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Attorney: Dustman; Wayne J., Suter; Stuart R., Lentz; Edward T.


Number of patents: 14
Last date: May 12, 1992

NumberTitleIssue Date
5112922Polystyrene anion exchange polymers
Polymers bearing a quaternary ammonium group are disclosed as being useful in lowering serum cholesterol levels in man. A compound of the invention is N,N-dimethyl-N-(2-(N,N-dimethylcarbamoyl)ethyl)-ammoniomethyl-substitut ed polystyrene, chloride salt....
05/12/1992
5110939Intermediates in the preparation of steriod 5-alpha-reductase inhibitors
Invented are 4-aza-5-alpha-8(14)-17 substituted-androsten-3-ones having an 8(14), 7(8), or 16(17) double bond, optionally also having a 1(2) double bond, pharmaceutical compositions containing the compounds, and methods of using these compounds to inhibit...
05/05/1992
5110875Polystyrene anion exchange polymers
Polymers bearing a quaternary ammonium group are disclosed as being useful in lowering serum cholesterol levels in man. A compound of the invention is N-(2-N,N-dimethylamino)ethyl)-N,N-dimethylammoniomethyl-substituted polystyrene, chloride salt....
05/05/1992
5098701Crosslinked pyridinomethacrylate polymers
Pyridiniomethacrylate polymers are described which are of use in the treatment of elevated serum cholesterol levels. A compound of the invention is cross-linked 3-(N-methyl-3-pyridinio)propyl methacrylate chloride....
03/24/1992
504143311-keto or hydroxy 3,5-diene steroids as inhibitors of steriod 5-଱-reductase
Invented are carboxyl and carboxyl alkyl ester substituted 11-keto and hydroxy analogues of synthetic steroidal compounds, pharmaceutical compositions containing these compounds, and methods of using these compounds to inhibit steroid 5-଱-reductase....
08/20/1991
50325867-keto or hydroxy 3,5-diene steroids as inhibitors of steroid 5-alpha reductase
Invented are carboxyl and carboxyl alkyl ester substituted 7-keto and hydroxy analogues of synthetic steroidal compounds, pharmaceutical compositions containing these compounds, and methods of using these compounds to inhibit steroid 5-଱-reductase. ...
07/16/1991
5026882Phosphinic acid substituted steroids as inhibitors of steroid 5଱-reductase
The invention relates to 3-phosphinic acid steroidal compounds, pharmaceutical compositions containing these compounds, and methods of using these compounds to inhibit steroid 5଱-reductase....
06/25/1991
5023250Steroidal 14଱-carboxy-alkyl derivatives as regulators of HMG-COA reductase
New 14଱-carboxyalkyl sterols are regulators of HMG-CoA reductase and inhibitors of mammalian 14଱-methyl demethylase and are useful in lowering serum cholesterol levels and treating fungal infections....
06/11/1991
5017568Steriod 5-alpha-reductase inhibitors
Invented are substituted acrylate analogues of steroidal synthetic compounds, pharmaceutical compositions containing these compounds, and methods of using these compounds to inhibit steroid 5-଱-reductase. Also invented are intermediates used in prep...
05/21/1991
4997954Process for preparing substituted isoindolinone derivatives
This invention relates to an improved process for the preparation of substituted indolinone derivatives using reductive cyclization conditions....
03/05/1991
49702043-substituted nitro-steroid derivatives as 5-଱-reductase inhibitors
Invented are 3-nitro- substituted steroidal synthetic compounds, pharmaceutical compositions containing the compounds, and methods of using these compounds to inhibit steroid 5-଱-reductase including using these compounds to reduce prostate size. Als...
11/13/1990
4970205Sulfonic acid substituted aromatic steroids as inhibitors of steroid 5-଱-reductase
Invented are sulfonic acid substituted analogues of steroidal synthetic compounds, pharmaceutical compositions containing these compounds, and methods of using these compounds to inhibit steroid 5-଱-reductase, including using these compounds to redu...
11/13/1990
4954446Aromatic steroid 5-଱-reductase inhibitors
Invented are substituted acrylate analogues of steroidal synthetic compounds, pharmaceutial compositions containing the compounds, and methods of using these compounds to inhibit steroid 5-଱-reductase including using these compounds to reduce prosta...
09/04/1990
4946834Phosphonic acid substituted steroids as steroid 5଱-reductase inhibitors
Invented are substituted acrylate analogues of steroidal synthetic compounds, pharmaceutical compositions containing the compounds, and methods of using these compounds to inhibit steroid 5଱-reductase. Also invented are intermediates used in prepari...
08/07/1990
 
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