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| Number | Title | Issue Date |
| 8158156 | Abuse-deterrent multi-layer pharmaceutical composition comprising an opioid antagonist and an opioid agonist Provided herein is a pharmaceutical composition comprising an antagonist, an agonist, a seal coat, and a sequestering polymer, wherein the antagonist, agonist, seal coat and at least one sequestering polymer are all components of a single unit, and wherein the seal ... | 04/17/2012 |
| 8153814 | Sulfonamide derivatives The present invention relates to compounds of the formula and pharmaceutically acceptable salts, solvates or tautomers thereof, to processes for the preparation of, intermediates used in the preparation of, and compositions... | 04/10/2012 |
| 8134023 | Preparation of pregabalin and related compounds Materials and methods for preparing (S)-(+)-3-aminomethyl-5-methyl-hexanoic acid and structurally related compounds via enzymatic kinetic resolution are disclosed. ... | 03/13/2012 |
| 8134007 | Pyridine derivatives The present invention relates to compounds of the formula (I): and pharmaceutically acceptable salts thereof, to processes for the preparation of, intermediates used in the preparation of, and compositions containing such c... | 03/13/2012 |
| 8133883 | Compositions containing piperacillin and tazobactam useful for injection An aminocarboxylic acid chelating agent, preferably EDTA, or a salt thereof has been found to be useful for inhibiting particulate formation in piperacillin/tazobactam parenteral combinations. The composition may also contain a buffer, preferably citrate, and option... | 03/13/2012 |
| 8088804 | N-hydroxyamide derivatives possessing antibacterial activity Described herein are N-hydroxyamide antibacterial compounds, methods for making the compounds, pharmaceutical compositions containing the compounds and methods of treating bacterial infections utilizing the compounds and pharmaceutical compositions compound of Formu... | 01/03/2012 |
| 8063044 | Pyrazole derivatives This invention relates to pyrazole derivatives of formula (I) or pharmaceutically acceptable salts, solvates or derivative thereofs, wherein R1 to R4 are defined in the description, and to processes for the preparation ther... | 11/22/2011 |
| 8044227 | Preparation of pregabalin and related compounds Materials and methods for preparing (S)-(+)-3-aminomethyl-5-methyl-hexanoic acid and structurally related compounds via enzymatic kinetic resolution are disclosed. ... | 10/25/2011 |
| 8022033 | Echinocandin/carbohydrate complexes A complex of an echinocandin compound with a carbohydrate is described having improved thermal stability and water solubility. A process for making the echinocandin/carbohydrate complex is also described as well as the use of the complex in pharmaceutical formulatio... | 09/20/2011 |
| 7951403 | Method of making pharmaceutical multiparticulates A process for forming drug multiparticulates having improved drug crystallinity is disclosed, comprising modifying a conventional melt-congeal process by adding a volatile cospecies either to the molten mixture or to the process atmosphere, or to both. ... | 05/31/2011 |
| 7919488 | Therapeutic compounds The present invention provides compounds of formula (I), or pharmaceutically acceptable salts or solvates thereof, methods for their preparation, methods for their use, and pharmaceutical formulations comprising them. ... | 04/05/2011 |
| 7915229 | Compositions containing piperacillin and tazobactam useful for injection An aminocarboxylic acid chelating agent, preferably EDTA, or a salt thereof has been found to be useful for inhibiting particulate formation in piperacillin/tazobactam parenteral combinations. The composition may also contain a buffer, preferably citrate, and option... | 03/29/2011 |
| 7868026 | Therapeutic compounds The present invention provides compounds of formula (I), or pharmaceutically acceptable salts or solvates thereof, methods for their preparation, methods for their use, and pharmaceutical formulations comprising them. ... | 01/11/2011 |
| 7838686 | Preparation of pregabalin and related compounds Materials and Methods for preparing (S)-(+)-3-aminomethyl-5-methyl-hexanoic acid and structurally related compounds via enzymatic kinetic resolution are disclosed. ... | 11/23/2010 |
| 7807838 | Methods for the preparation of HCV polymerase inhibitors The present invention relates to methods and compounds useful in the preparation of compounds of the formula (I). ... | 10/05/2010 |
| 7803827 | Kv1.5 potassium channel inhibitors The present invention relates to 1-N-amino-2-imidazolidinones and derivatives thereof which are effective as Kv1.5 potassium channel inhibitors providing atrial-selective antiarrhythmic agents. The present invention further relates to compositions comprising said Kv... | 09/28/2010 |
| 7795271 | Substituted pyrimidinones Disclosed are compounds Formula I and pharmaceutically acceptable salts thereof, wherein R1, R2, R4, and R5 are defined herein. These compounds are useful for treating diseases and ... | 09/14/2010 |
| 7795244 | Penem prodrugs Orally bioavailable prodrugs of sulopenem, e.g., and solvates and hydrates thereof, preparation thereof, formulation thereof, and use to treat and prevent infection in mammals such as humans. This abstract is not limiting t... | 09/14/2010 |
| 7795243 | Penem prodrugs Orally bioavailable prodrugs of sulopenem, e.g., and solvates and hydrates thereof, preparation thereof, formulation thereof, and use to treat and prevent infection in mammals such as humans. This abstract is not limiting t... | 09/14/2010 |
| 7790744 | Cyclic peptide antifungal agents and process for preparation thereof Provided are compounds of the formula (1): wherein R′ is hydrogen, methyl or NH2C(O)CH2—; R″ and R′″ are independently methyl or hydrogen; ... | 09/07/2010 |
| 7790740 | Imidazopyridine substituted tropane derivatives with CCR5 receptor antagonist activity for the treatment of HIV and inflammation The present invention provides compounds of formula (I) wherein R1 and R2 are as defined hereinabove. The compounds of the present invention are modulators, especially antagonists, of the activ... | 09/07/2010 |
| 7790197 | Pharmaceutical compositions of atorvastatin A wet granulated pharmaceutical composition comprising atorvastatin or a pharmaceutically acceptable salt thereof with less than about 5 weight % of an alkaline earth metal salt additive with a disintegrant which provides the atorvastatin with not more than about 3%... | 09/07/2010 |
| 7723334 | Highly selective norepinephrine reuptake inhibitors and methods of using the same Methods and compositions for treating humans suffering from, or preventing a human from suffering, a physiological or psychiatric disease, disorder, or a condition where inhibiting reuptake of norepinephrine is a benefit are disclosed. The compositions comprise a co... | 05/25/2010 |
| 7700618 | Sulfonyl benzimidazole derivatives This invention relates to compounds of the formula (I): or a pharmaceutically acceptable salt thereof, wherein A, R1, R2, R3, R4, R5, m and n are each as described herein, and compositions containing such compou... | 04/20/2010 |
| 7691877 | Pharmaceuticals The present invention relates to immune response modifiers of formula (I), which act selectively through agonism, of Toll-Like Receptors (TLRs), uses thereof, processes for the preparation thereof, intermediates used in the preparation thereof and compositions conta... | 04/06/2010 |
| 7670613 | Androgen modulators The present invention is directed to a new class of 4-cycloalkoxy benzonitriles and to their use as androgen receptor modulators. Other aspects of the invention are directed to the use of these compounds to decrease excess sebum secretions and to stimulate hair grow... | 03/02/2010 |
| 7655656 | Hair growth promoting agents The present invention is directed to crystalline forms of 6-[[(3S,4R)-3,4-dihydro-3-hydroxy-6-[(3-hydroxypheny)sulfonyl]-2,2,3-trimethyl-2H-1-benzopyran-4-yl]oxy]-2-methyl-3(2H)-pyridazinone, formulations containing at least one of these crystalline forms and their ... | 02/02/2010 |
| 7576128 | Androgen receptor modulators The present invention is directed to a new class of 4-oxo-benzonitriles, their use as androgen modulators, and to their use in the treatment of alopecia. ... | 08/18/2009 |
| 7563788 | Substituted Imidazo[1,2-a]pyridines as Antibacterial Agents Compounds of formula I and methods for their preparation are disclosed. Further disclosed are methods of making biologically active compounds of formula I as well as pharmaceutically acceptable compositions comprising compounds of formula I. Compounds of formula I a... | 07/21/2009 |
| 7507860 | Androgen modulators The present invention is directed to a new class of 4-cyano-phenoxy-alkyl carboxyl derivatives and to their use as androgen receptor modulators. Other aspects of the invention are directed to the use of these compounds to decrease excess sebum secretions and to stim... | 03/24/2009 |
| 7507742 | Spirocyclic derivatives The invention provides compounds of formula (I): wherein: m is 0, 1 or 2; X is O, S or N—CN; R is F, Cl or CN; A is a C3-6 c... | 03/24/2009 |
| 7473711 | Androgen modulators The present invention is directed to a class of 4-cyano-phenoxy derivatives of formula I and to their use as androgen receptor modulators. Other aspects of the invention are directed to the use of these compounds to decrease excess sebum secretions and to stimulate ... | 01/06/2009 |
| 7470715 | Estrogen modulators The present application is directed to a new class of isoxazoles and their use as estrogen modulators. ... | 12/30/2008 |
| 7338979 | Depigmentation agents The present invention is directed to 4-cyclopentyl resorcinol monohydrate, its Form I polymorph, formulations containing at least one of these compounds, and their use to lighten skin. ... | 03/04/2008 |
| 7306789 | Method of stimulating hair growth using benzopyrans The present invention is directed to methods of stimulating hair growth by administering particular benzopyran compounds. ... | 12/11/2007 |
| 7282592 | Resorcinol derivatives The present invention relates to certain resorcinol derivatives and their use as skin lightening agents. ... | 10/16/2007 |
| 7214694 | 3-ox(adi)azolylpropanohydroxamic acids useful as procollagen C-proteinase inhibitors Compounds of formula (I): wherein the substituents are as defined herein, and their salt, solvates, and prodrugs are procollagen C-proteinase (PCP) inhibitors useful in treating conditions mediated by PCP. ... | 05/08/2007 |
| 7202275 | Malonamic acids and derivatives thereof as thyroid receptor ligands The present invention relates to novel thyroid receptor ligands and, more particularly, relates to malonamic acids and derivatives thereof of Formula I, which are useful in the treatment of obesity, overweight condition, hyperlipidemia, glaucoma, cardiac arrhythmias... | 04/10/2007 |
| 7169890 | Process for the production of ramoplanin-like amide derivatives The invention regards a process for the production of ramoplanin-like derivatives of formula (I): RAMO-NC—CO—R (I), wherein the radical R represents a hydrocarbon radical and the portion RAMO-NH— represents deacylated ramoplanin, any of its factors or ramoplan... | 01/30/2007 |
| 7115745 | Benzyl urea and thiourea derivatives The present invention is directed to a new class of 6-benzyl urea/thiourea-quinolin-2-one derivatives and 2-oxo-6-benzylurea/thiourea-chromene derivatives. These compound are androgen antagonists and are useful in the treatment of alopecia, acne and other conditions... | 10/03/2006 |
