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| Number | Title | Issue Date |
| 6376256 | Rapid process for arraying and synthesizing bead-based combinatorial libraries A mixture of beads of uniform size from is deposited in an array by establishing discrete attachment areas each consisting either of a droplet of adhesive or a small area of a continuous adhesive layer exposed through an aperture in a mask. Beads which ar... | 04/23/2002 |
| 6365196 | Controlled release solid dosage forms of lithium carbonate A process for preparing controlled release solid dosage forms of lithium carbonate by using a dissolution rate stabilizer and a hydrophobic waxy material.... | 04/02/2002 |
| 6346531 | G-CSF mimetics Invented are G-CSF mimetics. Also invented are selected octacyclic compounds, pharmaceutical compositions containing these compounds, and methods of using these compounds as G-CSF mimetics. Also invented are novel processes used in preparing these compoun... | 02/12/2002 |
| 6303784 | Pharmaceutical aminophosphonic acid derivatives Aminophosphonates alpha substituted by phenol groups, of formula (I) have lipoprotein(a) lowering activity. ##STR1##... | 10/16/2001 |
| 6288247 | Process of making 3-phenyl-1-methylenedioxyphenyl-indane-2-carboxylic acid derivatives Invented is an improved process for preparing aromatic ring-fused cyclopentane derivatives. Preferred compounds prepared by this invention are indane carboxylates and cyclopentano[b]pyridine derivatives. The most preferred compounds prepared by this inven... | 09/11/2001 |
| 6280959 | Metal complexes The invention describes zinc chelated dimeric cell-surface receptor ligands, pharmaceutical compositions containing these compounds, methods of using these compounds as agonist of dimeric cell-surface receptors. Novel processes used in preparing the compo... | 08/28/2001 |
| 6210900 | Method of encoding a series of combinatorial libraries and developing structure activity relationships Invented is a method of preparing combinatorial libraries and combinatorial libraries prepared thereby. Also invented is a method for identifying compounds having desired characteristics from a combinatorial library or a set of combinatorial libraries by ... | 04/03/2001 |
| 6194544 | Cyclic semi-random peptide libraries Cyclic penta- and hexa-peptide libraries containing one or more known amino acids, one or more randomized amino acids and a conformationally constraining element are disclosed. These peptide libraries may be used for screening for new bioactive peptides a... | 02/27/2001 |
| 6147232 | Process of making 3-phenyl-1-methylenedioxyphenyl-indane-2-carboxylic acid derivatives Invented is an improved process for preparing aromatic ring-fused cyclopentane derivatives. Preferred compounds prepared by this invention are indane carboxylates and cyclopentano[b]pyridine derivatives. The most preferred compounds prepared by this inven... | 11/14/2000 |
| 6143907 | 3-phenyl-1-methylenedioxyphenyl-indane-2-carboxylic acid derivatives Invented is an improved process for preparing aromatic ring-fused cyclopentane derivatives. Preferred compounds prepared by this invention are indane carboxylates and cyclopentanopyridine derivatives. The most preferred compounds prepared by this inventio... | 11/07/2000 |
| 6133289 | Paroxetine hydrochloride form A or C Invented are methods of treatment using novel forms of paroxetine hydrochloride anhydrate.... | 10/17/2000 |
| 6121290 | Use of GABA uptake inhibitors as anti-tussive agents Invention is a method of treating cough in a mammal, including a human, which comprises administering to such mammal an effective amount of an inhibitor of GABA uptake.... | 09/19/2000 |
| 6114549 | Process of making 3-phenyl-1-methylenedioxyphenyl-indane-2-carboxylic acid derivatives Invented is an improved process for preparing aromatic ring-fused cyclopentane derivatives. Preferred compounds prepared by this invention are indane carboxylates and cyclopentano[b]pyridine derivatives. The most preferred compounds prepared by this inven... | 09/05/2000 |
| 6113944 | Paroxetine tablets and process to prepare them Invented is a novel pharmaceutical composition containing Paroxetine.... | 09/05/2000 |
| 6113914 | Osp A proteins of Borrelia burgdorferi subgroups, encoding genes and vaccines The invention relates to novel Borrelia, and OspA antigens derived therefrom. These antigens show little homology with known OspA's and are therefore useful as vaccine and diagnostic reagents. Multicomponent vaccines based on OspA's from different Borreli... | 09/05/2000 |
| 6063927 | Paroxetine derivatives Piperidine compounds, processes for preparing them, pharmaceutical compositions comprising them and their use in therapy are disclosed.... | 05/16/2000 |
| 6060464 | Compounds and pharmaceutical compositions containing them Aminophosphonates alpha substituted by phenol groups of formula (I) have lipoprotein(a) lowering activity. ##STR1##... | 05/09/2000 |
| 6037469 | 6-(substituted methylene) penems and intermediates Compounds of formula (I) in which: R1 is hydrogen or an organic substituent group; R2 is a fused bicyclic heterocyclic ring system of general formula (a) wherein R4 and R5 are independently hydrogen or one or mo... | 03/14/2000 |
| 5996428 | System to test thermal oxidizer efficiency An apparatus (9) for testing the efficiency of a thermal oxidizer (200) is described. The apparatus provides for a test chemical to be directed into a thermal oxidizer so that the entry and exit flow rates of test chemical through the termal oxidizer may ... | 12/07/1999 |
| 5990102 | Substituted azetidin-2-ones for treatment of atherosclerosis Compounds of formula (I) in which R1 and R2, which may be the same or different, is each selected from hydrogen, halogen or C.sub.(1-8) alkyl; R3 is aryl or aryl C.sub.(1-4) alkyl which may be optionally substituted; X is ... | 11/23/1999 |
| 5972935 | Biphenyl(thio)amide and bipennylethan(thi) one derivatives, their preparation and their use as 5-HT1D receptor antagonists The invention relates to novel heterocyclic compounds of formula (I) or a salt or N-oxide thereof, in which R is a group of formulae (i), (ii) or (iii), where R1 is hydrogen, halogen, C1-6 alkyl, C3-6 cycloalkyl, COC1... | 10/26/1999 |
| 5972951 | Tetracyclic spiro compounds, process for their preparation and their use as 5HT1D receptor antagonists Novel piperidine derivatives of formula (I), processes for their preparation, pharmaceutical compositions containing them and their use as medicaments for the treatment of CNS disorders are disclosed.... | 10/26/1999 |
| 5952325 | Tricyclic spiro compounds process for their preparation and their use of 5HT1D receptor antagonists Novel amide derivatives of formula (I), processes for their preparation, pharmaceutical compositions containing them and their use as medicaments are disclosed. ##STR1##... | 09/14/1999 |
| 5952340 | Use of granisetron for the treatment of postoperative nausea and vomiting The present invention is directed to a method for the treatment of post-operative nausea and vomiting wherein granisetron is administered to a patient in need thereof.... | 09/14/1999 |
| 5942236 | Osp A proteins of Borrelia burgdorferi subgroups, encoding genes and vaccines The invention relates to novet Borrelia, and OspA antigens derived therefrom. These antigens show little homology with known OspA's and are therefore useful as vaccine and diagnostic reagents. Multicomponent vaccines based on OspA's from different Borreli... | 08/24/1999 |
| 5929059 | Pharmaceutical compositions containing granisetron and dexamethasone A method of treatment of nausea and vomiting is disclosed which comprises administering to a human or animal subject granisetron and an antiemetic corticosteroid.... | 07/27/1999 |
| 5919932 | Biphenylamide derivatives as 5HT1D antagonists Biphenyl amide derivatives as 5HT1D antagonists, processes for their preparation, pharmaceutical compositions containing them and their use for the treatment of CNS disorders.... | 07/06/1999 |
| 5882681 | Stabilized tablet formulation Invented are stabilized tablet formulations of substituted 3,5-diene steroidal compounds. Also invented are methods of preparing stabilized tablet formulations of substituted 3,5-diene steroidal compounds.... | 03/16/1999 |
