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| Number | Title | Issue Date |
| 8137616 | System for multi color real time PCR The invention is directed to a system for performing multi-color real time PCT, comprising a flexible real time PCT instrument and a specific composition or reaction mixture for performing multiplex PCR: In particular, the present invention is directed to a composit... | 03/20/2012 |
| 8057997 | Nucleic acid binding compounds containing pyrazolo[3,4-D]pyrimidine analogues of purin-2,6-diamine and their uses The present invention is in the field of nucleic acid binding compounds comprising 7-substituted 7-deaza-8aza-2,6-diamino-purine bases, compounds useful for the preparation of such compounds, various uses thereof and methods for the determination of nucleic acids us... | 11/15/2011 |
| 8039215 | Multiplex quantitative nucleic acid amplification and melting assay The invention is a single-tube multiplex assay, capable of simultaneously amplifying, detecting and quantifying multiple nucleic acid targets, using multiple hybridization probes, labeled with the same fluorescent reporter label, but each having a distinct melting t... | 10/18/2011 |
| 8026068 | Use of silica material in an amplification reaction This invention relates to a method for the isolation of a target nucleic acid using a material with an unmodified silica surface and subsequent amplification of the target nucleic acid in the presence of the material with an unmodified silica surface. The method is ... | 09/27/2011 |
| 7981606 | Control for nucleic acid testing The present invention is related to a method for detecting a target biomolecule in test sample by adding an internal control biomolecule to the test sample; to a negative control sample, to a positive control sample and to a reagent control sample or adding an inter... | 07/19/2011 |
| 7972579 | Device for the automatic opening and closing of reaction vessels The invention relates to a device for the automatic opening and closing of reaction vessels. It comprises a holding device for the non-rotatable holding of one or more reaction vessels, a gripper for the gripping of a lid for the reaction vessel, wherein the gripper... | 07/05/2011 |
| 7920971 | Quantification schemes for quantifying nucleic acids Method and apparatus, including computer program products, implement techniques for quantifying a target nucleic acid (target) in a test sample. The techniques include providing a target and a defined initial amount of an internal control nucleic acid (control) diff... | 04/05/2011 |
| 7919063 | Device with a compressible matrix having homogeneous flow profile A fluidic device containing a flow through chamber comprising an inlet port, an outlet port, and a fluid permeable, compressible matrix located in the chamber between said inlet port and said outlet port, and said compressible matrix having a higher flow resistance ... | 04/05/2011 |
| 7914737 | Multi-level diagnostic apparatus with a lift system A new multi-level apparatus is disclosed for high throughput processing of samples. The apparatus does not need interruptions for reloading disposables. ... | 03/29/2011 |
| 7897378 | Method and device for purifying nucleic acids The invention concerns a method for isolating and purifying nucleic acids from a sample and a device that is suitable therefore. ... | 03/01/2011 |
| 7890268 | De-novo sequencing of nucleic acids The present invention is directed to an improved analysis procedure for the comparative sequencing of nucleic acids using multistage mass spectrometry. More precisely, the invention is directed to a method enabling the de-novo sequencing of nucleic acid molecules us... | 02/15/2011 |
| 7829800 | Device and method for the gravimetric determination of liquid volumes and analyzer system comprising such a device A device for the gravimetric volume determination of liquid volumes. The device comprises a housing (11) having the shape and dimensions of a standard rack used in a clinical diagnostic analyzer system for holding sample or reagent containers, and the followi... | 11/09/2010 |
| 7820110 | Drop catcher The invention relates to a device for catching drops from a pipette mechanically attached to a pipetting device in the field of nucleic acid purification and amplification. Furthermore, a method for pipetting a liquid with a decreased potentiality of contamination o... | 10/26/2010 |
| 7741467 | Non-fluorescent energy transfer The present invention relates generally to the transfer of non-fluorescent energy between donor and acceptor moieties. In certain embodiments, the invention provides biomolecules that include substantially non-fluorescent donor moieties. Processes involving these do... | 06/22/2010 |
| 7612187 | 2-azapurine compounds and their uses Within oligonucleotides 2-azapurine and especially 2-azaadenine bases form specifically base pairs with guanine. This base pair is of analogous stability as an adenine-thymine but less stable than a guanine-cytosine base pair. Therefore, the incorporation of 2-azaad... | 11/03/2009 |
| 7601265 | Apparatus for retaining magnetic particles within a flow-through cell An apparatus for retaining magnetic particles within a segment of a flow-through cell during flow of a fluid through the cell comprises (a) optionally, an electrical current source; (b) an electromagnet having a winding connected to the current source and an air gap... | 10/13/2009 |
| 7572581 | 2′-terminator nucleotide-related methods and systems The present invention provides methods of extending primer nucleic acids and sequencing target nucleic acids. The methods include the use of 2′-terminator nucleotides to effect chain termination. In addition to related reaction mixtures and kits, the invention als... | 08/11/2009 |
| 7566775 | N- and C-linked purine bases and structurally related heterocycles as universal nucleosides used for oligonucleotides hybridization The present invention is directed to a nucleic acid binding compound comprising N8- or C8-linked purine bases or structurally related heterocycles, a compound useful for the preparation of such compound, a binding product of this nucleic acid b... | 07/28/2009 |
| 7560231 | Mannitol and glucitol derivatives The present invention is related to compounds comprising mannitol or glucitol derivatives which may be used to build up oligomeric compounds. The invention is further related to uses of these oligomeric compounds for hybridization and as probes. In addition, methods... | 07/14/2009 |
| 7550291 | Vessel system for the treatment and/or storage of liquids Vessel systems for treating and/or storing liquids are provided. The vessel systems comprise a two-dimensional vessel arrangement with a plurality of vessels which are open at the top and which are interconnected to form a unit, and a two-dimensional closure arrange... | 06/23/2009 |
| 7537935 | System for providing biological materials A process and closure arrangement is provided for isolating purified biological material. The process includes placing biological materials in separate lysis vessels, adding lysis liquids to the biological materials in the lysis vessels, and transferring the liquids... | 05/26/2009 |
| 7501504 | Detectable labeled nucleoside analogs and methods of use thereof The invention relates to detectable labels useful for detection of nucleotide sequences. Specifically, the invention relates to labeled-imidazole-PEG compounds, such as nucleosides, nucleotides, and nucleic acids incorporating such compounds, and methods utilizing s... | 03/10/2009 |
| 7501240 | Method for bisulfite treatment The invention is related to the detection of a methylated cytosine in a nucleic acid wherein guanidinium hydrogen sulfite is used for the preparation of a solution containing guanidinium ions and sulfite ions and subsequent modification of the nucleic acid. Thereby,... | 03/10/2009 |
| 7482939 | Electrical drop surveillance The present invention provides a method, an apparatus and a computer program to detect the liquid leakage of a liquid transfer device. In particular, the present invention is directed to a method, an apparatus and a computer program that detects the liquid leakage o... | 01/27/2009 |
| 7462328 | Pipette for disposable tips of different size The present invention is directed to a pipette comprising mounting surfaces of different diameters for the use of disposable tips of different size, which permits easy discarding of the tips after use. Such pipettes can be used in manual and automatic pipetting syst... | 12/09/2008 |
| 7456266 | Detectable labeled nucleoside analogs and methods of use thereof The invention relates to detectable labels useful for detection of nucleotide sequences. Specifically, the invention relates to labeled-imidazole-PEG compounds, such as nucleosides, nucleotides, and nucleic acids incorporating such compounds, and methods utilizing s... | 11/25/2008 |
| 7445900 | Homogeneous assay system A process of detecting a target nucleic acid using labeled oligonucleotides uses the 5′ to 3′ nuclease activity of a nucleic acid polymerase to cleave annealed labeled oligonucleotide from hybridized duplexes and release labeled oligonucleotide fragments for det... | 11/04/2008 |
| 7413855 | Method for bisulfite treatment The present application is directed to a method for performing a bisulfite reaction to determine methylation positions in a nucleic acid, i.e. methylated and non-methylated cytosines, whereby the nucleic acid is incubated in a solution comprising the nucleic acid fo... | 08/19/2008 |
| 7378241 | Method for determining the efficiency of nucleic acid amplifications The present invention concerns a method for determining the efficiency of the amplification of a target nucleic acid comprising the following steps: (i) preparation of a dilution series of the target nucleic acid, (ii) amplifying the target nucleic acid under define... | 05/27/2008 |
| 7256035 | System for thermocycling of fluids in cartridges System for thermocycling of fluids in cartridges comprising a thermocycling unit in thermal contact with a first substantially planar and heat conducting wall of a cartridge, a light source for transmitting light into the interior of said cartridge through a second ... | 08/14/2007 |
| 7244602 | Polymerase chimeras The invention concerns polymerase chimeras which are composed of amino acid fragments representing domains and which combine properties of naturally occurring polymerases that are advantageous with regard to a particular application. It has surprisingly turned out t... | 07/17/2007 |
| 7238795 | Nucleic acid binding compounds containing pyrazolo[3,4-d]pyrimidine analogues of purin-2,6-diamine and their uses The present invention is in the field of nucleic acid binding compounds comprising 7-substituted 7-deaza-8aza-2,6-diamino-purine bases, compounds useful for the preparation of such compounds, various uses thereof and methods for the determination of nucleic acids us... | 07/03/2007 |
| 7220847 | Detectable labeled nucleoside analogs and methods of use thereof The invention relates to detectable labels useful for detection of nucleotide sequences. Specifically, the invention relates to labeled-imidazole-PEG compounds, such as nucleosides, nucleotides, and nucleic acids incorporating such compounds, and methods utilizing s... | 05/22/2007 |
| 7179590 | High temperature reverse transcription using mutant DNA polymerases The present invention relates to improved reverse transcription methods using a modified thermostable DNA polymerases, particularly in a magnesium ion buffer. These methods are particularly useful in combined reverse-transcription/amplification reactions. ... | 02/20/2007 |
| 7141377 | Process for discrimination of nucleic acid sequence variants A process of detecting a target nucleic acid using labeled oligonucleotides uses the 5′ to 3′ nuclease activity of a nucleic acid polymerase to cleave annealed labeled oligonucleotide from hybridized duplexes and release labeled oligonucleotide fragments for det... | 11/28/2006 |
| 7118867 | Quantitative multiplex PCR with high dynamic range The invention provides a method for quantitative multiplex PCR of two targets whereby one target is present in at least 100-fold molar excess over that of the other target. The method further comprises the addition of a thermostable DNA polymerase with a final conce... | 10/10/2006 |
| 7063945 | N -and c -linked purine based and structurally related heterocycles as universal nucleosides used oligonucleotides hybridization The present invention is directed to a nucleic acid binding compound comprising N8- or C8-linked purine bases or structurally related heterocycles, a compound useful for the preparation of such compound, a binding product of this nucleic acid b... | 06/20/2006 |
| 7053384 | Reference device for evaluating the performance of a confocal laser scanning microscope, and a method and system for performing that evaluation A reference device for evaluating the performance of a confocal laser scan microscope. The reference device comprises a substrate (53) and reference fluorescing matter distributed over a surface of the substrate (53). The reference fluorescing matter h... | 05/30/2006 |
| 6794142 | Amplification using modified primers The present invention provides modified primers for use in the amplification of a nucleic acid sequence. Amplifications carried out using the modified primers result in less template-independent non-specific product (primer dimer) compared to amplifications carried ... | 09/21/2004 |
