03/16/2004 |
| 6696245 | Methods for selecting functional polypeptides The invention provides a method for selecting, from a repertoire of polypeptides, a population of functional polypeptides which bind a target ligand in a first binding site and a generic ligand in a second binding site, which generic ligand is capable of ... | 02/24/2004 |
