Fischer; H. Eric - US Patent Attorneys and Agents

Attorney: Fischer; H. Eric

Number of patents: 29
Last date: September 20, 2011

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Number	Title	Issue Date
8022228	Crystal form of asenapine maleate The invention relates to an orthorhombic crystal form of compound trans-5-chloro-2,3,3a,12b-tetrahydro-2-methyl-1H-dibenz[2,3:6,7]oxepino[4,5-c]pyrrole(Z)-2-butenedioate, to methods for the preparation of this crystal form and to pharmaceutical compositions comprisi...	09/20/2011
8017642	Functionally selective ALPHA2C adrenoreceptor agonists In its many embodiments, the present invention provides a novel class of naphthene- and indane-type as inhibitors of α2C adrenergic receptor agonists, methods of preparing such compounds, pharmaceutical compositions containing one or more such compounds, methods of...	09/13/2011
8003624	Functionally selective ALPHA2C adrenoreceptor agonists In its many embodiments, the present invention provides a novel class of indolines as inhibitors of α2C adrenergic receptor agonists, methods of preparing such compounds, pharmaceutical compositions containing one or more such compounds, methods of preparing pharma...	08/23/2011
7985748	ALPHA2C adrenoreceptor agonists In its many embodiments, the present invention relates to a novel class of phenylmorpholine and phenylthiomorpholine compounds useful as α2C adrenergic receptor agonists, pharmaceutical compositions containing the compounds, and methods of treatment, prevention, in...	07/26/2011
7964739	Process for the preparation of asenapine and intermediate products used in said process The invention relates to a novel process for the preparation of asenapine, i.e. trans-5-chloro-2-methyl-2,3,3a,12b-tetrahydro-1H-dibenz[2,3:6,7]oxepino[4,5-c]pyrrole, as well as to novel intermediate products for use in said process. ...	06/21/2011
7910775	Synthesis of 2-Hydroxy-N,N-dimethyl-3-[[2-[[1(R)-(5-methyl-2-furanyl)propyl]amino]-3,4-dioxo-1-cyclobuten-1-yl]amino]benzamide Disclosed is a process for making the compound of formula I: using the compounds of formulas II, Q, and XI or XII: wherein A is selected from the group consisting of Br, Cl and I ...	03/22/2011
7872147	Intermediate compounds for the preparation of -5-chloro-2-methyl-2,3,3a,12b-tetrahydro-1-dibenz[2,3:6,7]oxepino[4,5-]pyrrole Disclosed are novel amino acid derivatives of formula (I) and (II) processes for the preparation thereof, and their use in the preparation of trans-5-chloro-2-methyl-2,3,3a,12b-tetrahydro-1H-dibenz[2,3:6,7]oxepino-[4,5-c]py...	01/18/2011
7803828	Functionally selective alpha2C adrenoreceptor agonists In its many embodiments, the present invention provides a novel class of indolines as inhibitors of α2C adrenergic receptor agonists, methods of preparing such compounds, pharmaceutical compositions containing one or more such compounds, methods of preparing pharma...	09/28/2010
7786306	Process for resolving chiral piperidine alcohol and process for synthesis of pyrazolo[1,5-a] pyrimidine derivatives using same The present invention provides a method of resolving piperdin-yl-alkylene-alcohols, in high yield at high enantiomeric purity, for example 2-piperidin-2-yl-ethanol. ...	08/31/2010
7786301	Process for preparing xanthine phosphodiesterase V inhibitors and precursors thereof A process for preparing xanthine phosphodiesterase V inhibitors, and compounds utilized in said process. The process includes a five-step methodology for efficient synthesis of Compound 5 without intermediate purifications or separations, a dihalogenation step to sy...	08/31/2010
7772276	Exo-selective synthesis of himbacine analogs This application discloses a novel process for the synthesis of himbacine analogs, as well as the compounds produced thereby. The synthesis proceeds by alternative routes including the cyclic ketal amide route, the chiral carbamate amide route, and the chiral carbam...	08/10/2010
7750167	Process for the preparation of asenapine and intermediate products used in said process The invention relates to a novel process for the preparation of asenapine, i.e. trans-5-chloro-2-methyl-2,3,3a,12b-tetrahydro-1H-dibenz[2,3:6,7]oxepino[4,5-c]pyrrole, as well as to novel intermediate products for use in said process. ...	07/06/2010
7745626	Stereoselective alkylation of chiral 2-methyl-4-protected piperazines In an illustrative embodiment, the present invention describes the synthesis of the following compound and similar compounds, in high stereochemical purity by a novel stereoselective alkylation process: ...	06/29/2010
7741358	Crystal form of asenapine maleate The invention relates to an orthorhombic crystal form of compound trans-5-chloro-2,3,3a,12b-tetrahydro-2-methyl-1H-dibenz [2,3:6,7]oxepino[4,5-c]pyrrole (Z)-2-butenedioate, to methods for the preparation of this crystal form and to pharmaceutical compositions compri...	06/22/2010
7737284	Synthesis of temozolomide and analogs This invention relates to a novel process for the synthesis of Temozolomide, an antitumor compound, and analogs, and to intermediates useful in this novel process. ...	06/15/2010
7728165	Process and intermediates for the preparation of (1,2,5)-6,6-dimethyl-3-azabicyclo[3,1,0]hexane-2-carboxylates or salts thereof In one embodiment, the present application relates to a process of making a compound of formula I. and to certain intermediate compounds that are made within the process of making the compound of formula I. ...	06/01/2010
7723531	Process for the preparation of 6,6-dimethyl-3-azabicyclo-[3.1.0]-hexane compounds and enantiomeric salts thereof The present invention provides for a process for preparing racemic methyl 6,6-dimethyl-3-azabicyclo[3,1,0]hexane-2-carboxylate, its corresponding salt: (2S, 3R, 4S)-methyl 6,6-dimethyl-3-azabicyclo[3,1,0]hexane-2-carboxylate di-p-toluoyl-D-tartaric acid (“D-DTTA�...	05/25/2010
7687631	Synthesis of diethyl{[5-(3-fluorophenyl)-pyridine-2yl]methyl}phosphonate This application discloses a novel process for the preparation of phosphonate esters useful as intermediates in the preparation of himbacine analogs, themselves useful as thrombin receptor antagonists. The chemistry taught herein can be exemplified by the following ...	03/30/2010
7678948	Synthesis of 3-(5-nitrocyclohex-1-enyl) acrylic acid and esters thereof This application discloses provides a process for the introduction of nitro-group functionality into a compound which contains also a site of unsaturation and/or oxygen functionality by direct (one step) oxidation of an oxime functional group mediated by a molybdenu...	03/16/2010
7605275	Exo- and diastereo- selective syntheses of himbacine analogs This application discloses a novel process for the preparation of himbacine analogs useful as thrombin receptor antagonists. The process is based in part on the use of a base-promoted dynamic epimerization of a chiral nitro center. The chemistry taught herein can be...	10/20/2009
7192962	Xanthine phosphodiesterase V inhibitor polymorphs Crystalline polymorphs of 1-ethyl-3,7-dihydro-8-[(1R,2R) -(hydroxycyclopentyl)amino]-3-(2-hydroxyethyl)-7-[(3-bromo-4-methoxyphenyl)methyl]-1H-Purine-2,6-dione in Form 1 and Form 2, which exhibit x-ray powder diffraction profiles substantially the same as those show...	03/20/2007
7161024	Process for the preparation and purification of 2-(alkoxyalkylidene)-3-ketoalkanoic acid esters from 3-ketoalkanoic acid esters In its several embodiments, this invention discloses a novel process to prepare the compounds of Formula 3: wherein R1 is lower alkyl, and R2 and R3 can be the same or different, ...	01/09/2007
7129357	Synthesis of quinoline 5-carboxamides useful for the preparation of PDE IV inhibitors In one embodiment, the present application discloses a process for making the compound of the formula: ...	10/31/2006
7074923	Process for preparing xanthine phosphodiesterase V inhibitors and precursors thereof A process for preparing xanthine phosphodiesterase V inhibitors, and compounds utilized in said process. The process includes a five-step methodology for efficient synthesis of Compound 5 without intermediate purifications or separations, a dihalogenation step to sy...	07/11/2006
7071342	Synthesis of 2-hydroxy-N,N-dimethyl-3-[ [2-[1 (R)-(5-methyl-2-furanyl)propyl]amino]-3,4-dioxo-1-cyclobuten-1-yl]aminobenzamide Disclosed is a process for making the compound of formula I: using the compounds of formulas II, Q, and XI or XII: wherein A is selected from the group consi...	07/04/2006
7018489	Artificial aging control of aluminum alloys A method of artificially aging an aluminum alloy product to achieve a property in the product having the steps of aging the product to achieve the property by heating the product over an aging period, the aging period including a time period where the product is in ...	03/28/2006
7003930	Blended thermoformable RF sealable plastic A thermoformable, RF-sealable material for use in packaging. The material is produced from a blend including between approximately 5% and 50% by weight of PETG, and between approximately 50% and 95% by weight of PET. A small amount of color concentrate may be added ...	02/28/2006
D512909	Slider device for a resealable closure	12/20/2005
6887066	Apparatus for molding a plastic closure with air-assisted ejection An apparatus for molding a plastic closure includes a male mold assembly including a forming pin and an outer pin sleeve which cooperate with a female mold for defining a mold cavity. To facilitate mechanical stripping of a molded closure from the forming pin, press...	05/03/2005

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Attorney: Fischer; H. Eric