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| Number | Title | Issue Date |
| 8071776 | Thienopyridines as allosteric potentiators of the M4 muscarinic receptor The present invention relates to selective allosteric potentiators of the Formula (I): or pharmaceutically acceptable salts thereof, for the treatment of disorders associated with M4 muscarinic receptors. ... | 12/06/2011 |
| 7541344 | Modulation of survivin expression Compounds and compositions are provided for modulating the expression of survivin. The compounds, exemplified by those acting through an RNAi antisense mechanism of action, include double-stranded and single-stranded constructs, as well as siRNAs, canonical siRNAs, ... | 06/02/2009 |
| 7449477 | 7-phenyl-isoquinoline-5-sulfonylamino derivatives as inhibitors of akt (protein kinase B) The present invention relates to compounds Formula (I) as inhibitors of AKT activity, which are useful for the treatment of susceptible neoplasms and viral infections. ... | 11/11/2008 |
| 7381826 | Crystalline forms of {2-[1-(3,5-bis-trifluoromethyl-benzyl)-5-pyridin-4-yl-1H-[1,2,3]triazol-4-yl]-pyridin-3-yl}-(2-chlorophenyl)-methanone The present invention provides novel crystalline forms of {2-[1-(3,5-bistrifluoromethylbenzyl)-5-pyridin-4-yl-1H-[1,2,3]triazol-4-yl]-pyridin-3-yl}-(2-chlorophenyl)-methanone, compositions thereof, intermediates thereof, methods of using the same, processes for maki... | 06/03/2008 |
| 7320994 | Triazole derivatives as tachykinin receptor antagonists This application relates to a compound of Formula (I) or a pharmaceutically acceptable salt thereof, pharmaceutical compositions thereof, and its use as an inhibitor of the NK-1 subtype of tachykinin receptors, as well as a process for its preparation and intermedia... | 01/22/2008 |
| 7307069 | Antisense oligonucleotide modulation of STAT3 expression Compounds, compositions and methods are provided for inhibiting the expression of human STAT3. The compositions comprise antisense oligonucleotides targeted to nucleic acids encoding STAT3. Methods of using these oligonucleotides for inhibition of STAT3 expression a... | 12/11/2007 |
| 7288530 | Antisense modulation of survivin expression Antisense compounds, compositions and methods are provided for modulating the expression of Survivin. The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding Survivin. Methods of using these compound... | 10/30/2007 |
| 7230011 | Benzenesulfonic acid indol-5-yl esters as antagonists of the 5ht receptor The present invention relates to compounds of formula I: which are antagonists of 5-HT6 receptor. ... | 06/12/2007 |
| 7179804 | Tachykinin receptor antagonists The present invention relates to selective NK-1 receptor antagonists of Formula (I); or a pharmaceutically acceptable salt thereof, for the treatment of disorders associated with an excess of tachykinins ... | 02/20/2007 |
| 7157488 | N-(2-Arylethyl) benzylamines as antagonists of the 5-HTreceptor The present invention provides compounds of formula I pharmaceutically acceptable salts thereof, and pharmaceutical compositions thereof, which are antagonists of the 5-HT6 receptor. The present invent... | 01/02/2007 |
| 7138521 | Crystalline of N-[4-[2-(2-Amino-4,7-dihydro-4oxo-3H-pyrrolo[2,3-D]pyrimidin-5-YL)ethyl]benzoyl]-L-glutamic acid and process therefor The invention relates to the field of pharmaceutical and organic chemistry and provides an improved process for preparing the novel heptahydrate crystalline salt of multitargeted antifolate N-[4-[2-(2-amino-4,7-dihydro-4-oxo-3H-pyrrolo[2,3-d]-pyrimidin-5-yl)ethyl]be... | 11/21/2006 |
| 7098192 | Antisense oligonucleotide modulation of STAT3 expression Compounds, compositions and methods are provided for inhibiting the expression of human STAT3. The compositions comprise antisense oligonucleotides targeted to nucleic acids encoding STAT3. Methods of using these oligonucleotides for inhibition of STAT3 expression a... | 08/29/2006 |
| 6844338 | Piperidyindoles as serotonin receptor ligands A pharmaceutical compound of the formula (I) in which R1 and R2 are each hydrogen or C1-6 alkyl, R3 is —SR10, —SOR10, —SO2R10, —COR10, —CH2OH or â... | 01/18/2005 |
| 6727255 | Piperidinyl and piperazinyl tachykinin receptor antagonists This invention provides a novel series of non-peptidyl compounds which are useful in the treatment or prevention of a physiological disorder associated with an excess of tachykinins. This invention also provides methods for the treatment of such physiological disord... | 04/27/2004 |
| 6358971 | Anti-viral compounds The present invention relates to compounds of Formula (I) below, which inhibit the growth of picornaviruses, Hepatitus viruses, enteroviruses, cardioviruses, polioviruses, coxsackieviruses of the A and B groups, echo virus and Mengo virus. ##STR1## w... | 03/19/2002 |
| 6329366 | Pharmaceutical compounds A pharmaceutical compound of the formula ##STR1## in which R1 and R2 are each hydrogen, halo, cyano or methyl, the dotted line represents an optional double bond, ##STR2## where R4 and R5 are each hydrogen, C1-6... | 12/11/2001 |
