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| Number | Title | Issue Date |
| 8173807 | Pyridine, pyrimidine and pyrazine derivatives as GPCR agonists Compounds of formula (I): R1-A-V—B—R2, wherein V is phenyl or a 6-membered heteroaryl ring containing up to three N-atoms, or pharmaceutically acceptable salts thereof, are agonists of GPR116 and are useful for the treatment of obesity, and... | 05/08/2012 |
| 8173624 | Methods of using substituted tetracycline compounds to modulate RNA A method for modulating RNA with tetracycline compounds is described. ... | 05/08/2012 |
| 8168810 | 7-phenyl-substituted tetracycline compounds 7-phenyl-substituted tetracycline compounds, methods of treating tetracycline responsive states, and pharmaceutical compositions containing the 7-phenyl-substituted tetracycline compounds are described. ... | 05/01/2012 |
| 8158622 | Pyrrolopyridine-2-carboxylic acid amide inhibitors of glycogen phosphorylase Compounds represented by Formula (I): or pharmaceutically acceptable salts thereof, are inhibitors of glycogen phosphorylase and are useful in the prophylactic or therapeutic treatment of diabetes, ... | 04/17/2012 |
| 8153644 | Diacylglycerol acyltransferase inhibitors Provided herein are compounds of the formula (I): as well as pharmaceutically acceptable salts thereof, wherein the substituents are as those disclosed in the specification. These compounds, and the pharmaceutical compositi... | 04/10/2012 |
| 8124766 | Inhibitors of diacylglycerol acyltransferase Provided herein are compounds of the formula (I): as well as pharmaceutically acceptable salts thereof, wherein the substituents are as those disclosed in the specification. These compounds, and the pharmaceutical compositi... | 02/28/2012 |
| 8124605 | Compositions and methods for modulating a kinase cascade The invention relates to compounds and methods for modulating one or more components of a kinase cascade. ... | 02/28/2012 |
| 8119622 | 7-phenyl-substituted tetracycline compounds 7-phenyl-substituted tetracycline compounds which are substantially free of positional isomers, methods of treating tetracycline responsive states, and pharmaceutical compositions containing the 7-phenyl-substituted tetracycline compounds are described. 7-substitute... | 02/21/2012 |
| 8115011 | Diacylglycerol acyltransferase inhibitors Provided herein are compounds of the formula (I): as well as pharmaceutically acceptable salts thereof, wherein the substituents are as those disclosed in the specification. These compounds, and the pharmaceutical compositi... | 02/14/2012 |
| 8106225 | Methods of preparing substituted tetracyclines with transition metal-based chemistries The present invention relates to novel chemistries which allow for heretofore unobtainable substituted tetracycline compounds which exhibit significant activity in tetracycline responsive states. The methods disclosed herein utilize reactive tetracycline-based precu... | 01/31/2012 |
| 8101782 | Compounds that inhibit cholinesterase Compounds that inhibit cholinesterase activity and, upon hydrolysis release a pharmacologically active agent. The compounds of the invention are employed in methods to treat an individual. The pharmacologically active agent obtained by hydrolysis of the compound can... | 01/24/2012 |
| 8101591 | 9-aminoacyl tetracycline compounds and methods of use thereof A compound of formula (I): ... | 01/24/2012 |
| 8088820 | Substituted tetracycline compounds for the treatment of malaria This invention provides a method for treating or preventing malaria in a subject. The method includes administering to the subject an effective amount of a substituted tetracycline compound, such that malaria is treated or prevented. In one aspect, the invention rel... | 01/03/2012 |
| 8088768 | Protein kinase and phosphatase inhibitors The present invention provides a method for identifying inhibitors of protein kinases and/or protein phosphatases. Methods are also provided for inhibiting protein kinase and/or protein phosphatase activity. Specific non-peptide protein tyrosine kinase and/or protei... | 01/03/2012 |
| 8088755 | 11a, 12-derivatives of tetracycline compounds 11a,12-dehydrotetracycline compounds are described. ... | 01/03/2012 |
| 8058299 | Diacylglycerol acyltransferase inhibitors Provided herein are compounds of the formula (I): as well as pharmaceutically acceptable salts thereof, wherein the substituents are as those disclosed in the specification. These compounds, and the pharmaceutical compositi... | 11/15/2011 |
| 8048867 | 9-substituted minocycline compounds The present invention pertains, at least in part, to novel 9-substituted minocycline compounds. These minocycline compounds can be used to treat numerous tetracycline compound-responsive states, such as bacterial infections and neoplasms, as well as other known appl... | 11/01/2011 |
| 8044207 | Pyridinoylpiperidines as 5-HTagonists The invention relates to compounds of formula I: or pharmaceutically acceptable acid addition salts thereof, where; R1 is C1-C6 alkyl, substituted C1-C | 10/25/2011 |
| 8012951 | 7-N-substituted phenyl tetracycline compounds 7-substituted tetracycline compounds, methods of treating tetracycline responsive states, and pharmaceutical compositions containing the 7-substituted tetracycline compounds are described. ... | 09/06/2011 |
| 7968574 | Biaryl compositions and methods for modulating a kinase cascade The invention relates to compounds and methods for modulating one or more components of a kinase cascade. The invention relates to compounds of the formula I: or a pharmaceutically acceptable salt thereof. The compounds of ... | 06/28/2011 |
| 7960366 | Substituted tetracycline compounds as synergistic antifungal agents Methods and compositions for treating for the synergistic treatment of fungal associated disorders are discussed. ... | 06/14/2011 |
| 7939529 | Process for the preparation of compositions for modulating a kinase cascade and methods of use thereof The invention relates to compositions comprising 2-(5-(4-(2-morpholinoethoxy)phenyl)pyridin-2-yl)-N-benzylacetamide and its mesylate and dihydrochloride salts. More specifically, the invention provides an efficient process for the synthesis of 2-(5-(4-(2-morpholinoe... | 05/10/2011 |
| 7935687 | Methods for treating spinal muscular atrophy using tetracycline compounds Methods for using tetracycline compounds for the treatment of spinal muscular atrophy are described. ... | 05/03/2011 |
| 7901894 | Kinase inhibitors The present invention provides a method for identifying inhibitors of protein kinases. Methods are also provided for inhibiting protein kinase activity. Specific non-peptide protein tyrosine kinase inhibitors are provided. The protein kinases produced using the meth... | 03/08/2011 |
| 7897784 | Process for preparing five-membered heterocyclyl tetracycline compounds and methods of use thereof The present invention provides processes for preparing a compound of Formula (I): or a pharmaceutically acceptable salt thereof, wherein A is a pyrrole, tetrazole or triazole ring. ... | 03/01/2011 |
| 7897639 | Carbamoyl esters that inhibit cholinesterase and release pharmacologically active agents Carbamoyl esters inhibit cholinesterase activity and, upon hydrolysis release a pharmacologically active agent. In one embodiment, the carbamoyl ester has the following structure: wherein A is selected from the group consis... | 03/01/2011 |
| 7893282 | 7-substituted fused ring tetracycline compounds 7-substituted fused ring tetracycline compounds, methods of treating tetracycline responsive states, and pharmaceutical compositions containing the 7-substituted fused ring tetracycline compounds are described. ... | 02/22/2011 |
| 7875649 | 7, 8 and 9-substituted tetracycline compounds 7, 8 and 9-substituted tetracycline compounds, methods of treating tetracycline responsive states, and pharmaceutical compositions containing the 7, 8 and 9-substituted tetracycline compounds are described. ... | 01/25/2011 |
| 7858601 | 4-substituted tetracyclines and methods of use thereof The present invention pertains, at least in part, to novel substituted tetracycline compounds. These tetracycline compounds can be used to treat numerous tetracycline compound-responsive states, such as bacterial infections and neoplasms, as well as other known appl... | 12/28/2010 |
| 7858600 | 7- and 9- carbamate, urea, thiourea, thiocarbamate, and heteroaryl-amino substituted tetracycline compounds Substituted tetracycline compounds, methods of synthesis, and methods of use are discussed. Tetracyclines useful for treating tetracycline related disorders are also discussed. Intermediates useful for synthesizing other tetracycline compounds are also included.... | 12/28/2010 |
| 7851470 | Composition and methods for modulating a kinase cascade The invention relates to compounds and methods for modulating one or more components of a kinase cascade. ... | 12/14/2010 |
| 7851460 | 7-phenyl-substituted tetracycline compounds 7-phenyl-substituted tetracycline compounds, methods of treating tetracycline responsive states, and pharmaceutical compositions containing the 7-phenyl-substituted tetracycline compounds are described. ... | 12/14/2010 |
| 7838542 | Bicyclic compositions and methods for modulating a kinase cascade The invention relates to compounds of the class of 2-carboxamide substituted indoles and methods for modulating one or more components of a kinase cascade. The compounds of the invention are useful for osteoporosis, hepatitis B, opthalmic disease, diabetes, athroscl... | 11/23/2010 |
| 7825129 | Thieno[2,3-c] isoquinolines for use as inhibitors of PARP The present invention relates to compounds for the inhibition of poly(ADP-ribose) polymerase (PARP). In some embodiments, the compounds have the Formula: wherein the constituent variables are as defined herein. The inventio... | 11/02/2010 |
| 7825105 | 3, 10, and 12a substituted tetracycline compounds The present invention pertains to novel 3, 10, and/or 12a-substituted tetracycline compounds. These tetracycline compounds can be used to treat numerous tetracycline compound-responsive states, such as bacterial infections and neoplasms, as well as other known appli... | 11/02/2010 |
| 7820641 | Substituted tetracycline compounds The present invention pertains, at least in part, to novel substituted tetracycline compounds. These tetracycline compounds can be used to treat numerous tetracycline compound-responsive states, such as bacterial infections and neoplasms, as well as other known appl... | 10/26/2010 |
| 7807660 | Tetracycline compounds for treatment of related disorders Methods and compositions for treating Cryptosporidium parvum related disorders in a mammal are discussed. Several novel tetracycline compounds useful for treating Cryptosporidium parvum related disorders are also included. ... | 10/05/2010 |
| 7803813 | Substituted 2-carbonylamino-6-piperidinaminopyridines and substituted 1-carbonylamino-3-piperidinaminobenzenes as 5-HT1F agonists The present invention relates to compounds of formula I: or a pharmaceutically acceptable acid addition salt thereof, wherein X is C(R3c)═ or N═; R1 is C2-C6 alkyl, substitute... | 09/28/2010 |
| 7795307 | Carbamoyl esters that inhibit cholinesterase and release pharmacologically active agents Carbamoyl esters inhibit cholinesterase activity and, upon hydrolysis release a pharmacologically active agent. In one embodiment, the carbamoyl ester has the following structure: Formula (I) wherein A is selected from the group consisting of an unsubstituted aryl, ... | 09/14/2010 |
| 7772216 | Protein kinase and phosphatase inhibitors and methods for designing them The present invention provides a method for identifying inhibitors of protein kinases and/or protein phosphatases. Methods are also provided for inhibiting protein kinase and/or protein phosphatase activity. Specific non-peptide protein tyrosine kinase and/or protei... | 08/10/2010 |
