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...that Thomas Edison's patent application on his phonograph was approved by the Patent Office in just seven weeks? In contrast, it took Gordon Gould, the inventor of the laser, 30 years to obtain his patent -- finally awarded in 1988!
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| Number | Title | Issue Date |
| 8143378 | Polymer factor VIII moiety conjugates Conjugates of a Factor VIII moiety and one or more water-soluble polymers are provided. Typically, the water-soluble polymer is poly(ethylene glycol) or a derivative thereof. Also provided are compositions comprising the conjugates, methods of making the conjugates,... | 03/27/2012 |
| 8133865 | von Willebrand factor- and factor VIII-polymer conjugates having a releasable linkage The present invention provides von Willebrand Factor-polymer conjugates and Factor VIII-polymer conjugates, each having a releasable linkage. Methods of making conjugates, methods for administering conjugates, are also provided. ... | 03/13/2012 |
| 8097645 | Compounds for activating TGF-β signaling Compositions and methods for treatment and prevention of disorders and conditions characterized by reduced TGF-β signaling are described. ... | 01/17/2012 |
| 8076412 | Water-soluble polymer alkanals The present invention is directed to alkanal derivatives of water-soluble polymers such as poly(ethylene glycol), their corresponding hydrates and acetals, and to methods for preparing and using such polymer alkanals. The polymer alkanals of the invention are prepar... | 12/13/2011 |
| 8008435 | Polymer stabilized neuropeptides A substantially hydrophilic conjugate is provided having a peptide that is capable of passing the blood-brain barrier covalently linked to a water-soluble nonpeptidic polymer such as polyethylene glycol. The conjugate exhibits improved solubility and in vivo stabili... | 08/30/2011 |
| 7981871 | Modified macromolescules and associated methods of synthesis and use Described herein are compounds such as macromolecules that have been modified in order to facilitate crosslinking by introduction of at least one hydrazide-reactive group and/or aminooxy-reactive group, and methods of making and using thereof for scar-free wound hea... | 07/19/2011 |
| 7928069 | Crosslinked compounds and methods of making and using thereof Described herein are crosslinked compounds useful in numerous treatments. Described herein are methods of making crosslinked compounds via (1) die oxidative coupling of two or more thiol compounds or (2) by the reaction between at least one thiol compound with at le... | 04/19/2011 |
| 7863421 | Polymer-factor VIII moiety conjugates Conjugates of a Factor VIII moiety and one or more water-soluble polymers are provided. Typically, the water-soluble polymer is poly(ethylene glycol) or a derivative thereof. Also provided are compositions comprising the conjugates, methods of making the conjugates,... | 01/04/2011 |
| 7861915 | Soldering process A process by which molten solder is purified in-situ, making the soldering process more efficient and yielding better results, particularly for lead-free soldering. Lead-free solder becomes practical for use since the temperature for reliable soldering is reduced. A... | 01/04/2011 |
| 7858749 | Polymer-factor VIII moiety conjugates Conjugates of a Factor VIII moiety and one or more water-soluble polymers are provided. Typically, the water-soluble polymer is poly(ethylene glycol) or a derivative thereof. Also provided are compositions comprising the conjugates, methods of making the conjugates,... | 12/28/2010 |
| 7838595 | Water-soluble polymer alkanals The present invention is directed to alkanal derivatives of water-soluble polymers such as poly(ethylene glycol), their corresponding hydrates and acetals, and to methods for preparing and using such polymer alkanals. The polymer alkanals of the invention are prepar... | 11/23/2010 |
| 7829118 | Modified hyaluronic acid polymer compositions and related methods The present application provides compositions comprising hyaluronic acid having low levels of functional group modification, mixtures formed by controlled reaction of such lightly modified hyaluronic acid with suitable difunctional or multi-functional crosslinkers, ... | 11/09/2010 |
| 7829074 | Hydroxypatite-targeting poly(ethylene glycol) and related polymers Isolatable, hydroxyapatite-targeting polymeric structures, and biologically active conjugates thereof, are provided. The polymeric structure includes a linear or branched water-soluble and non-peptidic polymer backbone, such as a PEG backbone, having at least two te... | 11/09/2010 |
| 7786221 | Multi-armed, monofunctional, and hydrolytically stable derivatives of poly (ethylene glycol) and related polymers for modification of surfaces and molecules Multi-armed, monofunctional, and hydrolytically stable polymers are described having the structure wherein Z is a moiety that can be activated for attachment to biologically active molecules such as proteins and wherein P a... | 08/31/2010 |
| 7744861 | Multi-arm polymer prodrugs Provided herein are water-soluble prodrugs. The prodrugs of the invention comprise a water-soluble polymer having three or more arms, at least three of which are covalently attached to an active agent, e.g., a small molecule. The conjugates of the invention provide ... | 06/29/2010 |
| 7714114 | Conjugates of an EPO moiety and a polymer Conjugates of an EPO moiety and one or more non-peptidic water-soluble polymers are provided. Typically, the non-peptidic water-soluble polymer is poly(ethylene glycol) or a derivative thereof. Also provided are compositions comprising such conjugates, methods of ma... | 05/11/2010 |
| 7655747 | Soluble, degradable poly(ethylene glycol) derivatives for controllable release of bound molecules into solution PEG and related polymer derivatives having weak, hydrolytically unstable linkages near the reactive end of the polymer are provided for conjugation to drugs, including proteins, enzymes, small molecules, and others. These derivatives provide a sufficient circulation... | 02/02/2010 |
| 7585875 | Substituted pyrazolo[1,5-a]pyridine compounds and their methods of use The present invention is directed to substituted pyrazolo[1,5-a]pyridines and related methods for their synthesis and use. ... | 09/08/2009 |
| 7547509 | Cyanovirin variant-polymer conjugates The present invention provides variants of cyanovirin-N and water-soluble polymer conjugates thereof, and methods of preparing such conjugates. The cyanovirin-N of the invention are particularly suited for site-selective covalent attachment of one or more water solu... | 06/16/2009 |
| 7511094 | Water-soluble polymer alkanals The present invention is directed to alkanal derivatives of water-soluble polymers such as poly(ethylene glycol), their corresponding hydrates and acetals, and to methods for preparing and using such polymer alkanals. The polymer alkanals of the invention are prepar... | 03/31/2009 |
| 7432331 | Hydrolytically stable maleimide-terminated polymers The present invention is directed to hydrolytically stabilized maleimide-functionalized water soluble polymers and to methods for making and utilizing such polymers and their precursors. ... | 10/07/2008 |
| 7432330 | Hydrolytically stable maleimide-terminated polymers The present invention is directed to hydrolytically stabilized maleimide-functionalized water soluble polymers and to methods for making and utilizing such polymers and their precursors. ... | 10/07/2008 |
| 7419600 | Method for purifying a branched water-soluble polymer Multi-armed, monofunctional, and hydrolytically stable polymers are described having the structure wherein Z is a moiety that can be activated for attachment to biologically active molecules such as proteins and wherein P a... | 09/02/2008 |
| 7417069 | Halogenated triptolide derivatives as immunomodulators and anticancer agents Compounds having the structure I: are useful for inducing cell death (apoptosis) and in immunosuppression. In structure I, CR1R2 is selected from CHOH, C═O, CHF, CF... | 08/26/2008 |
| 7378469 | Method for the preparation of 1-benzotriazolyl carbonate esters of poly(ethylene glycol) The invention provides a method for preparing a 1-benzotriazolylcarbonate ester of a water-soluble and non-peptidic polymer by reacting a terminal hydroxyl group of a water-soluble and non-peptidic polymer with di(1-benzotriazolyl)carbonate in the presence of an ami... | 05/27/2008 |
| 7329721 | Maleamic acid polymer derivatives and their bioconjugates The present invention is directed to maleamic acid derivatives of water soluble polymers, to chemically stable water-soluble polymer succinamic acid-active agent conjugates, and to methods for reproducibly preparing, characterizing and using such polymer reagents an... | 02/12/2008 |
| 7316811 | Multi-arm polypeptide-poly (ethylene glycol) block copolymers as drug delivery vehicles The invention provides a multi-arm block copolymer for use in delivering a variety of bioactive agents. The copolymer of the invention contains a central core from which extend multiple (3 or more) copolymer arms. Each copolymer arm possesses an inner polypeptide se... | 01/08/2008 |
| 7267941 | Cyanovirin variant-polymer conjugates The present invention provides variants of cyanovirin-N and water-soluble polymer conjugates thereof. The cyanovirin-N of the invention are particularly suited for site-selective covalent attachment of one or more water soluble polymers, to provide polymer conjugate... | 09/11/2007 |
| 7157546 | Water-soluble polymer alkanals The present invention is directed to alkanal derivatives of water-soluble polymers such as poly(ethylene glycol), their corresponding hydrates and acetals, and to methods for preparing and using such polymer alkanals. The polymer alkanals of the invention are prepar... | 01/02/2007 |
| 7101932 | Method for the preparation of 1-benzotriazolyl carbonate esters of poly (ethylene glycol) The invention provides a method for preparing a 1-benzotriazolylcarbonate ester of a water-soluble and non-peptidic polymer by reacting a terminal hydroxyl group of a water-soluble and non-peptidic polymer with di(1-benzotriazolyl)carbonate in the presence of an ami... | 09/05/2006 |
| 7060259 | Hydrolytically degradable carbamate derivatives of poly(ethylene glycol) Poly(ethylene glycol) carbamate derivatives useful as water-soluble prodrugs are disclosed. These degradable poly(ethylene glycol) carbamate derivatives also have potential applications in controlled hydrolytic degradation of hydro... | 06/13/2006 |
| 7030278 | Polyethylene(Glycol) derivatives with proximal reactive groups An activated, substantially water soluble poly(ethylene glycol) is provided having of a linear or branched poly(ethylene glycol) backbone and at least one terminus linked to the backbone through a hydrolytically stable linkage, wherein the terminus is branched and h... | 04/18/2006 |
| 6921527 | Composition for pulmonary administration comprising a drug and a hydrophobic amino acid According to the subject invention, dispersible dry powder pharmaceutical-based compositions are provided, including methods for their manufacture and dry powder dispersion devices. A dispersible dry powder pharmaceutical-based composition is one having a moisture c... | 07/26/2005 |
| 6896906 | Storage stable powder compositions of interleukin-4 receptor The present invention provides storage stable dry powder compositions of IL-4R. The powder compositions demonstrate superior chemical and physical stability over their solution counterparts, particularly upon storage under varying conditions of temperature and humid... | 05/24/2005 |
| 6890518 | Compositions of chemically modified insulin The present invention provides active, hydrophilic polymer-modified derivatives of insulin. The insulin derivatives of the invention are, in one aspect, suitable for delivery to the lung and exhibit pharmakokinetic and/or pharmacodynamic properties that are signific... | 05/10/2005 |
| 6838075 | Inhaleable spray dried 4-helix bundle protein powders having minimized aggregation The present invention provides highly dispersible spray-dried powder compositions, and in particular, inhaleable dry powder compositions for aerosolized delivery to the lungs. The powders of the invention are produced by spray drying a 4 α-helix bundle protein unde... | 01/04/2005 |
| 6838076 | Pulmonary administration of chemically modified insulin The present invention provides active, hydrophilic polymer-modified derivatives of insulin. The insulin derivatives of the invention are, in one aspect, suitable for delivery to the lung and exhibit pharmakokinetic and/or pharmacodynamic properties that are signific... | 01/04/2005 |
| 6835372 | Compositions comprising an active agent The present invention provides a highly dispersible formulation comprising an active agent and a dipeptide or tripeptide comprising at least two leucyl residues. The composition of the invention possesses superior aerosol properties and is thus preferred for aerosol... | 12/28/2004 |
| 6825031 | Storage of materials Materials which are not themselves storage-stable at room temperature are made suitable for storage by mixing them with a carrier substance and spray drying the resulting mixture so as to form particles containing both the material and the carrier substance in which... | 11/30/2004 |
| 6797258 | Compositions and methods for the pulmonary delivery of aerosolized macromolecules According to the subject invention, dispersible dry powder pharmaceutical-based compositions are provided, including methods for their manufacture and dry powder dispersion devices. A dispersible dry powder pharmaceutical-based composition is one having a moisture c... | 09/28/2004 |
