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| Number | Title | Issue Date |
| 8128937 | N protein mutants of porcine reproductive and respiratory syndrome virus The present invention provides a genetically modified PRRS virus, methods to make it and related polypeptides, polynucleotides and various components. Vaccines comprising the genetically modified virus and polynucleotides are also provided. ... | 03/06/2012 |
| 8092808 | Ovo vaccination of in avian species The present invention provides a method of inducing an immune response against Campylobacter in an avian species, especially a domesticated avian species such as chicken, turkey, duck, goose and quail, by administering, in ovo, live cells of Campylobacter.... | 01/10/2012 |
| 8058050 | Cellular permissivity factor for viruses and uses thereof The present invention provides methods and compositions related to the generation of host cells permissive for virus growth, particularly Porcine Reproductive and Respiratory Syndrome (PRRS) virus. ... | 11/15/2011 |
| 8007789 | Antibiotics GE 81112 factors A, B, B1, pharmaceutically acceptable salts and compositions, and use thereof The invention relates to antibiotic substances of microbial origin, arbitrarily denominated antibiotic GE 811112 factor A, factor B1 and factor B, which are produced by fermentation of Streptomyces sp. DSMZ 14386, the pharmaceutically acceptable salts and com... | 08/30/2011 |
| 7879337 | Mutant porcine reproductive and respiratory syndrome virus The present invention provides a genetically modified PRRS virus which has been modified such that the conserved cysteine in the E protein has been deleted or changed to a non-cysteine residue and polynucleotides that encode it. Vaccines comprising the genetically m... | 02/01/2011 |
| 7790169 | Methods of vaccine administration, new feline caliciviruses, and treatments for immunizing animals against feline paraovirus and feline herpes virus The present invention relates to a vaccine for immunizing a cat against feline viruses. The present invention also relates to a nucleic acid clone that encodes the capsid protein of the isolated feline calicivirus. The present invention further relates to a live or ... | 09/07/2010 |
| 7754464 | Cellular permissivity factor for viruses and uses thereof The present invention provides methods and compositions related to the generation of host cells permissive for virus growth, particularly Porcine Reproductive and Respiratory Syndrome (PRRS) virus. ... | 07/13/2010 |
| 7691389 | Infectious cDNA clone of north american porcine reproductive and respiratory syndrome (PRRS) virus and uses thereof The invention provides isolated polynucleotide molecules, including plasmids; viral vectors; and transfected host cells that comprise a DNA sequence encoding an infectious RNA sequence encoding a North American PRRS virus; and also North American PRRS viruses encode... | 04/06/2010 |
| 7618797 | Infectious cDNA clone of North American porcine reproductive and respiratory syndrome (PRRS) virus and uses thereof The invention provides isolated polynucleotide molecules that comprise a DNA sequence encoding an infectious RNA sequence encoding a genetically-modified North American PRRS virus, wherein the polynucleotide molecule lacks at least one detectable antigenic epitope o... | 11/17/2009 |
| 7544362 | N protein mutants of porcine reproductive and respiratory syndrome virus The present invention provides a genetically modified PRRS virus, methods to make it and related polypeptides, polynucleotides and various components. Vaccines comprising the genetically modified virus and polynucleotides are also provided. ... | 06/09/2009 |
| 7534441 | Immunogenic LHRH compositions and methods relating thereto The present invention relates generally to an immunogenic LHRH composition and more particularly to an immunogenic LHRH composition comprising a LHRH C-terminal fragment of at least five amino acids. The present invention is useful, inter alia, as a prophylactic and... | 05/19/2009 |
| 7468185 | Vaccine for periodontal disease The present invention relates to novel bacterial isolates identified by their 16S rRNA DNA, that cause periodontal disease in companion animals, polynucleotide sequences contained therein, polypeptides encoded by such polynucleotide sequences and vaccines comprising... | 12/23/2008 |
| 7384773 | Crystal of HIV protease-cleaved human beta secretase and method for crystallization thereof The x-ray crystal structure of human BACE or BACE-like proteins is useful for solving the structure of other molecules or molecular complexes, and identifying and/or designing potential modifiers of human BACE activity. ... | 06/10/2008 |
| 7381741 | 3-amino-2-phenylpyrrolidine derivatives 3-amino-2-phenylpyrrolidine compounds useful as NK-1 antagonists, with pharmaceutical compositions and methods of treatment comprising same, are disclosed. ... | 06/03/2008 |
| 7247706 | Double mutant alpha-7 nicotinic acetylcholine receptors The invention relates ton novel methods for measuring ion channel transmission and methods and compositions useful in the indentification of ligand gated channel agonists and modulators. ... | 07/24/2007 |
| 7217556 | Crystallization and structure determination of glycosylated human beta secretase, an enzyme implicated in Alzheimer's disease The x-ray crystal structure of BACE or BACE-like proteins is useful for solving the structure of other molecules or molecular complexes, and identifying and/or designing potential modifiers of BACE activity. ... | 05/15/2007 |
| 7067626 | Human ion channel proteins The present invention provides novel ion channel polypeptides and polynucleotides that identify and encode them. In addition, the invention provides expression vectors, host cells and methods for their production. The invention also provides methods for the identifi... | 06/27/2006 |
| 7005285 | Human p21-activated kinase 5 polypeptide The present invention provides a human polypeptide homolog of P21-activated kinase (PAK) polynucleotides which identify and encode PAK5 serine/threonine kinase. In addition, the invention provides expression vectors, host cells and methods for its prod... | 02/28/2006 |
| 6861529 | Cycloalkypyrrole-3-carboxylic acid derivatives and heterocycloalkylpyrrole-3-carboxylic acid derivatives This invention relates to cycloalkylpyrrole-3-carboxylic acid derivatives and heterocycloalkylpyrrole-3-carboxylic acid derivatives that bind with high selectively and/or high affinity to the benzodiazepine site of GABAA receptors. This invention also rel... | 03/01/2005 |
| 6696418 | Somatostatin antagonists and agonists that act at the SST subtype 2 receptor Compounds according to the formula: ##STR1## and pharmaceutically acceptable salts, solvates or hydrates thereof; wherein group Ar is optionally substituted (C6 -C10)aryl or (C1 -C9)heteroaryl; X is a direct lin... | 02/24/2004 |
| 6693226 | Transgenic mice expressing human p25 The invention provides transgenic, non-human animals and transgenic non-human mammalian cells harboring a transgene encoding a p25 (activator of the protein kinase cdk 5) polypeptide. The two neuropathological lesions associated with Alzheimer's disease (... | 02/17/2004 |
| 6288246 | Process for preparing hydroxamic acids The present invention relates to a process for preparing hydroxamic acids from hydroxylic acid intermediates wherein the carboxylic acid intermediate does not possess reactive substituents such as hydroxy or amino groups.... | 09/11/2001 |
| 5767099 | Cationic amphiphiles containing amino acid or dervatized amino acid groups for intracellular delivery of therapeutic molecules Novel cationic amphiphiles are provided that facilitate transport of biologically active (therapeutic) molecules into cells. The amphiphiles contain lipophilic groups derived from steroids, from mono or dialkylamines, or from alkyl or acyl groups; and cat... | 06/16/1998 |
| 5747471 | Cationic amphiphiles containing steroid lipophilic groups for intracellular delivery of therapeutic molecules Novel cationic amphiphiles are provided that facilitate transport of biologically active (therapeutic) molecules into cells. The amphiphiles contain lipophilic groups derived from steroids, from mono or dialkylamines, or from ether or ester-linked alkyl g... | 05/05/1998 |
| 5650096 | Cationic amphiphiles for intracellular delivery of therapeutic molecules Novel cationic amphiphiles are provided that facilitate transport of biologically active molecules into cells. Typically, the amphiphiles contain lipophilic groups derived from steroids or from mono or dialkylamines, and two cationic groups, protonatable ... | 07/22/1997 |
