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"What, sir, would you make a ship sail against the wind and currents by lighting a bonfire under her deck? I pray you, excuse me, I have not the time to listen to such nonsense."
Napoleon Bonaparte ; When told of the Robert Fulton steamboat
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| Number | Title | Issue Date |
| 8163698 | Dolastatin 15 derivatives Compounds of the present invention include cell growth inhibitors which are peptides of Formula I, A-B-D-E-F-(G)r-(K)s-L (I), and acid salts thereof, wherein A, B, D, E, F, G and K are α-amino acid residues, and s and ... | 04/24/2012 |
| 8148526 | Reverse amide compounds as protein deacetylase inhibitors and methods of use thereof The present invention relates to novel “reverse amide” compounds comprising a zinc chelator group, and the use of such compounds in the inhibition of HDAC6 and in the treatment of various diseases, disorders or conditions related to HDAC6. ... | 04/03/2012 |
| 8038840 | Process for refining and producing cellulose, lignin and xylose from biomass material A process for refining and producing cellulose, lignin and xylose from biomass material comprises the following steps: pulverizing and screening the biomass material; and then dipping the biomass material in organic acid with lower boiling point and decomposing it i... | 10/18/2011 |
| 8022056 | Compositions and methods for the treatment of cancer The present invention relates to the use of specific compounds related to the indolocarbazole K252a, for the preparation of pharmaceutical compositions for the treatment of various forms of cancer. ... | 09/20/2011 |
| 8003631 | Composition and method for the treatment of tauopathies The present invention refers to the use of a specific indolocarbazole compound of general formula (1) or a pharmaceutically-acceptable a salt thereof for the preparation of a pharmaceutical composition for the prevention or treatment of a neurodegenerative and/or de... | 08/23/2011 |
| 7833547 | Ibuprofen and narcotic analgesic compositions Provided herein are compositions and methods of making compositions of ibuprofen in combination with a narcotic analgesic. Specifically provided is a pharmaceutical tablet composition comprising ibuprofen; a narcotic analgesic; colloidal silicon dioxide; a filler se... | 11/16/2010 |
| 7807779 | Antineoplastic peptides The present invention provides antineoplastic peptides of formula I, R1R2N—CHX—CO—A—B-D-E-(G)s-K wherein R1, R2, X, A, B, D, E, G, K and s have the meanings stated in the description.... | 10/05/2010 |
| 7807637 | Polymyxin derivatives and uses thereof The present invention relates to a polymyxin derivative wherein R1, R2 and R3 are optional and R1, R2, R3, R5, R8 and R9 are cationic or neutral amino acid residues selected so that the total number of positive charges at physiological pH is at least two but no more... | 10/05/2010 |
| 7745581 | T-bet compositions and methods of use thereof Isolated nucleic acid molecules encoding T-bet, and isolated T-bet proteins, are provided. The invention further provides antisense nucleic acid molecules, recombinant expression vectors containing a nucleic acid molecule of the invention, host cells into which the ... | 06/29/2010 |
| 7662786 | Dolastatin 15 derivatives Compounds of the present invention include cell growth inhibitors which are peptides of Formula I, A-B-D-E-F-(G)r-(K)s-L (I), and acid salts thereof, wherein A, B, D, E, F, G and K are α-amino acid residues, and s and... | 02/16/2010 |
| 7592147 | Modulation of IL-2 production by T-bet The instant invention is based, at least in part, on the dentification of a mechanism by which T-bet modulates IL2 production. The present invention pertains to methods of identifying agents that modulate the kinase-mediated interaction of T-bet with RelA, as well a... | 09/22/2009 |
| 7485698 | Pharmaceutical composition for preventing or treating malignant glioma An object of the present invention is to provide a novel malignant glioma antitumor agent and malignant glioma antitumor agent for animals, and in order to achieve this object, in the present invention a polypeptide indicated by the following (a) or (b), or a mixtur... | 02/03/2009 |
| 7449544 | p21 peptides The present invention relates to p21 derived peptides capable of inhibiting CDK/cyclin complexes, particularly cyclins A or E/CDK2, by modifying the interaction with their substrates. The peptides are derived from a C-terminal region of p21 and display selectivity f... | 11/11/2008 |
| 7419999 | Gamma lactams as prostaglandin agonists and use thereof 1,2-substituted 5-pyrrolidinone compounds are provided, and methods of treatment and pharmaceutical composition that utilize or comprise one or more such compounds. Compounds of the invention are useful for a variety of therapies, including treating or preventing pr... | 09/02/2008 |
| 7417092 | End-capped polymer chains and products thereof Methods are described herein for converting carbocationically terminated polymers to anionically terminated polymers. These methods comprise: (a) providing a carbocationically terminated polymeric moiety; (b) reacting the carbocationically terminated polymeric moiet... | 08/26/2008 |
| 7374739 | Calcium phosphate bone replacement materials and methods of use thereof Methods of making porous calcium phosphate bone replacement materials are discussed. ... | 05/20/2008 |
| 7368528 | Antineoplastic peptides The present invention provides antineoplastic peptides of formula I, R1R2N—CHX—CO-A-B-D-E-(G)s-K I wherein R1, R2, X, A, B, D, E, G, K, and s have the meanings stated in the description. ... | 05/06/2008 |
| 7365169 | T-bet antibodies Isolated nucleic acid molecules encoding T-bet, and isolated T-bet proteins, are provided. The invention further provides, e.g., anti-T-bet antibodies. Methods of using the T-bet compositions of the invention are also disclosed, including, e.g., methods for detectin... | 04/29/2008 |
| 7358415 | Methods and compositions relating to modulation of hepatocyte growth, plasma cell differentiation or T cell subset activity by modulation of XBP-1 activity The invention demonstrates that the transcription factor XBP-1 is a regulator of hepatocyte growth, plasma cell differentiation and T cell subset activity. Methods for identifying modulators of hepatocyte growth, plasma cell differentiation and/or T cell subset acti... | 04/15/2008 |
| 7357915 | Method of imaging cell death in vivo A method of imaging apoptosis in vivo, using radiolabeled annexin, is described. ... | 04/15/2008 |
| 7335750 | Hybrid compositions for intracellular targeting Hybrid compounds comprising a first domain and a second domain are provided. The first domain and the second domain are preferably covalently linked, and the first domain comprises a domain which is capable of specific binding to Gb3; and the second domai... | 02/26/2008 |
| 7311907 | Lentiviral packaging cells Novel packaging cell lines which produce recombinant retrovirus, free of detectable helper-virus are disclosed. Also disclosed are methods of making the cell lines and methods of producing recombinant retroviruses from the cell lines. Retroviruses produced by the ce... | 12/25/2007 |
| 7304012 | Catalyst A process for preparing a supported catalyst or catalyst precursor containing carbon, said process comprising: a. preparing a liquid mixture of (i) at least one catalyst support or catalyst support precursor; (ii) at least one metal-containing compound, wherein said... | 12/04/2007 |
| 7288653 | Inhibitors of proton-gated cation channels and their use in the treatment of ischaemic disorders This invention relates to the use of compounds capable of inhibiting the activity of a proton-gated cation channel in the treatment of alleviation of diseases or disorders associated with, or mediated by a drop in extra cellular pH. ... | 10/30/2007 |
| 7268111 | Therapeutic agents and methods of use thereof for the modulation of angiogenesis The present invention provides angiogenesis inhibitor compounds comprising a MetAP-2 inhibitory core coupled to a peptide, as well as pharmaceutical compositions comprising the angiogenesis inhibitor compounds and a pharmaceutically acceptable carrier. The present i... | 09/11/2007 |
| 7262202 | Inhibitors of cyclin dependent kinases as anti-cancer agent The present invention relates to 2-substituted 4-heteroaryl-pyrimidines, their preparation, pharmaceutical compositions containing them and their use as inhibitors of cyclin-dependent kinases (CDKs) and hence their use in the treatment of proliferative disorders suc... | 08/28/2007 |
| 7208468 | Verotoxin pharmaceutical compositions and medical treatments therewith Pharmaceutical compositions comprising known verotoxins, particularly, verotoxin 1, have been found to be useful in the treatment of mammalian neoplasia, particularly, ovarian cancer and skin cancer. Surprisingly, although verotoxin 1 has previously been shown to ha... | 04/24/2007 |
| 7183329 | Process for the activation of a catalyst comprising a cobalt compound and a support A process for the preparation of a catalyst which comprises activating a catalyst precursor comprising a cobalt compound and a support with a gas comprising at least 5 mol % of a hydrocarbon. ... | 02/27/2007 |
| 7175828 | Modulators of β-amyloid peptide aggregation comprising D-amino acids Compounds that modulate natural β amyloid peptide aggregation are provided. The modulators of the invention comprise a peptide, preferably based on a β amyloid peptide, that is comprised entirely of D-amino acids. Preferably, the peptide comprises 3–5 D-amino ac... | 02/13/2007 |
| 7157420 | Therapeutic agents and methods of use thereof for the modulation of angiogenesis The present invention provides methods of treating an autoimmune disorder (e.g., lupus erythematosus, multiple sclerosis, myasthenia gravis, vasculitis and diabetes mellitus) in a subject by administering to the subject a therapeutically effective amount of one or m... | 01/02/2007 |
| 7153931 | Transport vectors The invention relates to modified and truncated forms of the membrane transport vector penetratin. Such truncated forms include 7-mer peptides that may in themselves include further variation. ... | 12/26/2006 |
| 7125663 | Genes, compositions, kits and methods for identification, assessment, prevention, and therapy of cervical cancer The invention relates to newly discovered nucleic acid molecules and proteins associated with cervical cancer including pre-malignant conditions such as dysplasia. Compositions, kits, and methods for detecting, characterizing, preventing, and treating human cervical... | 10/24/2006 |
| 7109171 | Methods for treating FSH related conditions with GnRH antagonists Methods for treating FSH related conditions, such as prostatic intraepithelial neoplasia, pedophilia, infertility, or vaginal bleeding, with GnRH antagonists are disclosed. The methods of the invention generally feature administering to a subject a GnRH antagonist s... | 09/19/2006 |
| 7105482 | Methionine aminopeptidase-2 inhibitors and methods of use thereof The present invention provides methods of treating, parasitic infections, thymoma, and lymphoid malignancies in a subject by administering to the subject a therapeutically effective amount of one or more of the compounds of the invention. ... | 09/12/2006 |
| 7101967 | Transport vectors The invention relates to modified and truncated forms of the membrane transport vector penetratin. Such truncated forms include 7-mer peptides that may in themselves include further variation. ... | 09/05/2006 |
| 7084108 | Therapeutic agents and methods of use thereof for the modulation of angiogenesis The present invention provides angiogenesis inhibitor compounds comprising a MetAP-2 inhibitory core coupled to a peptide, as well as pharmaceutical compositions comprising the angiogenesis inhibitor compounds and a pharmaceutically acceptable carrier. The present i... | 08/01/2006 |
| 7071165 | LHRH antagonist peptides Novel LHRH antagonist peptides, pharmaceutical compositions thereof, and methods of use thereof, are disclosed. The LHRH antagonist comprise a peptide compound, wherein a residue of the peptide compound corresponding to the amino acid at position 6 of natural mammal... | 07/04/2006 |
| 7056985 | End-capped polymer chains and products thereof According to an aspect of the present invention, a method is provided in which a double diphenylethylene compound is reacted with a polymer that contains a carbocationically terminated chain thereby providing a 1,1-diphenylene end-functionalized chain. Subsequently,... | 06/06/2006 |
| 7052830 | Hepatitis C virus peptides and uses thereof Novel hepatitis C virus (HCV) polypetides are provided which are not encoded by the standard HCV open reading frame. These alternate reading frame polypeptides are useful, inter alia, in vaccine compositions, in diagnosing HCV infection, and as therapeutic targets. | 05/30/2006 |
| 7049395 | Anti-inflammatory compounds and uses thereof The present invention provides anti-inflammatory compounds, pharmaceutical compositions thereof, and methods of use thereof for treating inflammatory disorders. The present invention also provides methods of identifying anti-inflammatory compounds and methods of inh... | 05/23/2006 |
