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| Number | Title | Issue Date |
| 7250418 | Compounds as CRFreceptor antagonists The present invention relates to compounds of Formula I, or a stereoisomer thereof, a pharmaceutically acceptable salt thereof, or a prodrug thereof. The compounds of the inventions are CRF1 receptor a... | 07/31/2007 |
| 7176198 | 1-pyrazole and 1-pyrrole-azabicyclic compounds for the treatment of disease The invention provides compounds of Formula I: wherein Azabicyclo is where the variables have the definitions discussed herein. These compounds may be in the... | 02/13/2007 |
| 7067515 | Quinuclidines-substituted-multi-cyclic-heteroaryls for the treatment of disease The invention provides compounds of Formula I: where in W is These compounds may be in the form of pharmaceutical salts or compositions, racemic mixtures, or... | 06/27/2006 |
| 7001900 | Azabicyclic compounds for the treatment of disease The invention provides compounds of Formula I: wherein Azabicyclo is W is a six-membered heterocyclic ring system having 1–2 nitrogen atoms or a 10-membered bicyclic-six-... | 02/21/2006 |
| 6951868 | Azabicyclic-phenyl-fused-heterocyclic compounds for treatment of disease The invention provides compounds of Formula I: wherein Azabicyclo is any of: These compounds may be in the form of pharmaceutical salts or compositions, and racemic mixtu... | 10/04/2005 |
| 6921760 | Aralkyl and aralkylidene heterocyclic lactams and imides The present invention relates to compounds of the formula Orosco wherein R1, R2, R3, X, Y and the dashed line are defined as in the specification, to intermedia... | 07/26/2005 |
| 6919359 | Azabicyclic-substituted-heteroaryl compounds for the treatment of disease The invention provides compounds of Formula I: Azabicyclo-N(R1)—C(═X)—W Formula I These compounds may be in the form of pharmaceutical salts or compositions, racemic mixtures, or pure enantiomers thereof. The compounds of Fo... | 07/19/2005 |
| 6911545 | Crystals of glucokinase and methods of growing them Crystalline forms of mammalian Gluckokinase of sufficient size and quality to obtain structural data by X-ray crystallography are presented. Methods of growing such crystals are also disclosed. ... | 06/28/2005 |
| 6911543 | Azabicyclic-substituted fused-heteroaryl compounds for the treatment of disease The invention provides compounds of Formula I: wherein Azabicyclo is These compounds may be in the form of pharmaceutical salts or co... | 06/28/2005 |
| 6881734 | Pharmaceutical composition for the treatment of CNS and other disorders The present invention relates to a method of treating disorders of the Central Nervous System (CNS) and other disorders in a mammal, including a human, by administering to the mammal a CNS-penetrant α7 nicotinic receptor agonist. It also relates to pharmaceutical c... | 04/19/2005 |
| 6881844 | Indole-3-carboxamides as glucokinase activators The present invention provides glucokinase activators of formula I: wherein R1, R2 and R3 are defined in the specification. Glucokinase activators are useful for increasing insulin secr... | 04/19/2005 |
| 6828337 | Selective retinoid agonists This invention relates to new RAR selective retinoid agonists of formula I wherein the symbols are as defined in the specification to their pharmaceutically acceptable salts, individual isomers... | 12/07/2004 |
| 6809110 | Thiazole derivatives The present invention provides compounds of formula (I) wherein R1 to R10, X, Y and n are indicated in the specification, and pharmaceutically acceptable salts and esters thereof. The compounds ar... | 10/26/2004 |
| 6803384 | Diaminopropionic acid derivatives A compound of formula Id and pharmaceutically acceptable salts and esters thereof, wherein the substituent designations are as provided in the specification. Compounds of the invention are useful for treating reperfusi... | 10/12/2004 |
| 6800650 | Pyridine and quinoline derivatives The present invention provides compounds of formula (I) wherein R1, R2, R3 and R4 are as defined in the specification, and pharmaceutically acceptable salts thereof. The compou... | 10/05/2004 |
| 6784298 | Hydantoin-containing glucokinase activators Hydantoin compounds which are active as glucokinase activators to increase insulin secretion which makes them useful for treating type II diabetes. ... | 08/31/2004 |
| 6756380 | 5-phenyl-pyrimidine derivatives Compounds of the general formula are described: wherein R1 is hydrogen or halogen; R2 is hydrogen, halogen, lower alkyl or lower alkoxy; R3 is halogen, trifluoromethy... | 06/29/2004 |
| 6747049 | Oxazole derivatives Compounds of formula I are provided as well as pharmaceutically acceptable salts and esters thereof, wherein R1 to R3 and n have the significance given in the specification can be used to treat non-... | 06/08/2004 |
| 6727261 | Pyrido[2,1-A]Isoquinoline derivatives The present invention provides compounds of formula (I) wherein R1, R2, R3, R4, R5 and R6 are as defined in the specification, and pharmaceutically accept... | 04/27/2004 |
| 6696467 | Quinoline derivatives Compounds of general formula I ##STR1## as well as pharmaceutically acceptable salts and esters thereof, are potent inhibitors of neuropeptide Y and can be used in the form of pharmaceutical preparations for the treatment or prevention of various disease ... | 02/24/2004 |
| 6660492 | Chimeric serine proteases A chimeric serine protease whose protease domain is composed of two domain halves (half-sides) with a ଲ-folded sheet structure, wherein the first domain half corresponds to the first domain half of a first serine protease and the second domain half ... | 12/09/2003 |
| 6642381 | Pyrimido[5,4-e][1,2,4]triazine-5,7-diamine compounds as protein tyrosine phosphatase inhibitors The invention relates to pyrimido[5,4-e][1,2,4]triazine-5,7-diamine compounds which are useful for inhibiting protein tyrosine phosphatases, particularly PTP1B.... | 11/04/2003 |
| 6642389 | Oxazole derivatives The present invention relates to novel oxazole compounds which act as PPAR and PPARγ agonists and are accordingly useful for the treatment of diseases modulated by PPAR and PPARγ such as diabetes.... | 11/04/2003 |
| 6610846 | Heteroaromatic glucokinase activators 2,3-Di-substituted N-heteroaromatic propionamides with said substitution at the 3-position being a substituted phenyl group and at the 2-position being a methyl cycloalkyl ring, said propionamides being glucokinase activators which increase insulin secret... | 08/26/2003 |
| 6294668 | Vinylpyrrolidinone cephalosporin derivatives The present invention relates to cephalosporin derivatives of the general formula ##STR1## where R.sup.1 is halogen, lower alkyl, phenyl, benzyl, styryl, naphthyl or heterocyclyl; the lower alkyl, phenyl, benzyl, styryl, naphthyl and heterocyclyl bei... | 09/25/2001 |
