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| Number | Title | Issue Date |
| 5206219 | Oral compositions of proteinaceous medicaments Proteinaceous medicaments such as erythropoetin, insulin and calcitonin are formulated in a medium comprising a polyol pharmaceutical solvent combined as co-solvent with a lipid pharmaceutical solvent. The formulation is adapted for oral administration as... | 04/27/1993 |
| 5183829 | Oral liquid compositions of non-steroidal anti-inflammatory drugs Pharmaceutically elegant oral compositions of non-steroidal anti-inflammatory drugs or their salts are prepared by adding selected dispersing agents such as a polyvinylpyrrolidone, hydroxypropyl-methylcellulose or hydroxypropylcellulose to the NSAIDs in a... | 02/02/1993 |
| 5084446 | Aluminum complex of polysulfonated sucrose A sucralfate-like chemical compound which is free flowing but turns viscid upon contact with acid or non-acid aqueous liquid. The compound is prepared by adding an excess of aluminum chlorohydrate to sucrose octaammonium sulfate in aqueous alcohols.... | 01/28/1992 |
| 5059626 | Liquid oral pharmaceutical compositions of non-steroidal anti-inflammatory drugs A one phase, liquid composition for oral administration comprises a NSAID such as an anthranilic acid derivative plus a di- or triglyceride of a medium chain fatty acid edible oil which has the characteristics of a pharmaceutical solvent carrier as known ... | 10/22/1991 |
| 5011852 | Liquid oral pharmaceutical compositions of non-steroidal anti-inflammatory drugs A one phase, liquid composition for oral administration comprises a NSAID such as an indoleacetic acid derivative or a pyrroleacetic acid derivative plus a di- or triglyceride of a medium chain fatty acid edible oil which has the characteristics of a phar... | 04/30/1991 |
| 4918103 | Liquid oral pharmaceutical compositions of non-steroidal anti-inflammatory drugs A pharmaceutically elegant, one phase, liquid composition for oral administration comprises a NSAID such as ibuprofen plus a di- or triglyceride of a medium chain fatty acid edible oil which has the characteristics of a pharmaceutical solvent carrier as k... | 04/17/1990 |
| 4880835 | Oral liquid pharmaceutical compositions of sulindac Pharmaceutically elegant oral liquid compositions of sulindac are prepared using calcium sulindac in a vehicle comprising a glycol, a polyol, optional ethanol and pharmaceutical additives.... | 11/14/1989 |
| 4587361 | Anthelmintic benzamides Flukicidal N-[4-(1-phenylethenyl)phenyl]-2-hydroxy-3,5-dihalobenzamides are prepared by reacting a halosalicylic acid with a 1-(4-aminophenyl)-1-phenylethylene in the presence of a halo condensing agent. A species of the invention is N-[4-(1-phenylet... | 05/06/1986 |
| 4587045 | Intermediates for preparing octapeptide vasopressin antagonists Certain octapeptides, which have structures characterized by being a six unit cyclic peptide ring with a dipeptide tail which lacks a glycine unit at position 9, have potent vasopressin antagonist activity. The compounds here claimed are in general charac... | 05/06/1986 |
| 4507288 | ଲ-Glycerophosphate salts of antimalarial phenanthrenemethanol compounds The compounds of formula (I) ##STR1## wherein R1 is hydrogen or an alkyl radical containing one to six carbon atoms and R2 is an alkyl radical containing one to six carbon atoms possess markedly increased activity against malari... | 03/26/1985 |
| 4247558 | Pyridyl alkylguanidines The compounds are novel N-substituted-N'-heterocyclic alkylthioureas, guanidines and 1-nitro-2,2-diaminoethylene compounds which are histamine H2 -antagonists.... | 01/27/1981 |
| 4242346 | Bis-2N-alkylene tetrahydroisoquinoline compounds Bis-2N-alkylene tetrahydroisoquinoline compounds are inhibitors of phenylethanolamine N-methyl-transferase.... | 12/30/1980 |
| 4238493 | 2-(Substituted amino)-3-nitro-2,3-unsaturated nitrogen heterocycles 2,3-Unsaturated nitrogen-containing heterocyclic compounds with a 3-nitro group and a 2-heterocyclyl alkylamino group. The alkyl group of 2-position substituents is preferably interrupted by sulfur or oxygen. The compounds of the invention are preferably ... | 12/09/1980 |
| 4238494 | 2-Heterocyclic alkylamino-3-nitropyrroles 3-Nitro-2-substituted aminopyrroles are histamine H2 -receptor antagonists. The 2-position substituent is a fully-unsaturated heterocyclyl alkyl group preferably with with alkyl group interrupted by sulfur or oxygen. The 4- and 5-positions of t... | 12/09/1980 |
| 4234588 | Pyrimidine compounds The compounds are substituted pyrimidine compounds which are histamine H2 -antagonists. A specific compound of the present invention is 2-[2-(5-dimethylaminomethyl)-2-furylmethylthio)ethylamino]-5-(3-pyridylmet hyl)-4-pyrimidone.... | 11/18/1980 |
| 4230865 | Pharmacologically active triazole and thiadiazole thiourea and urea compounds The compounds are substituted thioalkyl-, aminoalkyl- and oxyalkyl-thioureas and ureas which are inhibitors of histamine activity.... | 10/28/1980 |
| 4228291 | Pharmacologically active thiadiazole guanidine compounds The compounds are substituted thioalkyl-, aminoalkyl- and oxyalkyl-guanidines which are inhibitors of histamine activity.... | 10/14/1980 |
| 4228170 | 7- and/or 8-Sulfur substituted 1,2,3,4-tetrahydroisoquinoline compounds 1,2,3,4-Tetrahydroisoquinoline compounds having 7- and/or 8-sulfur substituents are inhibitors of phenylethanolamine N-methyltransferase.... | 10/14/1980 |
| 4226874 | Pharmacologically active thiourea and urea compositions and methods of use The compounds are substituted thioalkyl-, aminoalkyl- and oxyalkyl-thioureas and ureas which are inhibitors of histamine activity.... | 10/07/1980 |
| 4227000 | Intermediates in the process for making histamine antagonists A process for making substituted 2-aminopyrimidones which are histamine H2 - antagonists which comprises reacting a 2-nitroaminopyrimidone with a heteroarylalkylamine, heteroarylalkylthioalkylamine, or heteroarylalkoxyalkylamine. One particular... | 10/07/1980 |
| 4221802 | Pharmacologically active guanidine compounds for inhibiting H-2 histamine receptors The compounds are substituted thioalkyl-, aminoalkyl- and oxyalkyl-guanidines which are inhibitors of histamine activity.... | 09/09/1980 |
| 4220652 | Isothiazolyl alkylaminoethylene compounds The compounds are ethylene derivatives which are inhibitors of histamine activity, in particular, inhibitors of H-2 histamine receptors. A compound of this invention is 1-nitro-2-methylamino-2-[2-((4-methyl-5-imidazolyl)methylthio)ethylamino]e thylene... | 09/02/1980 |
| 4220767 | Triazinones The compounds are substituted 1,2,4-triazin-5-ones which are histamine H2 -antagonists. Two specific compounds of the present invention are 3-[2-(5-methyl-4-imidazolylmethylthio)ethylamino]-6-(3-methoxybenzyl)-1,2, 4-triazin-5-one and 3-[2-... | 09/02/1980 |
| 4219553 | Alkoxy pyridyl substituted alkanes The compounds are C2 -C8 straight chain alkanes terminally substituted, symmetrically or unsymmetrically, by N-(N'-substituted guanidino), N-(N',N"-disubstituted guanidino), N-(N'-substituted thioureido), N-(nitromethylene amidino) o... | 08/26/1980 |
| 4218452 | Substituted 4-pyrimidone compounds, compositions and methods of use The compounds are substituted isocytosines which are histamine H2 -antagonists. Two specific compounds of the present invention are 2-[2-(5-methyl-4-imidazolylmethylthio)ethylamino]-5-(3-methoxybenzyl)-4-py rimidone and 2-[2-(5-methyl-4-imi... | 08/19/1980 |
| 4218464 | 4- and 5-Substituted 2,3-dihydro-1H-isoindoles, pharmaceutical compositions and method of inhibiting phenylethanolamine N-methyltransferase Pharmaceutical compositions and methods of inhibiting phenylethanolamine N-methyltransferase using novel 2,3-dihydro-1H-isoindole compounds having 4- and 5-substituents.... | 08/19/1980 |
| 4216318 | Heterocyclic alkyl 4-pyrimidones The compounds are substituted isocytosines which are histamine H2 -antagonists. Two specific compounds of the present invention are 2-[2-(5-methyl-4-imidazolylmethylthio)ethylamino]-5-(3-pyridylmethyl)-4-py rimidone and 2-[2-(3-bromo-2-pyri... | 08/05/1980 |
| 4215217 | Process for preparing 4-substituted imidazole compounds A process for preparing 4-(oxy, thio or amino)methylimidazole compounds via displacement of the trisubstituted phosphonium group from 4-(trisubstituted phosphonium)-methylimidazole compounds is disclosed.... | 07/29/1980 |
| 4215126 | Alkoxy pyridine compounds The compounds are alkoxypyridine compounds which are histamine H2 -antagonists. Two specific compounds of the present invention are N-cyano-N'-methyl-N"-[2-((3-methoxy-2-pyridyl)methylthio)ethyl]guanidine and 1-methylamino-1-[2-((3-methoxy... | 07/29/1980 |
| 4215125 | Pyridyl ureas, thioureas and guanidines The compounds are N,N'-substituted thioureas, ureas and guanidines which are H-2 histamine receptor inhibitors. A compound of this invention is N,N'-bis-[2-(2-pyridylmethylthioethyl]-N"-cyanoguanidine.... | 07/29/1980 |
| 4212875 | Imidazolyl alkyl bisamidines Bisamidines carrying one unsaturated nitrogen heterocycle-containing substituent, representative of which is 1-[N'-(2-(5-methyl-4-imidazolyl)methylthio)ethyl)guanidino]-8-[N'-methyl-g uanidino]octane, are histamine H2 -antagonists.... | 07/15/1980 |
| 4210652 | Pharmacologically active 1,3-bis[1-(2-heteroalkylthio)ethylamino)-2-nitrovinyl-1-amino]propane derivatives The compounds are C2 -C8 straight chain alkanes terminally substituted, symmetrically or unsymmetrically, by N-(N'-substituted guanidino), N-(N',N"-disubstituted guanidino), N-(N'-substituted thioureido), N-(nitromethylene amidino) o... | 07/01/1980 |
| 4210587 | 7-Acylamino-3-[1-[2-(carboxymethylamino)ethyl]tetrazol-5-ylthio methyl]-3-cephem-4-carboxylic acids Novel cephalosporins having various acyl substituents at the 7-position and a carboxymethylaminoethyl substituted tetrazolylthiomethyl group at the 3-position of the cephem nucleus are prepared. These compounds have antibacterial activity.... | 07/01/1980 |
| 4210658 | Amidinosulphonic acid derivatives Amidinosulphonic acid derivatives carrying an unsaturated nitrogen heterocycle-containing substituent, representative of which are N-methyl-N'[2-(5-methyl-4-imidazolylmethylthio)-ethyl]amidinosulphonic acid and N-methyl-N'[2-(3-chloropyrid-2-ylmethylthio)... | 07/01/1980 |
| 4208430 | Pharmaceutical compositions and method of inhibiting phenylethanolamine N-methyltransferase Pharmaceutical compositions and methods of inhibiting phenylethanolamine N-methyltransferase using substituted carbamimidothioic acid phenylalkyl esters.... | 06/17/1980 |
| 4206210 | Alkylthio-7,8-dihdroxy-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepines having dopaminergic activity A new series of lower alkylthio-7,8-dihydroxy-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepines having potent central dopaminergic activity of utility in treating Parkinson's disease. The 6-and 9-methylthio compounds are particularly of use.... | 06/03/1980 |
| 4205071 | Pharmaceutical compositions having immunosuppressant activity and methods therefor S-(Aminoalkyl)isothioureas which have immunosuppressant activity. Two specific compounds are 2-(3-dimethylaminopropylthio)-2-imidazoline and N,N'-dimethyl-S-(3-dimethylaminopropyl)isothiourea.... | 05/27/1980 |
| 4201775 | Bis[triethylphosphine)aurio]sulfonium sugars A new series of gold containing sugars having anti-arthritic activity are characterized by the presence of a bis[(triethylphosphine)aurio]sulfonium salt moiety at the 1-position of the glucopyranoside. The compounds are prepared by reacting a 1-S-triethyl... | 05/06/1980 |
| 4200738 | Method for preparing auranofin A new synthesis of auranofin comprising reacting 2,3,4,6-tetra-O-acetyl--D-glucopyranosyl bromide with a S-(triethylphosphineaurous)thiouronium salt.... | 04/29/1980 |
| 4200754 | Method for preparing 7,8-dichloro-1,2,3,4-tetrahydroisoquinoline A novel process for preparing 7,8-dichloro-1,2,3,4-tetrahydroisoquinoline by cyclizing N-acetyl-2,3-dichlorobenzylaminoacetaldehyde dimethyl acetal with a Lewis acid, reducing, and hydrolyzing the resulting acylated isoquinoline is disclosed.... | 04/29/1980 |
