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"That the automobile has practically reached the limit of its development is suggested by the fact that during the past year no improvements of a radical nature have been introduced."
Scientific American ; Jan. 2 edition, 1909
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| Number | Title | Issue Date |
| 7491718 | Sulfonamides having antiangiogenic and anticancer activity Compounds having methionine aminopeptidase-2 inhibitory (MetAP2) are described. Also described are pharmaceutical compositions comprising the compounds, methods of treatment using the compounds, methods of inhibiting angiogenesis, and methods of treating cancer.... | 02/17/2009 |
| 7470691 | Fused bicyclic aromatic compounds that are useful in treating sexual dysfunction The present invention relates to the use of compounds of formula (I) for the treatment of sexual dysfunction and to compositions containing compounds of formula (I) for the treatment of sexual dysfunction, wherein A, L, D a... | 12/30/2008 |
| 7468371 | Tricyclic pyrazole kinase inhibitors Compounds of the present invention are useful for inhibiting protein tyrosine kinases. Also disclosed are methods of making the compounds, compositions containing the compounds, and methods of treatment using the compounds. ... | 12/23/2008 |
| 7456169 | Heterocyclic kinase inhibitors Compounds having the formula are useful for inhibiting protein kinases. Also disclosed are methods of making the compounds, compositions containing the compounds, and methods of treatment using the compounds. ... | 11/25/2008 |
| 7449485 | N-sulfonylurea apoptosis promoters Compounds having the formula are apoptosis promoters. Also disclosed are methods of making the compounds, compositions containing the compounds, and methods of treatment using the compounds. ... | 11/11/2008 |
| 7449584 | N-(2((4-Hydroxyphenyl)amino)pyridin-3-yl)-4-methoxybenzenesulfonamide Crystalline Form 1 N-(2-((4-Hydroxyphenyl)amino)pyridin-3-yl)-4-methoxybenzenesulfonamide Crystalline Form 1, ways to make it, compositions containing it and methods of treatment of diseases using it are disclosed. ... | 11/11/2008 |
| 7446206 | N-((2Z)-2-((4-hydroxyphenyl) amino)-1,2-dihydro-3-pyridinyl)-4-methoxybenzenesulfonamide crystalline form 2 N-((2Z)-2-((4-Hydroxyphenyl)imino)-1,2-dihydro-3-pyridinyl)-4-methoxybenzenesulfonamide Crystalline Form 2, ways to make it, compositions containing it and methods of treatment of diseases using it are disclosed. ... | 11/04/2008 |
| 7432245 | Pharmaceutical formulation comprising a peptide angiogenesis inhibitor Parenteral formulations of peptides which are useful for sustained release are disclosed. Also disclosed are methods of preparation for the formulations. ... | 10/07/2008 |
| 7395928 | Child-resistant blister package A child-resistant blister card package is disclosed having a plurality of unit package regions for enclosing one unit dosage form, each comprising a cavity and a closure sheet to seal the cavity. Once a unit package region is detached, the corner defined by lines of... | 07/08/2008 |
| 7365093 | Endothelin antagonists A compound of the formula (I): or a pharmaceutically acceptable salt thereof is disclosed, as well as processes for and intermediates in the preparation thereof, and a method of antagonizing endothelin. ... | 04/29/2008 |
| 7358251 | N-sulfonylurea apoptosis promoters Compounds having the formula are apoptosis promoters. Also disclosed are methods of making the compounds, compositions containing the compounds, and methods of treatment using the compounds. ... | 04/15/2008 |
| 7208517 | Endothelin antagonists A compound of the formula (I): or a pharmaceutically acceptable salt thereof is disclosed, as well as processes for and intermediates in the preparation thereof, a method of antagonizing endothelin, methods for t... | 04/24/2007 |
| 7202363 | Thienopyridine and furopyridine kinase inhibitors Compounds having the formula are useful for inhibiting protein tyrosine kinases. The present invention also discloses methods of making the compounds, compositions containing the compounds, and methods of treatme... | 04/10/2007 |
| 7196200 | Antibacterial compounds Bacterial protein synthesis-inhibiting compounds having formula (I) and salts, prodrugs, and salts of prodrugs thereof, processes for making the compounds and intermediates in the processes, compositions containi... | 03/27/2007 |
| 7135468 | Antibacterial compounds Bacterial protein synthesis-inhibiting compounds having formula (I) and salts, prodrugs, salts of prodrugs, and metabolites thereof, processes for making the compounds and intermediates in the processes, composit... | 11/14/2006 |
| 7135484 | Azabicyclic compounds are central nervous system active agents Compounds of formula (I) are novel CNS active agents that are useful for treating pain and for treating other disorders associated with the cholinergic system. ... | 11/14/2006 |
| 7129260 | Isoindolinone kinase inhibitors Compounds having the formula are useful for inhibiting protein tyrosine kinases. The present invention also discloses methods of making the compounds, compositions containing the compounds, and methods of treatme... | 10/31/2006 |
| 7074932 | Preparation of quinoline-substituted carbonate and carbamate derivatives The invention relates to a process for preparing quinoline-substituted carbonate and carbamate compounds, which are important intermediates in the synthesis of 6-O-substituted macrolide antibiotics. The process employs metal-catalyzed coupling reactions to provide a... | 07/11/2006 |
| 7071314 | Arylation method for the functionalization of O-allyl erythromycin derivatives An efficient arylation technique for use in the synthesis of erythromycin derivatives, involving a modified Heck reaction which employs less than six mole percent of palladium catalyst and no phosphine is disclosed. With this modified Heck reaction, an O-alkenylaryl... | 07/04/2006 |
| 7030115 | N-sulfonylurea apoptosis promoters Compounds having the formula are apoptosis promoters. Also disclosed are methods of making the compounds, compositions containing the compounds, and methods of treatment using the compounds. ... | 04/18/2006 |
| 7030262 | 3-Amino-2-hydroxyalkanoic acids and their prodrugs Compounds having the formula are useful for treating conditions which arise from or are exacerbated by angiogenesis. Also disclosed are pharmaceutical compositions comprising the compounds, methods of treatment using th... | 04/18/2006 |
| 6992069 | Tricyclic macrolide antibacterial compounds Antibacterial compounds having formula (I) and salts, prodrugs, and salts of prodrugs thereof, processes for making the compounds and intermediates used in the processes, compositions containing the compounds, and metho... | 01/31/2006 |
| 6946481 | Endothelin antagonists A compound of the formula (I): or a pharmaceutically acceptable salt thereof is disclosed, as well as processes for and intermediates in the preparation thereof, and a method of antagonizing endothelin. ... | 09/20/2005 |
| 6933283 | 11-deoxy azalide antibacterials Antibacterial compounds having formula (I) and formula (II) and salts, prodrugs, and salts of prodrugs thereof, processes for making the compounds and intermediates used ... | 08/23/2005 |
| 6924304 | Cell proliferation inhibitors Compounds having formula (I) inhibit cellular proliferation. Processes for the preparation of the compounds, pharmaceutical compositions containing the compounds, and methods of treatment using the compounds are disclo... | 08/02/2005 |
| 6887863 | Hydrazide and alkoxyamide angiogenesis inhibitors Compounds having the formula are methionine aminopeptidase type 2 (MetAP2) inhibitors and are useful for inhibiting angiogenesis. Also disclosed are MetAP2-inhibiting compositions and methods of inhibiting angiogenesis... | 05/03/2005 |
| 6831096 | Inhibitors of neuraminidases Disclosed are compounds of the formula: which are useful for inhibiting neuraminidases from disease-causing microorganisms, especially, influenza neuraminidase. Also disclosed are compositions and methods for preventin... | 12/14/2004 |
| 6831068 | Macrolide antibacterial compounds Antibacterial compounds having formula (I) and salts, prodrugs, and salts of prodrugs thereof, processes for making the compounds and intermediates used in the processes, compositions containing the compounds, and meth... | 12/14/2004 |
| 6764996 | 9a-azalides with antibacterial activity Compounds of formula (I) formula (II) formula (III) and formula (IV) or pha... | 07/20/2004 |
| 6753408 | Peptides having antiangiogenic activity Peptides of formula (I) Xaa1-Xaa2-Xaa3-Xaa4-Xaa5-Xaa6-Xaa7-Xaa8-Xaa9-Xaa10-Xaa11 (I), are useful for inhibit... | 06/22/2004 |
| 6720338 | N-acylsulfonamide apoptosis promoters N-Benzoyl arylsulfonamides having the formula: are BCL-X1 inhibitors and are useful for promoting apoptosis. Also disclosed are BCL-X1 inhibiting compositions and methods of promoting apoptosis in a mammal. ... | 04/13/2004 |
| 6716963 | Peptide antiangiogenic drugs Peptides having the formula: A0-A1-A2-A3-A4-A5-A6-A7-A8-A9-A10 wherein A0 is selected from hydrogen or... | 04/06/2004 |
| 6710185 | Process for the preparation of cell proliferation inhibitors The instant invention discloses a process for the synthesis of substituted indole cell proliferation inhibitors. ... | 03/23/2004 |
| 6632961 | Antiangiogenic drug to treat cancer, arthritis and retinopathy Compounds having Formula I ##STR1## or pharmaceutically acceptable salts or prodrugs thereof, are useful for treating pathological states which arise from or are exacerbated by angiogenesis. The invention also relates to pharmaceutical compositions c... | 10/14/2003 |
| 6627743 | 6-O-methylerythromycin A crystal form III The present invention relates to a novel 6-O-methylerythromycin A crystal form, a process for preparing the crystal form, and methods for using the crystal form to prepare a 6-O-methylerythromycin A crystal form II.... | 09/30/2003 |
| 6579986 | Preparation of quinoline-substituted carbonate and carbamate derivatives The invention relates to a process for preparing quinoline-substituted carbonate and carbamate compounds, which are important intermediates in the synthesis of 6-O-substituted macrolide antibiotics. The process employs metal-catalyzed coupling reactions t... | 06/17/2003 |
| 6551616 | Extended release formulations of erythromycin derivatives Disclosed is a pharmaceutical composition for extended release of an erythromycin derivative in the gastrointestinal environment. The composition comprises an erythromycin derivative and a pharmaceutically acceptable polymer so that, when ingested orally,... | 04/22/2003 |
| 6521658 | Cell proliferation inhibitors Compounds having formula (I) ##STR1## inhibit cellular proliferation. Processes for the preparation of the compounds, pharmaceutical compositions containing the compounds, and methods of treatment using the compounds are disclosed.... | 02/18/2003 |
| 6518305 | Five-membered carbocyclic and heterocyclic inhibitors of neuraminidases Disclosed are compounds of the formula: ##STR1## which are useful for inhibiting neuraminidases from disease-causing microorganisms, especially, influenza neuraminidase. Also disclosed are compositions and methods for preventing and treating diseases caus... | 02/11/2003 |
| 6512114 | Process for the preparation of Midazolam The present invention provides a process for the synthesis of Midazolam I ##STR1## from a compound of formula II, ##STR2## using thermodynamic, basic workup conditions. Additional steps to isolate the pure bulk product follow.... | 01/28/2003 |
