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| Number | Title | Issue Date |
| 7553966 | Glucocorticoid mimetics, methods of making them, pharmaceutical compositions, and uses thereof Compounds of Formula (IA) and Formula (IB) wherein R1, R2, R3, R4, R5, and R6 are as defined herein for Formula (IA) or Formula (IB), or a tautomer, prodrug,... | 06/30/2009 |
| 7312030 | Adaptation sites of porcine reproductive and respiratory syndrome virus A method for determining the capability of an arterivirus to replicate in a permissive cell is disclosed. The method includes determining an amino acid at a position that corresponds to an amino acid of a protein of a porcine reproductive and respiratory syndrome vi... | 12/25/2007 |
| 7309598 | gM-negative EHV-mutants This invention relates to Equine Herpes Viruses (EHV) wherein the protein gM is essentially absent or modified and non-functional with respect to its immunomodulatory capacity. Further aspects of the invention relate to nucleic acids coding said viruses, pharmaceuti... | 12/18/2007 |
| 7220750 | Bicyclic heterocycles, pharmaceutical compositions containing these compounds, their use and processes for preparing them The present invention relates to bicyclic heterocycles of general formula wherein Ra to Rc, A to E and X are defined as in claim 1, the tautomers, stereoisomers and salts thereof, pa... | 05/22/2007 |
| 7217711 | Piperazin-1-yl and 2-([1,4]diazepan-1-yl)-imidazo[4,5-d]-pyridazin-4-ones, the preparation thereof and their use as pharmaceutical compositions The present invention relates to substituted imidazo[4,5-d]pyridazin-4-ones of general formula wherein R1 to R3 and n are defined as in claims 1 to 8, the tautomers, enantiomer... | 05/15/2007 |
| 7214797 | Fluorenecarboxylic acid esters, process for the manufacture thereof, and use thereof as medicaments Fluorenecarboxylic acid esters of general formula 1 wherein X− and the groups A, R, R1, R2, R3, R3′, R4, and R4′ have the meaning... | 05/08/2007 |
| 7202368 | Process for the preparation of 4-(benzimidazolymethylamino) benzamidines A process for preparing an optionally substituted 4-benzimidazol-2-ylmethylamino)benzamidine, the process comprising: (a) condensing an optionally suitably substituted diaminobenzene with 2-[4-(1,2,4-oxadiazol-5-on-3-yl)phenylamino... | 04/10/2007 |
| 7193089 | Process for manufacture of telmisartan A process for preparing telmisartan by reacting 2-n-propyl-4-methyl-6-(1′-methylbenzimidazol-2′-yl)benzimidazole with a compound of formula (IV) wherein Z is a leaving group, to obtain the compound 2-cyano-4â... | 03/20/2007 |
| 7189758 | Glucocorticoid mimetics, methods of making them, pharmaceutical formulations, and uses thereof A compound of Formula (I) wherein R1, R2, R3, R4, R5, and R6 are as defined herein, or a tautomer, prodrug, solvate, or salt thereof; pharmaceutic... | 03/13/2007 |
| 7179919 | Stereoselective synthesis of certain trifluoromethyl-substituted alcohols A process for stereoselective synthesis of a compound of Formula (I) wherein R1, R2, R3, R4, and R5 are as described herein. ... | 02/20/2007 |
| 7169934 | (R) 2-(4-amidinophenylaminomethyl)-1-methyl-5-[1-(carboxymethylamino)-1 (pyrrolidinocarbonyl)-ethyl]-benzimidazole, the monohydrochloride thereof, preparation thereof and the use as pharmaceutical composition Crystalline forms of the compounds (R)-2-(4-amidinophenylaminomethyl)-1-methyl-5-[1-(carboxymethylamino)-1-(pyrrolidinocarbonyl)-ethyl]-benzimidazole and the monohydrochloride thereof, processes for the preparation thereof and the use thereof as pharmaceutical compo... | 01/30/2007 |
| 7157471 | Haloalkyl- and piperidine-substituted benzimidazole-derivatives A compound of general formula 1 wherein R1, R5, R6, A, B, Y, i, j and m are defined as in the description and claims. It is another object of the present invention to prov... | 01/02/2007 |
| 7151114 | Use of substituted 2-phenylbenzimidazoles as medicaments The present invention relates to the use of a substituted 2-phenylbenzimidazole of formula I wherein R1, R2, R3, R4, R5 and m have the meanings given in the ... | 12/19/2006 |
| 7141681 | Continuous process for preparing dihydropyrones The invention relates to a continuous process for preparing dihydropyrones of general formula I, wherein the groups R1 and R2 have the meanings described herein. ... | 11/28/2006 |
| 7138420 | Substituted benzimidazole compounds Disclosed are substituted benzimidazole compounds of formula (I): wherein R1, R2, R3, R4 and Xa are defined herein. The compounds of the invention inhibit It... | 11/21/2006 |
| 7091184 | Hepatitis C inhibitor tri-peptides Compounds of formula (I): wherein R1 is hydroxyl or sulfonamide derivative; R2 is t-butyl or —CH2—C(CH3)3 or —CH2-cyclopentyl; R3 | 08/15/2006 |
| 7017391 | Method for measuring the leaktightness of sealed containers The present invention relates to a method for reliably and rapidly checking the leaktightness of sealed containers or their leakage rate by the action of a gas thereon. The method according to the invention is particularly suitable for checking the leaktightness of ... | 03/28/2006 |
| 6986346 | Closure-cap and container as a two-chamber cartridge for nebulisers for producing aerosols and active substance formulations, suitable for storage The invention relates to an apparatus comprising a closure-cap and a container in the form of a two-chamber cartridge in which an active ingredient and a solvent can be stored separately until the apparatus is used in a nebuliser, as well as an active substance conc... | 01/17/2006 |
| 6982256 | Tolerance of 4-(4-(2-pyrrolylcarbonyl)-1-piperazinyl)-3-trifluoromethyl-benzoylguanidine in intravenous administration The invention relates to new formulations for improving the local tolerance of intravenously administered 4-(4-(2-pyrrolylcarbonyl)-1-piperazinyl)-3-trifluoromethyl-benzoylguanidine or one of the pharmacologically acceptable acid addition salts thereof. ... | 01/03/2006 |
| 6974870 | Substituted 3-amino-thieno [2,3-b]pyridine-2-carboxylic acid amide compounds and processes for preparing and their uses Disclosed are compounds of formula (I): wherein R1 and R2 are defined herein, which are useful as inhibitors of the kinase activity of the IκB kinase (IKK) complex. The compounds are therefore us... | 12/13/2005 |
| 6945472 | Locking-stressing mechanism for a miniaturised high pressuriser A locking tensioning mechanism for a miniaturised high pressure generator is disclosed, which mechanism will allow delivery of a set volume of a liquid, and the volume to be delivered by a high pressure generator can be altered subsequently by adjusting one of the s... | 09/20/2005 |
| 6908928 | Crystalline tiotropium bromide monohydrate, processes for the preparation thereof, and pharmaceutical compositions Crystalline monohydrate of (1α,2β,4β,5α,7β)-7-[(hydroxydi-2-thienylacetyl)oxy]-9,9-dimethyl-3-oxa-9-azoniatricyclo[3.3.1.02,4]nonane bromide (tiotropium bromide monohydrate), processes for the preparation thereof, pharmaceutical compositions thereof,... | 06/21/2005 |
| 6610305 | Safe attenuated bovine viral diarrhea viruses for use in pregnant cows This invention relates to the use of specifically attenuated live BVD (bovine viral diarrhea) viruses for the preparation of a vaccine for use in the prevention and/or treatment of BVDV infections in breeding stocks of cattle, pregnant cows and for fetal ... | 08/26/2003 |
| 6610849 | Process for the manufacture of tropenol A process for preparing tropenol (I) ##STR1## or an acid addition salt thereof, the process comprising: (a) reducing a scopine ester of formula (II) ##STR2## wherein R is C1 -C4 -alkyl or C1 -C4 -alkylen... | 08/26/2003 |
| 5869482 | Dipyridio[2,3-b:3',2'-] azepines and their use in the prevention or treatment of HIV infection | 02/09/1999 |
