Did You Know...
...that Thomas Edison's patent application on his phonograph was approved by the Patent Office in just seven weeks? In contrast, it took Gordon Gould, the inventor of the laser, 30 years to obtain his patent -- finally awarded in 1988!
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| Number | Title | Issue Date |
| 5002874 | Genetically engineered eucaryotic host cells capable of expressing modified forms of eIF-2 Eucaryotic host cells are disclosed which contain a DNA molecule encoding an eIF-2 mutant and preferably a DNA sequence encoding a desired heterologous protein. The DNA sequences are linked to expression control sequences permitting expression of t... | 03/26/1991 |
| 4868119 | Hematopoietic growth factors A novel family of primate CSF-1-like polypeptides is provided via recombinant techniques.... | 09/19/1989 |
| 4868112 | Novel procoagulant proteins Novel procoagulant proteins are disclosed which comprise the amino acid sequence: wherein region A represents the polypeptide sequence Ala-20 through Arg-759 substantially as shown in Table 1; region B represents the polypeptide sequence Ser-1709 through ... | 09/19/1989 |
| 4843012 | Novel composition for nucleic acid purification A storage stable single phase aqueous composition is provided which is useful in isolatin nucleic acids from cell or virus cultures.... | 06/27/1989 |
| 4833239 | Method for the isolation and purification of DNA molecules A method for isolating and purifying nucleic acids from eukaryotic and prokaryotic cell cultures or viral cell cultures.... | 05/23/1989 |
| 4826766 | Production of amino acids using coupled aminotransferases This invention relates to a process for producing a desired alpha-amino acid, AAd, or a derivative thereof. The process comprises: (a) reacting a first alpha-amino acid, AANH.sbsb.2 ; a first alpha-keto acid, KAt ; a second alp... | 05/02/1989 |
| 4801536 | Method for producing heterologous proteins This invention concerns a method for producing a heterologous protein in a bacterial host cell such that the protein is exported from the host cell into the culture medium. The method involves culturing in a bacterial culture medium a genetically engineer... | 01/31/1989 |
| 4740461 | Vectors and methods for transformation of eucaryotic cells Eucaryotic cells cotransformed with product and selection genes yield considerably greater quantities of product after a novel subcloning strategy is employed: Transformants are identified for product yield, cultured under selection pressure and the proge... | 04/26/1988 |
| 4497814 | 2-(Pyridinyl)-1,2,4-triazolo[1,5-a]pyrimidines and derivatives useful in increasing cardiac contractility Disclosed are 2-(pyridinyl)-1,2,4-triazolo[1,5-a]pyrimidines and derivatives which are effective in increasing cardiac contractility. These compounds are useful in the treatment of congestive heart failure preferably by oral or parenteral administration.... | 02/05/1985 |
| 4493826 | Gentamicin-gleptoferron compositions Stable pharmaceutical compositions comprising gentamicin and gleptoferron prevention of iron deficiency anemia and bacterial infections in young mammals, especially piglets.... | 01/15/1985 |
| 4489071 | Betamethasone dipropionate cream An elegant topical cream composition, containing betamethasone dipropionate, for the treatment of inflammation.... | 12/18/1984 |
| 4489070 | Betamethasone dipropionate cream Disclosed is an elegant formulation of betamethasone dipropionate useful as a topical anti-inflammatory product.... | 12/18/1984 |
| 4482539 | Betamethasone dipropionate cream Disclosed is an elegant cream-like formulation of betamethasone dipropionate useful as a topical antiinflammatory product.... | 11/13/1984 |
| 4482564 | Triazolyl-substituted propane derivatives Disclosed are triazolyl-substituted propane derivatives useful in the treatment of fungal diseases of humans and animals. Also disclosed are the processes for preparing the compounds, pharmaceutical compositions containing them, and the method of treating... | 11/13/1984 |
| 4474813 | Pharmaceutical preparations comprising flutamide A pharmaceutical preparation comprising flutamide, useful in the treatment of prostatic carcinoma, is disclosed.... | 10/02/1984 |
| 4469228 | Interferon kit Disclosed is a kit for preparing a lyophilized alpha interferon gel formulation suitable for topical administration.... | 09/04/1984 |
| 4454143 | Tricyclic antihistamines Antihistamines of the formula ##STR1## wherein ##STR2## is a 5 or 6 membered ring which is phenyl or heterocyclic; ##STR3## is a six membered ring which is 2,3, or 4 pyridyl or is phenyl or substituted phenyl, with the proviso that is ... | 06/12/1984 |
| 4452800 | Salts of 3(n-butyl)-4-hydroxy-1-phenyl-1,8-naphthyridine-2(1H)-one and their use in treating chronic obstructive lung diseases There are disclosed certain alkali metal, alkaline earth metal, amine and amino acid salts of 3-(n-butyl)-4-hydroxy-1-phenyl-1,8-naphthyridine-2(1H)-one which, unlike the parent compound, are useful for orally treating chronic obstructive lung diseas... | 06/05/1984 |
| 4450164 | Imidazo[1,2-A]pyridines and use This invention relates to imidazo[1,2-a]pyridine derivatives which are useful in the treatment of peptic ulcer diseases.... | 05/22/1984 |
| 4443463 | (5R,6S,8R)-6-(1-Hydroxyethyl)-2-(hydroxyalkylthio)-penem-3-carboxylates Sodium, Potassium, Phthalidyl and Pivalyloxymethyl (5R,6S,8R)-6-(1-hydroxyethyl)-2-(2-hydroxyethylthio)-penem-3-carboxylates exhibit potent, broad spectrum antibacterial activity, are orally effective and chemically stable.... | 04/17/1984 |
| 4440690 | Process for the synthesis of 6-bromo-17,21-dihydroxy 3,11,20-trioxo-1,4-pregnadienes 17,21-diesters Disclosed is an improved process for the synthesis of 6-bromo-17,21-dihydroxy-3,11,20-trioxo-1,4,-pregnadienes 17,21-diesters. In particular, this invention relates to the conversion of 17,21-dihydroxy-3,11,20-trioxo-1,4-pregnadienes 17,21-diesters to ... | 04/03/1984 |
| 4435398 | Guanidine compounds Compounds of the formula ##STR1## and their pharmaceutically acceptable acid addition salts are disclosed. The compounds are useful as anthelmintics.... | 03/06/1984 |
| 4434896 | Tamper-resistant reclosable package Disclosed is a tamper-resistant reclosable package containing highly visible tamper indicators.... | 03/06/1984 |
| 4435413 | (5R-6S,8R )-6-(1-Hydroxyethyl)-2-(2-glycylaminoethylthio)-penem-3-carboxylic acid There is disclosed the antibacterial 5R,6S,8R-6-(1-hydroxyethyl)-2-(2-glycylaminoethylthio)penem-3-carboxylic acid, its pharmaceutically acceptable salts and esters as well as compositions containing them and methods for their use.... | 03/06/1984 |
| 4435412 | 5R,6S,8R-2-(1-Methyl-2-imidazolylmethy lthio)-6-(1-hydroxyethyl)penem-3-carboxylic acid There is disclosed the antibacterial 5R,6S,8R-2-(1-methyl-2-imidazolylmethylthio)-6-(1-hydroxyethyl)penem-3-car boxylic acid, its pharmaceutically acceptable salts and esters as well as compositions containing them and methods for their use.... | 03/06/1984 |
| 4434154 | Tanning and ultra-violet screening composition having high stability Cosmetic compositions for imparting artificial tan to human skin and shielding the skin from ultra-violet rays comprising dihydroxy acetone, octyl dimethyl PABA, water, oil, and surfactant. The composition has pH after compounding between 2.9 and 5.... | 02/28/1984 |
| 4433928 | Adjustable cosmetic wiper A wiper for a cosmetic applicator in which the size of the wiper orifice is adjustable.... | 02/28/1984 |
| 4431816 | 2,3-Dihydro-2-(imidazolylmethyl)benzo(b)thiophenes This invention relates to 2,3-dihydro-2-(imidazolylmethyl)benzo(b)thiophenes, to intermediates useful in their preparation, and to processes for preparing said intermediates. Also included in the invention are pharmaceutical compositions and the meth... | 02/14/1984 |
| 4431669 | Cyclopropyl substituted polyenes There is disclosed certain cyclopropyl substituted polyenes useful for treating dermatoses such as acne, psoriasis and epithelial cancers.... | 02/14/1984 |
| 4431658 | Aza penem compounds Described is a novel process for the preparation of penems and carbapenems useful as antibacterial agents which comprises the reaction of an appropriate 4-substituted-azetidine-2-one with an acid halide in the presence of a tertiary amine and an alkaline ... | 02/14/1984 |
| 4431645 | Antihypertensive agents Compounds of the formula ##STR1## and the pharmaceutically acceptable salts thereof, wherein R1, R2, R3 and R4 are independently selected from hydrogen or lower alkyl; n is 1 or 0; A and B taken together wi... | 02/14/1984 |
| 4431644 | Antihypertensive agents Compounds of the formula ##STR1## and the pharmaceutically acceptable salts thereof, wherein R1, R2 and R4 are independently selected from hydrogen and lower alkyl; R3 is hydrogen, lower alkyl or amino lowe... | 02/14/1984 |
| 4431654 | 6-(Hydroxyethyl)-2-[(heterocyclyl or aryl)thioalkylthio]-penem-3-carboxylates There are disclosed antibacterially effective compounds represented by the formula ##STR1## wherein R2 represents a substituted or unsubstituted single ring or double fused ring aryl or heterocyclyl radical bonded to the sulfur atom b... | 02/14/1984 |
| 4430510 | Process for the preparation of 2-(2,4-dichlorophenoxy)-phenylacetic acid The present invention relates to a novel process for the preparation of 2-(2,4-dichlorophenoxy)-phenylacetic acid a compound having useful anti-inflammatory properties. The process comprises reacting a 2-halo-phenylacetic acid or a salt thereof under basi... | 02/07/1984 |
| 4428962 | Indoles in treatment of peptic ulcers There are disclosed herein certain indole derivatives which are useful in the treatment of peptic ulcer diseases.... | 01/31/1984 |
| 4423055 | 6-Substituted-hydrocarbon-2-(substituted-thio)penem-3-carboxylic acids 6-Substituted-hydrocarbon-2-(substituted-thio)penem-3-carboxylic acids and congeners having useful antibacterial activity are disclosed. The compounds are prepared in a reaction sequence starting with a 4-acyloxy-2-azetidinone.... | 12/27/1983 |
| 4411906 | (5R,6S,8R)-6-(1-Hydroxyethyl)-2-(2-fluoroethylthio)-penem-3-carboxylates Disclosed herein are (5R,6S,8R)-6-(1-hydroxyethyl)-2-(2-fluoroethylthio)-penem-3-carboxylic acid and the metabolisable esters thereof and alkali metal salts thereof, which are potent antibacterial agents.... | 10/25/1983 |
| 4409226 | Imidazo[1,5-a]pyridines The invention relates to imidazo[1,5-a]pyridine derivatives which are useful in the treatment of peptic ulcer diseases.... | 10/11/1983 |
| 4406893 | N-Alkoxycarbonyl-N'-[2-nitro-4 or 5-alkylthiophenyl]-N"-[substituted alkyl]-guanidines useful as anthelmintics Compounds of the formula ##STR1## and their pharmaceutically acceptable salts are disclosed. The compounds are useful as anthelmintics.... | 09/27/1983 |
| 4405810 | 7-Aryl-hept-5-ynoic acids and derivatives thereof 7-arylhept-5-ynoic acids and derivatives thereof are anti-allergy and anti-inflammatory agents. As such, they are useful in the treatment of allergy-caused diseases, particularly chronic obstructive lung diseases.... | 09/20/1983 |
