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| Number | Title | Issue Date |
| 8071731 | Humanised anti-MAG antibody or functional fragment thereof The present invention relates to altered antibodies to myelin associated glycoprotein (MAG), pharmaceutical formulations containing them and to the use of such antibodies in the treatment and/or prophylaxis of neurological diseases/disorders. ... | 12/06/2011 |
| 8017115 | Therapeutical use of anti-myelin associated glycoprotein (MAG) antibodies A method of promoting oligodendrocyte survival in a human suffering from, or at risk of developing, stroke or other neurological diseases utilizes anti-MAG antibodies or functional fragments of such antibodies. ... | 09/13/2011 |
| 8003101 | Inflammatory mediator antagonists The present invention relates to methods of reducing cartilage degradation in a patient comprising administering to a patient in need thereof an effective amount of an antibody antagonist to the mature form of OSM. ... | 08/23/2011 |
| 7858753 | Immunoglobulins The present invention concerns immunoglobulins, such as antibodies, which specifically bind Oncostatin M (OSM), particularly human OSM (hOSM) and modulate the interaction between OSM and gp130. In typical embodiments, OSM is glycosylated. The invention also concerns... | 12/28/2010 |
| RE41974 | Method for culturing Chinese hamster ovary cells A biochemically defined culture medium for culturing engineered Chinese hamster ovary (CHO) cell lines, which is essentially free from protein, lipid and carbohydrate isolated from an animal source, having water, an osmolality regulator, a buffer, an energy source, ... | 11/30/2010 |
| 7696320 | Ligands that have binding specificity for VEGF and/or EGFR and methods of use therefor Disclosed are ligands that have binding specificity for vascular endothelial growth factor (VEGF), for epidermal growth factor receptor (EGFR), or for VEGF and EGFR. Also disclosed are methods of using these ligands. In particular, the use of these ligands for cance... | 04/13/2010 |
| 7662633 | Method of screening for inhibitors of osteopontin Amino acids 136 to 142 and amino acids 162 to 168 of human osteopontin constitute two sites at which osteopontin interacts with α4 integrins. Products capable of disrupting those interactions are useful in therapy, particularly in the treatment of inflammatory dise... | 02/16/2010 |
| 7612183 | Humanised anti-mag antibody or functional fragment thereof The present invention relates to altered antibodies to myelin associated glycoprotein (MAG), pharmaceutical formulations containing them and to the use of such antibodies in the treatment and/or prophylaxis of neurological diseases/disorders. ... | 11/03/2009 |
| 7557191 | Sialoadhesin factor-2 antibodies Monoclonal antibodies have been generated that bind to human sialoadhesion factor-2. These antibodies are useful as diagnostic and therapeutic reagents. ... | 07/07/2009 |
| 7504232 | Method of screening for inhibitors of osteopontin Amino acids (136 to 142) and amino acids (162 to 168) of human osteopontin constitute two sites at which osteopontin interacts with α4 integrins. Products capable of disrupting those interactions are useful in therapy, particularly in the treatment of inflammatory ... | 03/17/2009 |
| 7361734 | S8 rRNA-binding protein from the small ribosomal subunit of A Staphylococcus aureus S8 native crystalline structure and a Staphylococcus aureus S8 mode of binding with rRNA were identified. ... | 04/22/2008 |
| 7348009 | Recombinant allergen with reduced enzymatic activity The present invention provides a novel treatment for allergy comprising a recombinant allergen with reduced enzymatic activity, thereby reducing the potential for an allergic response upon contact with a wild-type allergen. ... | 03/25/2008 |
| RE39792 | Method for culturing Chinese hamster ovary cells A biochemically defined culture medium for culturing engineered Chinese hamster ovary (CHO) cell lines, which is essentially free from protein, lipid and carbohydrate isolated from an animal source, having water, an osmolality regulator, a buffer, an energy source, ... | 08/21/2007 |
| 7202071 | Peptidyl t-RNA hydrolase (PTH) The invention provides pth polypeptides and polynucleotides encoding pth polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing pth polypeptides to screen for antibacterial compounds. ... | 04/10/2007 |
| 7173117 | Codon optimised recombinant allergens The present invention relates to codon optimised polynucleotides which are efficiently expressed in mammalian cells and encode insect proteins from Dermaphagoids dust mite. In particular, the optimised codon polynucleotides encode a protein from Dermaphago... | 02/06/2007 |
| 7144703 | Composition Novel vaccine compositions are provided comprising a hepatitis B antigen formulated with aluminium phosphate. The vaccine compositions may additionally contain an inactivated hepatitis A virus, aluminium hydroxide and formol. The combined hepatitis A and B vaccine f... | 12/05/2006 |
| 7112331 | Vaccines against varicella zoster virus gene 63 product The present invention relates to compositions for the treatment or prevention of Zoster of individuals infected with Varicella Zoster virus (VZV), and to the prevention and treatment of Varicella infections. The compositions of the invention comprise the protein enc... | 09/26/2006 |
| 6929920 | Diagnosis of chronic obstructive pulmonary disease Methods of determining Chronic Obstructive Pulmonary Disease (COPD) severity in patients which comprises measuring the concentration of soluble E-cadherin (sE-cadherin) in the patient's urine and/or blood serum and determining the extent of severity by reference to ... | 08/16/2005 |
| 6899884 | Vaccine against mumps containing a jeryl-lynn virus strain A new mumps vaccine is presented, comprising a homogeneous pure isolate derived from the Jeryl-Lynn strain of mumps virus. In a preferred embodiment of the invention the vaccine produces higher seroconversion and anitbody titres than know commercial vaccines. ... | 05/31/2005 |
| 6838255 | MurC The invention provides MurC polypeptides and polynucleotides encoding MurC polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing MurC polypeptides to screen for antibacterial compounds. ... | 01/04/2005 |
| 6770462 | Methods for producing modified nucleic acid molecules A method for inserting a cassette into a nucleic acid molecule to produce a modified nucleic acid molecule, e.g., a nucleic acid-cassette fusion, is described. The method involves the use of polymerase chain reaction, thereby permitting precise targeting of the desi... | 08/03/2004 |
| 6706508 | Ornithine carbamoyltransferase The invention provides ornithine carbamoyltransferase polypeptides and DNA (RNA) encoding ornithine carbamoyltransferase polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing ornithine carbamoyltr... | 03/16/2004 |
