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| Number | Title | Issue Date |
| 6599910 | Substituted triazole compounds Novel substitued triazole compounds and compositions for use in therapy as CSBP/p38 kinase inhibitors.... | 07/29/2003 |
| 6569871 | Substituted imidazole compounds Novel 1,4,5 substituted imidazole compounds and compositions for use in therapy as CSBP/p38 kinase inhibitors.... | 05/27/2003 |
| 6562832 | Substituted imidazole compounds Novel 1,4,5-subsituted imidazole compounds and compositions for use in therapy as cytokine inhibitors.... | 05/13/2003 |
| 6548503 | Pyridin-4-yl or pyrimidin-4-yl substituted pyrazines The present invention is directed to novel pyridin-4-yl or pyrimidin-4-yl substituted pyrazine compounds and compositions for use in therapy.... | 04/15/2003 |
| 6548520 | Substituted imidazoles having anti-cancer and cytokine inhibitory activity The present invention is related to novel 2-alkyl substituted imidazoles of formula (I) useful for the treatment of CSBP kinase mediated diseases. ##STR1##... | 04/15/2003 |
| 6544558 | Pharmaceutical formulations comprised of amoxicillin in combination with clavulanic acid Syrup formulations comprising water and compacted granulates which are mixture of amoxycillin and clavulanic acid, together with an intra-granular disintegrant.... | 04/08/2003 |
| 6531600 | Treatment and compounds A method for the treatment of cerebrovascular disorders and/or disorders associated with cerebral senility and/or other disorders which method comprises the administration of an effective, non-toxic amount of a compound of formula (I): ##STR1## or if... | 03/11/2003 |
| 6528512 | Pyrimidine compounds useful in treating cytokine mediated diseases This invention relates to the novel amino substituted pyrimidine compounds of Formulas (I), (II) and (III), and pharmaceutical compositions comprising a compound of these Formulas and a pharmaceutically acceptable diluent or carrier. This invention also r... | 03/04/2003 |
| 6515008 | Formulation The present invention is directed to a novel pharmaceutical composition of polymorph B which has been found to be stable and palatable for long term commercial usage.... | 02/04/2003 |
| 6489325 | Substituted imidazole compounds The present invention relates to novel 1,4,5-substituted imidazole compounds and compositions for use in therapy as CSBP/p38 inhibitors.... | 12/03/2002 |
| 6475510 | Process for manufacturing bite-dispersion tablets This invention relates to a method for the manufacture of Bite-dispersion tablets which disperse easily and quickly in the oral cavity, after a gentle bite, without the aid of water, and if necessary includes masking the bitter taste of medicaments. The p... | 11/05/2002 |
| 6451785 | Beta lactams as antiproliferative agents A method of inhibiting or reducing cell proliferation in a human or mammal is disclosed. This method involves administering to a human or mammal an effective amount of CoA-independent transacylase inhibiting amount of a compound of the formula disclosed i... | 09/17/2002 |
| 6444198 | Effervescent laxatives The present invention is directed to a novel osmotic/effervescent system for the treatment of constipation and fecal impaction in a human or mammal in need thereof.... | 09/03/2002 |
| 6414150 | 4,5-disubstituted imidazole compounds The present invention is directed to novel 4,5-disubstituted imidazole compounds, and compositions for use in therapy as an anti-inflammatory agent, and as an inhibitor of cytokine p38/MAP kinase mediated diseases.... | 07/02/2002 |
| 6387898 | Treatment for CNS injuries This invention relates to a novel use of imidazole compounds in the treatment of CNS injuries.... | 05/14/2002 |
| 6372253 | Rapidly disintegrating methylcellulose tablets The present invention relates to a novel pharmaceutical composition and process for preparing swallowable methylcellulose tablets that disintegrate rapidly and meet USP disintegration standards in 0.1N hydrochloric acid as well as water.... | 04/16/2002 |
| 6372741 | Use of CSAID™ compounds as inhibitors of angiogenesis The present invention is to the novel use of a cytokine inhibitor, which cytokine is inhibited by the inhibition of the kinase CSBP/p38/RK, for the treatment of chronic diseases which are caused by excessive, undesired or inappropriate angiogenesis.... | 04/16/2002 |
| 6369068 | Amino substituted pyrimidine containing compounds Novel 1,4,5-substituted imidazole compounds and compositions for use in therapy as cytokine inhibitors.... | 04/09/2002 |
| 6368638 | Process of making an aqueous calcium carbonate suspension The present invention relates to a high dosage calcium carbonate aqueous antacid pharmaceutical suspension for oral use, and methods of preparation.... | 04/09/2002 |
| 6362193 | Cycloalkenyl substituted compounds Novel pyridyl or pyrimidinyl substituted cycloalkenyl compounds and compositions for use in therapy.... | 03/26/2002 |
| 6358528 | Pharmaceutical formulation A tablet formulation which comprises a core containing a pharmaceutically active material containing amoxycillin and clavulanate, coated with a release retarding coating, surrounded by a casing layer which includes a second pharmaceutically active materia... | 03/19/2002 |
| 6352720 | Pharmaceutical formulations comprised of compacted amoxicillin granulates The present invention discloses tablet formulations, produced by dry roller compaction comprising compacted granulates of a mixture of a medicament and an intra-granular disintegrant. The granulates are compacted together into a tablet with an extra-granu... | 03/05/2002 |
| 6350469 | Rapidly disintegrating methylcellulose tablets The present invention relates to a novel pharmaceutical composition and process for preparing swallowable methylcellulose tablets that disintegrate rapidly and meet USP standards in 0.1N hydrochloric acid as well as water.... | 02/26/2002 |
| 6345717 | Reinforced blister pack A blister pack wherein the material between the blisters is reinforced to confer rigidity relative to flexing deformation of the blister pack. The reinforcement may take the form of a reinforcing slab or sheet, or ribs in the blister pack material. The in... | 02/12/2002 |
| 6344196 | Compositions and method for reducing gastro-intestinal distress due to alpha-d-galactoside-linked/containing sugars A composition is provided for ingestion by mammals for in vivo conversion of alpha-D-galactoside comprising an amount of alpha-galactosidase effective to hydrolyze alpha-D-galactoside to D-galactose, and non-toxic, ingestible excipient(s) for said alpha-g... | 02/05/2002 |
| 6335340 | compounds of heteroaryl substituted imidazole, their pharmaceutical compositons and uses Compounds of 1,4,5-substituted imidazole wherein one of the substituents can be a substituted pyrimidine, pyridazine or 1,2,4-triazine. These compounds and their pharmaceutical compositions are used in treating cytokine mediated diseases by inhibiting the... | 01/01/2002 |
| 6329526 | Cycloalkyl substituted imidazoles 1,4,5-substituted imidazole compounds and compositions for use in therapy.... | 12/11/2001 |
| 6319490 | Liquid oral compositions comprising a calcium compound and an acidulant Acidic oral compositions having reduced tooth erosion characteristics, especially acid beverages such as fruit juice drink concentrates, or oral healthcare products such as mouthwashes, are prepared by adding a calcium compound to the acid composition so ... | 11/20/2001 |
| 6316025 | Swallow tablet comprising paracetamol The present invention relates to a swallow tablet or capsule formulation comprising paracetamol, sodium bicarbonate, and at least one pharmaceutically acceptable excipient.... | 11/13/2001 |
| 6306883 | Compounds This invention relates to the novel pyrazole compounds of Formula (I), and pharmaceutical compositions comprising a compound of formula (I) and a pharmaceutically acceptable diluent or carrier. This invention also relates to a method of inhibiting cytokines by... | 10/23/2001 |
| 6300495 | Process for the preparation of a metal salt of clavulanic acid A process for the preparation of a metal salt of clavulanic acid which comprises the reaction between an organic amine salt of clavulanic acid and a metal salt precursor compound, the reaction taking place in a liquid medium which comprises a liquid flori... | 10/09/2001 |
| 6299903 | Delayed release pharmaceutical formulation containing a ଲ-lactam antibiotic Pharmaceutical formulations for oral administration, comprising a matrix which comprises a ଲ-lactam antibiotic, a ଲ-lactamase inhibitor, and granules in a delayed release form dispersed within the matrix which comprise a ଲ-lactam antibio... | 10/09/2001 |
| 6294199 | Method of treating a bacterial infection comprising administering amoxycillin Bacterial infections may be treated using a high dosage regimen of amoxycillin. Preferably, the dosage is provided by a bilayer tablet.... | 09/25/2001 |
| 6288062 | Oxazoles for treating cytokine mediated diseases This invention relates to the novel oxazole compounds of Formula (I) and novel pharmaceutical compositions comprising a compound of Formula (I) and a pharmaceutically acceptable diluent or carrier. This invention also relates to a method of inhibiting cyt... | 09/11/2001 |
| 6274172 | Therapeutic effervescent compositions Granulates comprising an effervescent couple of anhydrous powdered monosodium citrate and powdered sodium bicarbonate and prepared using a roller compactor are formulated into pharmaceutical compositions.... | 08/14/2001 |
| 6268370 | Compounds Novel 2,4,5-triaryl imidazole compounds and compositions for use in therapy.... | 07/31/2001 |
| 6268156 | Cancer treatments The present invention is to a method of treating cancer in patients in need thereof with an effective amount of cimetidine. Cimetidine has been found to inhibit the expression of E-selectin, the ligands of sialyl Lewis X and sialyl Lewis A antigen-bearing... | 07/31/2001 |
| 6255491 | Synthesis of intermediate compounds for 4-adyl-5-pyrimidine imidazole substituted derivatives The present invention relates to a method for synthesizing imidazole derivatives having 4-aryl, 5-pyrimidine heterocyclic rings using a cycloaddition reaction.... | 07/03/2001 |
| 6251441 | Stable, optically clear compositions Stable aqueous compositions of biologically active oils for the preparation of optically clear products for use in human or animal healthcare, for example beverages, are prepared.... | 06/26/2001 |
| 6251914 | Cycloalkyl substituted imidazoles Novel 1,4,5-substituted imidazole compounds and compositions for use in therapy.... | 06/26/2001 |
