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| Number | Title | Issue Date |
| D494754 | Belt loop and ring for holding tools | 08/24/2004 |
| 6562870 | Treatment of AIDS-associated non-Hodgkin's lymphoma by gallium nitrate The present invention comprises an improved method of treatment of AIDS-associated non-Hodgkin's lymphoma by administering gallium nitrate in a pharmaceutically acceptable vehicle.... | 05/13/2003 |
| 6516761 | Adjustable overhead rocker cam Disclosed is an overhead rocker cam valve operating device for an internal combustion engine and which is particularly useful for race cars or high performance automobiles. The device includes a rocker cam and connecting fixed plate, the rocker cam arm be... | 02/11/2003 |
| 6273040 | Adjustable overhead rocker cam Disclosed is an overhead rocker cam valve operating device for an internal combustion engine which is particularly useful for race cars or high performance automobiles. The device includes a rocker cam and connecting link, the link being adjustable within... | 08/14/2001 |
| 6238699 | Pharmaceutical formulations containing a combination of carbidopa and levidopa An oral anti-Parkinson drug delivery system consisting of carbidopa and levodopa in immediate and sustained release compartments provides a significant clinical advantage over currently available carbidopa-levodopa preparations.... | 05/29/2001 |
| 5576739 | Carbon monoxide safety system Described is a system for measuring noxious gas concentration in an affected space and for controlling the device producing the noxious gas or for decreasing the concentration of the gas in the affected space. The invention is particularly described in re... | 11/19/1996 |
| 5536749 | Method for attenuation of sympathetic nervous system activity or onset of migraine by selectively metabolized beta-blocking agents Disclosed is a method for attenuating sympathetic nervous system hyperactivity or onset of migraine in a patient in need of such treatment, by the sublingual, buccal or intranasal administration to such patient of a therapeutically effective amount of a c... | 07/16/1996 |
| 5318984 | Imidazoles for the treatment of atherosclerosis Disclosed are compounds of the formula ##STR1## wherein R1 and R2 are selected independently from H, C1 -C8 unbranched alkyl, C3 -C8 branched alkyl, C3 -C7 cycloa... | 06/07/1994 |
| 5314887 | 2-amino-1, 4-dihydropyridine derivatives with calcium agonist and alpha.sub. -antagonist activity There are provided novel 1,4-dihydropyridine compounds possessing both calcium agonist and alpha1 -antagonist activity useful for treating congestive heart failure, pharmaceutical compositions containing them and methods of using these compound... | 05/24/1994 |
| 5308851 | Bispyridyl-containing heterocycles useful for treating cognitive disorders Bispyridyl-containing heterocycles, or pharmaceutically acceptable salts thereof, are useful in treating neurological disorders in mammals. The compounds have efficacy over a broad dosage ranges as measured in both neurotransmitter release assay and by hy... | 05/03/1994 |
| 5306821 | Process for the preparation of tertiary carbinamines This invention relates to a novel process for the preparation of tertiary carbinamines by double addition of organolanthanide reagents, especially organocerium reagents, to nitriles. It further relates to the preparation of such amines by the addition of ... | 04/26/1994 |
| 5290801 | Benzimidazoles for the treatment of atherosclerosis This invention relates to imidazoles, namely, fused-ring heterocycles as inhibitors of acyl-CoA: cholesterol acyltransferase (ACAT), pharmaceutical compositions containing them, processes for their preparation, and their use as antihypercholesterolemic an... | 03/01/1994 |
| 5278162 | 3,3'-disubstituted-1,3-dihydro-2H-pyrrolo[2,3-b]heterocyclic-2-one useful in the treatment of cognitive disorders of man Compounds of Formula I have been shown to enhance the release of the neurotransmitters acetylcholine, dopamine and serotonin; and thus may be useful in the treatment of diseases of man where subnormal levels of this neurochemical are found such as in Alzh... | 01/11/1994 |
| 5179117 | Antihypercholesterolemic 2-substituted imidazoles The compounds of the described invention are potent ACAT inhibitors and are useful in pharmaceutical compositions for the treatment of atherosclerosis and have the formulas: ##STR1## when Q is a double bond wherein: R1 and R2 ar... | 01/12/1993 |
| 5087565 | Synthetic process for preparation of 32 P-labeled nucleotides A process for the production of 32 P-labeled nucleotides in accordance with an enzymatic pathway utilizing phosphotransacetylase and acetate kinase.... | 02/11/1992 |
| 5064827 | Polyhydroxybenzyloxpropanolamines Compounds of the present invention, are represented by the general formula ##STR1## wherein R1 group which may be alkyl of from 1 to about 6 carbon atoms, alkenyl of from 2 to about 6 carbon atoms, alkynyl of from 2 to about 10 carbon atom... | 11/12/1991 |
| 4990668 | Optically active aryloxypropanolamines and arylethanolamines Described is a process for preparing a racemic or chiral aryloxypropanolamine (1) or arylethanolamine (2) of the formula ##STR1## wherein Ar is aryl, substituted aryl, heteroaryl, or aralkyl and R is alkyl, substituted alkyl, aralkyl, or WB wherein W... | 02/05/1991 |
| 4966914 | Oculoselective beta-blockers as antiglaucoma agents In accordance with the present invention, disclosed herein are compounds of the formula ##STR1## wherein R is hydrogen, straight or branched loweralkyl, cycloalkyl, amino, loweralkoxy or acylamino, and R1 is straight or branched loweralkyl... | 10/30/1990 |
| 4959390 | Polyhydroxybenzyloxypropanolamines Compounds of the present invention, are represented by the general formula ##STR1## wherein R1 group which may be alkyl of from 1 to about 6 carbon atoms, alkenyl of from 2 to about 6 carbon atoms, alkynyl of from 2 to about 10 carbon atom... | 09/25/1990 |
| 4923873 | Quinazoline substituted aminomethyl benzene derivatives The present invention relates to new compounds of the formula ##STR1## where X is ##STR2## alkylene, or --S-- where R1 is hydrogen, alkyl, or aryl; W is hydrogen, hydroxy, amino, alkyloxy, aryloxy, O-alkyl, or O-aralkyl; (Y)... | 05/08/1990 |
| 4906661 | Esters of aryloxypropanolamine derivatives Novel compounds of the general formula ##STR1## wherein R1 is lower alkyl, lower cycloalkyl, lower alkenyl, lower alkynyl, lower alkyl carboxymethyl, aryl carboxymethyl, aryl, or aralkyl; A is a direct bond, lower alkylene, or lower alkeny... | 03/06/1990 |
| 4895934 | Process for the preparation of clindamycin phosphate A method for the preparation of clindamycin phosphate by first preparing the novel intermediate, clindamycin phosphoryl benzylate. The method can be used to make other, structurally related compounds.... | 01/23/1990 |
| 4868181 | 1,4-dihydropyridine derivatives with calcium agonist and alpha1 -antagonist activity 1,4-Dihydropyridine derivatives which combine both calcium agonist and alpha1 -antagonist activity are useful in treating congestive heart failure. These derivatives are compounds having the formula: ##STR1## wherein Ar, R3, R | 09/19/1989 |
| 4857552 | Stable pharmaceutical composition An injectable, aqueous pharmaceutical composition for the treatment of cardiac conditions comprising an effective amount of methyl 3-[4-(2-hydroxy-3-isopropylamino)propoxy]phenylpropionate hydrochloride (esmolol) for treating such a cardiac condition, sai... | 08/15/1989 |
| 4849515 | Clindamycin-2-phosphoryl benzylate A novel compound, also known as 7(s)-chloro-7-deoxylincomycin-2-phosphoryl benzylate, useful an an intermediate in the production of the antibiotic, clindamycin-2-phosphate.... | 07/18/1989 |
| 4810704 | Substituted 2-amino-2-imidazolines as antifibrillatory agents Described are compounds of the formula: ##STR1## wherein Y denotes dimethylamino, methylpropynylamino, pyrrolidino, piperidino, or morpholino; R1 and R2 independently of each other denote hydrogen or loweralkyl; and X denotes lo... | 03/07/1989 |
| 4810717 | 2-hydroxypropylamine aryl ester derivatives Novel compounds of the general formula ##STR1## wherein Ar represents a substituted or unsubstituted aromatic or heterocyclic group; W represents alkylene of from 1 to about 10 carbon atoms; and B represents --NR2 COR1, --NR | 03/07/1989 |
| 4810714 | Substituted 2-amino-2-imidazolines as antifibrillatory agents Described are compounds of the formula: ##STR1## wherein Y denotes dimethylamino, methylpropynylamino, pyrrolidino, piperidino, or morpholino; R1 and R2 independently of each other denote hydrogen or loweralkyl; and X denotes lo... | 03/07/1989 |
| 4804677 | Esters of aryloxypropanolamine derivatives Novel compounds of the general formula ##STR1## wherein R1 is lower alkyl, lower cycloalkyl, lower alkenyl, lower alkynyl, lower alkyl carboxymethyl, aryl carboxymethyl, aryl, or aralkyl; A is a direct bond, lower alkylene, or lower alkeny... | 02/14/1989 |
| 4798892 | 2-hydroxypropylamine heteroaryl ester derivatives The present invention relates to compounds of the general formula ##STR1## wherein Ar represents a substituted or unsubstituted heterocyclic group; W represents alkylene of from 1 to about 10 carbon atoms; and B represents --NR2 COR1 | 01/17/1989 |
| 4778807 | Substituted 2-amino-2-imidazolines as antifibrillatory agents Described are compounds of the formula: ##STR1## wherein Y denotes dimethylamino, methylpropynylamino, pyrrolidino, piperidino, or morpholino; R1 and R2 independently of each other denote hydrogen or loweralkyl; and X denotes lo... | 10/18/1988 |
| 4764630 | Preparation of N,N-bis-trialkylsilyl carbodiimide A process for the preparation of N,N'-bis-trialkylsilyl carbodiimide, according to the following schematic diagram: ##STR1## where R1, R2 and R3 are each independently hydrogen, C1 -C20 alkyl, C | 08/16/1988 |
| 4755527 | Aryl substituted aminomethyl benzene derivatives The present invention relates to new compounds of the formula ##STR1## where X is ##STR2## alkylene, or --S--where R1 is hydrogen, alkyl, or aryl; W is hydrogen, hydroxy, amino, alkyloxy, aryloxy, O-alkyl, or O-aralkyl; (Y)A... | 07/05/1988 |
| 4748184 | Aryl substituted aminomethyl benzene derivatives having antiarrhythmic utility The present invention relates to new compounds of the formula ##STR1## wherein X is ##STR2## wherein R1 is hydrogen, lower alkyl, phenyl, benzyl, cinnamoyl, thiophene, furan, pyrrole, imidazole, pyrazole oxazole or thiazole; W is ... | 05/31/1988 |
| 4709042 | Process for the preparation of 2-(1-hydroxyalkyl)-5,5-diphenylhydantoin Described is a process for preparing 2-(1-hydroxyalkyl)-5,5-diphenylhydantoin having the formula ##STR1## wherein R1, R2 and R3 are each independently hydrogen, C1 -C20 alkyl, C3 -C | 11/24/1987 |
| 4692446 | Esters of aryloxypropanolamine derivatives and medicinal uses Novel compounds of the general formula ##STR1## wherein R1 is lower alkyl, lower cycloalkyl, lower alkenyl, lower alkynyl, lower alkyl carboxymethyl, aryl carboxymethyl, aryl, or aralkyl; A is a direct bond, lower alkylene, or lower alkeny... | 09/08/1987 |
| 4666924 | Certain pyridyl substituted aminomethyl benzene derivatives having anti-arrhythmic activity The present invention relates to new compounds of the formula ##STR1## where X is ##STR2## alkylene, or --S--where R1 is hydrogen, alkyl, or aryl; W is hydrogen, hydroxy, amino, alkyloxy, aryloxy, O-alkyl, or O-aralkyl; (Y)A... | 05/19/1987 |
| 4657919 | Pyridone esters as inotropic agents Described are compounds of the formula ##STR1## wherein R is hydrogen, lower alkyl, halo, cyano, hydroxy, amino, lower alkylamino, --CH2 NH2, --CH2 OH or --COOR"; R' is hydrogen, lower cycloalkyl or lower alkyl; R' is... | 04/14/1987 |
| 4636201 | Hypodermic syringe having a protective sheath cover Described is a hypodermic syringe which includes provision for a rigid sheath cover or sleeve which encompasses the rubber needle cover and provides protection in the operating mode as well as other advantages. The rubber needle cover is placed over the n... | 01/13/1987 |
| 4582855 | Aromatic and esters of hydroxypropylamines Novel compounds of the general formula ##STR1## wherein Ar represents a substituted or unsubstituted aromatic or heterocyclic group; W represents alkylene of from 1 to about 10 carbon atoms; and B represents --NR2 COR1, --NR | 04/15/1986 |
