Quotables
"To place a man in a multi-stage rocket and project him into the controlling gravitational field of the moon where the passengers can make scientific observations, perhaps land alive, and then return to earth--all that constitutes a wild dream worthy of Jules Verne. I am bold enough to say that such a man-made voyage will never occur regardless of all future advances."
Lee deForest, American radio pioneer ; 1957
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| Number | Title | Issue Date |
| 5837277 | Palatable pharmaceutical compositions A pharmaceutical granular composition and method for taste masking bitter, or unpleasant tasting drugs comprising a drug core of a nonsteriodal anti-inflammatory drug, and as a taste masking agents, methacrylate ester copolymers. The method comprises coat... | 11/17/1998 |
| 5780483 | IL-8 receptor antagonists This invention relates to novel compounds and a novel use of phenyl ureas in the treatment of disease scates mediated by the chemokine, Interleukin-8 (IL-8). In particular, this invention relates to the novel compounds of Formula (Ia) and their use in tre... | 07/14/1998 |
| 5773457 | Compositions The present invention involves the novel use of various classes of drugs, such as H2 and H3 agonists, as erectogenic agents in the treatment of male and female sexual dysfunction.... | 06/30/1998 |
| 5756499 | Substituted imidazole compounds Novel 1,4,5-substituted imidazole compounds and compositions for use in therapy as cytokine inhibitors.... | 05/26/1998 |
| 5739143 | Imidazole compounds and compositions Novel 1,4,5-substituted imidazole compounds and compositions for use in therapy as cytokine inhibitors.... | 04/14/1998 |
| 5734051 | 8-substituted xanthine derivatives and method of use thereof A method for the treatment of cerebrovascular disorders and/or disorders associated with cerebral senility and/or other disorders which method comprises the administration of an effective, non-toxic amount of a compound of formula (I): ##STR1## ... | 03/31/1998 |
| 5719122 | Pharmaceutical compositions containing a calcitonin Pharmaceutical compositions comprising a calcitonin and a polyglycolysed glyceride and a method of enhancing the transdermal or transmucosal absorption of calcitonin in a mammal are disclosed.... | 02/17/1998 |
| 5716972 | Pyridyl substituted imidazoles The novel compounds of Formula (I) have been found to be useful cytokine suppressive agents and therefore useful in the treatment and prophylaxis of disease states mediated thereby.... | 02/10/1998 |
| 5716955 | Substituted imidazole compounds Novel 1,4,5-substituted imidazole compounds and compositions for use in therapy as cytokine inhibitors.... | 02/10/1998 |
| 5686455 | Imidazole derivatives and their use as cytokine inhibitors As cytokine inhibitors 2,4,5-triarylimidazole compounds and compositions for use as cytokine inhibitors.... | 11/11/1997 |
| 5684153 | Process for the preparation of purine derivatives The present invention provides a process for the synthesis of penciclovir and famciclovir by 9-substituting the compound 2-amino-6-chloropurine (ACP) with 2-acetoxymethyl-4-(leaving group)-but-1-yl acetate, followed by displacement of the 6-chloro moiety ... | 11/04/1997 |
| 5684032 | Compounds This invention relates to novel carboxylic acid indole compounds and compositions for use in the treatment of disease states mediated by the chemokine, Interleukin-8 (IL-8).... | 11/04/1997 |
| 5674869 | Pharmaceutical treatment Use of a guanine derivative or a prodrug thereof in the treatment of viral infections.... | 10/07/1997 |
| 5670527 | Pyridyl imidazole compounds and compositions Novel 1, 4, 5-substituted imidazole compounds and compositions for use in therapy as cytokine inhibitors.... | 09/23/1997 |
| 5670170 | Pharamaceutical formulation A pharmaceutical formulation comprises a medicament and an effervescent couple, plus optionally other excipients. Preferred medicaments are antibiotics, together with a citric acid--sodium bicarbonate couple. The formulation is provided for make up with w... | 09/23/1997 |
| 5665753 | Cytokine inhibiting imidazole substituted hydroxamic acid derivatives The present invention relates to a series of novel imidazole substituted hydroxamic acid derivatives, and compositions useful thereof as inhibitors of matrix degrading metalloproteinases, in particular collagenase.... | 09/09/1997 |
| 5663368 | Synthesis of acid addition salts of hydroxylamines This invention relates to novel diastereomeric acid addition salts of homochiral hydroxylamines, to processes for obtaining such, to processes for the conversion thereof to the corresponding homochiral hydroxylamines, to certain novel homochiral hydroxyla... | 09/02/1997 |
| 5663334 | Process for preparing pyrimidyl imidazoles Novel 1,4,5-substituted imidazole compounds and compositions for use in therapy as cytokine inhibitors.... | 09/02/1997 |
| 5663053 | Inhibition of inflammatory lipid mediators Coenzyme A-independent transacylase is required for the release of free arachidonic acid, and the production of arachidonic acid metabolites and platelet activation factor. Blocking of this enzyme inhibits the production of these inflammatory mediators an... | 09/02/1997 |
| 5656644 | Pyridyl imidazoles Novel 2,4,5-triaryl imidazole compounds and compositions for use in therapy.... | 08/12/1997 |
| 5648373 | CoA-IT and PAF inhibitors Coenzyme A-independent transacylase is required for the release of free arachidonic acid, and the production of arachidonic acid metabolites and platelet activation factor. Blocking of this enzyme inhibits the production of these inflammatory mediators an... | 07/15/1997 |
| 5641685 | Method carboxy terminal protein or peptide sequencing The present invention provides for an efficient and novel method for the C-terminal sequencing of proteins or peptides by use of acetyl chloride or phosphoryl chloride by reaction with a suitable isothiocyanate for derivitazation of the carboxy terminus t... | 06/24/1997 |
| 5599988 | Large scale preparation of 2,4-dihydroxybenzaldehyde using a variation of the Vilsmeierhaack reaction and isolated intermediates A novel process for producing chiral hydroxylamines for use as intermediates to make chiral hydroxyureas, which process comprises a tandem condensation-cyclization reaction between a dimethylsulfoxoniurn methylide and an appropriately substituted nitrone ... | 02/04/1997 |
| 5597844 | Cimetidine granules coated with a partially hydrogenated vegetable oil A non-aqueous, chewable composition for oral delivery of unpalatable drugs is provided. The composition contains the drug intimately dispersed or dissolved in a pharmaceutically acceptable lipid that is solid at room temperatures. The composition also has... | 01/28/1997 |
| 5597715 | 7,42-Bis(O-demethyl)rapamycin A compound of formula (I) is obtainable by the cultivation of a microorganism from the genus Streptomyces, such as Streptomyces NCIMB 40515. In the presence of rapamycin, and recovery thereof from the culture medium. The compound, and pharmaceutical compo... | 01/28/1997 |
| 5593992 | Compounds Novel 1,4,5-substituted imidazole compounds and compositions for use in therapy as cytokine inhibitors.... | 01/14/1997 |
| 5593991 | Imidazole compounds, use and process of making Novel 1,4,5-substituted imidazole compounds and compositions for use in therapy as cytokine inhibitors.... | 01/14/1997 |
| 5583018 | Rapamycin derivative process for its preparation and its use The compound of formula (I) is useful as an antifungal and immunosuppressive agent. ##STR1##... | 12/10/1996 |
| 5559137 | Compounds This invention relates to the novel pyrazole compounds of Formula (I), and pharmaceutical compositions comprising a compound of Formula (I) and a pharmaceutically acceptable diluent or carrier. This invention also relates to a method of inhibiting cytokines by... | 09/24/1996 |
| 5547979 | TNF inhibition Derivatives of 2-pyrrolidinones are described which inhibit the production of TNF and are useful in the treatment of disease states mediated or exacerbated by TNF production.... | 08/20/1996 |
| 5496855 | Anti-inflammatory compounds This invention relates to the novel compounds and pharmaceutical compositions of Formulas (I) and (II). This invention also relates to a method of treating or reducing inflammation in a mammal in need thereof, which comprises administering to said mammal ... | 03/05/1996 |
| 5491229 | Rapamycin derivative A compound of formula (I). ##STR1##... | 02/13/1996 |
| 5470882 | Anti-inflammatory compounds This invention relates to the novel pharmaceutical compositions of Formulas (I) and (II) each of which comprises a compound of Formula (I) or (II) and a pharmaceutically acceptable diluent or carrier. This invention also relates to a method of treating or redu... | 11/28/1995 |
| 5447957 | Anti-inflammatory compounds This invention relates to the novel compounds and pharmaceutical compositions of Formula (I). This invention also relates to a method of treating or reducing inflammation in a mammal in need thereof, which comprises administering to said mammal an effecti... | 09/05/1995 |
| 5432182 | Compounds substituted quinoline derivatives Substituted 4-aminoquinazoline derivatives which are inhibitors of gastric acid secretion. A compound of the invention are the salts of strong acids of 3-butyryl-4-(2-methylphenylamino)-8-(hydroxymethyl)quinoline.... | 07/11/1995 |
| 5420154 | TNF inhibitors Derivatives of 2-pyrrolidinones are described which inhibit the production of TNF and are useful in the treatment of disease states mediated or exacerbated by TNF production.... | 05/30/1995 |
| 5317019 | Inhibition of interleukin-1 and tumor necrosis factor production by monocytes and/or macrophages A method of inhibiting the production of interleukin-1 by monocytes and/or macrophages in a human in need thereof which comprises administering to such a human an effective, interleukin-1 production inhibiting amount of a diaryl-substituted imidazole fuse... | 05/31/1994 |
| 5280043 | Sulphonamido containing phenylalkanoic acids as thromboxane A2 antagonists Phenylalkanoic acids containing a sulphonamido group, and their use in a method of treatment of thromboxane-A2 mediated diseases are disclosed. A compound of the invention is 4-[4-(phenyl-sulphonamido)phenyl]butyric acid.... | 01/18/1994 |
| 5275823 | Pharmaceutical compositions Chewable tablets containing unpleasant tasting medicaments such as cimetidine are provided. The palatability of the tablets is improved by including certain hygroscopic water-insoluble substances as extragranular excipients in amounts corresponding to 5% ... | 01/04/1994 |
| 5250527 | Pyridyl containing benzimidazoles, compositions and use The invention relates to 4-amino-2-pyridylmethylsulfinyl-(and thio)-benzimidazoles which are inhibitors of potassium stimulated H+ -K+ ATPase activity. A compound of the invention is 2-(4-amino-5-bromo-2-pyridylmethylsulphinyl)-5-met... | 10/05/1993 |
