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| Number | Title | Issue Date |
| 7138395 | Interleukin-1β converting enzyme inhibitors The present invention relates to novel compounds, compositions comprising said compounds, and uses thereof, said compounds having the formula: X is —CH2—, —O— or —NR9—; ... | 11/21/2006 |
| 7132539 | Melanocortin receptor ligands The present invention relates to compounds which comprise a nitrogen-containing ring scaffold substituted by an R1 alkyl units selected from the group consisting of C1–C12 linear or branched alkyl, C3–C8 cyc... | 11/07/2006 |
| 7087759 | Melanocortin receptor ligands Disclosed are MC-3/MC-4 receptor ligands, the ligands having the following formula: wherein A is a conformationally restricted ring system selected from the group consisting of: a) non-aromatic carbo... | 08/08/2006 |
| 7074752 | Fabric care compositions The present invention relates to fabric care compositions having enhanced fabric color protection, said compositions comprising a bleach scavenging system comprising: i) one or more organic sulfur compounds having the formula: ... | 07/11/2006 |
| 7041696 | Interleukin-1β converting enzyme inhibitors The present invention relates to interleukin-1β converting enzyme inhibitors having the formula: R is a carbocyclic or heterocyclic ring; R1 is a cysteine trap; R2a, R... | 05/09/2006 |
| 7026335 | Melanocortin receptor ligands The present invention relates to compounds which comprise a 4-substituted piperidine ring linked to a substituted or unsubstituted hydrocarbyl ring. The compounds, including all enatiomeric and diasteriomeric forms and pharmaceutically acceptable salts thereof, have... | 04/11/2006 |
| 7001899 | Interleukin converting enzyme inhibitors The present invention relates to novel compounds, compositions comprising said compounds, and uses thereof, said compounds having the formula: wherein each X is independently selected from: i) —C(W)2... | 02/21/2006 |
| 7002014 | Process for controlling crystal structure of risedronate The present invention relates to a process for controlling the crystal form of 3-pyridyl-1-hydroxy-ethylidene-1,1-bisphosphonic acid salt (Risedronate). The process employs a pH adjustment step to induce the proper hydrate form and thereby avoiding inadvertent nucle... | 02/21/2006 |
| 6987084 | Photo-labile pro-fragrance conjugates The present invention relates to photo-labile pro-fragrance conjugates comprising: a) a photo-labile unit which upon exposure to electromagnetic radiation is capable of releasing a pro-fragrance unit; and b) a pro-... | 01/17/2006 |
| 6960593 | 6,7-dihydro-5H-pyrazolo[1,2a]pyrazol-1-ones which control inflammatory cytokines The present invention relates to 2-(4-fluorophenyl)-3-(2-phenoxy-pyrimidin-4-yl)-6,7-dihydro-5H-pyrazolo-[1,2-a]pyrazol-1-one, including all enantiomeric and diasteriomeric forms and pharmaceutically acceptable salts thereof, having the formula: | 11/01/2005 |
| 6951916 | Melanocortin receptor ligands Disclosed are MC-4 and/or MC-3 receptor ligands having the formula: wherein B is a suitable linking group comprising a least one amino acid. ... | 10/04/2005 |
| 6919346 | Isoxazolone compounds useful in treating diseases associated with unwanted cytokine activity Isoxazolone compounds having the generic structure: are used to treat disease associated with unwanted cytokine activity, including rheumatoid arthritis, osteoarthritis, diabetes, HIV/AIDS, inflammatory bowel disease, ... | 07/19/2005 |
| 6911447 | Melanocortin receptor ligands Disclosed are MC-3/MC-4 receptor ligands, the ligands having the following formula: wherein A is a conformationally restricted ring system selected from the group consisting of: a) non-aromatic carbocyclic... | 06/28/2005 |
| 6872825 | Peptide β-turn mimetic compounds and processes for making them The subject invention involves compounds having structure (I), wherein: (a) R1 is hydrogen or alkyl; and R2 is selected from hydrogen, alkyl, aryl, heterocyclyl, carboxy and its esters and amides; or R1 and R2 are attached and are together alkylene or heteroalkylene... | 03/29/2005 |
| 6849627 | 6,7-dihydro-5H-pyrazolo[1,2-a]pyrazol-1-ones which control inflammatory cytokines The present invention relates to compounds which are capable of preventing the extracellular release of inflammatory cytokines, said compounds, including all enantiomeric and diasteriomeric forms and pharmaceutically acceptable salts thereof, have the formula: | 02/01/2005 |
| 6821971 | Fused pyrazolone compounds which inhibit the release of inflammatory cytokines The present invention relates to compound which are capable of preventing the extracellular release of inflammatory cytokines, said compounds, including all enantiomeric and diasteriomeric forms and pharmaceutically acceptable salts thereof, have the formula: | 11/23/2004 |
| 6803469 | Process for preparing quinolone antibiotic intermediates The present invention relates to a process for preparing a quinolone antibiotic intermediate having the formula: wherein R is C1-C2 alkyl, C1-C2 fluoroalkyl, C2-C | 10/12/2004 |
| 6790846 | Isoxazolone compounds useful in treating diseases associated with unwanted cytokine activity Isoxazolone compounds having the generic structure: are used to treat disease associated with unwanted cytokine activity, including rheumatoid arthritis, osteoarthritis, diabetes, HIV/AIDS, inflammatory bowel disease, Cr... | 09/14/2004 |
| 6787555 | Triazole compounds useful in treating diseases associated with unwanted cytokine activity The present invention relates to 4-aryl triazoles having the formula: wherein R1 is independently selected from the group consisting of: lower alkyl, lower alkenyl, lower alkynyl, lower heteroalkyl, lower hete... | 09/07/2004 |
| 6784293 | Process for making Boc-protected 3-aminohydantoins/thiohydantoins and 3-aminodihydrouracils/dihydrothiouracils The present invention provides a process for the efficient assembly of Boc-protected 3-aminohydantoins/thiohydantoins and 3-aminodihydrouracils/dihydrothiouracils via a one-pot solution phase or solid phase synthesis from readily available starting materials. ... | 08/31/2004 |
| 6740627 | Diols and polymeric glycols in dishwashing detergent compositions Disclosed are detergent compositions comprising organic diamines, anionic surfacants and amphoteric surfactants including amine oxide for hand dishwashing which, by incorporating certain organic solvents, results in a liquid dishwashing detergent composition that is... | 05/25/2004 |
| 6730668 | 6,7-dihydro-5H-pyrazolo[1,2-a]pyrazol-1-ones which control inflammatory cytokines The present invention relates to compound which are capable of preventing the extracellular release of inflammatory cytokines, said compounds, including all enantiomeric and diasteriomeric forms and pharmaceutically acceptable salts thereof, have the formula: | 05/04/2004 |
| 6727364 | Triazole compounds useful in treating diseases associated with unwanted cytokine activity The present invention relates to 4-aryl triazoles having the formula: wherein R1 is independently selected from the group consisting of: lower alkyl, lower alkenyl, lower alkynyl, lower heteroalkyl, lower hete... | 04/27/2004 |
| 6723788 | Enzyme inhibitors The present invention relates to compositions which comprise one or more polymer conjugates having the formula: wherein T is a heterocyclic unit which is capable of inhibiting one or more proteolytic enzymes; L is a link... | 04/20/2004 |
| 6696605 | Process for preparing -hydroxyamides and -ketoamides on a solid phase support The present invention relates to a process for preparing a -hydroxyamide or -ketoamide, said process comprising the steps of: a) reacting a resin which comprises a polymer-supported isocyanide with an aldehyde in the presence of a cataly... | 02/24/2004 |
| 6692536 | Use of a crystal growth inhibitor to reduce fabric abrasion There is provided the use of a crystal growth inhibitor for reducing the fabric abrasion occurring upon laundering treatment.... | 02/17/2004 |
| 6677337 | 1,2-dihydropyrazol-3-ones which controls inflammatory cytokines The present invention relates to compounds which are capable of preventing the extracellular release of inflammatory cytokines, said compounds, or enantiomeric and diasteriomeric forms or pharmaceutically acceptable salts thereof, have the formula: #... | 01/13/2004 |
| 6610646 | Enhanced duration fragrance delivery system having a non-distorted initial fragrance impression The present invention relates to sustained release fragrance accords wherein the initial fragrance release or bouquet is not distorted by the presence of an unbalanced accord. The systems of the present invention comprise: a) a pro-fragrance component... | 08/26/2003 |
| 6566357 | Spirocyclic-6,7-dihydro-5H-pyrazolo[1,2-a]pyrazol-1-ones which control inflammatory cytokines The present invention relates to compound which are capable of preventing the extracellular release of inflammatory cytokines, said compounds, including all enantiomeric and diasteriomeric forms and pharmaceutically acceptable salts thereof, have the form... | 05/20/2003 |
| 6541629 | Enzyme inhibitors The present invention relates to polymer conjugates having the formula: ##STR1## wherein T is a heterocyclic unit which is capable of inhibiting one or more proteolytic enzymes; L is a linking group; [Poly] is a polymeric unit, i indicates the number of s... | 04/01/2003 |
| 6504028 | Process for preparing benzoxazin-4-one polymer conjugates The present invention relates to a process for forming polymer conjugates which are useful as enzyme inhibitors. The process of the present invention comprises the steps of: a) reacting a polymer or copolymer alcohol to form a chloroformate; b) combining a sub... | 01/07/2003 |
