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Attorney: Dreger; Walter H., Brunelle; Jan P.


Number of patents: 19
Last date: March 02, 1999

NumberTitleIssue Date
5877273Peptides encoded by nuclease sequences of actinomycetales and application as immunogenic compositions
The present invention relates to nucleotide sequences of Actinomycetales, in particular of mycobacteria, to oligonucleotides contained within said nucleotide sequences, to their uses as primers for the synthesis of Actinomycetales DNA and as probes for th...
03/02/1999
5851761Probes, kits and methods for the detection and differentiation of mycobacteria
The invention provides nucleotide probes, kits and methods for the detection and differentiation of Mycobacteria. The gene probes, kits and methods are useful for the diagnosis of tuberculosis and/or for epidemiological study tools for investigating the p...
12/22/1998
5846728Oligonucleotide-polyamide conjugates
Methods are provided for the hybridization of a target polynucleotide with a conjugate. The conjugate comprises an oligonucleotide covalently bound to a linker that is covalently bound to an amino acid or a polyamide. The oligonucleotide portion of the co...
12/08/1998
5830255Formulation of phosphorus fertilizer for plants
Concentrated phosphorus fertilizers are disclosed that comprise a buffered composition of an organic acid and salts thereof and a phosphorous-containing acid and salts thereof. The concentrated phosphorus fertilizers can be diluted with water of pH rangin...
11/03/1998
5817305Anti-inflammatory compositions and methods
Therapeutic compositions and methods for the treatment of inflammation are disclosed. The compositions comprise at least one anti-inflammatory drug in combination with the lymphokine interleukin-4 (IL-4), which components interact synergistically in the t...
10/06/1998
5719054Recombinant virus vectors encoding human papillomavirus proteins
The invention provides a recombinant virus vector for use as an immunotherapeutic or vaccine. The recombinant virus vector comprises at least one pair of nucleotide sequences heterologous to the virus and which have sufficient sequence homology that recom...
02/17/1998
5677440Oligonucleotide-polyamide conjugates
Conjugates of the type Z--X--L are described wherein Z is a solid phase matrix, X is a single amino acid or a polyamide of two or more amino acid residues, and L is a linker that is capable of linking between the amino terminus of X and a 3'-phosphate of ...
10/14/1997
5672805Transgenic mice expressing the neurotoxic C-terminus of ଲ-amyloid precursor protein
The present invention provides non-human, transgenic animals for use as a model for the study of Alzheimer's Disease. The animals exhibit pathology associated with Alzheimer's Disease. The phenotype is conferred in the animals by the introduction of an am...
09/30/1997
5654258Herbicidal composition comprising trifluralin in a porous carrier
A solid, water dispersible, storage-stable trifluralin formulation comprises trifluralin supported inside porous, finely divided carrier particles, optionally together with at least one compatible wetting agent and/or dispersant additive, wherein the trif...
08/05/1997
5567597Hydrolytic enzyme inhibitors/inactivators and methods for using same
The present invention provides compounds that function as hydrolytic enzyme inhibitors (inactivators) and substrates. These compounds are useful in assays to detect and measure levels of hydrolytic enzyme activity and are more particularly useful in treat...
10/22/1996
5525465Oligonucleotide-polyamide conjugates and methods of production and applications of the same
Oligonucleotide-polyamide conjugates of the formula X--L--Y, where X is a polyamide, Y is an oligonucleotide, and L is a linker which forms a covalent bond with the amino-terminus of the polyamide X and the 3' phosphate group of the oligonucleotide Y. Con...
06/11/1996
5514200Formulation of phosphorus fertilizer for plants
Concentrated phosphorus fertilizers are disclosed that comprise a buffered composition of an organic acid and salts thereof and a phosphorous-containing acid and salts thereof. The concentrated phosphorus fertilizers can be diluted with water of pH rangin...
05/07/1996
5492825Mammalian inward rectifier potassium channel cDNA, IRK1, corresponding vectors, and transformed cells
This disclosure relates to two separate and distinct inward rectifier K+ channel expression products and the the genes which encode each expression product. The IRK1 gene (SEQ. ID NO: 1) encodes an inward rectifier K+ channel and t...
02/20/1996
5464754Assay and substrate for arachidonoyl-specific phospholipase A2
A non-radioactive, spectrophotometric, microtiter plate assay for human cystolic phospholipase A2 (cPLA2) is described. The assay utilizes a novel synthetic thiol-phospholipid analog as a substrate. In one embodiment, the substrate i...
11/07/1995
5434046Diagnostic assay based on cis-plain drug resistance gene
This invention relates to DNA encoding drug resistance to cis-platin. The invention also includes expression products of, and vectors and hosts comprising the DNA sequence encoding cis-platin resistance. Also included are immunodiagnostic assays of cis-pl...
07/18/1995
5427919Hydrolytic enzyme inhibitors/inactivators and methods for using same
The present invention provides compounds that function as hydrolytic enzyme inhibitors (inactivators) and substrates. These compounds are useful in assays to detect and measure levels of hydrolytic enzyme activity and are more particularly useful in treat...
06/27/1995
5403813Controlled release composition of biocide in an aqueous dispersion of viscous oil
A controlled release agricultural composition comprising an aqueous dispersion of: 1) a water insoluble matrix comprising a viscous oil (i.e., a hydrocarbon crude oil or post-refining residual oil) selected from the group consisting of bitumen, abietic ac...
04/04/1995
5308766Hydrolytic enzyme inhibitors/inactivators and methods for using same
The present invention provides compounds that function as hydrolytic enzyme inhibitors (inactivators) and substrates. These compounds are useful in assays to detect and measure levels of hydrolytic enzyme activity and are more particularly useful in treat...
05/03/1994
5290700Cell culture device
A cell culture device is disclosed where cells are confined in a liquid medium within a cell culture space. The cell culture space is delimited by at least three selectively permeable walls. One wall is formed by a sheet of tubes and is permeable to fresh...
03/01/1994
 
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