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| Number | Title | Issue Date |
| 8153581 | Process for producing an injectable medicament preparation The invention relates to a method for producing injectable medicament preparations containing a therapeutically and/or diagnostically effective substance which is comprised of an active agent, of a spacer molecule and of at least one protein-binding molecule. After ... | 04/10/2012 |
| 8124392 | Crystal structure of Aurora-2 protein and binding pockets thereof The present invention provides crystalline molecules or molecular complexes which comprise binding pockets of Aurora-2 or its homologues. The invention also provides crystals comprising Aurora-2. The present invention also relates to a computer comprising a data sto... | 02/28/2012 |
| 8067224 | Presenilin associated membrane protein (PAMP) and uses thereof Presenilin Associated Membrane Protein (PAMP), and nucleic acids encoding this protein, are provided. PAMP and PAMP nucleic acids provide diagnostic and therapeutic tools for evaluating and treating or preventing neurodegenerative diseases. In a specific embodiment,... | 11/29/2011 |
| 8002891 | Crystallization of C-Jun N-Terminal Kinase 3 (JNK3) The present invention relates to molecules and molecular complexes which comprise the active site binding pockets of JNK3 or close structural homologues of the active site binding pockets. ... | 08/23/2011 |
| RE42190 | Method of identifying a compound for inhibiting or stimulating human G protein-coupled receptors The invention disclosed in this patent document relates to transmembrane receptors, more particularly to endogenous, human orphan G protein-coupled receptors. ... | 03/01/2011 |
| 7893235 | Nucleic acids encoding the GPCR, RUP3, and methods of use thereof The invention disclosed in this patent document relates to transmembrane receptors, more particularly to endogenous, human orphan G protein-coupled receptors. ... | 02/22/2011 |
| 7883881 | Inhibitors of GSK-3 and crystal structures of GSK-3β protein and protein complexes The present invention relates to inhibitors of GSK-3 and methods for producing these inhibitors. The invention also provides pharmaceutical compositions comprising the inhibitors and methods of utilizing those compositions in the treatment and prevention of various ... | 02/08/2011 |
| 7846679 | Methods for detecting the presence of mutant mammalian presenilin protein The present invention describes the identification, isolation, cloning, and determination of the Alzheimer Related Membrane Protein (ARMP) gene on chromosome 14 and a related gene, E5-1, on chromosome 1. Normal and mutant copies of both genes are presented. Transcri... | 12/07/2010 |
| 7838247 | Antibody specific for mutant presenilin 2 and method of use thereof The present invention describes the identification, isolation, cloning, and determination of the Alzheimer Related Membrane Protein (ARMP) gene on chromosome 14 and a related gene, E5-1, on chromosome 1. Normal and mutant copies of both genes are presented. Transcri... | 11/23/2010 |
| 7820877 | Transgenic mammals having human IG loci including plural Vand Vregions and antibodies produced therefrom The present invention relates to transgenic non-human animals that are engineered to contain human immunoglobulin gene loci. In particular, animals in accordance with the invention possess human Ig loci that include plural variable (VH and Vκ) gene regio... | 10/26/2010 |
| 7816492 | Human G protein-coupled receptors The invention disclosed in this patent document relates to transmembrane receptors, more particularly to endogenous, human orphan G protein-coupled receptors. ... | 10/19/2010 |
| 7809541 | Crystal structure of aurora-2 protein and binding pockets thereof The present invention provides crystalline molecules or molecular complexes which comprise binding pockets of Aurora-2 or its homologues. The invention also provides crystals comprising Aurora-2. The present invention also relates to a computer comprising a data sto... | 10/05/2010 |
| 7772366 | Inhibitors of interleukin-1β converting enzyme The present invention relates to novel classes of compounds which are inhibitors of interleukin-1β converting enzyme. The ICE inhibitors of this invention are characterized by specific structural and physicochemical features. This invention also relates to pharmace... | 08/10/2010 |
| 7767879 | Transgenic animal model of neurodegenerative disorders The present invention provides a transgenic animal model of Alzheimer's Disease designated TgCRND8 as well as a method for making such model, which allows for the characterization of the etiology of the disease as well as for provide a system for the development and... | 08/03/2010 |
| 7666647 | Inhibitors of GSK-3 and crystal structures of GSK-3β protein and protein complexes The present invention relates to inhibitors of GSK-3 and methods for producing these inhibitors. The invention also provides pharmaceutical compositions comprising the inhibitors and methods of utilizing those compositions in the treatment and prevention of various ... | 02/23/2010 |
| 7666646 | Crystal structure of human Pim-1 kinase protein complexes and binding pockets thereof, and uses thereof in drug design The present invention relates to the X-ray analysis of crystalline molecules or molecular complexes of human Pim-1. The present invention also relates to Pim-1-like binding pockets. The present invention provides a computer comprising a data storage medium encoded w... | 02/23/2010 |
| 7655446 | Crystal structure of Rho-kinase I kinase domain complexes and binding pockets thereof The present invention relates to human Rho-kinase I (ROCK I), ROCK I binding pockets, ROCK I-like binding pockets. More particularly, the present invention provides a computer comprising a data storage medium encoded with the structure coordinates of such binding po... | 02/02/2010 |
| 7558717 | Crystal structure of human JAK3 kinase domain complex and binding pockets thereof The present invention relates to human Janus Kinase 3 (JAK3) and JAK3-like binding pockets. The present invention provides a computer comprising a data storage medium encoded with the structure coordinates of such binding pockets. This invention also relates to meth... | 07/07/2009 |
| 7527952 | Crystals of inosine monophosphate dehydrogenase/oxidized inosine monophosphate thiomidate intermediate/mycophenolic acid (IIMPDH/XMP*/MPA) The present invention relates to a data storage medium encoded with the corresponding structure coordinates of molecules and molecular complexes which comprise the active site binding pockets of IMPDH. Such data storage material is capable of displaying such molecul... | 05/05/2009 |
| 7527946 | Interferon-beta-1a-immunoglobulin fusion proteins and uses A fusion polypeptide is described having the amino acid sequence X-Y-Z, or portion thereof, comprising the amino acid sequence of a glycosylated interferon-beta (X); Y is an optional linker moiety; and Z is a polypeptide comprising at least a portion of a polypeptid... | 05/05/2009 |
| 7507798 | Antibody specific for mutant presenilin 1 The present invention describes the identification, isolation, cloning, and determination of the Alzheimer Related Membrane Protein (ARMP) gene on chromosome 14 and a related gene, E5-1, on chromosome 1. Normal and mutant copies of both genes are presented. Transcri... | 03/24/2009 |
| 7494795 | Crystal structure of FMS-like tyrosine kinase The invention relates to FMS-like tyrosine kinase (FLT3), FLT3 binding pockets or FLT3-like binding pockets. The invention relates to a computer comprising a data storage medium encoded with the structure coordinates of such binding pockets. The invention also relat... | 02/24/2009 |
| 7439326 | Presenilin associated membrane protein (PAMP)and uses thereof Presenilin Associated Membrane Protein (PAMP), and nucleic acids encoding this protein, are provided. PAMP and PAMP nucleic acids provide diagnostic and therapeutic tools for evaluating and treating or preventing neurodegenerative diseases. In a specific embodiment,... | 10/21/2008 |
| 7435871 | Transgenic animals bearing human Igλ light chain genes The invention relates to transgenic animals bearing one or more human λ light chain loci. The invention also relates to methods and compositions for making transgenic animals that have incorporated human λ light chain loci. The invention further relates to methods... | 10/14/2008 |
| 7371920 | Transgenic mouse model of neurodegenerative disorders The present invention provides a transgenic animal model of Alzheimer's Disease designated TgCRND8 as well as a method for making such model, which allows for the characterization of the etiology of the disease as well as for provide a system for the development and... | 05/13/2008 |
