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| Number | Title | Issue Date |
| 8177826 | Methods and devices for extracting thermal energy from the body core of a mammal Methods and devices for extracting thermal energy from the core body of a mammal are provided. In practicing the subject methods, a portion of the mammal, e.g. a limb or portion thereof, is placed in a sealed enclosure to produce an enclosed portion of the mammal. A... | 05/15/2012 |
| 8172762 | Simultaneous blood flow and hematocrit sensor Embodiments of the present invention provide blood flow sensors that can be used for measurement of various physiological parameters under a wide array of conditions. In some embodiments, the blood flow sensor can be implanted into a blood vessel and left in place i... | 05/08/2012 |
| 8168074 | Modification of polymer surface with shielded plasma Methods and systems for modifying a surface of a polymer with a shielded plasma are provided. The surface may be modified to create a surface with increased crosslinking and/or a particular mechanical property, such as a coefficient of friction. A shielding arrangem... | 05/01/2012 |
| 8167889 | Use of vibration with orthopedic cements Methods of employing bone defect filling, e.g., orthopedic cements, such as calcium phosphate cements and the like, are provided. A feature of the subject methods is that vibration is employed in conjunction with the use of the cement, e.g., in preparation of the ce... | 05/01/2012 |
| 8153376 | Means and methods for diagnosing and/or treating a subject at risk of developing heart failure The present invention relates to a method for identifying a subject at risk of developing heart failure, comprising: (a) determining the level of one or more biological markers in a biological sample of said subject; (b) comparing the level of said biological marker... | 04/10/2012 |
| 8148094 | Methods and compositions for detecting the activation state of multiple proteins in single cells The invention provides methods and compositions for simultaneously detecting the activation state of a plurality of proteins in single cells using flow cytometry. The invention further provides methods and compositions of screening for bioactive agents capable of co... | 04/03/2012 |
| 8124407 | Circular nucleic acid vectors, and methods for making and using the same Circular nucleic acid vectors that provide for persistently high levels of protein expression are provided. The circular vectors of the subject invention are characterized by being devoid of expression-silencing bacterial sequences, where in many embodiments the sub... | 02/28/2012 |
| 8123684 | Methods for configuring implantable satellite effectors Techniques for controlling one or more modular circuits (“satellites”) that are intended for placement in a subject's body. The one or more satellites are controlled by sending signals over a bus that includes first and second conduction paths. Also coupled to t... | 02/28/2012 |
| 8121690 | Treatment of female fertility conditions through modulation of the autonomic nervous system Methods are provided for treating a subject for a fertility condition. In accordance with the subject methods, at least a portion of a subject's autonomic nervous system is modulated to increase the sympathetic activity/parasympathetic activity ratio in a manner tha... | 02/21/2012 |
| 8121687 | Cardiac motion characterization by strain measurement Methods for evaluating motion of a cardiac tissue location, e.g., heart wall, are provided. In the subject methods, timing of a signal obtain from a strain gauge stably associated with the tissue location of interest is employed to evaluate movement of the cardiac t... | 02/21/2012 |
| 8118812 | Use of vibration in composite fixation Methods of employing bone defect filling, e.g., orthopedic cements, in conjunction with hard tissue securing devices, e.g., screws, plates or rods, are provided. A feature of the subject methods is that the cement is introduced to a target bone site through a passag... | 02/21/2012 |
| 8115618 | RFID antenna for in-body device RFID antennas for ingestible devices, such as ingestible event markers, are provided. Aspects of the ingestible devices of the invention include RFID signal transmission antennas with a battery that is activated upon being exposed to fluid in the body. Embodiments o... | 02/14/2012 |
| 8114021 | Body-associated receiver and method Receivers, which may be external or implantable, are provided. Aspects of receivers of the invention include the presence of one or more of: a high power-low power module; an intermediary module; a power supply module configured to activate and deactivate one or mor... | 02/14/2012 |
| 8105624 | Topical patch for pain relief using cooling agent Topical patch preparations that contain an odorless physiological cooling agent, and methods for using the same are provided. The subject topical patch preparations are made up of an adhesive gel composition that is present on a support, where the adhesive gel compo... | 01/31/2012 |
| 8100849 | Method and apparatus to remove substances from vessels of the heart and other parts of the body to minimize or avoid renal or other harm or dysfunction To accomplish isolation and removal of a substance from a vasculature, a catheter is employed to occlude a vessel of the vasculature. The substance is thus isolated in the vasculature and can be removed. In this way, the substance is removed before entering other pa... | 01/24/2012 |
| 8097248 | Mite composition, use thereof, method for rearing the phytoseiid predatory mite , rearing system for rearing said phytoseiid mite and methods for biological pest control on a crop The present invention relates to a novel mite composition comprising a population of the phytoseiid predatory mite species Amblyseius swirskii. and a factitious host population, which may be employed for rearing said phytoseiid predatory mite species or for r... | 01/17/2012 |
| 8093450 | Non-aggregating fluorescent proteins and methods for using the same Nucleic acid compositions encoding non-aggregating chromo/fluoroproteins and mutants thereof, as well as the proteins encoded by the same, are provided. The proteins of interest are polypeptides that are non-aggregating colored and/or fluorescent proteins, where the... | 01/10/2012 |
| 8080261 | 1-chloro-2,4-dinitrobenzene non-aqueous gel compositions and methods for using the same Gel compositions that contain 1-dichloro-2,4-dinitrobenzene (DNCB) are provided. Embodiments of the subject gel compositions include DNCB, an organic solvent and a viscosity agent, wherein the organic solvent and viscosity agent are inert with respect to the DNCB. A... | 12/20/2011 |
| 8076308 | Inhibition of autophagy genes in cancer chemotherapy There is provided compositions and methods for improving the therapeutic efficacy of various cancer treatments, for example endocrine therapy, chemotherapy or radiation therapy, by inhibiting the expression of one or more genes involved in the cellular autophagy res... | 12/13/2011 |
| 8062661 | Methods and compositions for treating skin wounds Methods of debriding a skin wound are provided. Embodiments of the subject methods include contacting the skin wound with a hydrogel patch debridement composition to debride the wound. Also provided are systems and kits for use in practicing the subject methods.... | 11/22/2011 |
| 8057853 | Method for applying a cured covering layer on a substrate Provided are methods for applying a covering layer to a substrate, including applying an adhesive layer in non-cross-linked state to the substrate and applying thereto a cross-linked covering layer, characterized in that the covering layer is provided with openings,... | 11/15/2011 |
| 8055353 | Medical carriers comprising a low-impedance conductor, and methods of making and using the same Medical carriers that include a low-impedance conductor are provided. The low-impedance conductors are configured to provide electrical conductivity along a length of the medical carrier. An aspect of the low-impedance conductors is the presence of a longitudinally ... | 11/08/2011 |
| 8055345 | Self-referencing communication in implantable devices Various aspects of the present invention enable robust, reliable control functionality for effectors present on intraluminal, e.g., vascular leads, as well as other types of implantable devices. Aspects of the invention include implantable integrated circuits that h... | 11/08/2011 |
| 8055334 | Evaluation of gastrointestinal function using portable electroviscerography systems and methods of using the same Portable electroviscerography systems are provided. Aspects of the systems include a body-associated receiver and an ingestible identifier unit, both of which are configured to detect visceral electrical signals. The system communicates with an extra-corporeal data ... | 11/08/2011 |
| 8054140 | Low voltage oscillator for medical devices Low voltage oscillators that provide a stable output frequency with varying supply voltage are provided. The subject oscillators find use in a variety of different types of devices, e.g., medical devices, including both implantable and ex-vivo devices. ... | 11/08/2011 |
| 8049020 | Substituted -acyl homoserine lactones The substituted N-acyl homoserine lactones have the formula (I) wherein R is a saturated or unsaturated straight chain or branched chain aliphatic hydrocarbyl group containing from 5 to 14 carbon atoms; R2 is H or a 1-4C alkyl group; R3 is H or... | 11/01/2011 |
| 8044099 | Synthetic bifunctional molecules containing drug moiety and pharmacokinetic modulating moiety Bifunctional molecules and methods for their use are provided. The subject bifunctional molecules are conjugates of a drug moiety and a pharmacokinetic modulating moiety, where these two moieties are optionally joined by a linking group. The bifunctional molecules a... | 10/25/2011 |
| 8039795 | Ion sources for improved ionization Improved apparatuses and methods are provided for ionizing samples and analyzing the samples with mass spectrometry. ... | 10/18/2011 |
| 8036835 | Probe design methods and microarrays for comparative genomic hybridization and location analysis Methods and systems for identifying and selecting nucleic acid probes for detecting a target with a nucleic acid probe array or comparative genome hybridization microarray, comprising selecting a plurality of potential target sequences, generating a plurality of can... | 10/11/2011 |
| 8036748 | Ingestible therapy activator system and method An ingestible therapy activator system and method are provided. In one aspect, the ingestible therapy activator includes an ingestible device having an effector module to send an effector instruction and a responder module associated with a therapeutic device. The r... | 10/11/2011 |
| 8036743 | Automated optimization of multi-electrode pacing for cardiac resynchronization One embodiment of the present invention provides a system for automatically optimizing CRT procedures using a multi-electrode pacing lead. During operation, the system performs a first set of iterations to select one or more satellites on one or more pacing leads in... | 10/11/2011 |
| 8034917 | Primer-directed chromosome painting An oligonucleotide composition is provided. The subject composition comprises: a mixture of at least 10 of sets of oligonucleotides, wherein each of the sets of oligonucleotides comprises at least 100 different oligonucleotides of the following formula: X1 | 10/11/2011 |
| 8034359 | Tissue targeted antigenic activation of the immune response to cancers The invention provides in part methods of treating cancers of a specific organ or tissue by administering a composition that is antigenically specific for one or more microbes that are pathogenic in the specific organ or tissue in which the cancer is situated. The f... | 10/11/2011 |
| 8027823 | Methods and system for viewing genomic data A computer-implemented method for viewing experimental data is provided. In certain embodiments the method comprises: a) inputting genomic array data and cytogenetic data into a computer memory; and b) producing a graphical user interface comprising: i) a chromosoma... | 09/27/2011 |
| 8021844 | Enzymatic labeling of RNA Methods are described in which a sample containing RNA is contacted with an enzyme having an RNA ligation activity in the presence of a labeled substrate to provide labeled RNA. Methods of performing an array analysis of a labeled RNA sample are also described. ... | 09/20/2011 |
| 8017328 | Genome partitioning using a nicking endonuclease A method for partitioning a genome is provided. In certain embodiments, the method comprises: a) nicking a region of the genome using a sequence-specific nicking endonuclease to produce a nicked double-stranded genomic region; b) hybridizing the nicked double-strand... | 09/13/2011 |
| 8012765 | Method for mixing a film of fluid A method and apparatus is provided for mixing a film of fluid, particularly a film of chemical, biochemical, or biological fluids undergoing a reaction. The apparatus comprises a means for nucleating a bubble using a discrete heat source, such as a resistor, and mov... | 09/06/2011 |
| 8012682 | Nucleic acids encoding chromophores/fluorophores and methods for using the same Nucleic acid compositions encoding novel chromo/fluoroproteins and mutants thereof are provided. The subject proteins of interest are proteins that are colored and/or fluorescent, where this feature arises from the interaction of two or more residues of the protein.... | 09/06/2011 |
| 8002870 | Agricultural compositions and methods for making and using the same Soil amendment/foliar nutrient compositions and methods for their manufacture and use are provided. The compositions are aqueous compositions that include a carbon skeleton energy component (CSE); a macronutrient; a vitamin cofactor; a complexing agent; and at least... | 08/23/2011 |
| 7998967 | Methotrexate adjuvants to reduce toxicity and methods for using the same Methods are provided for using methotrexate (MTX) in which reduced host toxicity is observed. Aspects of the methods include administering to a subject an effective amount of MTX in conjunction with a MTX toxicity-reducing adjuvant, such as a 2,2′-anhydropyrimidin... | 08/16/2011 |
