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| Number | Title | Issue Date |
| 7972624 | Method of manufacturing modified release dosage forms In one embodiment a dosage form comprises at least one active ingredient and a molded matrix which comprises 10-100% of a material having a melting point of less than about 100 degrees C. selected from the stamp consisting of thermoplastic polyalkylene oxides, low m... | 07/05/2011 |
| 7968120 | Modified release dosage forms In one embodiment a dosage form comprises at least one active ingredient and a molded matrix which comprises 10-100% of a material having a melting point of less than about 100 degrees C. selected from the stamp consisting of thermoplastic polyalkylene oxides, low m... | 06/28/2011 |
| 7723295 | Peptides and compounds that bind to a receptor Peptide compounds that bind to and activate the thrombopoietin receptor (c-mpl or TPO-R) or otherwise act as a TPO agonist are disclosed. ... | 05/25/2010 |
| 7615533 | TPO peptide compounds for treatment of anemia Peptide compounds that bind to and activate the thrombopoietin receptor (c-mpl or TPO-R) or otherwise act as a TPO agonist are disclosed. ... | 11/10/2009 |
| 7579356 | Thia-tetraazaacenaphthylene kinase inhibitors The present invention is directed to novel thia-tetraazaacenaphthylene compounds of Formula (I): and pharmaceutically acceptable forms thereof and their synthesis and use as inhibitors of ATP-protein kinase interactions. | 08/25/2009 |
| 7576056 | Peptides and compounds that bind to a receptor Peptide compounds that bind to and activate the thrombopoietin receptor (c-mpl or TPO-R) or otherwise act as a TPO agonist are disclosed. ... | 08/18/2009 |
| 7575888 | Method of determining chymase activity with secretory leukocyte protease inhibitor It is now discovered that human chymase cleaves human SLPI at a specific site and that this cleavage can be used as an indicator of chymase activity. The present invention provides methods of diagnosing a chymase-associated disease or evaluating the efficiency of a ... | 08/18/2009 |
| 7575882 | Compositions and methods for identifying modulators of TRPV2 It has now been discovered that certain cannabinoids specifically activate TRPV2 channel activity. Based on the discovery, novel compositions and methods for screening, identifying and characterizing compounds that increase or decrease the biological activity of a T... | 08/18/2009 |
| 7563922 | Processes for the preparation of 4-[[4-[[4-(2-cyanoethenyl)-2,6-dimethylphenyl]amino]-2-pyrimidinyl]amino]benzonitrile Processes for the preparation of 4-[[4-[[4-(2-cyanoethenyl)-2,6-dimethylphenyl]-amino]-2-pyrimidinyl]amino]benzonitrile of formula (I), a N-oxide, a pharmaceutically acceptable acid addition salt, a quaternary amine or a stereochemically isomeric form thereof are pr... | 07/21/2009 |
| 7482320 | Modulation of smooth muscle cell proliferation There is provided a novel use for vascular endothelial growth factor, herein designated VEGF-X, and a CUB domain present in the sequence of VEGF-X, which enhance smooth muscle cell proliferation and can be used to treat diseases associated with reduced smooth muscle... | 01/27/2009 |
| 7459557 | Substituted isoindole-1,3-diones The present invention relates to substituted isoindole-1,3-dione compounds of Formula (I) and pharmaceutically acceptable forms thereof, as α1a/α1d adrenoreceptor modulators for the treatment of beni... | 12/02/2008 |
| 7452708 | Human PRSS11-like S2 serine protease and uses thereof A novel human cDNA, termed PRSS11-L, was isolated which encodes a polypeptide that belongs to the S2/HtrA serine protease family. The PRSS11-L mRNA is widely expressed in several tissues throughout the body by multi-tissue Northern blotting. The full-length PRSS11-L... | 11/18/2008 |
| 7446210 | Factor Xa compounds The present invention is directed to novel compounds of Formula I: and forms and pharmaceutical compositions thereof, and the use thereof as inhibitors of Factor Xa. ... | 11/04/2008 |
| 7432343 | Diagnostic application of mail The present invention provides nucleic acids. Polypeptides, antibodies and cells related to MAIL (Molecule possessing Ankyrin repeats Induced by LPS; or IκB-ζ), a novel member of the IκB family, expressed in LPS stimulated monocytes and uses thereof. The isolated... | 10/07/2008 |
| 7399856 | Processes for the preparation of 4-[[4-[[4-(2-cyanoethenyl)-2,6-dimethylphenyl]amino]-2-2pyrimidinyl]amino]benzonitrile Processes for the preparation of 4-[[4-[[4-(2-cyanoethenyl)-2,6-dimethylphenyl]-amino]-2-pyrimidinyl]amino]benzonitrile of formula (I), a N-oxide, a pharmaceutically acceptable acid addition salt, a quaternary amine or a stereochemically isomeric form thereof are pr... | 07/15/2008 |
| 7375203 | Canine cold- and menthol-sensitive receptor 1 The present invention provides nucleic acid and polypeptide sequences describing a novel canine cold- and menthol-sensitive receptor, herein named as canine CMR1 (cCMR1). The isolated nucleic acid or polypeptide molecule of the invention can be used in detection ass... | 05/20/2008 |
| 7285413 | Isolation tool for viable c-kit expressing cells A tool for the isolation of c-kit expressing cells is provided. This tool consists of a c-kit plasmid targeting vector which is capable of integrating into the wild type c-kit allele and encodes a chimeric fluorescent protein comprising a nucleolar localization sign... | 10/23/2007 |
| 7214705 | Bafilomycin-like metabolite from a novel species The invention provides a compound of formula (I) and pharmaceutically acceptable salts thereof. Processes for the isolating of this bafilomycin metabolite from a novel Micromonospora species, pharmaceutical compositions containing this metabolite and methods ... | 05/08/2007 |
| 7205298 | Substituted triazine kinase inhibitors The present invention provides substituted 1,3,5-triazine compounds as kinase inhibitors and a method for treating or ameliorating a kinase mediated disorder. ... | 04/17/2007 |
| 7125879 | HIV inhibiting pyrimidines derivatives This invention concerns HIV replication inhibitors of formula (I) the N-oxides, the pharmaceutically acceptable addition salts, the quaternary amines and the stereochemically isomeric forms thereof, wherein the ring containing −a1=a2−a... | 10/24/2006 |
| 7115598 | Substituted 1,4-diazepines and uses thereof The present invention is directed to novel 1,4-diazepines, pharmaceutical compositions thereof, and the use thereof as inhibitors of HDM2-p53 interactions. Compounds have Formula I: or a solvate, hydrate or pharm... | 10/03/2006 |
| 7101990 | Bax-responsive genes for drug target identification in yeast and fungi The use of nucleic acids and polypeptides which are involved in a pathway eventually leading to programmed cell death of yeast or fungi for the preparation of a medicament for treating diseases associated with yeast or fungi or for the treatment of prolifeative diso... | 09/05/2006 |
| 7067512 | Substituted 1,4-benzodiazepines and uses thereof The present invention is directed to novel 1,4-benzodiazepines, pharmaceutical compositions thereof, and the use thereof as inhibitors of HDM2-p53 interactions. Compounds have Formula I: or a solvate, hydrate or ... | 06/27/2006 |
| 7063953 | Human voltage gated sodium channel β1A subunit and methods of use DNAs encoding human voltage gated sodium channel β1A subunit have been cloned and characterized. The recombinant protein is capable of forming biologically active protein. The cDNA's have been expressed in recombinant host cells that produce active recombinant prot... | 06/20/2006 |
| 7049084 | Neuroblastoma cell lines expressing the α2δ subunit of calcium channels and methods therefore The present invention provides methods for identifying test substances that bind to the α2δ subunit of a calcium channel. ... | 05/23/2006 |
| 7045312 | Method of monitoring a biological system by labeling with an apo metal binding protein The present invention is directed to reporter molecules and tags that may be used to monitor a target substance in a biological system. More particularly, the present invention relates to the use of an apo metal binding protein as a reporter molecule or tag. An apo ... | 05/16/2006 |
| 7037917 | HIV replication inhibiting pyrimidines This invention concerns the use of compounds of formula the N-oxides, the pharmaceutically acceptable addition salts, quaternary amines and the stereochemically isomeric forms thereof, wherein -a1=a2 | 05/02/2006 |
| 7034019 | Prodrugs of HIV replication inhibiting pyrimidines The present invention concerns compounds of formula (A1)(A2)N—R1 (I),the N-oxide forms, the pharmaceutically acceptable addition salts, the quaternary amines and stereochemically isomeric forms thereof, wherein R1 is sub... | 04/25/2006 |
| 7022818 | Rat neurotrophic factor receptor, GFRα-4 There is disclosed a novel mammalian receptor protein designated GFRα-4 and the nucleic acid sequence encoding therefor. Also provided is an expression vector comprising the nucleic acid sequence and host cells transformed or transfected with the vector. Host cells... | 04/04/2006 |
| 6958211 | Methods of assessing HIV integrase inhibitor therapy Methods and products for the evaluation of HIV treatment are provided. The methods are based on evaluating molecular events at the HIV integrase resulting in altered therapeutic efficacy of tho investigated compounds. The methods rely on providing an integrase gene ... | 10/25/2005 |
| 6841682 | Heterocycles useful in the treatment of benign prostatic hyperplasia This invention relates a to a series of heterocyclic substituted piperazines of Formula I pharmaceutical compositions containing them and intermediates used in their manufacture. The compounds of the invention selectiv... | 01/11/2005 |
