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| Number | Title | Issue Date |
| 8119621 | Tetrahydro-cyclopentyl pyrazole cannabinoid modulators This invention is directed to a tetrahydro-cyclopentyl pyrazole cannabinoid modulator compound of formula (I): and a method for use in treating, ameliorating or preventing a cannabinoid receptor mediated syndrome, disorder ... | 02/21/2012 |
| 8101592 | Hexahydro-cyclooctyl pyrazole cannabinoid modulators This invention is directed to a hexahydro-cyclooctyl pyrazole cannabinoid modulator compound of formula (I): and a method for use in treating, ameliorating or preventing a cannabinoid receptor mediated syndrome, disorder or... | 01/24/2012 |
| 8039628 | Process for preparing (alpha S, beta R)-6-bromo-alpha-[2-(dimethylamino) ethyl]-2-methoxy-alpha-1-naphthalenyl-beta-phenyl-3-quinolineethanol The present invention relates to a process for isolating (αS,βR)-6-bromo-α-[2-(dimethylamino)ethyl]-2-methoxy-α-1-naphthalenyl-β-phenyl-3-quinolineethanol from a mixture of stereoisomeric forms of 6-bromo-α-[2-(dimethylamino)ethyl]-2-methoxy-α-1-naphth... | 10/18/2011 |
| 8017606 | Quinoline derivatives as antibacterial agents Use of a compound for the manufacture of a medicament for the treatment of a bacterial infection provided that the bacterial infection is other than a Mycobacterial infection, said compound being a compound of Formula (Ia) or (Ib) | 09/13/2011 |
| 8012957 | Tetrahydro-1H-1,2,6-triaza-azulene cannabinoid modulators This invention is directed to a tetrahydro-1H-1,2,6-triaza-azulene cannabinoid modulator compound of formula (I): and a method for use in treating, ameliorating or preventing a cannabinoid receptor mediated syndrome, disord... | 09/06/2011 |
| 7998979 | Antibacterial quinoline derivatives The present invention relates to novel substituted quinoline derivatives according to the general formula (Ia) or formula (Ib): including any stereochemically isomeric form thereof, a pharmaceutically acceptable salt thereo... | 08/16/2011 |
| 7951829 | Benzimidazole modulators of VR1 The invention is directed to compounds of Formula (I): to pharmaceutical compositions containing such compounds and to methods of treatment using them. ... | 05/31/2011 |
| 7851498 | Hexahydro-cyclooctyl pyrazole cannabinoid modulators This invention is directed to a hexahydro-cyclooctyl pyrazole cannabinoid modulator compound of formula (I): and a method for use in treating, ameliorating or preventing a cannabinoid receptor mediated syndrome, disorder or... | 12/14/2010 |
| 7829584 | Pyridines and pyridine N-oxides as modulators of thrombin The present invention describes compounds of Formula I: wherein W, X, Y, Z, and Q are defined herein, or a pharmaceutically acceptable salt thereof, for the prophylaxis, or treatment of diseases and conditions related to th... | 11/09/2010 |
| 7825151 | Hexahydro-cyclooctyl pyrazole cannabinoid modulators This invention is directed to a hexahydro-cyclooctyl pyrazole cannabinoid modulator compound of formula (I): and a method for use in treating, ameliorating or preventing a cannabinoid receptor mediated syndrome, disorder or... | 11/02/2010 |
| 7282602 | Medicinal disulfide salts This invention relates to novel salts of medicinal disulfides. The compounds include a terminal sulfonate or phosphonate moiety, and have many uses, such as toxicity reducing agents when administered with many antineoplastic agents. ... | 10/16/2007 |
| 7235589 | Method of treating patients undergoing kidney dialysis This invention relates to a method of treating patients who are receiving dialysis treatments. The method includes administering to a patient in need of treatment an effective amount of a thiol or reducible disulfide compound according to the formula set forth in th... | 06/26/2007 |
| 7132544 | Process for the preparation of tetrasubstituted imidazole derivatives and novel crystalline structures thereof The present invention relates to a process for preparing tetrasubstituted imidazole derivatives of the general formula (I) wherein R1, R2, R3 and R4 ... | 11/07/2006 |
| 6723849 | Process for making camptothecin derivatives A process for synthesizing highly lipophilic derivatives of camptothecin. The process includes reacting dissolved, underivatized camptothecin with an aldehyde in a modified Minisci-type alkylation reaction to produce 7-substituted derivatives of camptothecin. ... | 04/20/2004 |
| 6596320 | Method for treating cancer having greater efficacy and reduced adverse effects A method of treating patients with cancer that involves administration of a combination regimen of a platinum agent, a taxane agent, and a formula I toxicity-reducing agent. The preferred order of administration is the formula I compound, followed by the ... | 07/22/2003 |
| 6525037 | Method of treating atherosclerosis and complications resulting therefrom This invention relates to a method of treating patients afflicted with atherosclerosis or to prevent the development of atherosclerosis in patients assessed to be high risk of developing the disease. The method includes administering to a patient in need ... | 02/25/2003 |
| 6504049 | Process for synthesizing pharmaceutically active disulfide salts A process for synthesizing pharmaceutically active disulfides, particularly Dimesna and certain derivatives thereof. The process includes reacting an alkylene salt with a sulfurating reagent, then alkalizing the intermediate and flowing oxygen through the... | 01/07/2003 |
| 6468993 | Method for reducing development of osteoporosis This invention relates to a method of treating patients afflicted with osteoporosis. The method includes administering to a patient in need of treatment an effective amount of a thiol or reducible disulfide compound according to the formula set forth in t... | 10/22/2002 |
| 6468963 | Methods and formulations for reducing toxicity associated with diabetes treatments Formulations and methods for reducing the unwanted toxicity and complications associated with treatments for diabetes mellitus. The formulations include co-formulations of an anti-diabetic agent and a toxicity reducing agent of the formula described in th... | 10/22/2002 |
| 6352979 | Method of treating snakebite and complications resulting therefrom This invention relates to a method of treating snakebite victims, especially those at risk from neurotoxic effects from snakebite or those already exhibiting symptoms of neurotoxicity. The method includes administering to a patient in need of treatment an... | 03/05/2002 |
| 6291441 | Method of treating inflammatory bowel disorders This invention relates to a method of treating patients suffering from the inflammatory bowel disorders. The method includes administering to a patient in need of treatment an effective amount of a thiol or reducible disulfide compound according to the fo... | 09/18/2001 |
| 6274622 | Method of treating diabetic ophthalmopathy This invention relates to a method of treating patients afflicted with diabetic ophthalmopathy. The method includes administering to a patient in need of treatment an effective amount of a thiol or reducible disulfide compound according to the formula set... | 08/14/2001 |
| 6255355 | Method of inhibiting angiogenesis This invention relates to a method of treating patients in need of angiogenesis inhibition. The method includes administering to a patient in need of treatment an effective amount of a thiol or reducible disulfide compound according to the formula set for... | 07/03/2001 |
| 6245815 | Method of treating alcoholism and complications resulting therefrom This invention relates to a method of treating patients afflicted with alcoholism. The method includes administering to a patient in need of treatment an effective amount of a thiol or reducible disulfide compound according to the formula set forth in the... | 06/12/2001 |
| 6225295 | Method of treating acetaminophen overdose A method of treating patients suffering from acetaminophen overdose is disclosed. The method comprises administering to a patient in need of treatment an effective amount of a thiol or reducible disulfide compound according to the formula set forth in the... | 05/01/2001 |
| 6218540 | Process for preparing camptothecin A process for preparing the anti-cancer drug camptothecin (CPT) and certain derivatives thereof. The process includes the reacting of three base reagents and a five-step process for synthesizing optically pure CPT in high overall yield from inexpensive st... | 04/17/2001 |
| 6197831 | Method of treating septic shock This invention relates to a method of treating patients afflicted with septic shock. The method includes administering to a patient in need of treatment an effective amount of a thiol or reducible disulfide compound according to the formula set forth in t... | 03/06/2001 |
| 6194579 | Highly lipophilic camptothecin derivatives Novel compounds, formulations and methods of treating patients with cancer are provided for in this invention. The compounds are derivatives of camptothecin, and specifically relate to compounds having novel substitutions at the C-7 position of the campto... | 02/27/2001 |
| 6177411 | Method for treating heavy metal poisoning This invention relates to a method of treating patients afflicted with heavy metal poisoning. The method includes administering to a patient in need of treatment an antidotal amount of a thiol or reducible disulfide compound according to the formula set f... | 01/23/2001 |
| 6172119 | Method of treating acute renal failure This invention relates to a method of treating patients afflicted with acute renal failure. The method includes administering to a patient in need of treatment an effective amount of a thiol or reducible disulfide compound according to the formula set for... | 01/09/2001 |
| 6169080 | Highly lipophilic camptothecin derivatives This invention relates to novel derivatives of camptothecin, and will, particularly to derivatives having a substitution at the C-7 position, or at one of the C-9, C-10, C-11 or C-12 positions, or to disubstituted derivatives having a first substitution a... | 01/02/2001 |
| 6160167 | Mercaptans and disulfides This invention relates to novel compositions of matter which either terminate in a sulfhydryl moiety or are disulfides. The compounds also include a terminal sulfonate or phosphonate moiety, and have many uses, such as toxicity reducing agents when admini... | 12/12/2000 |
| 6143796 | Method for reducing development of free radical induced malignancies This invention relates to a method of treating patients at risk of developing a free radical induced malignancy. The method includes administering an effective amount of a thiol or reducible disulfide compound according to the formula set forth in the spe... | 11/07/2000 |
| 6100247 | Method of treating diabetic neuropathy This invention relates to a method of treating patients afflicted with diabetic neuropathy. The method includes administering to a patient in need of treatment an effective amount of a thiol or reducible disulfide compound according to the formula set for... | 08/08/2000 |
| 6077838 | Method of treating hangover This invention relates to a method of treating patients afflicted with hangover. The method includes administering to a patient in need of treatment an effective amount of a thiol or reducible disulfide compound according to the formula set forth in the s... | 06/20/2000 |
| 6075053 | Method of reducing or reversing neuropathy This invention relates to a method of treating patients afflicted with peripheral neuropathy. The method includes administering to a patient in need of treatment an effective amount of a thiol or reducible disulfide compound according to the formula set f... | 06/13/2000 |
| 6066668 | Formulations and methods of reducing toxicity of antineoplastic agents This invention provides for pharmaceutical formulations of compounds which are useful as protective agents when administered to patients also receiving antineoplastic drugs. The invention also includes methods of reducing the toxicity of various antineopl... | 05/23/2000 |
| 6066645 | Formulations and methods of reducing toxicity of antineoplastic agents This invention provides for pharmaceutical formulations of compounds which are useful as protective agents when administered to patients also receiving antineoplastic drugs. The invention also includes methods of reducing the toxicity of various antineopl... | 05/23/2000 |
| 6057361 | Formulations and methods of reducing toxicity of antineoplastic agents This invention provides for pharmaceutical formulations of compounds which are useful as protective agents when administered to patients also receiving antineoplastic drugs. The invention also includes methods of reducing the toxicity of various antineopl... | 05/02/2000 |
| 6057303 | Highly lipophilic Camptothecin derivatives Derivatives of Camptothecin are disclosed, particularly derivatives having multiple substitutions at the `A`, `B` and `E` rings thereof. The novel compounds are useful in treating a wide variety of susceptible tumors and are potent inhibitors of Topoisome... | 05/02/2000 |
