Did You Know...
...that the inventor of the electric motor was a blacksmith named Thomas Davenport? Described as "a brilliantly unsuccessful inventor", Davenport invented the first rotary electric motor. In 1836 he headed out -- on foot -- from his Vermont home to file a patent application at the Patent Office in Washington, D.C. By the time he got there, he had squandered away his money and couldn't afford the $30 filing fee so he turned around and went home. When he later mailed in his application with money he'd raised, the Patent office was destroyed in a fire. He did finally get credit for his invention on Feb. 5, 1837.
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| Number | Title | Issue Date |
| 6200750 | Mammalian homologous recombination activating sequences and method of identification and their use thereof Methods of identifying homologous recombination activators are provided. These recombination activators can be use for gene therapy.... | 03/13/2001 |
| 6149774 | AC waveforms biasing for bead manipulating chucks AC waveforms biasing of bead transporter chucks and their accumulated charge sensing circuits tailored for low resistivity substrates and beads where if traditional DC quasi-static biasing potentials were used, the bead attraction potentials of the chuck ... | 11/21/2000 |
| 6150334 | Serine protease inhibitors-tripeptoid analogs The present invention relates to certain compounds comprising substituted oxadiazole, thiadiazole and triazole structures which are useful as inhibitors of serine proteases, including human neutrophil elastase (HNE). Compounds described herein are charact... | 11/21/2000 |
| 6140304 | Method of and nutritional and pharmaceutical compositions for reduction of hyperinsulinemia A method and nutritional and pharmaceutical compositions are provided for the reduction of hyperinsulinemia and the improvement of disease conditions related to hyperinsulinemia by administering a nutritional composition to modify hormonal response.... | 10/31/2000 |
| 6103743 | Unsaturated amino acid derivatives Described herein are compounds having the general formula: ##STR1## Ar1 and Ar2 are independently selected aryl groups, optionally substituted with substituents selected from the group consisting of alkyl, cycloalkyl, alkoxy, al... | 08/15/2000 |
| 6100238 | Indole and tetrahydroisoquinoline containing Alpha-keto oxadiazoles as serine protease inhibitors The present invention relates to certain substituted oxadiazole nonpeptides, which are useful as inhibitors of human neutrophil elastase (HNE) for the treatment of HNE-mediated processes implicated in conditions such as adult respiratory distress syndrome... | 08/08/2000 |
| 6096368 | Bead transporter chucks using repulsive field guidance and method Bead transporter chucks for selective pick up and discharging of polymer beads for chemical synthesis or analysis, whereby repulsive field conductors are arranged around bead electrodes used for selectively attracting and retaining beads. Problems of bead... | 08/01/2000 |
| 6074688 | Method for electrostatically depositing a medicament powder upon predefined regions of a substrate Method for electrostatically depositing select doses of medicament powder at select locations on a substrate. Specifically, the apparatus contains a charged particle emitter for generating charged particles that charge a predefined region of a substrate a... | 06/13/2000 |
| 6063194 | Dry powder deposition apparatus Provided is, among other things, a dry deposition apparatus for depositing grains on a substrate comprising: an electrostatic chuck having one or more collection zones, wherein the substrate is layered on the chuck for processing; a charged grain delivery appa... | 05/16/2000 |
| 6060314 | Utility-high carbon dioxide and light quality and quantity in woody plant propagation The present invention relates to the propagation of plants and plant tissue. In particular, the present invention provides a method for propagating woody plant material comprising culturing the material in the presence of carbon dioxide in excess of about... | 05/09/2000 |
| 6040155 | Multifunctional protein and DNA sequence encoding same The present invention provides nucleic acid and corresponding amino acid sequences of a multifunctional protein that has been found to be useful in numerous medical and cosmetic contexts. A protein having "multifunctional activity," is defined herein as i... | 03/21/2000 |
| 6037325 | Substituted heterocyclic compounds useful as inhibitors of (serine proteases) human neutrophil elastase The present invention relates to certain substituted oxadiazole, thiadiazole and triazole peptoids which are useful as inhibitors of serine proteases including human neutrophil elastase, equivalently known as human leukocyte elastase.... | 03/14/2000 |
| 6030612 | Antimicrobial uses of multifunctional enzyme The invention relates to a multifunctional enzyme that can be derived from crustaceans or fish. The enzyme has at least one of a chymotrypsin, trypsin, elastase, collagenase and exo peptidase activity, and a molecular weight between about 20 kd and about ... | 02/29/2000 |
| 6015791 | Serine protease inhibitors-cycloheptane derivatives The present invention relates to certain substituted oxadiazole, thiadiazole, and triazoles, in particular those including a cycloheptane structure, that are useful as serine protease inhibitors, including inhibitors for human neutrophil elastase. Compoun... | 01/18/2000 |
| 6008015 | Glycine transporter Provided are, among other things, nucleic acid sequences encoding the GlyT1d form of glycine transporter, vectors, methods of producing the transporter, and methods for identifying bioactive agents.... | 12/28/1999 |
| 6007865 | Reversing the formation of advanced glycosylation endproducts The present invention relates to compositions and methods for inhibiting and reversing nonenzymatic cross-linking (protein aging). Accordingly, compositions are disclosed which comprise an agent capable of inhibiting the formation of advanced glycosylatio... | 12/28/1999 |
| 6004933 | Cysteine protease inhibitors The present invention relates to cysteine protease inhibitors of the general formula (I): ##STR1## wherein Z is a cysteine protease binding moiety; X and Y are S, O or optionally substituted N; and R1 is optionally substituted alkyl or ... | 12/21/1999 |
| 6001814 | Serine protease inhibitors The present invention relates to certain substituted oxadiazole nonpeptides, which are useful as inhibitors of human neutrophil elastase (HNE) for the treatment of HNE-mediated processes implicated in conditions such as adult respiratory distress syndrome... | 12/14/1999 |
| 6001813 | Val-pro containing -keto oxadiazoles as serine protease inhibitors The present invention relates to certain substituted oxadiazole tripeptides, which are useful as inhibitors of human neutrophil elastase (HNE) for the treatment of HNE-mediated processes implicated in conditions such as adult respiratory distress syndrome... | 12/14/1999 |
| 6001811 | Serine protease inhibitors--N-substituted derivatives The present invention relates to oxadiazole, thiadiazole, and triazole peptoids that are inhibitors of serine protease, specifically human neutrophil elastase; which proteases are useful in treatment of adult respiratory distress syndrome, septic shock, a... | 12/14/1999 |
| 6001854 | Pharmaceutical for treating of neurological and neuropsychiatric disorders The invention provides a pharmaceutical for treatment of neurological and neuropsychiatric disorders comprising a compound of the following formulas I and II: ##STR1## or a pharmaceutically acceptable salt thereof.... | 12/14/1999 |
| 5998379 | Serine protease inhibitors-proline analogs The present invention relates to certain substituted oxadiazole, thiadiazole, and triazole peptoids that are useful as inhibitors of serine proteases, in particular human neutrophil elastase. Serine protease inhibitors of the invention are useful in the t... | 12/07/1999 |
| 5975304 | Sealed containers with tabs and method of making the same Provided are a container comprising a tabbed sealing unit, blister pack containers comprising such sealing units, and methods of making such sealing units and containers.... | 11/02/1999 |
| 5968823 | Glycine transporter-transfected avian cells and uses thereof The present invention relates to materials and methods for the identification of agents that regulate glycine transport in or out of cells, particularly in or out of neuronal and neuronal-associated cells. Such materials include non-mammalian cells having... | 10/19/1999 |
| 5962246 | dUTPase, its isoforms, and diagnostic and other uses The invention provides the DNA and amino acid sequence of dUTPase, an enzyme which is essential for life and which is increased during periods of cellular proliferation. The human form of the dUTPase enzyme has been found to have two isoforms, a nuclear a... | 10/05/1999 |
| 5958406 | Acne treatment with multifunctional enzyme The invention relates to a multifunctional enzyme that can be derived from crustaceans or fish. The enzyme has at least one of a chymotrypsin, trypsin, elastase, collagenase and exo peptidase activity, and a molecular weight between about 20 kd and about ... | 09/28/1999 |
| 5947840 | Adjustable weight golf club The present invention provides for golf clubs, in particular woods, which include a three dimensional weighting system including at least two weight ports which are attached to the outside of the clubhead. The weights are directly axially aligned to, and ... | 09/07/1999 |
| 5945102 | Crustacean and fish derived multifunctional enzyme The invention relates to a multifunctional enzyme that can be derived from crustaceans or fish. The enzyme has at least one of a chymotrypsin, trypsin, elastase, collagenase and exo peptidase activity, and a molecular weight between about 20 kd and about ... | 08/31/1999 |
| 5919653 | Nucleic acids encoding a human glycine transporter The invention provides nucleic acids and proteins derived from the sequence of the human GlyT-2 transporter of the amino acid glycine.... | 07/06/1999 |
| 5910509 | Antimicrobial agent for agriculture The invention provides a method of treating or preventing a fungal infection comprising administering to a plant having a fungal infection a composition comprising an effective amount of a compound of formula I, wherein said compound is the following or a... | 06/08/1999 |
| 5888401 | Method and apparatus for reducing membrane fouling The present invention is directed, among other things, to methods for reducing fouling of a separation membrane having a concentrate side subject to a concentrate pressure (Pc) and a permeate side subject to permeate pressure (Pp), comprising raising an i... | 03/30/1999 |
| 5888962 | Nitrile perfumery material The present invention relates to a perfumery material composed of a mixture of 3-methyl-5-phenyl-pentanenitrile and 3-methyl-5-cyclohexyl-pentanenitrile, which can be combined with other perfumery materials.... | 03/30/1999 |
| 5861283 | DNA encoding a limbic system-associated membrane protein The present invention is directed to nucleic acid sequences encoding a limbic-system associated membrane protein ("LAMP") and to purified proteins with LAMP activity. LAMP is a self-binding, antibody-like cell surface adhesion protein, the presence of whi... | 01/19/1999 |
| 5859027 | Antimicrobial agent The invention provides a method of treating a fungal infection comprising administering to an animal having a fungal infection a composition comprising an infection treating effective amount of a compound of formula I, wherein said compound is the followi... | 01/12/1999 |
| 5855907 | Method of treatment of migraine The present invention relates to, among other things, methods of treatment of migraine headache in humans with reduced side effects by the topical administration of a migraine-ameliorating effective amount of an opioid, singly, or in combination with othe... | 01/05/1999 |
| 5850032 | Method for production of plant biological products in precocious neomorphic embryoids The present invention relates to making precocious neomorphic embryoids (PNE) and their use for producing biological products. Specifically, the invention provides a method for increasing taxol production from embryogenic Taxus cultures by making precocio... | 12/15/1998 |
| 5830994 | Peptide derivatives of alpha-MSH and their application Provided is a compound containing a peptide of at least 4 amino acids including the following sequence: His Phe* Arg, wherein Phe* represents phenylalanine or a halogenated derivative of phenylalanine the said peptide being conjugated with thioctic acid, ... | 11/03/1998 |
| 5824486 | Glycine transporter-transfected cells and uses thereof The present invention relates to materials and methods for the identification of agents that regulate glycine transport in or out of cells, particularly in or out of neuronal and neuronal-associated cells. Such materials include non-mammalian cells having... | 10/20/1998 |
| 5709995 | Hepatitis C virus-derived peptides capable of inducing cytotoxic T lymphocyte responses The hepatitis C virus (HCV) is the major cause of non-A, non-B vital hepatitis. The most striking feature of HCV induced liver disease is its tendency toward chronicity and slowly progressive liver cell injury. HLA Class I-restricted cytotoxic T lymphocyt... | 01/20/1998 |
| 5694672 | Bolt and pin extraction tool The invention provides a binding device extraction tool suitable for use in tight quarters that is made up of: (a) a coupling device for attaching an inertial impact tool for creating a force along a force axis; (b) a substantially cylindrical hollow grip... | 12/09/1997 |
