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| Number | Title | Issue Date |
| 5587461 | Aromatic acids The invention relates to novel aromatic acids, especially to compounds of formula ##STR1## wherein R1 is lower alkyl, R2 is lower alkyl, R3 is hydrogen, carboxy or sulfo, R4 is carboxy or sulfo, G is an ... | 12/24/1996 |
| 5545631 | N-substituted aminoalkanephosphinic acid derivatives, compositions thereof, and their use as anti-epileptics Compounds having GABAB -antagonistic properties, for example those of formula I ##STR1## wherein one of the radicals R1, R2 and R3 is hydrogen or an aliphatic, cycloaliphatic, araliphatic or aromatic radica... | 08/13/1996 |
| 5541195 | 1-acylpiperidine compounds 1-Acylpiperidine compound of the formula I ##STR1## in which R1 is an optionally substituted aralkyl, aryloxyalkyl, heteroaralkyl, aroyl, heteroaroyl, cycloalkylcarbonyl, aralkanoyl, heteroarylalkanoyl, aralkoxycarbonyl or arylcarbamoyl ra... | 07/30/1996 |
| 5516806 | Ornithine decarboxylase inhibiting cyclic aminooxy compounds Compounds of formula (I): H2 N--(CH2)n --A--(CH2)m --O--NH2 and salts thereof are described in which the radical A is C3 -C6 cycloalkylene; n is 0 or 1 and, independently t... | 05/14/1996 |
| 5508408 | Quinoline compound Compounds of formula I ##STR1## wherein R1 -R5, X, Ar and Y are as defined in the description, have valuable pharmaceutical properties and are especially effective as leukotriene antagonists. They are prepared in a manner known ... | 04/16/1996 |
| 5491144 | Substituted diaminophthalimides and analogues Compounds of formula I ##STR1## wherein Ar1, Ar2, A1, A2, R and X are as defined in the description, exhibit valuable pharmaceutical properties and are effective especially against diseases responsive to th... | 02/13/1996 |
| 5486452 | Devices and kits for immunological analysis New devices and kits for solid-phase immuno-assays comprising a solid porous support, preferably in the form of a sheet, where antigens or immuno-globulins or both of them are bound by direct application in any suitable geometry, e.g. as an assay of dots ... | 01/23/1996 |
| 5466468 | Parenterally administrable liposome formulation comprising synthetic lipids The invention relates to pharmaceutical compositions in the form of parenterally, especially intravenously, administrable liposome dispersions or dry preparations, especially lyophilisates, that can be used therefor, comprising the zinc-phthalocyanine com... | 11/14/1995 |
| 5463047 | Intermediates for the manufacture of 4-acyloxy-3-hydroxyethylazetidinones The invention relates to the 3-(1'-hydroxyethyl)-2-azetidinone of formula ##STR1## which can be transformed into 4-acyloxy-3-(1-hydroxyethyl)-2-azetidinone derivatives. The latter can be used as starting materials for the manufacture of a large numbe... | 10/31/1995 |
| 5461076 | Hydrazones Compounds of formula I ##STR1## wherein A, X, Z and R1 -R5 are as defined in the description, and their salts have valuable pharmaceutical properties and are effective especially against tumors. They are prepared in a manner kno... | 10/24/1995 |
| 5461040 | Substituted aminoalkylphosphinic acids P-substituted aminoalkylphosphinic acids of the formula ##STR1## wherein R denotes an optionally fluorinated methyl group, R1 denotes hydrogen, lower alkyl, lower alkoxy, hydroxy, halogen or a fluorinated methyl group and R2 and... | 10/24/1995 |
| 5457209 | 4-[(cyanophenyl)-1-(1,2,3-triazolyl)methyl]-benzonitrile Compounds of formula I ##STR1## wherein Z, R, R1, R2 and X are as defined in the description, have valuable pharmaceutical properties and are effective especially against tumours. They are prepared in a manner known per se.... | 10/10/1995 |
| 5455254 | Substituted benzofuranylpiperidine as a nootropic agent 4-(7-Bromo-5-methoxybenzofuran-2-yl)piperidine (brofarornine) of formula I ##STR1## and its pharmaceutically acceptable salts can be used as active ingredients in medicaments for retarding the degeneration of nerve cells that accompanies degenerative... | 10/03/1995 |
| 5428159 | Method of manufacture of (-)-galanthamine in high yield and purity substantially free of epigalanthamine (-)-Galanthamine is obtained in substantially high yield and purity substantially without concomitant production of epigalanthamine by conversion of racemic narwedine to (-)-narwedine and subsequent reduction to (-)-galanthamine using bulky organo-aluminu... | 06/27/1995 |
| 5424441 | N-aralkyl-and N-heteroaralkyl-aminoalkanephosphinic acids N-aralkyl- and N-heteroaralkyl-aminoalkanephosphinic acids of formula I ##STR1## wherein R is an aliphatic, cycloaliphatic, cycloaliphatic-aliphatic, araliphatic or heteroarylaliphatic radical having at least 2 carbon atoms, R1 is hydrogen... | 06/13/1995 |
| 5413994 | Pharmaceutical compositions containing di-phosphonic acid amidines Compounds of formula I ##STR1## wherein R, R1, R2 and q are as defined in the description, have valuable pharmacological properties and are especially effective as calcium metabolism regulators. They are prepared in a manner kno... | 05/09/1995 |
| 5409927 | Morpholin- and thiomorpholin-4-ylamides There are described compounds of formula I ##STR1## wherein R1 is hydrogen or lower alkyl, R2 is hydrogen, lower alkyl, lower alkoxycarbonyl, phenyl- or naphthyl-lower alkoxycarbonyl, heterocyclylcarbonyl wherein heterocyclyl co... | 04/25/1995 |
| 5407922 | Certain N-substituted-amino-alkane phosphinic acid derivatives having anti-epileptic properties Compounds having GABAB -antagonistic properties, for example those of formula I ##STR1## wherein one of the radicals R1, R2 and R3 is hydrogen or an aliphatic, cycloaliphatic, araliphatic or aromatic radica... | 04/18/1995 |
| 5399714 | Process for the preparation of substituted indoles The invention relates to a novel process for the preparation of compounds of formula I ##STR1## wherein R is straight-chain C2 -C4 alk-1-en-1-yl, and salts thereof, and to a novel starting material and the use thereof.... | 03/21/1995 |
| 5399578 | Acyl compounds Compounds of the formula ##STR1## in which R1 is an aliphatic hydrocarbon radical which is unsubstituted or substituted by halogen or hydroxyl, or a cycloaliphatic or araliphatic hydrocarbon radical; X1 is CO, SO2, or... | 03/21/1995 |
| 5399576 | Thiazoles Novel thiazoles of formula I ##STR1## wherein R1 and R4 are lower alkyl, lower alk-2-en-1-yl or lower alk-2-yn-1-yl, R2 and R3 are each independently of the other hydrogen or lower alkyl or together form lo... | 03/21/1995 |
| 5395855 | Hydrazones Compounds of formula I ##STR1## wherein A, X, Z and R1 -R5 are as defined in the description, and their salts have valuable pharmaceutical properties and are effective especially against tumors. They are prepared in a manner kno... | 03/07/1995 |
| 5389681 | Parenteral solutions for diclofenac salts The invention relates to a pharmaceutical composition in the form of a sterilizable parenteral solution comprising a diclofenac salt and stabilizers, such as ethyl lactate combined with glutathione or N-acetylcysteine.... | 02/14/1995 |
| 5386029 | Process for the manufacture of 4-acyloxy-3-hydroxyethyl-azetidinones The invention relates to a novel process for the manufacture of (3R,1'R)-4-acyloxy-3-(1'-hydroxyethyl)-2-azetidinones of formula ##STR1## in which R1 represents lower alkyl or aryl, by enantioselective reduction of the carbonyl group in a ... | 01/31/1995 |
| 5384319 | Aminoalkylphenyl compounds Aminoalkylphenyl derivatives of formula I ##STR1## wherein alk, R1 -R6, X and Y are as defined in the description, and salts thereof, exhibit properties inhibiting the biosynthesis of interleukin-1 (IL-1) and analgesic propertie... | 01/24/1995 |
| 5382675 | Polycyclic compounds and processes for the preparation thereof A tetrahydropyran-4-yloxy-alkanoic acid of formula III ##STR1## wherein R2 is hydrogen or C1-4 alkyl and R3 is hydrogen or C1-4 alkyl.... | 01/17/1995 |
| 5382659 | Aromatic acids The invention relates to novel aromatic acids, especially to compounds of formula ##STR1## wherein R1 is lower alkyl, R2 is lower alkyl, R3 is hydrogen, carboxy or sulfo, R4 is carboxy or sulfo, G is an ... | 01/17/1995 |
| 5380726 | Substituted dialkylthio ethers Substituted dialkylthio ethers of formula I ##STR1## wherein R1 -R6, alk, X and Y are as defined in the description, and salts thereof, exhibit properties inhibiting the biosynthesis of interleukin-1 (IL-1) and analgesic propert... | 01/10/1995 |
| 5378721 | Heteroarylmethylbenzenes Compounds of formula I ##STR1## wherein Z, X, R, R0, R1, R2 and R3 are as defined in the description, have valuable pharmaceutical properties and are effective especially against tumors. They are prepared i... | 01/03/1995 |
| 5378710 | 17ଲ-substituted aza-androstane derivatives Compounds of the formula ##STR1## wherein carbon atoms 1 and 2 are linked by a single bond or a double bond, R1 is hydrogen, methyl or ethyl, and A is a group of the formula --N(--R2)--X-- wherein R2 is hydrogen or C | 01/03/1995 |
| 5378719 | Imidazoles Novel imidazoles of formula I ##STR1## wherein R1 and R4 are lower alkyl, lower alk-2-en-1-yl or lower alk-2-yn-1-yl, R2 and R3 are each independently of the other hydrogen or lower alkyl or together form l... | 01/03/1995 |
| 5376685 | Arylhydrazones using as SAMDC inhibitors Compounds of formula I ##STR1## wherein A, X1, X2, X3, X4, Y, Z and R1 to R6 have the meanings given in the description, have valuable pharmaceutical properties and are effective espec... | 12/27/1994 |
| 5376378 | Copolymer of (meth)acryloxy-alkyl-siloxysilane and alkyl(meth)acrylates and the use thereof as pressure sensitive adhesives A new polymer, the feed monomers and molar percents of which, exclusive of a polymerization initiator and crosslinker, are: A. (I) 42 mole % to 58 mole % of a siloxy silane of formula I, (II) 42 mole % to 58 mole % of an unsubstituted alkyl (meth)acrylate of f... | 12/27/1994 |
| 5376669 | -fluoro--(1,2,3-triazolyl)-phenylmethyl derivatives useful as aromatase inhibitors Compounds of formula I ##STR1## wherein Z, R, R1, R2 and X are as defined in the description, have valuable pharmaceutical properties and are effective especially against tumors. They are prepared in a manner known per se.... | 12/27/1994 |
| 5374645 | Transdermal administation of ionic pharmaceutically active agents via aqueous isopropanol A composition for the transdermal administration of ionic pharmaceutically active agents comprising the active agent along with a suitable counter ion, water, and isopropanol, at an adjusted pH is disclosed. Also disclosed are transdermal systems which em... | 12/20/1994 |
| 5369110 | Biphenylyl compounds Biphenylyl compounds of formula ##STR1## wherein the variables R1, R2, R3, p, q and X and the rings A and B are as defined in claim 1, in free form or in salt form, can be prepared in a manner known per se and can be ... | 11/29/1994 |
| 5369117 | 5-(3-formylamino-4-hydroxyphenyl)-3-(1- (4-methoxyphenyl)prop-2-yl)-oxazolidines The present invention relates to novel oxazolidines of formula (1) ##STR1## wherein R1 and R2 are simultaneously hydrogen or both are the same lower alkyl radical or together are 4- to 7-membered lower alkylene, and to the salts... | 11/29/1994 |
| 5359083 | Process for the preparation of substituted indoles The invention relates to a novel process for the preparation of compounds of formula I ##STR1## wherein R is straight-chain C2 -C4 alk-1-en-1-yl, and salts thereof, and to a novel starting material and the use thereof.... | 10/25/1994 |
| 5358940 | Chelate complexes and processes for their preparation Naphthalocyanine-chelate complexes of formula I ##STR1## are described which contain as central atom M aluminum, gallium, indium, fin, ruthenium or preferably germanium and in which the remaining symbols are as defined in claim 1. The complexes can b... | 10/25/1994 |
| 5354761 | Bipyridyls Compounds of formula I ##STR1## wherein Y, Z, S, S', m, n and R1 -R4 are as defined in the description, have valuable pharmaceutical properties and are effective especially against protozoal infections. They are prepared in a ma... | 10/11/1994 |
