Did You Know...
...that after Parker Brothers executives turned down the game of Monopoly because it had "52 fundamental errors" (including taking too long to play), a copy of the game wound up in the home of the company president who stayed up until 1 a.m. to finish playing it? He was so impressed by the game that the next day he wrote to inventor Charles Darrow and offered to buy it!
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| Number | Title | Issue Date |
| 8138305 | Analogues of GLP-1 The present invention is directed to peptide analogues of glucagon-like peptide-1, the pharmaceutically-acceptable salts thereof, to methods of using such analogues to treat mammals and to pharmaceutical compositions useful therefore comprising said analogues. ... | 03/20/2012 |
| 8138218 | Growth hormone secretagogues A family of peptides and peptidomimetic compounds useful as GHS analogs according to either formula (I) or (II) as depicted below: or a pharmaceutically acceptable salts thereof, wherein the variables are as defined in the specification. | 03/20/2012 |
| 8076281 | Use of a ghrelin agonist to improve the catabolic effects of glucocorticoid treatment A method and pharmaceutical composition for inhibiting the effect of glucocorticoids, particularly dexamethasone, which suppress growth hormone secretion, by administering ghrelin or a ghrelin analogue, for example, [Aib2, Glu3(NH-hexyl)]hGhrel... | 12/13/2011 |
| 8039435 | Melanocortin receptor ligands The present invention is directed to compounds according to formula, (R2R3)-A1-c(A2-A3-A4-A5-A6-A7-A8-A9)-A10-R1... | 10/18/2011 |
| 7977455 | Analogues of GLP-1 The present invention is directed to peptide analogues of glucagon-like peptide-1, the pharmaceutically-acceptable salts thereof, to methods of using such analogues to treat mammals and to pharmaceutical compositions useful therefor comprising said analogues. ... | 07/12/2011 |
| 7932231 | Compositions and methods for stimulating gastrointestinal motility The present invention relates to a method of treating a transient impairment of the motility of the gastrointestinal system resulting from postoperative ileus in a patient wherein said method includes the step of administering a therapeutically effective amount of a... | 04/26/2011 |
| 7919577 | Adrenocorticotropic hormone analogs and related methods ACTH analog compounds of the present invention include compounds comprising an ACTH peptide sequence with one or more structural modifications that can have one or more of the following preferred ACTH analog biological functions: (1) reduction of corticosteroid secr... | 04/05/2011 |
| 7897566 | Analogues of GLP-1 Disclosed are peptide analogues of glucagon-like peptide-1, the pharmaceutically-acceptable salts thereof, methods of using such analogues to treat mammals and pharmaceutical compositions useful therefor comprising said analogues. ... | 03/01/2011 |
| 7811989 | Peptide YY analogs The invention provides analogs of PYY. The invention also provides compositions and methods useful for controlling biological activities such as cell proliferation, nutrient transport, lipolysis, and intestinal water and electrolyte secretion. ... | 10/12/2010 |
| 7691859 | Prenyl transferase inhibitors A family of imidazole compounds useful for inhibiting the activity of prenyl transferases. The compounds are covered by the following formula: wherein X is (CHR11)n3(CH2)n4Z(CH | 04/06/2010 |
| 7662784 | Method for decreasing body weight using a somatostatin receptor agonist The present invention relates to a method of decreasing body weight in a patient. The method includes the step of administering a therapeutically effective amount of a somatostatin or a somatostatin agonist to said patient. A pharmaceutical/cosmetic composition comp... | 02/16/2010 |
| 7638546 | Imidazolyl derivatives The present invention is directed to imidazolyl derivatives of formula (I) where the substituents are defined in the specification, which are useful as agonist or antagonists of somatostatin receptors. ... | 12/29/2009 |
| 7632811 | Analogs of parathyroid hormone The present invention is directed to peptide analogues of fragment of parathyroid hormone (PTH) or parathyroid hormone-related protein (PTHrP), a method of using said analogues alone or in combination with a bisphosphonate or calcitonin to treat osteoporosis and pha... | 12/15/2009 |
| 7589058 | Ghrelin analogs The invention comprises peptidyl analogs that possess agonist or antagonist ghrelin activity, along with therapeutic and non-therapeutic uses thereof. ... | 09/15/2009 |
| 7579435 | Somatostatin-dopamine chimeric analogs Disclosed is a series of somatostatin-dopamine chimeric analogs which retain both somatostatin and dopamine activity in vivo. An example is: 6-n-propyl-8β-ergolinglmethylthioacetyl-D-Phe-c-(Cys-Tyr-D-Trp-Lys-Abu-Cys)-Thr-NH2. ... | 08/25/2009 |
| 7572883 | Somatostatin-dopamine chimeric analogs Disclosed is a series of somatostatin-dopamine chimeric analogs which retain both somatostatin and dopamine activity in vivo. An example is: 6-n-propyl-8β-ergolinglmethylthioacetyl-D-Phe-c(Cys-Tyr-D-Trp-Lys-Abu-Cys)-Thr-NH2 ... | 08/11/2009 |
| 7566734 | Imidazolyl derivatives The present invention is directed to imidazolyl derivatives of formula (I) where the substituents are defined in the specification, which are useful as agonists or antagonists of somatostatin receptors. ... | 07/28/2009 |
| RE40850 | Analogs of parathyroid hormone The present invention is directed to peptide analogues of fragment of parathyroid hormone (PTH) or parathyroid hormone-related protein (PTHrP), a method of using said analogues alone or in combination with a bisphosphonate or calcitonin to treat osteoporosis and pha... | 07/14/2009 |
| 7553975 | Farnesyl transferase inhibitors A family of compounds capable of inhibiting the activity of farnesyl transferase. ... | 06/30/2009 |
| 7550423 | Somatostatin antagonists The invention features somatostatin antagonists having a D-amino acid at the second residue. ... | 06/23/2009 |
| 7531621 | PTH2 receptor selective compounds This invention relates to a series of PTH and PTHrP analogues that selectively bind to PTH2 receptors and as such may be useful in treating abnormal CNS functions; abnormal pancreatic functions; divergence from normal mineral metabolism and homeostasis; male inferti... | 05/12/2009 |
| 7517853 | Somatostatin-dopamine chimeric analogs The invention features somatostatin-dopamine chimeric analogs and methods relating to their therapeutic use for the treatment of neoplasia, acromegaly, and other conditions. ... | 04/14/2009 |
| 7456253 | Growth hormone releasing peptides Disclosed are peptide and peptidomimetic compounds generally according to formula (I), and pharmaceutically acceptable salts thereof, that are useful as GHRP analogs: R1-A2-A3-A4-A5-R2 (I) or a pharma... | 11/25/2008 |
| 7445612 | Safety injection device for a liquid or semi-solid composition The invention features a safety injection device for injecting a liquid or semi-solid composition into a subject. ... | 11/04/2008 |
| 7410948 | Analogs of parathyroid hormone The present invention is directed to peptide analogues of fragment of parathyroid hormone (PTH) or parathyroid hormone-related protein (PTHrP), a method of using said analogues alone or in combination with a bisphosphonate or calcitonin to treat osteoporosis and pha... | 08/12/2008 |
| 7408024 | Somatostatin antagonists The present invention is directed to a somatostatin antagonist according to formula (I): A1-cyclo {D-Cys-A2-D-Trp-A3-A4-Cys}-A5Y1, wherein A1 is an optionally substituted aromatic a-amino a... | 08/05/2008 |
| 7378488 | Somatostatin antagonists The present invention is directed to a somatostatin antagonist according to formula (I), wherein A1 is an optionally substituted aromatic ∝-amino acid; A2 is an optionally substituted aromatic ∝-amino acid; A3 is Dab, Dap, Lys or... | 05/27/2008 |
| 7368427 | GLP-1 analogues The present invention is directed to peptide analogues of glucagon-like peptide-1, the pharmaceutically-acceptable salts thereof, to methods of using such analogues to treat mammals and to pharmaceutical compositions useful therefor comprising said analogues. ... | 05/06/2008 |
| 7361656 | Prenyl transferase inhibitors A family of imidazole compounds useful for inhibiting the activity of prenyl transferases. The compounds are covered by the following formula: wherein X is (CHR11)n3(CH2)n4Z(CH | 04/22/2008 |
| 7342122 | Bisphosphonate complexes Bisphosphonate compounds are disclosed, particularly bisphosonate conjugates useful in the treatment of soft tissues surrounding bone and bone-related diseases, such as bone cancer and osteoporosis. ... | 03/11/2008 |
| 7323484 | Farnesyl transferase inhibitors The present invention is directed to compounds of the formula wherein the variables are as defined in the specification. The compounds are useful for inhibiting farnesyl transferase and for the treatment of tumor... | 01/29/2008 |
| 7312304 | Somatostatin agonists Claimed are a series of somatostatin agonists and uses thereof, according to formula (I), A1-cyclo[Cys-A2-D-Trp-A3-A4-Cys]-A5-Y1, (I) wherein A1, A2, A | 12/25/2007 |
| 7268213 | Analogues of GLP-1 The present invention is directed to peptide analogues of glucagon-like peptide-1, the pharmaceutically-acceptable salts thereof, to methods of using such analogues to treat mammals and to pharmaceutical compositions useful therefor comprising said analogues. ... | 09/11/2007 |
| 7241737 | Urotensin-II agonists and antagonists The present invention is directed to a novel class of cyclic polypeptides of the formula: (R1)a-AA1-cyclo[AA2-AA3-AA4-AA5-AA6-Cys]-AA7-R2, pharmaceutically ... | 07/10/2007 |
| 7238666 | Method of inhibiting fibrosis with a somatostatin agonist The present invention relates to a method of inhibiting fibrosis in a patient. The method comprises administering a therapeutically effective amount of a somatostatin, a somatostatin agonist or apharmaceutically acceptable salt thereof to said patent. ... | 07/03/2007 |
| 7238695 | Imidazolyl derivatives The present invention is directed to imidazolyl derivatives or pharmaceutically acceptable salts thereof which are useful as agonists or antagonists of somatostatin receptors, having the following formula (I), wh... | 07/03/2007 |
| 7235628 | Analogues of GLP-1 The present invention is directed to peptide analogues of glucagon-like peptide-1, the pharmaceutically-acceptable salts thereof, to methods of using such analogues to treat mammals and to pharmaceutical compositions useful thereof comprising said analogues. ... | 06/26/2007 |
| 7205378 | Lactone bearing absorbable polymers The present invention pertains to biodegradable polymers comprising a non-polymerizable lactone, biodegradable compositions comprising the polymer and a therapeutic agent, the use of the compositions for the sustained release of therapeutic agents, wherein the thera... | 04/17/2007 |
| 7179490 | Sustained release ionic conjugate A method of spherifying a sustained release ionic conjugate which contains a free carboxyl group-containing biodegradable polymer and a free amino group-containing drug which are ionically bonded to each other. ... | 02/20/2007 |
| 7144859 | Somatostatin agonists The present invention is directed to cyclic peptides of formula (I): X-A1-cyclo(D-Cys-A3-A4-Lys-A6-A7)-A8-Y, or a pharmaceutically acceptable salt thereof. The peptides bind selectively to the somatos... | 12/05/2006 |
