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| Number | Title | Issue Date |
| 6544520 | Hepatitis B virus inhibitors Peptides and other molecules which inhibit the assembly of the hepatitis B virus, methods of treatment, and pharmaceutical compositions comprising them.... | 04/08/2003 |
| 6541606 | Stabilized protein crystals formulations containing them and methods of making them This invention relates to methods for the stabilization, storage and delivery of biologically active macromolecules, such as proteins, peptides and nucleic acids. In particular, this invention relates to protein or nucleic acid crystals, formulations and ... | 04/01/2003 |
| 6500933 | Methods of preparing carbohydrate crosslinked glycoprotein crystals The present invention relates to the field of carbohydrate crosslinked glycoprotein crystals. Advantageously, such crosslinked glycoprotein crystals display stability to harsh environmental conditions, while maintaining the structural and functional integ... | 12/31/2002 |
| 6359118 | Carbohydrate crosslinked glycoprotein crystals The present invention relates to the field of carbohydrate crosslinked glycoprotein crystals. Advantageously, such crosslinked glycoprotein crystals display stability to harsh environmental conditions, while maintaining the structural and functional integ... | 03/19/2002 |
| 6297355 | Polypeptides displaying HBV antigenicity or hbv antigen specificity Recombinant DNA molecules and hosts transformed with them which produce polypeptides displaying HBV antigenicity and genes coding therefor and methods of making and using these molecules, hosts, genes and polypeptides. The recombinant DNA molecules of thi... | 10/02/2001 |
| 6270955 | Pharmaceutical compositions and methods for producing antibodies to hepatitis b virus and kits and methods for detecting antibodies to hepatitis b virus Recombinant DNA molecules and hosts transformed with them which produce polypeptides displaying HBV anti-genicity and genes coding therefor and methods of making and using these molecules, hosts, genes and polypeptides. The recombinant DNA molecules of th... | 08/07/2001 |
| 6268122 | Recombinant DNA molecules and their method of production Recombinant DNA molecules and hosts transformed with them which produce polypeptides displaying HBV antigenicity and genes coding therefor and methods of making and using these molecules, hosts, genes and polypeptides. The recombinant DNA molecules of thi... | 07/31/2001 |
| 6140475 | Controlled dissolution crosslinked protein crystals Protein crystals crosslinked with a multifunctional crosslinking agent are produced that have the ability to change from an insoluble and stable form to a soluble and active form and to release protein activity at a controlled rate when a change in enviro... | 10/31/2000 |
| 6042824 | Methods using cross linked protein crystal formulations as catalysts in organic solvents The present invention relates to the application of biocatalysis technology for performing selective chemical reactions. In one embodiment, this invention relates to crosslinked protein crystal formulations and their use as catalysts in chemical reactions... | 03/28/2000 |
| 6011001 | Method of protein therapy by orally administering crosslinked protein crystals A protein such as an enzyme or antibody is immobilized by crosslinking crystals of the protein with a multifunctional crosslinking agent. The crosslinked protein crystals may be lyophilized for storage. A preferred protein is an enzyme such as thermolysin... | 01/04/2000 |
| 6004768 | Biosensors, extracorporeal devices and methods for detecting substances using crosslinked protein crystals Proteins such as enzymes and antibodies are immobilized by crosslinking crystals of the proteins such as microcrystals having a cross-section of 10-1 mm or less with a multifunctional crosslinking agent. The crosslinked protein crystals may be ... | 12/21/1999 |
| 5976529 | Methods of enzyme therapy by orally administering crosslinked enzyme crystals A protein such as an enzyme or antibody is immobilized by crosslinking crystals of the protein with a multifunctional crosslinking agent. The crosslinked protein crystals may be lyophilized for storage. A preferred protein is an enzyme such as thermolysin... | 11/02/1999 |
| 5945407 | Methods and compositions using butyrate esters of threitol The present invention relates to the use of butyrate esters of threitol, alone or in combination with other agents, in pharmaceutical compositions and methods for increasing fetal hemoglobin and gamma globin in a patient. These methods are particularly us... | 08/31/1999 |
| 5932212 | Crosslinked protein crystal formulations and their use as catalysts in organic solvents The present invention relates to the application of biocatalysis technology for performing selective chemical reactions. In one embodiment, this invention relates to crosslinked protein crystal formulations and their use as catalysts in chemical reactions... | 08/03/1999 |
| 5912269 | Butyrate prodrugs derived from lactic acid This invention relates to butyrate prodrugs derived from lactic acid and pharmaceutical compositions and methods employing them, either alone or in combination with other agents, for increasing gamma globin and fetal hemoglobin in a patient. These compoun... | 06/15/1999 |
| 5883123 | Butyrate prodrugs derived from lactic acid This invention relates to butyrate prodrugs derived from lactic acid and pharmaceutical compositions and methods employing them, either alone or in combination with other agents, for increasing gamma globin and fetal hemoglobin in a patient. These compoun... | 03/16/1999 |
| 5880152 | Butyrate prodrugs derived from lactic acid This invention relates to butyrate prodrugs derived from lactic acid and pharmaceutical compositions and methods employing them, either alone or in combination with other agents, for increasing gamma globin and fetal hemoglobin in a patient. These compoun... | 03/09/1999 |
| 5849296 | Crosslinked protein crystals A protein such as an enzyme or antibody is immobilized by crosslinking crystals of the protein with a multifunctional crosslinking agent. The crosslinked protein crystals may be lyophilized for storage. A preferred protein is an enzyme such as thermolysin... | 12/15/1998 |
| 5846705 | Nucleotide sequence of two circular SSDNA associated with banana bunchy top virus and method for detection of banana bunchy top virus Nucleotide sequences of two circular single-stranded DNAs associated with Banana Bunchy Top Virus and the proteins encoded by the open reading frames in the nucleotide sequences are provided. A method for detecting Banana Bunchy Top Virus using the PCR te... | 12/08/1998 |
| 5801022 | Method of producing a product with crosslinked crystals of thermolysin A protein such as an enzyme or antibody is immobilized by crosslinking crystals of the protein with a multifunctional crosslinking agent such as glutaraldehyde, and if desired lyophilizing the crosslinked crystals for storage. Crosslinking of the protein ... | 09/01/1998 |
| 5763590 | Isolation of an Mr 52,000 FK506 binding protein and molecular cloning of a corresponding human cDNA An FK506 binding protein of mammalian origin of approximate size (Mr) 52,000, isolated by FK506 affinity chromatography and a corresponding human cDNA of approximate size 2.2 Kb, isolated by screening a human placenta cDNA library with a DNA pr... | 06/09/1998 |
| 5660997 | Methods for determining antibodies specific for sex associated sperm membrane proteins Substantially pure sex-associated membrane (SAM) proteins are used in methods to detect specific antibodies binding to X- or Y-SAM proteins.... | 08/26/1997 |
| 5654177 | Production of human somatomedin C A process for selecting DNA sequences that are optimal for the production of polypeptides in hosts transformed with those DNA sequences. These DNA sequences, which code for a variety of human and animal proteins, permit the high level expression of those ... | 08/05/1997 |
| 5618710 | Crosslinked enzyme crystals A protein such as an enzyme of antibody is immobilized by crosslinking crystals of the protein with a multifunctional crosslinking agent. The crosslinked protein crystals may be lyophilized for storage. A preferred protein is an enzyme such as thermolysin... | 04/08/1997 |
| 5487984 | Processes for producing tumor necrosis factor A process of producing mammalian tumor necrosis factors (TNF) and TNF-like polypeptides by culturing eukaryotic or prokaryotic hosts transformed with DNA sequences encoding those polypeptides. A process for purifying TNF-like polypeptides using an anion e... | 01/30/1996 |
| 5439939 | Pharmaceutical compositions and methods using isobutyramide for treating betaglobin disorders This invention relates to treatment of betaglobin disorders, such as sickle-cell anemia and beta-thalassemia, by administering compositions of isobutyramide.... | 08/08/1995 |
