William F. Semple, a dentist, was awarded the first US Patent on chewing gum in 1869. His recipe contained powdered chalk.
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| Number | Title | Issue Date |
| 5998654 | Retinoic acid receptor antagonist compounds and methods Trienoic compounds having activity as antagonists for retinoic acid receptors are provided. Also provided are pharmaceutical compositions incorporating such compounds and methods for their therapeutic use.... | 12/07/1999 |
| 5580559 | Hybrid plasminogen activator Novel single-chain hybrid plasminogen activators having an amino acid sequence composed of at least two subsequences corresponding in amino acid identity and number to subsequences of human t-PA and of human u-PA, and mutants thereof in which at least one... | 12/03/1996 |
| 5571894 | Recombinant antibodies specific for a growth factor receptor The invention concerns recombinant antibodies directed to the extracellular domain of the human growth factor receptor c-erbB-2 comprising a light chain variable domain and a heavy chain variable domain of a monoclonal antibody, monoclonal antibodies dire... | 11/05/1996 |
| 5563074 | Immunological detection methods The present invention relates to monoclonal antibodies that are distinguished by a high degree of selectivity and affinity towards triasulfurone and that are therefore outstandingly suitable for use in an immunoassay for the rapid and effective detection ... | 10/08/1996 |
| 5559007 | Bacterial shuttle vectors The invention relates to the field of genetic engineering and provides novel DNA molecules which comprise multifunctional origins of replication and/or a DNA sequence coding for the most abundant protein in the supernatant of cultures of Lactococcus Spec.... | 09/24/1996 |
| 5558997 | Monoclonal antibodies to mycosphaerella species The invention relates to monoclonal antibodies that react specifically with members of the genus Mycosphaerella and hybridomas that produce such antibodies. The invention is further directed to a method for making a hybridoma cell line that produces monoc... | 09/24/1996 |
| 5541310 | Herbicide resistant plants Disclosed are plants, plant tissue and plant seed, whose growth and development are tolerant of, or resistant to various imidazole and triazole herbicidal compounds, at levels which normally are inhibitory to the plants. The tolerance or resistance is con... | 07/30/1996 |
| 5534409 | Cytokine regulated transcription factor The present invention discloses isolated nucleic acids encoding MGF and recombinant proteins encoded thereby. In addition to being useful for the production of recombinant MGF, these nucleic acids are also useful as probes. In a further aspect of the inve... | 07/09/1996 |
| 5530195 | Bacillus thuringiensis gene encoding a toxin active against insects The present invention is drawn to a novel toxin gene purified and isolated from Bacillus thuringiensis var kurstaki and given the designation CryIE(c). The novel toxin gene encodes a protein of approximately 130 kDa in size and is active against Lepidopte... | 06/25/1996 |
| 5519125 | Plant adenylosuccinate synthetase and DNA coding therefor The present invention provides novel plant DNA sequences coding for native adenylosuccinate synthetase (ADSS). Methods for using the complete or partial ADSS coding sequence as a probe for diagnostic, mapping and other purposes are taught. Generation of t... | 05/21/1996 |
| 5508184 | Process for transforming plant protoplast The present invention relates to an improved process for transforming plant protoplasts using simple, purely chemical, process steps, and to the plant material obtainable by this method. The transfer of the genetic material into the plant cell is carried out ... | 04/16/1996 |
| 5501975 | DNA molecules encoding an ER-located endoprotease The invention concerns novel DNA molecules encoding a modified, endoplasmic reticulum-located "dibasic processing endoprotease" and the use of said endoplasmic reticulum-located "dibasic processing endoprotease" for the correct processing of heterologous ... | 03/26/1996 |
| 5466585 | Interferon-induced human protein in pure form, monoclonal antibodies thereto, and test kits containing these antibodies The invention relates to purified proteins induced in human cells by interferon or ଲ, RNAs, DNAs and hybrid vectors coding for said proteins, hosts transformed with such a hybrid vector, processes for the preparation and purification of thes... | 11/14/1995 |
| 5447862 | Pectin lyase genes of aspergillus niger Recombinant DNA molecules coding for pectin lyase (PL) expression systems and derivatives thereof, such as the structural genes of PLA, PLB, PLC, PLD, PLE and PLF, and corresponding regulatory sequences, e.g. promoter, signal and terminator sequences, and... | 09/05/1995 |
| 5422249 | Process for the manufacture of thrombin inhibitors The invention relates to DNA sequences that code for the amino acid sequence of the thrombin inhibitor hirudin, hybrid vectors containing such DNA sequences, host cells transformed with such hybrid vectors, novel polypeptides with thrombin-inhibiting acti... | 06/06/1995 |
| 5397697 | Identification of plant-responsive genes of bacteria The invention is a method for identifying and cloning bacterial genes that are responsive to the presence of a plant host, comprising mutating a bacterial culture with a transposon containing a promoterless marker gene, exposing the bacterial mutants to r... | 03/14/1995 |