Bizarre Patents
Decorative Jeweled Wheel Cover
An improved wheel is provided wherein decorative items such as gem stones are embedded in either the wheel surface, a special mounting section attached to the wheel surface, or to a spoke strap that wraps around each spoke and positions embedded gem stones on the outside surface of the spoke.
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| Number | Title | Issue Date |
| 8178566 | Crystal form of epothilone B and use in pharmaceutical compositions The invention relates to new crystal forms of epothilone B. ... | 05/15/2012 |
| 8076321 | Compositions for treatment of systemic mastocytosis The present invention relates to the use of the combination of tyrosine phosphate inhibitors AMN107 and PKC412 for the preparation of a drug for the treatment of a mast cell-related proliferative disease. The present invention is also drawn to a combination treatmen... | 12/13/2011 |
| 8017621 | Inhibitors of the mutant form of kit The present invention relates to the treatment of KIT dependent diseases that are characterized by a mutant form of KIT whereby the mutant KIT is identified and an appropriate inhibitor of the mutant KIT selected form midostaurin, vatalanib and compound A is adminis... | 09/13/2011 |
| 8008330 | Combinations comprising epothilones and pharmaceutical uses thereof The invention relates to a combination which comprises (a) a bisphosphonate, a platinum compound or a vasculostatic compound and (b) an epothilone derivative of formula I wherein A represents O or NRN, wherein R | 08/30/2011 |
| 7973032 | Staurosporine derivatives for use in alveolar rhabdomyosarcoma This invention relates to staurosporine derivatives are effective when used in combination with ionizing radiation for the delay of progression or treatment of a proliferative disease, especially a disease associated with a PAX/FKHR translocation including a PAX3/FK... | 07/05/2011 |
| 7973031 | Staurosporine derivatives as inhibitors of FLT3 receptor tyrosine kinase activity The present invention relates to the use of staurosporines derivatives for the preparation of a drug for the treatment of diseases involving deregulated FLT3 receptor tyrosine kinase activity, especially for the curative and/or prophylactic treatment of leukemias an... | 07/05/2011 |
| 7956053 | Inhibitors of tyrosine kinases The invention relates to compounds of formula wherein the substituents R1, R2 and R4 have the meaning as set forth and explained in the description of the invention, to processes for the preparation of these compounds, p... | 06/07/2011 |
| 7893076 | Crystalline form F of Imatinib mesylate The invention relates to the F-crystal form, G-crystal form, H-crystal form, I-crystal form and K-crystal form of the methanesulfonic acid addition salt of 4-(4-methylpiperazin-1-ylmethyl)-N-[4-methyl-3-(4-(pyridin-3-yl)pyrimidin-2-ylamino)phenyl]-benzamide, certain... | 02/22/2011 |
| 7888341 | Combination of glivec (STI571) with a cyclin-dependent kinase inhibitor, especially flavopiridol, in the treatment of cancer The present invention pertains to a combination for simultaneous, separate or sequential use which comprises (a) a cyclin-dependent kinase inhibitor and (b) 4-(4-methylpiperazin-1-ylmethyl)-N-[4-methyl-3-(4-pyridin-3-yl)pyrimidin-2-ylamino)phenyl]-benzamide and to i... | 02/15/2011 |
| 7879860 | Delta and epsilon crystal forms of Imatinib mesylate The invention relates to the delta and epsilon crystal form of the methanesulfonic acid addition salt of 4-(4-methylpiperazin-1-ylmethyl)-N-[4-methyl-3-(4-(pyridin-3-yl)pyrimidin-2 -ylamino)phenyl]-benzamide (the compound of formula I, see below), certain processes ... | 02/01/2011 |
| 7875601 | Cancer treatment with epothilones The invention relates to the treatment of a proliferative disease, especially according to certain treatment regimens, with an epothilone, especially with epothilone A and more preferably epothilone B; as well as to the treatment of certain cancers with such an epot... | 01/25/2011 |
| 7825247 | N-phenyl-2-pyrimidine-amine derivatives The present invention relates to novel amides and a process for preparing these amides. ... | 11/02/2010 |
| 7816359 | N-phenyl-2-pyrimidine-amine derivatives The present invention relates to novel amides and a process for preparing these amides. ... | 10/19/2010 |
| 7754716 | Combination comprising a vasculostatic compound and an alkylating agent for the treatment of a tumor The invention relates to a pharmaceutical combination which comprises (a) a vasculostatic compound, (b) an alkylating agent and (c) optionally at least one pharmaceutically acceptable carrier for simultaneous, separate or sequential use for the treatment of a tumor ... | 07/13/2010 |
| 7723339 | Combination comprising a signal transduction inhibitor and an epothilone derivative The present invention relates to a combination comprising N-{5-[4-(4-methyl-piperazino-methyl) -benzoylamido]-2-methylphenyl}-4-(3-pyridyl)-2-pyrimidine-amine and an epothiione derivative; pharmaceutical composition comprising said combination; method of treatment c... | 05/25/2010 |
| 7612052 | Combinations comprising epothilones and pharmaceutical uses thereof The invention relates to a combination which comprises (a) a bisphosphonate, a platinum compound or a vasculostatic compound and (b) an epothilone derivative of formula I wherein A represents O or NRN, wherein R | 11/03/2009 |
| 7579467 | -phenyl-2-pyrimidine-amine derivatives The present invention relates to novel amides and a process for preparing these amides. ... | 08/25/2009 |
| 7569698 | Process for the isolation and purification of epothilones The invention relates to a desorption process for epothilones, especially epothilone A and/or epothilone B, from resins and new production, work-up or purification processes or manufacturing methods for epothilones comprising said desorption process, as well as the ... | 08/04/2009 |
| 7557105 | N-oxides of N-phenyl-2-pyrimidine-amine derivatives The invention relates to N-phenyl-2-pyrimidine-amine derivatives in which at least one nitrogen atom carries an oxygen atom to form the corresponding N-oxides, to processes for the preparation thereof, to pharmaceutical compositions comprising those compounds, and t... | 07/07/2009 |
| 7544799 | Crystal modification of a N-phenyl-2-pyrimidineamine derivative, processes for its manufacture and its use The invention relates to a new crystalline form of the methanesulfonic acid addition salt of 4-(4-methylpiperazin-1-ylmethyl)-N-[4-methyl-3-(4-pyridin-3-yl)pyrimidin-2-ylamino)phenyl]-benzamide of formula 1, which may be used for example for tumour therapy. | 06/09/2009 |
| 7470792 | Process for the preparation of epothilone derivatives, new epothilone derivatives as well as new intermediate products for the process and the methods of preparing same The present invention provides a synthesis for the preparation of epothilone derivatives of formula 9 wherein R1 is methyl, and R2 is an unsubstituted or substituted aryl; an unsubstituted or substituted heteroaryl; or an u... | 12/30/2008 |
| 7456283 | N-phenyl-2-pyrimidine-amine derivatives The present invention relates to novel amides and a process for preparing these amides. ... | 11/25/2008 |
| 7112611 | 1g(α)-amino-N-hydroxy-acetamide derivatives The invention relates to α-amino-N-hydroxy-acetamide derivatives of formula (I), wherein R is di-lower alkyl amino, 1,2,3-triazol-2yl or 1,2,4-triazol-4-yl, m represents an integer from 1 up to and including 10, and n represents an integer from 0 up to and includin... | 09/26/2006 |
| 7087608 | Use of PDGF receptor tyrosine kinase inhibitors for the treatment of diabetic nephropathy The present invention relates to the use of PDGF receptor tyrosine kinase inhibitors, especially of N-phenyl-2-pyrim-idine-amine derivatives of formula (I), in which the symbols and substituents have the meaning as defined herein in free form or in pharmaceutically ... | 08/08/2006 |
| 7081532 | N-phenyl-2-pyrimidine-amine derivatives The invention relates to N-phenyl-2-pyrimidine-amine derivatives of formula (I) wherein the substituents are defined as in the description, to processes for the preparation thereof, to medicaments comprising thos... | 07/25/2006 |
| 7045523 | Combination comprising N-{5-[4-(4-methyl-piperazino-methyl)-benzoylamido]-2-methylphenyl}-4-(3-pyridyl)-2-pyrimidine-amine and telomerase inhibitor A method of treating BCR-ABL positive leukemia in a warm-blooded animal comprising administering the combination of N-{5-[4-(4-methyl-piperazino-methyl)-benzoylamido]-2-methylphenyl}-4-(3-pyridyl)-2-pyrimidine-amine, or a pharmaceutically acceptable salt thereof, an... | 05/16/2006 |
| 6974816 | Combination for the treatment of endothelial damage The invention relates to a combination of (a) an inhibitor of platelet-derived growth factor (PDGF) activity and (b) a vector for vascular endothelial growth factor (VEGF-, especially VEGF-C) gene transfer, a pharmaceutical preparation comprising (a) and (b) in comb... | 12/13/2005 |
| 6946561 | Process for the isolation and purification of epothilones The invention relates to a desorption process for epothilones, especially epothilone A and/or epothilone B, from resins and new production, work-up or purification processes or manufacturing methods for epothilones comprising said desorption process, as well as the ... | 09/20/2005 |
| 6894051 | Crystal modification of a N-phenyl-2-pyrimidineamine derivative, processes for its manufacture and its use The invention relates to a new crystalline form of the methanesulfonic acid addition salt of 4-(4-methylpiperazin-1-ylmethyl)-N-[4-methyl-3-(4-pyridin-3-yl)pyrimidin-2-ylamino)phenyl]benzamide of formula 1, which may be used for example for tumor therapy. ... | 05/17/2005 |
| 6878720 | VEGF receptor tyrosine kinase inhibitors Described are compunds of formula (I), wherein W is O or S; X is NR8; Y is CR9R10—(CH2)n wherein R9 and R10 are independently of each other hydrogen or lower alkyl, and n is an integer of from and i... | 04/12/2005 |
| 6858404 | Genes for the biosynthesis of epothilones Nucleic acid molecules are isolated from Sorangium cellulosum that encode polypeptides necessary for the biosynthesis of epothilone. Disclosed are methods for the production of epothilone in recombinant hosts transformed with the genes of the invention. In th... | 02/22/2005 |
| 6833384 | Deacetylase inhibitors The present invention provides hydroxamate compounds which are deacetylase inhibitors. The compounds are suitable for pharmaceutical compositions having anti-proliferative properties. ... | 12/21/2004 |
| 6818661 | Anthranylalkyl and cycloalkyl amides and use thereof as VEGF receptor inhibitors The invention relates to substituted anthranylalkyl and cycloalkyl amides of general formula (I) and to their use as medicaments for treating diseases caused by persistent angiogenesis. ... | 11/16/2004 |
| 6774143 | Method for treating cells resistant to antineoplastic agents The present invention relates to methods for treating multidrug resistant cells, preferably multidrug resistant cancer cells with discodermolide. Discodermolide is found to be effective in limiting the growth of otherwise growth unregulated cells having tubulin muta... | 08/10/2004 |
| 6767906 | 2-amino-6-anilino-purines and their use as medicaments This application discloses 2-amino-6-anilino-purine derivatives of the formula I in which q is 1-5, and R1 is α) —S(═O)k—NR6R7, in which k... | 07/27/2004 |
| 6713305 | Metastasis-associated antigen and antibodies thereto There are provided membrane-associated polypeptides having the sequence shown in SEQ ID Nos. 1 and 9. Also provided are immunogenic determinants derived from said polypeptides and antibodies raised thereto. The polypeptides, their derived antigenic determinants and ... | 03/30/2004 |
| 6706731 | Pyridine derivatives inhibiting angiogenesis and/or VEGF receptor tyrosine kinase The invention relates to pyridine derivatives of formula I: wherein the substituents and symbols are defined as indicated in the description, processes for the preparation thereof, their usage in the preparation of a pha... | 03/16/2004 |
| 6683100 | Organic compounds Pharmaceutical formulations comprising an epothilone in the form of an infusion concentrate or a lyophilised composition, and methods of administration of an epothilone in suitable form for parenteral administration.... | 01/27/2004 |
| 6656711 | Fermentative preparation process for and crystal forms of cytostatics The invention relates to a new process for concentrating epothilones in culture media, a new process for the production of epothilones, a new process for separating epothilones A and B and a new strain obtained by mutagenesis for the production of epothil... | 12/02/2003 |
| 6635666 | Cancer treatment with epothilones The invention relates to the treatment of a proliferative disease, especially according to certain treatment regimens, with an epothilone, especially with epothilone A and more preferably epothilone B; as well as to the treatment of certain cancers with s... | 10/21/2003 |
