FOLEY HOAG, LLP - US Patent Attorneys and Agents

Attorney: FOLEY HOAG, LLP

Number of patents: 38
Last date: March 27, 2012

Number	Title	Issue Date
8143002	Methods for isolating and characterizing endogenous mRNA-protein (mRNP) complexes Cellular mRNA-protein (mRNP) complexes are partitioned in vivo by contacting a biological sample with at least one ligand that specifically binds at least one component of a mRNP complex. Suitable biological samples comprise at least one mRNA-protein (mRNP) complex ...	03/27/2012
8133840	Stable composite material comprising supported porous gels This invention relates to a stable composite material comprising a support member that has a plurality of pores extending through the support member, and a macroporous crosslinked gel that is located in, and fills, the pores of the support member, in which crosslink...	03/13/2012
8128922	Superior molecular vaccine linking the translocation domain of a bacterial toxin to an antigen Nucleic acids encoding a chimeric or fusion polypeptide which polypeptide comprises a first domain comprising a translocation polypeptide; and a second domain comprising at least one antigenic peptide are disclosed. The preferred translocation polypeptide is a bacte...	03/06/2012
8114379	Diagnostic and therapeutic alkyl piperidine/piperazine compounds and process Piperidine or piperazine compounds useful for treating neurodegenerated diseases characterized by the lack of dopamine neurons activity or for imaging the dopamine neurons are provided. The compounds are characterized by the formulae:	02/14/2012
8105774	PGC-1β, PGC-1 homologue and uses therefor The invention provides isolated nucleic acid molecules, designated PGC-1β nucleic acid molecules, which encode novel PGC-1 related coactivator molecules. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing PGC-1β...	01/31/2012
8092782	Polybiotin compounds of magnetic resonance imaging and drug delivery The invention relates generally to biotin-containing compounds that are useful as imaging agents and drug-delivery agents. Another aspect of the invention relates to the aforementioned compounds chelated to a metal atom. In a preferred embodiment, the metal atom is ...	01/10/2012
8071143	Methods for the treatment or prevention of diabetes mellitus and other metabolic imbalances The invention relates to methods for treatment and prevention of a metabolic imbalance, including diabetes mellitus and other related diseases or disorders, using an extract from a fruit of genus Elaeis. ...	12/06/2011
8041007	Methods and systems for determining the average atomic number and mass of materials Disclosed herein are methods and systems of scanning a target for potential threats using the energy spectra of photons scattered from the target to determine the spatial distributions of average atomic number and/or mass in the target. An exemplary method comprises...	10/18/2011
8026230	Methods and compositions for treating cancer using proteasome inhibitors The present invention relates to therapeutic compositions for treating cancer or preventing the growth of cancer cells, e.g., tumor growth, in a subject. The present invention also relates to methods for treating cancer, e.g., inhibiting tumor growth, in a subject w...	09/27/2011
8026224	Tumor cells with increased immunogenicity and uses therfor Tumor cells modified to express a T cell costimulatory molecule are disclosed. In one embodiment, the costimulatory molecule is a CD28/CTLA4 ligand, preferably a B lymphocyte antigen B7. The tumor cells of the invention can be modified by transfection with nucleic a...	09/27/2011
7993959	Methods for producing multiple distinct transistors from a single semiconductor Provided are methods for producing multiple distinct transistors from a single semiconductor layer, and apparatus incorporating transistors so produced. ...	08/09/2011
7947652	Compositions and methods for modulating PGC-1α to treat huntington's disease The present invention provides methods for modulating mitochondrial function, modulating lesion formation in the brain, modulating neurite growth, modulating neuronal degeneration, and treating and preventing neurological diseases or disorders comprising modulating ...	05/24/2011
7893108	Antiviral methods and compositions Disclosed herein are antiviral compounds, such as anti-human cytomegalovirus antiviral compounds, pharmaceutical compositions and antiviral methods. ...	02/22/2011
7888509	Chiral 1,8-diarylnaphthalenes, methods of making them, and their use as sensors One aspect of the invention relates to 1,8-diarylnaphthalene compounds. In certain embodiments, a compound of the invention is an N-oxide of a 1,8-diarylnaphthalene. In certain embodiments, the aryl group is an optionally substituted acridyl group. In certain embodi...	02/15/2011
7871459	Apparatus and methods for non-regenerative and regenerative hot gas desulfurization Disclosed is a doped cerium oxide sorbent that can effectively and regenerably remove H2S in the temperature range of about 500° C. to about 1000° C. Regenerable sorbents (e.g., ZnO, La2O3, CeO2) and methods of using the...	01/18/2011
7858803	Imaging tracers for early detection and treatment of amyloid plaques caused by Alzheimer's disease and related disorders The present invention relates to compounds and methods for imaging and treating Alzheimer's disease or an amyloidosis-associated pathological condition that utilize a novel amyloid imaging tracer for detecting amyloid deposits in a subject suffering from these condi...	12/28/2010
7858784	Ligands for transition-metal-catalyzed cross-couplings, and methods of use thereof Ligands for transition metals are disclosed herein, which may be used in various transition-metal-catalyzed carbon-heteroatom and carbon-carbon bond-forming reactions. The disclosed methods provide improvements in many features of the transition-metal-catalyzed reac...	12/28/2010
7858742	Lymphoma associated molecules and uses therefor The invention provides isolated nucleic acids molecules, designated BAL nucleic acid molecules, which are differentially expressed in non-Hodgkin's lymphoma. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing BAL ...	12/28/2010
7842835	Histone deacetylase inhibitors and methods of use thereof The invention provides novel classes of HDAC inhibitors. Methods of sensitizing a cancer cell to the cytotoxic effects of radiotherapy are also provided as well as methods for treating cancer and methods for treating neurological diseases. Additionally, the inventio...	11/30/2010
7838699	Embolization using degradable crosslinked hydrogels One aspect of the present invention relates to a method of temporarily embolizing a blood vessel using a hydrolytically degradable crosslinked hydrogel as an embolus. In certain embodiments, the hydrolytically degradable crosslinked hydrogel substantially hydrolyzes...	11/23/2010
7824913	Bioengineered tissue constructs and methods for producing and using thereof Cultured tissue constructs comprising cultured cells and endogenously produced extracellular matrix components without the requirement of exogenous matrix components or network support or scaffold members. Some tissue constructs of the invention are comprised of mul...	11/02/2010
7799528	Therapeutic and diagnostic applications of genes differentially expressed in lympho-hematopoietic stem cells The invention is based at least in part on the discovery of novel group of genes and/or their encoded gene products that are differentially represented in two substantially enriched CD34+/CD38−/Lin− and CD34+/[CD38/Lin...	09/21/2010
7767202	Modulation of systemic immune responses by transplantation of hematopoietic stem cells transduced with genes encoding antigens and antigen presenting cell regulatory molecules The invention provides methods and compositions for the modulation of systemic immune responses by transplantation of hematopoietic stem cells transduced with genes encoding antigens and antigen presenting cell regulatory molecules. The invention includes bi-cistron...	08/03/2010
7759082	Electroprocessed fibrin-based matrices and tissues The invention is directed to formation and use of electroprocessed fibrin as an extracellular matrix and, together with cells, its use in forming engineered tissue. The engineered tissue can include the synthetic manufacture of specific organs or tissues which may b...	07/20/2010
7722868	Agents that modulate the interaction of B7-1 polypeptide with PD-L1 and methods of use thereof Disclosed are methods for modulating an immune response including a method for inhibiting the interaction between a B7 polypeptide and a PD-1 ligand, the method comprising contacting an immune cell bearing a PD-1 ligand, or an immune cell bearing a B7 polypeptide, w...	05/25/2010
7709214	Methods for upregulating an immune response with agents that inhibit the intereaction between PD-L2 and PD-1 The invention provides isolated nucleic acids molecules, designated PD-L2 nucleic acid molecules, which encode novel B7-related molecules which are ligands for PD-1. The invention also provides antisense nucleic acid molecules, recombinant expression vectors contain...	05/04/2010
7700301	Methods for screening for compounds that modulate PD-1 signaling Disclosed are screening assays for identifying compounds which modulate the activity of, or signaling via, B7-4, or PD-1, especially which modulate the binding of B7-4 or PD-1 to a target molecule. ...	04/20/2010
7691840	Analogs of benzoquinone-containing ansamycins and methods of use thereof The present invention provides analogs of benzoquinone-containing ansamycins and uses thereof for treating and modulating disorders associated with hyperproliferation, such as cancer. The present invention provides analogs of benzoquinone-containing ansamycins where...	04/06/2010
7691578	Methods and compositions for treating obesity The present invention relates to therapeutic compositions for treating or preventing obesity and obesity-related disorders in a subject. The present invention also relates to the use of PGC-1 expression levels to determine the safe dosage range for known or putative...	04/06/2010
7682313	Implantable pressure monitor A system and method for the intra corporal, telemetric measuring of blood pressure, particularly within the heart or a great vessel, includes a substantially rigid sensor chip mounted in a holder and an antenna. The holder is anchored within an appropriate location ...	03/23/2010
7659382	Methods and compositions for the treatment and prevention of HIV infection using TRIM5α The invention provides novel TRIM polypeptides, proteins, and nucleic acid molecules. In addition to isolated, full-length TRIM proteins, the invention further provides isolated TRIM fusion proteins, antigenic peptides and anti-TRIM antibodies. The invention also pr...	02/09/2010
7638492	Methods of upmodulating an immune response with non-activating forms of B7-4 The invention identifies PD-1 as a receptor for B7-4. B7-4 can inhibit immune cell activation upon binding to an inhibitory receptor on an immune cell. Accordingly, the invention provides agents for modulating PD-1, B7-4, and the interaction between B7-4 and PD-1 in...	12/29/2009
7635757	B7-4 Antibodies and uses therefor The invention provides isolated nucleic acids molecules, designated B7-4 nucleic acid molecules, which encode novel B7-4 polypeptides. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing B7-4 nucleic acid molecules...	12/22/2009
7634058	Methods and systems for determining the average atomic number and mass of materials Disclosed herein are methods and systems of scanning a target for potential threats using the energy spectra of photons scattered from the target to determine the spatial distributions of average atomic number and/or mass in the target. An exemplary method comprises...	12/15/2009
7632660	Lymphoma associated molecules and uses therefor The invention provides isolated nucleic acids molecules, designated BBAP nucleic acid molecules, which encode proteins that interact with or bind to BAL molecules, which are differentially expressed in non-Hodgkin's lymphoma. The invention also provides antisense nu...	12/15/2009
7618400	Dressing for securing and protecting a needle A device for securing and protecting a needle, the device comprising a first portion (3) and a second portion (5), each provided with an adhesive face covered in a detachable anti-adhesive sheet, the first portion (3) being for securing to the s...	11/17/2009
7608613	Analogs of benzoquinone-containing ansamycins and methods of use thereof The present invention provides analogs of benzoquinone-containing ansamycins and uses thereof for treating and modulating disorders associated with hyperproliferation, such as cancer. The present invention provides analogs of benzoquinone-containing ansamycins where...	10/27/2009
7569546	Apolipoprotein A1 mimetics and uses thereof The present invention provides peptidomimetics derived from Apolipoprotein A-I, which is useful for beneficially influencing lipid parameters and/or plasma cholesterol levels. The invention also provides pharmaceutical compositions and methods of treatment for eleva...	08/04/2009

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