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| Number | Title | Issue Date |
| 7220854 | Sugar moiety labeled nucleotide, and an oligo- or polynucleotide, and other compositions comprising such sugar moiety labeled nucleotides The present invention provides a nucleotide having the formula, wherein PM is a phosphate moiety, SM is a ribose or a deoxyribose sugar moiety, and BASE is a pyrimidine, purine or 7-deazapurine moiety. PM is atta... | 05/22/2007 |
| 7064197 | System, array and non-porous solid support comprising fixed or immobilized nucleic acids Nucleic acids are fixed or immobilized to non-porous solid supports (substrates), and include systems containing such supports and arrays with fixed or immobilized nucleic acids. These compositions are useful for nucleic acid analyses and a host of applications, inc... | 06/20/2006 |
| 6992180 | Oligo- or polynucleotides comprising phosphate-moiety labeled nucleotides The present invention provides a nucleotide having the formula, Sig-PM-SM-BASE wherein PM is a phosphate moiety, SM is a sugar moiety and BASE is a pyrimidine, purine or 7-deazapurine moiety. PM is attached to the 3′ or the 5′ position of the... | 01/31/2006 |
| 6986985 | Process for producing multiple nucleic acid copies in vivo using a protein-nucleic acid construct This invention provides in vitro processes for producing copies of specific nucleic acids using protein-nucleic acid constructs which are part of conjugates which are introduced into cells. Illustrative of the elements useful in these constructs for producing copies... | 01/17/2006 |
| 6764821 | Detecting the presence of specific target nucleic acid sequences through stem-loop formation This invention provides novel processes for amplifying nucleic acid sequences of interest, including linear and non-linear amplification. In linear amplification, a single initial primer or nucleic acid construct is utilized to carry out the amplification process. I... | 07/20/2004 |
| 6743605 | Linear amplification of specific nucleic acid sequences This invention provides novel processes for amplifying nucleic acid sequences of interest, including linear and non-linear amplification. In linear amplification, a single initial primer or nucleic acid construct is utilized to carry out the amplification process. I... | 06/01/2004 |
| 6566068 | Process for detecting a nucleic acid of interest using an oligo- or polynucleotide probe and intercalators Disclosed is a nucleic acid hybridization assay composition for detecting the presence or absence of a target oligo- or polynucleotide in a sample. The composition comprises: a solid matrix having at least one surface which is substituted with a first int... | 05/20/2003 |
| 5384241 | Specific binding assay compound with inhibitive self-quenching characteristics Disclosed is an assay system including a compound comprising an analyte-specific moiety having substituted thereon a polymer comprising plurality of self-quenching emitter moieties and a plurality of isocharged functionality separating the emitter moietie... | 01/24/1995 |
| 5288609 | Capture sandwich hybridization method and composition This invention provides methods and compositions for the detection of a target genetic material having a desired base sequence or gene. Also disclosed are methods and compositions for the detection of mutants. The methods and compositions are based in par... | 02/22/1994 |
| 5260433 | Saccharide specific binding system labeled nucleotides The present invention provides nucleotides and polynucleotides which are chemically modified or labeled so as to be capable of ready detection when attached to and/or incorporated in nucleic acid material. More particularly, this invention provides a nucl... | 11/09/1993 |
| 5241060 | Base moiety-labeled detectable nucleatide The present invention provides nucleotides and polynucleotides which are chemically modified or labeled so as to be capable of ready detection when attached to and/or incorporated in nucleic acid material. More particularly, this invention provides a nucl... | 08/31/1993 |
| 5175269 | Compound and detectable molecules having an oligo- or polynucleotide with modifiable reactive group A detectable molecule of the formula A3 --(--X--R1 --E--Detb)m where A3 is A2 or a polymer, where A3 has at least one modifiable reactive group selected from the group consisting of amino,... | 12/29/1992 |
