Did You Know...
...that one person who claimed to be the inventor of the television is Russian emigre Vladimir Zworykin? In 1929 David Sarnoff, founder of RCA, asked Zworykin what it would take to develop TV for commercial use. He said: a year and a half and $100,000. In reality, it took 20 years and $50 million! Before his death in 1982 at the age of 92, Zworykin said of his invention: "The technique is wonderful. It is beyond my expectations. But the programs! I would never let my children even come close to this thing."
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| Number | Title | Issue Date |
| 7846904 | Compositions and methods for increasing telomerase activity The present invention relates to methods for increasing telomerase activity in cells. Such compositions include pharmaceutical, including topical, and nutraceutical formulations. The method and compositions are useful for treating diseases subject to treatment by an... | 12/07/2010 |
| 7824849 | Cellular telomerase vaccine and its use for treating cancer The invention provides dendritic cell (DC) preparations that present a telomerase reverse transcriptase (TRT) peptide in the context of an MHC class I or MHC class II molecule. The DCs may be pulsed with a TRT polypeptide, or may comprise a recombinant polynucleotid... | 11/02/2010 |
| 7732402 | Mammalian telomerase Nucleic acids comprising the RNA component of a mammalian telomerase are useful as pharmaceutical, therapeutic, and diagnostic reagents. ... | 06/08/2010 |
| 7585966 | Inhibitory polynucleotides directed against the RNA component of telomerase This invention provides inhibitory polynucleotides, such as antisense molecules, directed against accessible regions in the telomerase ribonucleoprotein. The polynucleotides are useful for inhibiting the activity of telomerase in cells and for treating cancer. ... | 09/08/2009 |
| 7563618 | Oligonucleotide conjugates Oligonucleotide conjugates, where an oligonucleotide is covalently attached to an aromatic system, are provided. In particular embodiments the oligonucleotide is complementary to the RNA component of human telomerase and is covalently attached to a nucleobase via an... | 07/21/2009 |
| 7494982 | Modified oligonucleotides for telomerase inhibition Compounds comprising an oligonucleotide moiety covalently linked to a lipid moiety are disclosed. The oligonucleotide moiety comprises a sequence that is complementary to the RNA component of human telomerase. The compounds inhibit telomerase activity in cells with ... | 02/24/2009 |
| 7402307 | Method for identifying and killing cancer cells The invention provides a method for activating a T lymphocyte by contacting the T lymphocyte with a dendritic cell (DC) that presents a telomerase reverse transcriptase (TRT) peptide in the context of an MHC class I or MHC class II molecule. The DC may be pulsed wit... | 07/22/2008 |
| 7378244 | Telomerase promoters sequences for screening telomerase modulators Telomerase reverse transcriptase is part of the telomerase complex responsible for maintaining telomere length and increasing the replicative capacity of progenitor cells. Telomerase activity is turned off in mature differentiated cells, but is turned back on again ... | 05/27/2008 |
| 7262288 | Nucleic acids encoding human telomerase reverse transcriptase and related homologs The invention provides compositions and methods related to human telomerase reverse transcriptase (hTRT), the catalytic protein subunit of human telomerase. The polynucleotides and polypeptides of the invention are useful for diagnosis, prognosis and treatment of hu... | 08/28/2007 |
| 7256042 | Process for making hepatocytes from pluripotent stem cells It has been discovered that when pluripotent stem cells are cultured in the presence of a hepatocyte differentiation agent, a population of cells is derived that has a remarkably high proportion of cells with phenotypic characteristics of liver cells. In one example... | 08/14/2007 |
| 7199234 | Regulatory segments of the human gene for telomerase reverse transcriptase The invention provides compositions and methods related to human telomerase reverse transcriptase (hTRT), the catalytic protein subunit of human telomerase. The polynucleotides and polypeptides of the invention are useful for diagnosis, prognosis and treatment of hu... | 04/03/2007 |
| 7195911 | Mammalian cells that have increased proliferative capacity The present invention is directed to cells comprising a recombinant polynucleotide sequence that encodes a telomerase reverse transcriptase protein, variant, or fragment having telomerase catalytic activity when complexed with a telomerase RNA. ... | 03/27/2007 |
| 7138383 | Treating cancer using an oligonucleotide N3′->N5′ thiophosphoramidate Oligonucleotides with a novel sugar-phosphate backbone containing at least one internucleoside 3′-NHP(O)(S−)O-5′ linkage, and methods of synthesizing and using the inventive oligonucleotides are provided. The inventive thiophosphoramidate oligonucle... | 11/21/2006 |
| 7091021 | Inactive variants of the human telomerase catalytic subunit The invention provides compositions and methods related to human telomerase reverse transcriptase (hTRT), the catalytic protein subunit of human telomerase. Catalytically active and inactive human telomerase reverse transcriptase variants comprising deletions or oth... | 08/15/2006 |
| 7067283 | Producing telomerase activators and inhibitors by screening with purified telomerase This invention provides purified telomerase and methods of purifying it. The methods involve the use of several sequential steps, including the use of matrices that bind molecules bearing negative charges, matrices that bind molecules bearing positive charges, inter... | 06/27/2006 |
| 7041438 | Use of human embryonic stem cells for drug screening and toxicity testing This disclosure provides an improved system for culturing human pluripotent stem (pPS) cells in the absence of feeder cells. The role of the feeder cells can be replaced by supporting the culture on an extracellular matrix, and culturing the cells in a conditioned m... | 05/09/2006 |
| 7033831 | Islet cells from human embryonic stem cells This disclosure provides a system for producing pancreatic islet cells from embryonic stem cells. Differentiation is initiated towards endoderm cells, and focused using reagents that promote emergence of islet precursors and mature insulin-secreting cells. High qual... | 04/25/2006 |
| 7005262 | Methods for detecting nucleic acids encoding human telomerase reverse transcriptase The present invention is directed to methods of identifying in a sample nucleic acids that encode human telomerase reverse transcriptase (hTRT) or its fragments. The present invention is also directed to oligonucleotide primers used in such methods. The invention is... | 02/28/2006 |
| 6927285 | Genes for human telomerase reverse transcriptase and telomerase variants The present invention is directed to novel telomerase nucleic acids and amino acids. In particular, the present invention is directed to nucleic acid and amino acid sequences encoding various telomerase protein subunits and motifs, including the 123 kDa and 43 kDa t... | 08/09/2005 |
| 6921665 | Selective antibody targeting of undifferentiated stem cells This invention provides a system for producing differentiated cells from a stem cell population for use wherever a relatively homogenous cell population is desirable. The cells contain an effector gene under control of a transcriptional control element (such as the ... | 07/26/2005 |
| 6921664 | Telomerase The present invention is directed to expression vectors comprising a polynucleotide that encodes a human telomerase reverse transcriptase (hTRT) protein, variant, or fragment. The present invention is also directed to host cells that comprise expression vectors comp... | 07/26/2005 |
| 6833269 | Making neural cells for human therapy or drug screening from human embryonic stem cells This invention provides populations of neural progenitor cells, differentiated neurons, glial cells, and astrocytes. The populations are obtained by culturing stem cell populations (such as embryonic stem cells) in a cocktail of growth conditions that initiates diff... | 12/21/2004 |
| 6808880 | Method for detecting polynucleotides encoding telomerase The present invention is directed to novel telomerase nucleic acids and amino acids. In particular, the present invention is directed to nucleic acid and amino acid sequences encoding various telomerase protein subunits and motifs, including the 123 kDa and 43 kDa t... | 10/26/2004 |
| 6800480 | Methods and materials for the growth of primate-derived primordial stem cells in feeder-free culture Methods and materials for culturing primate-derived primordial stem cells are described. In one embodiment, a cell culture medium for growing primate-derived primordial stem cells in a substantially undifferentiated state is provided which includes a low osmotic pre... | 10/05/2004 |
| 6787133 | Using purified telomerase to identify telomerase activators and inhibitors This invention provides purified telomerase and methods of purifying it. The methods involve the use of several sequential steps, including the use of matrices that bind molecules bearing negative charges, matrices that bind molecules bearing positive charges, inter... | 09/07/2004 |
| 6777203 | Telomerase promoter driving expression of therapeutic gene sequences The present invention is related to novel nucleic acids comprising telomerase reverse transcriptase (TERT) cis-acting transcriptional control sequences, including TERT human and mouse promoter sequences. The present invention is further directed to methods of using ... | 08/17/2004 |
| 6767719 | Mouse telomerase reverse transcriptase This invention provides for murine telomerase reverse transcriptase (mTERT) enzyme proteins and nucleic acids, including methods for isolating and expressing these nucleic acids and proteins, which have application to the control of cell ... | 07/27/2004 |
| 6713055 | Glycosyltransferase vectors for treating cancer This disclosure provides a system for specifically killing cancer cells which can be used in the course of human therapy. Vectors of the invention comprise an encoding sequence for a glycosyltransferase, under control of a tumor or tissue specific transcriptional co... | 03/30/2004 |
| 6673987 | Strategy for maintaining pregnancy Pregnancy in animals such as the pig usually does not continue to term when there are only a few embryos in the uterus. Currently available technology for maintaining pregnancy involves a series of hormone injections, and the failure rate is high. It has ... | 01/06/2004 |
| 6667176 | cDNA libraries reflecting gene expression during growth and differentiation of human pluripotent stem cells This disclosure provides a system for obtaining expression libraries from primate pluripotent stem (pPS) cells. pPS cells can be maintained in vitro without requiring a layer of feeder cells to inhibit differentiation. The role of the feeder cells is repl... | 12/23/2003 |
| 6642048 | Conditioned media for propagating human pluripotent stem cells This invention provides media that support the growth of primate pluripotent stem cells in feeder-free culture, and cell lines useful for producing such media and other purposes. Conventionally, it has been necessary to grow pluripotent embryonic cells on... | 11/04/2003 |
| 6627619 | Antisense compositions for detecting and inhibiting telomerase reverse transcriptase The present invention provides TRT antisense oligonucleotides, methods of detecting TRT, methods of diagnosing telomerase-related conditions, methods of diagnosing and providing a prognosis for cancer, and methods of treating telomerase-related conditions... | 09/30/2003 |
| 6617110 | Cells immortalized with telomerase reverse transcriptase for use in drug screening The invention provides compositions and methods related to human telomerase reverse transcriptase (hTRT), the catalytic protein subunit of human telomerase. The polynucleotides and polypeptides of the invention are useful for diagnosis, prognosis and trea... | 09/09/2003 |
| 6610839 | Promoter for telomerase reverse transcriptase The invention provides compositions and methods related to human telomerase reverse transcriptase (hTRT), the catalytic protein subunit of human telomerase. The polynucleotides and polypeptides of the invention are useful for diagnosis, prognosis and trea... | 08/26/2003 |
| 6147276 | Quiescent cell populations for nuclear transfer in the production of non-human mammals and non-human mammalian embryos A method of reconstituting a mammalian embryo involves transferring the nucleus from a quiescent donor cell into a suitable recipient cell. The donor cell is quiescent, in that it is caused to exit from the growth and division cycle at G1 and to arrest in... | 11/14/2000 |
| 6096499 | Mammalian DNA primase screen and activity modulating agents The invention provides DNA primase assays suitable for identifying DNA primase modulating agents, methods of modulating DNA primase activity and compositions which modulate DNA primase.... | 08/01/2000 |
| 6054314 | Method for collecting cells from internal organs A substantially non-invasive and efficient method for collecting cells from the internal organs of a subject is provided. In one embodiment, energy from an external energy source is applied to the subject that is sufficient to loosen the cells from an int... | 04/25/2000 |
