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| Number | Title | Issue Date |
| 6133026 | Condensed plasmid-liposome complex for transfection A plasmid-liposome composition for transfection of a cell is described. The composition includes plasmid molecules condensed with a polycationic condensing agent and cationic liposomes. Also disclosed is a method for preparing the plasmid-liposome complex... | 10/17/2000 |
| 6125709 | Sampling tube and method for manufacturing such sampling tube The invention relates to a sampling tube comprising a glass tube (2) with two closed ends (3), the sampling tube (1) being filled, at least over a portion of the length of the tube, with an adsorption material (4), the adsorption material (4) being confin... | 10/03/2000 |
| 6114149 | Amplification of mixed sequence nucleic acid fragments A method of amplifying a mixture of different-sequence DNA fragments which may be formed from RNA transcription, or derived from genomic single- or double-stranded DNA fragments. The fragments are treated with terminal deoxynucleotide transferase and a se... | 09/05/2000 |
| 6094969 | Device for checking a closure or a connecting weld for tightness The invention relates to a device for checking for tightness a closure or a connecting weld provided in a flexible fluid-filled hose, which device comprises two clamping members slidable relative to each other, forming in an inserted position a profile wi... | 08/01/2000 |
| 6089159 | Chambered doctor blade system System for applying a pumpable substance (printing liquid) to running material webs, comprising a chambered doctor blade casing provided with a space for pumpable substance; an inlet and an outlet for pumpable substance; and at least two doctor blades det... | 07/18/2000 |
| 6087091 | Method of selecting a compound for producing analgesia A method of producing analgesia in nociceptive and neuropathic pain is disclosed. The method includes administering to a subject an omega conopeptide which is characterized by its ability to (a) inhibit electrically stimulated contraction of the guinea pi... | 07/11/2000 |
| 6080409 | Immunostimulatory method Disclosed are therapeutic compositions and methods for inducing cytotoxic T cell responses in vitro and in vivo. The therapeutic compositions consist of antigen presenting cells activated by contact with a polypeptide complex constructed by joining togeth... | 06/27/2000 |
| 6063612 | Antiviral reagents based on RNA-binding proteins The present invention describes the generation of site-directed RNA cleaving agents. These agents consist of RNA-binding proteins, or polypeptides derived thereof, which are modified to contain a moiety capable of cleaving RNA backbones. Alternatively, th... | 05/16/2000 |
| 6063248 | Process chamber isolation system in a deposition apparatus An improvement in an apparatus having an external casing defining a processing chamber for deposition of a film on a substrate and an opening in the processing chamber through which a substrate is introduced for deposition is described. The improvement co... | 05/16/2000 |
| 6063731 | Brassinosteroid analogs useful as plant growth regulators Disclosed are compositions and methods for promoting plant growth. The compounds are cyclopropyl- and cyclobutyl-substituted brassinosteroids having high growth promoting ability. They may be used alone or in combination with other plant growth regulating... | 05/16/2000 |
| 6060450 | Method for treatment of autoimmune diseases Methods of treating autoimmune disorders, such as multiple sclerosis, are disclosed. The methods employ administration of interferon-tau (IFN͌) in a therapeutically-effective dose.... | 05/09/2000 |
| 6056973 | Therapeutic liposome composition and method of preparation Reagents for use in preparing a therapeutic liposome composition sensitized to a target cell are described. The reagents include a liposomal composition composed of pre-formed liposomes having an entrapped therapeutic agent and a plurality of targeting co... | 05/02/2000 |
| 6054635 | Raspberry promoter and methods for expression of transgenes in plants The present invention is directed to the identification and isolation of a promoter region from a raspberry genome. The promoter is operably linked, in a native raspberry genome, to the coding region of a raspberry E4 gene. The raspberry E4 gene promoter ... | 04/25/2000 |
| 6054429 | Epidural method of producing analgesia A improved method of treating pain is disclosed. The method includes administering to a subject an N-type voltage-sensitive calcium channel blocking omega conopeptide which is characterized by its ability to (a) inhibit electrically stimulated contraction... | 04/25/2000 |
| 6051251 | Liposome loading method using a boronic acid compound A method for loading a therapeutic compound having a cis diol moiety into pre-formed liposomes is described. The method includes adding to a suspension of liposomes (i) the compound to be loaded into the liposomes and (ii) a boronic acid compound, thereby... | 04/18/2000 |
| 6048973 | Sugar-regulatory sequences in alpha-amylase genes A chimeric plant promoter which is responsive to sugar depletion or deprivation is disclosed. The promoter includes a promoter element and, carried in the element, a heterologous sequence from the rice Amy3D that is responsive to sugar depletion. Also dis... | 04/11/2000 |
| 6043094 | Therapeutic liposome composition and method A method of liposome-based therapy for a mammalian subject is disclosed. The method uses liposomes with outer surfaces that contain an affinity moiety effective to bind specifically to a biological surface at which the therapy is aimed, and a hydrophilic ... | 03/28/2000 |
| 6033894 | Kaposi's Syndrome Herpesvirus protease and assembly protein compositions and methods Kaposi's Sarcoma Herpesvirus (KSHV) protease and assembly protein sequences are disclosed. Also disclosed are polynucleotides that encode the protease and assembly protein. The invention includes screening and detection methods, as well as KSHV protease i... | 03/07/2000 |
| 6030941 | Polymer composition for delivering substances in living organisms Polymeric compositions effective for delivering compounds in living organisms are described. The compositions include polypeptides which exhibit solubility in both hydrophilic and lipophilic environments by undergoing a reversible pH-dependent transition ... | 02/29/2000 |
| 6030956 | Combination gene therapy for human cancers A method of treating cancer in a subject, by administering to the subject a combination of genes including wt p53, Pax5 and HSV-tk genes is disclosed. The method may involve subsequently treating the subject with ganciclovir.... | 02/29/2000 |
| 6019789 | Expandable unit cell and intraluminal stent A unit cell for use in a medical device, such as a stent, is disclosed along with a description of a stent formed from a plurality of unit cells and for use in the treatment of restenosis or other vascular narrowing. The unit cell is designed and configur... | 02/01/2000 |
| 6015795 | Bovine viral diarrhea virus II vaccine and method of immunization This invention relates to the identification of Bovine Viral Diarrhea Virus group II (BVDV-II) nucleic acid sequences (e.g., gp53 sequences), to methods of using the nucleic acid sequences for detecting BVD-II virus in animal sera, to polypeptide viral an... | 01/18/2000 |
| 6015843 | Process for making silanized colloidal silica A method of preparing an aqueous suspension of organosilanized colloidal silica particles is disclosed. Such particles are used in a variety of applications including density gradient separation media, anti-abrasion coatings and toner materials. The discl... | 01/18/2000 |
| 6010632 | Hydrothermal oxidation of organic compounds with heterogenous neutralizing reagent A process for hot or supercritical water oxidative decomposition of wastes, particularly halogenated organic compounds, is described. The process employs a heterogeneous reagent which accelerates the decomposition and is effective to neutralize acidic byp... | 01/04/2000 |
| 6007924 | Magnetic recording medium having a multilayer magnetic recording structure including a 10-30 angstrom CoCr interlayer An improvement in a magnetic recording medium having an underlayer and first and second magnetic recording layers is described. The improvement, effective to reduce media noise, includes deposition of an interlayer between the first and second magnetic re... | 12/28/1999 |
| 5998604 | Polynucleotide purification method A method of purifying a hydrophobically substituted polynucleotide by reverse phase HPLC is described. The hydrophobic substituent may be removed from the polynucleotide under non-acidic conditions; the purification method is thus especially useful for ac... | 12/07/1999 |
| 5998599 | Growth arrest gene compositions and methods Disclosed is a novel gene and growth arrest gene product encoded by the gene. Expression of the growth arrest gene B4B results in inhibition of cellular proliferation. The gene and gene product serve as markers of cancerous or pre-cancerous conditions, an... | 12/07/1999 |
| 5993851 | Method for preparing biphasic multilamellar lipid vesicles A biphasic multilamellar lipid vesicle comprising a plurality of spaced apart lipid bilayers that include a liposome-forming component and optionally a biologically active agent entrapped within the lipid bilayers. The lipid vesicle also comprises periphe... | 11/30/1999 |
| 5993852 | Biphasic lipid vesicle composition for transdermal administration of an immunogen A composition for transdermal administration of an immunogen is described. The immunogen is entrapped in lipid vesicles having a oil-in-water emulsion in the central core compartment. The vesicles are administered transdermally to elicit an immune respons... | 11/30/1999 |
| 5994305 | Method of treating inflammation A method of producing analgesia in nociceptive and neuropathic pain is disclosed. The method includes administering to a subject an omega conopeptide which is characterized by its ability to (a) inhibit electrically stimulated contraction of the guinea pi... | 11/30/1999 |
| 5989322 | Corrosion inhibition method and inhibitor compositions The present invention provides a method and compositions useful for inhibiting corrosion of a corrodible metal resulting from contact of water and air with the metal. In this method, a stannous salt and a hydrocarbyl substituted succinimide of a polyethyl... | 11/23/1999 |
| 5985916 | Polymer-platinum compounds A polymer-platinum compound for use in tumor treatment is described. The compound is composed of a biodegradable diamido-diamine polymer linked to a platinum species. The platinum species is released from the polymer to yield a platinum species having ant... | 11/16/1999 |
| 5985651 | Thermocycling apparatus and method A thermocycling apparatus comprising a plurality of capillaries for moving DNA-containing samples between two or more discrete zones maintained at selected elevated temperatures.... | 11/16/1999 |
| 5976546 | Immunostimulatory compositions Disclosed are therapeutic compositions and methods for inducing cytotoxic T cell responses in vitro and in vivo. The therapeutic compositions consist of antigen presenting cells activated by contact with a polypeptide complex constructed by joining togeth... | 11/02/1999 |
| 5972716 | Fluorescence monitoring device with textured optical tube and method for reducing background fluorescence An improved fluorescence monitoring apparatus for measuring fluorescent emission from a sample in response to sample irradiation by an emission beam is disclosed. The apparatus employs a sample tube having surface roughness characteristics which substanti... | 10/26/1999 |
| 5972623 | Collagen-peptide assay method The invention includes a method of determining the level of Type I collagen fragments in a biological fluid using an antibody which is immunospecific for an epitope contained in one of the following sequences: (1) Ala-Hyp-Gly-Asp-Arg-Gly-Glu-Hyp-Gly-Pro-Hyp-Gl... | 10/26/1999 |
| 5972379 | Liposome composition and method for administering a quinolone A liposome composition for treating a bacterial infection is described. The composition includes liposomes having a surface coating of hydrophilic polymer chains and an entrapped drug-conjugate composed of ciprofloxacin conjugated to an amino acid.... | 10/26/1999 |
| 5964651 | Apparatus for polishing planar substrates through rotating plates An apparatus for polishing one or more planar substrates, such as magnetic disks, between rotating polishing plates is described. The apparatus is designed to optimize uniformity and flatness of the substrates by maintaining a substantially constant paral... | 10/12/1999 |
| 5965427 | Human RAD50 gene and methods of use thereof Substantially-isolated polynucleotides encoding human RAD50 polypeptides, human RAD50 genomic sequences, and methods of use thereof.... | 10/12/1999 |
| 5965118 | Polymer-platinum compounds A polymer-platinum compound for use in tumor treatment is described. The compound is composed of a polymer backbone having platinum-containing side chains spaced along the polymer backbone. The side chains are composed of an oligopeptide attached at one e... | 10/12/1999 |
