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| Number | Title | Issue Date |
| 8138315 | Anti-alpha V immunoliposome compositions, methods and uses An immunoliposome composition targeted to the alphaV-integrin subunit of integrin receptors comprised of ligand-targeted liposomes bearing at least one targeting-ligand derived from an antibody and having binding specificity for at least one integrin receptor compri... | 03/20/2012 |
| 7955597 | Anti-IL-6 antibodies, compositions, methods and uses The present invention relates to at least one novel chimeric, humanized or CDR-grafted anti-IL-6 antibodies derived from the murine CLB-8 antibody, including isolated nucleic acids that encode at least one such anti-IL-6 antibody, vectors, host cells, transgenic ani... | 06/07/2011 |
| 7833786 | Anti-IL-6 antibodies, compositions, methods and uses The present invention relates to at least one novel chimeric, humanized or CDR-grafted anti-IL-6 antibodies derived from the murine CLB-8 antibody, including isolated nucleic acids that encode at least one such anti-IL-6 antibody, vectors, host cells, transgenic ani... | 11/16/2010 |
| 7790405 | Solution phase biopanning method using engineered decoy proteins The invention relates to a method of directing selection of biological therapeutic molecules to specific functional domains of the target biologic molecule. Selection is directed by the use of closely related molecules, where one is a decoy and the other contains th... | 09/07/2010 |
| 7777018 | CDR-grafted anti-tissue factor antibodies and methods of use thereof The present invention provides CDR-grated antibodies against human tissue factor that retain the high binding affinity of rodent monoclonal antibodies against tissue factor but have reduced immunogenicity. The present humanized antibodies are potent anticoagulants a... | 08/17/2010 |
| 7612182 | Anti-IL-6 antibodies, compositions, methods and uses The present invention relates to at least one novel chimeric, humanized or CDR-grafted anti-IL-6 antibodies derived from the murine CLB-8 antibody, including isolated nucleic acids that encode at least one such anti-IL-6 antibody, vectors, host cells, transgenic ani... | 11/03/2009 |
| 7605235 | Anti-tissue factor antibodies and compositions Isolated anti-tissue factor antibodies, immunoglobulins, cleavage products and other specified portions and variants thereof having enhanced ADCC activity, as well as anti-tissue factor antibody compositions, encoding or complementary nucleic acids, vectors, host ce... | 10/20/2009 |
| 7550142 | Anti-integrin antibodies, compositions, methods and uses The present invention relates to at least one novel anti-alpha-V subunit antibodies, including isolated nucleic acids that encode at least one anti-alpha-V subunit antibody, alpha-V subunit, vectors, host cells, transgenic animals or plants, and methods of making an... | 06/23/2009 |
| 7547767 | Growth arrest specific gene 6 peptides, antibodies, compositions, methods and uses The present invention provides novel proteins and peptides from the receptor binding region of human Growth Arrest Specific Gene 6 (Gas6) and antibodies, including specified portions or variants, specific for at least one such Gas6 peptide or fragment thereof. The a... | 06/16/2009 |
| 7544790 | CDR-grafted anti-tissue factor antibodies and methods of uses there of The present invention provides CDR-grated antibodies against human tissue factor that retain the high binding affinity of rodent monoclonal antibodies against tissue factor but have reduced immunogenicity. The present humanized antibodies are potent anticoagulants a... | 06/09/2009 |
| 7521206 | Anti-TNF antibodies, compositions, methods and uses The present invention relates to at least one novel anti-TNF antibodies, including isolated nucleic acids that encode at least one anti-TNF antibody, TNF, vectors, host cells, transgenic animals or plants, and methods of making and using thereof, including therapeut... | 04/21/2009 |
| 7514539 | Epitope directed selection of antibodies to murine tissue factor A tissue factor antibody which binds to non-human tissue factor and is useful as a surrogate in preclinical testing where the human therapeutic tissue factor candidate antibody does not interact with the homolog target protein in a manner that would provide meaningf... | 04/07/2009 |
| 7427471 | Modified “S” antibodies The invention relates to the field of antibodies, and particularly to modified antibodies, methods of preparing modified antibodies and uses thereof. More particularly, the invention relates to the preparation of more active IgG antibodies by the addition of an extr... | 09/23/2008 |
| 7365154 | Peptides antagonistic to an anti-angiogenic antibody and uses therefor The invention concerns antagonists of alphav-containing integrins which have therapeutic activity in oncology applications and methods for selecting such antagonists using a peptide which competes for alphaV-integrin binding with a known monoclonal antibody having d... | 04/29/2008 |
| 7291721 | Anti-IL-6 antibodies, compositions, methods and uses The present invention relates to at least one novel chimeric, humanized or CDR-grafted anti-IL-6 antibodies derived from the murine CLB-8 antibody, including isolated nucleic acids that encode at least one such anti-IL-6 antibody, vectors, host cells, transgenic ani... | 11/06/2007 |
| 7288390 | Anti-dual integrin antibodies, compositions, methods and uses The present invention relates to at least one novel anti-dual integrin antibodies, including isolated nucleic acids that encode at least one anti-dual integrin antibody, dual integrin, vectors, host cells, transgenic animals or plants, and methods of making and usin... | 10/30/2007 |
| 7235380 | CDR-grafted anti-tissue factor antibodies and methods of use thereof The present invention provides CDR-grafted antibodies against human tissue factor that retain the high binding affinity of rodent monoclonal antibodies against tissue factor but have reduced immunogenicity. The present humanized antibodies are potent anticoagulants ... | 06/26/2007 |
| 7163681 | Anti-integrin antibodies, compositions, methods and uses The present invention relates to at least one novel anti-alpha-V subunit antibodies, including isolated nucleic acids that encode at least one anti-alpha-V subunit antibody, alpha-V subunit, vectors, host cells, transgenic animals or plants, and methods of making an... | 01/16/2007 |
| 7074755 | Erythropoietin conjugate compounds with extended half-lives The invention provides biologically active erythropoietin (EPO) conjugate compositions wherein EPO is covalently conjugated to a non-antigenic hydrophilic polymer covalently linked to an organic molecule that increases the circulating serum half-life of the composit... | 07/11/2006 |
| 7070786 | RSV proteins, antibodies, compositions, methods and uses The present invention relates to at least one novel RSV proteins, antibodies, including isolated nucleic acids that encode at least one RSV protein or antibody, RSV vectors, host cells, transgenic animals or plants, and methods of making and using thereof, including... | 07/04/2006 |
| 6297242 | N-substituted amidine and guanidine oxazolidinone antibacterials and methods of use thereof N-substituted amidine and guanidine oxazolidinone compounds of the formula: ##STR1## in which the substituents have the meaning indicated in the description. These compounds are useful as antibacterial agents.... | 10/02/2001 |
| 6291454 | Dithiepino[6,5-b]pyridines, and related compositions and methods This invention provides novel dithiepino[6,5-b]pyridines of the following formulae. ##STR1## These compounds are useful as calcium channel antagonists with cardiovascular, antiasthinatic and antibronchoconstriction activity. Thus, this invention also... | 09/18/2001 |
| 6288235 | Methods for the synthesis of highly substituted 2,4-dioxopiperidine libraries The invention relates to methods of synthesizing libraries of diverse and complex highly substituted 2,4-dioxopiperidine compounds of the general formula: ##STR1## wherein R1, R2 and R3 are as herein described, novel ... | 09/11/2001 |
| 6251956 | Combination progestin oral contraceptive regimen An oral contraception regimen which comprises sequentially administering two or more progestational agents exhibiting different effects on the human endometrium in combination with an estrogen. The invention is also directed to an extended use oral contra... | 06/26/2001 |
| 6235876 | Liquid phase process for the preparation of GNRH peptides A liquid phase process for preparing GnRH peptide analogs of the formula: G-AA1 -(A)D-Phe-AA3 -AA4 -(R2 -AA5 -AA6 -AA7 -AA8 -Pro-AA10 -NH2 Formula 1 whic... | 05/22/2001 |
| 6228986 | Solid-phase synthesis of novel 14-membered macroycles for high throughput screening The preparation of 14-membered macrocycles from a resin-bound orthogonally protected lysine residue is described. Reductive alkylation of the a-nitrogen followed by acylation with an Fmoc-aminoacid provides a protected dipeptide precursor. Removal of the ... | 05/08/2001 |
| 6194395 | Cyclodextrin cladribine formulations There is provided by the present invention liquid injectable and oral solid pharmaceutical dosage forms containing a mixture of cladribine (2-chloro-2'-deoxyadenosine; 2-CdA) and cyclodextrin.... | 02/27/2001 |
| 6149935 | Solid matrix system for transdermal drug delivery A matrix for containing drugs for transdermal delivery systems is disclosed. The matrix, formed of a skin-adhesive acrylate copolymer, attains high rates of drug delivery without the addition of drug delivery rate enhancers. In preferred embodiments the m... | 11/21/2000 |
| 6120795 | Manufacture of liposomes and lipid-protein complexes by ethanolic injection and thin film evaporation A method for preparing liposomal suspensions which comprises preparing a solution of a poorly soluble protein or other poorly soluble compound and an encapsulating amount of a suitable lipid in an alcoholic solvent, injecting the resulting solution into a... | 09/19/2000 |
| 6083969 | 1,3- and 2,3-diarylcycloalkano and cycloalkeno pyrazoles as selective inhibitors of cyclooxygenase-2 and antiinflammatory agents This invention is directed to certain 1,3- and 2,3-diarylpyrazole antiinflammatory compounds of the general formulae: ##STR1## wherein R1 and R2 are independently selected from the group consisting of hydrogen, halogen, (C1... | 07/04/2000 |
| 6077869 | Aryl phenylhydrazides as selective COX-2 inhibitors for treatment of inflammation This invention relates to the use of compounds of formula I as selective COX-2 inhibitors and antiinflammatory agents: ##STR1## wherein: X and Y are selected from hydrogen, halogen, alkyl, nitro, amino or other oxygen and sulfur containing functional... | 06/20/2000 |
| 6028202 | 1,5-diarylpyrazoles Compounds of Formula I ##STR1## wherein, R1 through R7 are described herein. These compounds inhibit the production of arachidonic acid products associated with 5-lipoxygenase and cyclooxygenase and are useful in the treatment o... | 02/22/2000 |
| 6013764 | Liquid phase peptide synthesis of KL-4 pulmonary surfactant The invention relates to improved liquid phase processes for the preparation of the 21 residue protein component, (Lys-Leu4)4 -Lys, of the pulmonary surfactant KL-4. These process are amenable to large scale synthesis and one process... | 01/11/2000 |
| 5976578 | Liquid antacid compositions Liquid antacid compositions containing a tri- or di-ester buffer have a reduced final product pH providing for a more efficacious preservative system and better tasting product without compromising to acid neutralization capacity of the antacid.... | 11/02/1999 |
| 5977302 | Liquid phase process for the preparation of GnRH peptides A liquid phase process for preparing GnRH peptide analogs of the formula: G-AA1 -(A)D-Phe-AA3 -AA4 -(R2)-AA5 -AA6 AA7 -AA8 -Pro-AA10 -NH2 Formula 1 which c... | 11/02/1999 |
| 5972939 | Cyclopentene derivatives useful as antagonists of the motilin receptor The compounds of formula I are useful in treating gastrointestinal disorders associated with antagonizing the motilin receptor disorders. The compounds compete with erythromycin and motilin for the motilin receptor. In addition the compounds are antagonis... | 10/26/1999 |
| 5952303 | Lyophilized pulmonary surfactant peptide compositions An improved solid pharmaceutical composition comprising a lyophilized liposomal KL4 pulmonary surfactant composition comprising: (a) about 1 to about 10 percent weight KL4 polypeptide; and (b) 50 to about 100 weight percent phospholipid comprised of about 3 parts ... | 09/14/1999 |
| 5942532 | 2-substituted phenyl-benzimidazole antibacterial agents The invention relates to benzimidazole antibacterial compounds of the Formula I: ##STR1## as described herein, pharmaceutical compositions containing the compounds, and methods for their production and use. These compounds are effective in inhib... | 08/24/1999 |
| 5925769 | Acetylenic 1,5-diarylpyrazoles as antiinflammatory agents Compounds of Formula I ##STR1## wherein, R1 through R7 are described herein. These compounds inhibit the production of arachidonic acid products associated with 5-lipoxygenase and cyclooxygenase and are useful in the treatment o... | 07/20/1999 |
| 5914135 | Liquid antacid compositions Calcium carbonate liquid antacid compositions containing one or more pH adjusting agents to maintain the pH above 9.0, preferably above 9.5. The resultant antacid liquid possesses superior resistance to microbial attack and enhanced taste properties.... | 06/22/1999 |
