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| Number | Title | Issue Date |
| 8138383 | Membrane active heteropolymers The present invention is directed to a class of membrane active polymers useful for cellular delivery of compounds. Conjugation of the described membrane active polymers to targeting, anti-opsonization, and anti-aggregation agents provides polymers suitable for in v... | 03/20/2012 |
| 8137695 | Polyconjugates for in vivo delivery of polynucleotides The present invention is directed to compounds, compositions, and methods useful for delivering polynucleotides or other cell-impermeable molecules to mammalian cells. Described are polyconjugates systems that incorporate targeting, anti-opsonization, anti-aggregati... | 03/20/2012 |
| 8021875 | Methods for expression of transgenes The present invention relates to compositions and methods for increasing long term expression in vitro and in vivo, comprising sequences and gene expression cassettes that increase expression of genes to which they are operably linked. ... | 09/20/2011 |
| 8017109 | Endosomolytic poly(acrylate) polymers The present invention is directed to membrane active polymers useful for cellular delivery of compounds. Described are polyconjugates systems that incorporate targeting, anti-opsonization, anti-aggregation, and transfection activities into small biocompatible in viv... | 09/13/2011 |
| 8008355 | Endosomolytic poly(vinyl ether) polymers The present invention is directed to membrane active polymers useful for cellular delivery of compounds. Described are polyconjugates systems that incorporate targeting, anti-opsonization, anti-aggregation, and transfection activities into small biocompatible in viv... | 08/30/2011 |
| 7985406 | Membrane active heteropolymers The present invention is directed to a class of membrane active polymers useful for cellular delivery of compounds. Conjugation of the described membrane active polymers to targeting, anti-opsonization, and anti-aggregation agents provides polymers suitable for in v... | 07/26/2011 |
| 7909138 | Ladder security bracket and safety system A system of increased safety when performing work using a ladder is described. The system includes a ladder bracket for temporarily attachment of a ladder to a structure to stabilize or secure the ladder. The bracket is easy to install and acts to limit or prevent s... | 03/22/2011 |
| 7871818 | Membrane active polymers We describe a class of polymaleic anhydride polymers capable of disrupting cell membranes. Co-delivery of these polymers with biologically active compounds increases cellular cytoplasmic delivery of the compounds. ... | 01/18/2011 |
| 7803782 | Intravenous delivery of polynucleotides to cells in mammalian limb An intravenous delivery method is described that enables delivery of polynucleotides to extravascular cells of a mammalian limb. The method involves the injection of polynucleotides into a distal vein of a limb that is transiently occluded. Polynucleotide delivery i... | 09/28/2010 |
| 7781415 | Process for delivering sirna to cardiac muscle tissue A process for delivering a polynucleotide to a cardiac tissue cell in a mammal is described, comprising introducing a composition consisting of a polynucleotide into a blood vessel and increasing permeability of the blood vessel to the polynucleotide. The polynucleo... | 08/24/2010 |
| 7682626 | Polyvinylethers for delivery of polynucleotides to mammalian cells A class of polymers for delivery of polynucleotides to cells in described. More specifically, amphiphilic polyvinylethers and compositions containing amphiphilic polyvinylethers are described. ... | 03/23/2010 |
| 7642248 | Devices and processes for distribution of genetic material to mammalian limb A process is described for the delivery of a therapeutic polynucleotide to limb muscle tissue suffering from or potentially suffering from Muscular Dystrophy. The polynucleotide is inserted into a mammalian limb vessel such as an artery. Delivery efficiency and dist... | 01/05/2010 |
| 7589059 | Delivery of molecules and complexes to mammalian cells in vivo Disclosed is a system for providing in vivo delivery of molecules or complexes to extravascular mammalian cells using an intravascular administration route. The molecules or complexes are inserted in an injection solution into a mammalian vasculature. Insertion of t... | 09/15/2009 |
| 7547683 | Nucleic acid injected into hepatic vein lumen Processes are described for obtaining high levels of gene expression in primates after injection of nucleic acid to the liver via the lumen of the hepatic vein. The described process results in high level of gene expression with transient increases in liver enzymes.... | 06/16/2009 |
| 7524680 | Polyampholytes for delivering polyions to a cell An polyampholyte is utilized in a condensed polynucleotide complex for purposes of nucleic acid delivery to a cell. The complex can be formed with an appropriate amount of positive and/or negative charge such that the resulting complex can be delivered to the extrav... | 04/28/2009 |
| 7507722 | Intravascular delivery of nucleic acid Disclosed is a process for transfecting genetic material into a mammalian cell to alter endogenous properties of the cell. The process comprises designing a polynucleotide for transfection. Then the polynucleotide is inserted into a mammalian blood vessel. Prior to ... | 03/24/2009 |
| 7501394 | Compounds for targeting hepatocytes We describe compounds that bind to and are internalized by hepatocytes. Association of these compounds to other molecules or complexes can be used to target the molecules or complexes to hepatocytes in vivo or in vitro. ... | 03/10/2009 |
| 7498017 | Compositions for delivering nucleic acids to cells Cyclic amidinium containing compounds and their methods of preparation are described. Compositions containing these compounds facilitate delivery of biologically active polymers to cells in vitro and in vivo. ... | 03/03/2009 |
| 7491538 | Gene expression with covalently modified polynucleotides A process and compound wherein nucleic acids can be modified with a host of molecules and maintain their ability to be expressed. A modifying chemical attachment of polyions to polynucleotides can be used to facilitate the change of tertiary structure of the nucleic... | 02/17/2009 |
| 7482160 | Process of making a compound by forming a polymer from a template drug A method of forming polymers in the presence of nucleic acid using template polymerization. These methods can be used for the delivery of nucleic acids, for condensing the nucleic acid, for forming nucleic acid binding polymers, for forming supramolecular complexes ... | 01/27/2009 |
| 7476401 | Protein and peptide delivery to mammalian cells in vitro Compositions and methods for delivery of proteins and peptides to mammalian cells in vitro are described. Specifically, polypeptide-surfactant complexes formed from noncovalent hydrophobation of polypeptides and reversible hydrophobic modification of polypeptides ar... | 01/13/2009 |
| 7473419 | Intravascular delivery of nucleic acid Disclosed is a process for providing for expression of an exogenous nucleic acid in an extravascular parenchymal cell of a mammal. The nucleic acid is inserted into a vessel of a mammal and the permeability of the vessel is increased. Increasing permeability of the ... | 01/06/2009 |
| 7470539 | Formation of polyampholytes in the presence of a polyion Polyampholyte are able to condense nucleic acid to form small complexes which can be utilized in the delivery of nucleic acid to mammalian cells. The polyampholytes can be formed prior to interaction with nucleic acid or they can be formed in the presence of nucleic... | 12/30/2008 |
| 7442764 | Reversible modification of amine-containing compounds An process for the reversible modification of an amine-containing compound is described. Modification of the compound can be used to facilitate delivery of molecules to cells in vitro and in vivo or to alter interactions or activities the compounds. The described mo... | 10/28/2008 |
| 7439051 | Process for utilizing epitopes recognized by natural antibodies The present invention relates to compositions and methods for the selection and use of surface exposed epitopes. The present invention includes in vivo and in vitro phage peptide diplay methods for the identification and selection of peptides and peptide associated ... | 10/21/2008 |
| 7435723 | Process for delivery of polynucleotides to the prostate Disclosed is a system for providing in vivo delivery of polynucleotides to mammalian prostate cells using an intravascular administration route. The polynucleotides are inserted in an injection solution into a mammalian vasculature. Insertion of the injection soluti... | 10/14/2008 |
| 7396821 | Intravascular delivery of nucleic acid Disclosed is a process for transfecting genetic material into a mammalian cell to alter endogenous properties of the cell. The process comprises designing a polynucleotide for transfection. Then the polynucleotide is inserted into a mammalian blood vessel. Prior to ... | 07/08/2008 |
| 7396919 | Charge reversal of polyion complexes An ionic polymer is utilized in “recharging” (another layer having a different charge) a condensed polynucleotide complex for purposes of nucleic acid delivery to a cell. The resulting recharged complex can be formed with an appropriate amount of positive or neg... | 07/08/2008 |
| 7348453 | Labile linkage for compound delivery to a cell Described are ortho carboxy phenol derived acetals and compositions containing ortho carboxy phenol derived acetals which are useful for delivering biologically active compounds to cells. The acetals can be used to reversibly link up to three different molecules and... | 03/25/2008 |
| 7326780 | Compounds and processes for single-pot attachment of a label to nucleic acid Compounds and methods are provided for a single-pot covalent attachment of a label to nucleic acids comprising forming a covalently attachable labeling reagent for alkylating the molecule. Then, combining the covalently attachable labeling reagent with a mixture con... | 02/05/2008 |
| 7262056 | Enhancing intermolecular integration of nucleic acids using integrator complexes We disclose compositions and processes for enhancing transposon mediated integration of a nucleic acid molecule into another target nucleic acid molecule. Integration by an integrator complex is enhanced by cationic reagents. ... | 08/28/2007 |
| 7220400 | Compositions for delivering nucleic acids to cells Cyclic amidinium containing compounds and their methods of preparation are described. Compositions containing these compounds facilitate delivery of biologically active polymers to cells in vitro and in vivo. ... | 05/22/2007 |
| 7214369 | Devices and processes for distribution of genetic material to mammalian limb A process is described for the delivery of a therapeutic polynucleotide to limb muscle tissue suffering from or potentially suffering from ischemia. The polynucleotide is inserted into a mammalian limb vessel such as an artery. Delivery efficiency and distribution i... | 05/08/2007 |
| 7208314 | Compositions and methods for drug delivery using pH sensitive molecules A system relating to the delivery of desired compounds (e.g., drugs and nucleic acids) into cells using pH-sensitive delivery systems. The system provides compositions and methods for the delivery and release of a compound to a cell. ... | 04/24/2007 |
| 7192605 | Nucleic acid transfer complexes The present invention relates to compositions and methods for transferring nucleic acids into cells in vitro and in vivo. The compositions comprise a transfection reagent and one or more detergents. In preferred embodiments, the compositions comprise delivery system... | 03/20/2007 |
| 7148205 | Intravascular delivery of non-viral nucleic acid Disclosed is a process for transfecting genetic material into a mammalian cell to alter endogenous properties of the cell. The process comprises designing a polynucleotide for transfection. Then the polynucleotide is inserted into a mammalian vessel such as a tail v... | 12/12/2006 |
| 7138382 | Compositions and methods for drug delivery using pH sensitive molecules A system relating to the delivery of desired compounds (e.g., drugs and nucleic acids) into cells using pH-sensitive delivery systems. The system provides compositions and methods for the delivery and release of a compound to a cell. ... | 11/21/2006 |
| 7101995 | Compositions and processes using siRNA, amphipathic compounds and polycations Described is a deliverable composition with low toxicity comprising an amphipathic compound, a polycation, and a siRNA. The composition may be used in the process of delivering a siRNA to an animal cell or more particularly, a mammal cell. ... | 09/05/2006 |
| 7098030 | Polyampholytes for delivering polyions to a cell An polyampholyte is utilized in a condensed polynucleotide complex for purposes of nucleic acid delivery to a cell. The complex can be formed with an appropriate amount of positive and/or negative charge such that the resulting complex can be delivered to the extrav... | 08/29/2006 |
| 7094605 | Formation of polyampholytes in the presence of a polyion Polyampholyte are able to condense nucleic acid to form small complexes which can be utilized in the delivery of nucleic acid to mammalian cells. The polyampholytes can be formed prior to interaction with nucleic acid or they can be formed in the presence of nucleic... | 08/22/2006 |
