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"The abolishment of pain in surgery is a chimera. It is absurd to go on seeking it...knife and pain are two words in surgery that must forever be associated in the consciousness of the patient."
Dr. Alfred Velpeau, French surgeon ; 1839
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| Number | Title | Issue Date |
| 8168629 | Analgesic combination of tramadol and meloxicam Disclosed is a pharmaceutical composition, comprising a combination of a dose of meloxicam or a pharmaceutically acceptable salt thereof and a dose of tramadol or a pharmaceutically acceptable salt thereof, the combination in an amount sufficient to provide an analg... | 05/01/2012 |
| 8057341 | Low-noise chain actuation A chain drive with at least two sprocket wheels provided with teeth having an evolvent spline, and a toothed chain that engages therewith, especially for a vehicle propulsion system, which toothed chain includes individual rows of link plates that have openings, whe... | 11/15/2011 |
| 8048451 | Pharmaceutical compositions for inhalation The invention provides microparticles for use in a pharmaceutical composition for pulmonary administration, each microparticle comprising a particle of an active substance having, on its surface, particles of a hydrophobic material suitable for delaying the dissolut... | 11/01/2011 |
| 8017148 | Pharmaceutical formulation containing opioid agonist, opioid antagonist and irritant agent Disclosed in certain embodiments is an oral dosage form comprising: a therapeutically effective amount of an opioid analgesic; an opioid antagonist; and an irritant in an effective amount to impart an irritating sensation to an abuser upon ... | 09/13/2011 |
| 8002257 | Web conversion and collating apparatus and method A web conversion and collating apparatus is provided. The web conversion and collating apparatus includes a cutting apparatus cutting a printed web into a first signature and a second signature, a transport conveyor for transporting the first signature and the secon... | 08/23/2011 |
| 7985051 | Gas turbine vane A gas turbine vane, especially a vane pertaining to an aircraft engine, comprising a blade and a vane footing. The blade is defined by a flow inlet edge or a front edge, a flow outlet edge or a rear edge, and a blade surface extending between the front edge and the ... | 07/26/2011 |
| 7966704 | Clasp for jewelry A clasp which is lockable in both an open and a closed position includes a body having a first opening, a second opening, and an internal space; a connector fixed to the body for linking to a chain; a first spring; and a moveable connector. The movable connector, in... | 06/28/2011 |
| 7943174 | Controlled release hydrocodone formulations A solid oral controlled-release oral dosage form of hydrocodone is disclosed. The dosage form comprising an analgesically effective amount of hydrocodone or a pharmaceutically acceptable salt thereof, and a sufficient amount of a controlled release material to rende... | 05/17/2011 |
| 7943173 | Pharmaceutical combinations of oxycodone and naloxone Disclosed in certain embodiments is a pharmaceutical composition comprising from 10 to 40 mg of oxycodone or a pharmaceutically acceptable salt thereof and 0.65 to 0.90 mg naloxone or a pharmaceutically acceptable salt thereof. ... | 05/17/2011 |
| 7939543 | Method of reducing α, β unsaturated ketones in opioid compositions The present invention is directed to a process for reducing the level of α, β-unsaturated ketone in an opioid analgesic composition by hydrogenation the opioid analgesic composition with diimide or a diimide progenitor. ... | 05/10/2011 |
| 7914818 | Opioid agonist formulations with releasable and sequestered antagonist Disclosed are oral dosage forms, comprising (i) a therapeutically effective amount of an opioid agonist; (ii) an opioid antagonist in releasable form; and (iii) a sequestered opioid antagonist which is not released when the dosage form is administered intact, and me... | 03/29/2011 |
| 7846476 | Once-a-day oxycodone formulations The invention is directed to sustained release formulations containing oxycodone or a pharmaceutically acceptable salt thereof which provide a mean C24/Cmax oxycodone ratio of 0.6 to 1.0 or 0.7 to 1 after oral administration at steady state to ... | 12/07/2010 |
| 7874309 | Compressor The invention relates to a compressor, particularly for air conditioners in motor vehicles, comprising a safety device for limiting high pressure, whereby the safety device is hermetically sealed until first responding, after which it slowly reduces the system press... | 01/25/2011 |
| 7835844 | Method and system for control of an automatic friction clutch arranged between an engine and a gearbox on a motor vehicle An automatic friction clutch in a drive train of a motor vehicle is controlled to transfer a clutch torque that includes an engine torque-dependent component and a clutch slip-dependent component. ... | 11/16/2010 |
| 7834564 | Actuating device for motor vehicle components A device for actuating components of a motor vehicle has at least two electric motors, each of which has at least one stator unit and one rotor unit, and a control device for the electric motors, which has at least one logic device and one power device. The control ... | 11/16/2010 |
| 7744880 | Cell growth inhibitors containing anti-glypican 3 antibody Provided is a cell growth inhibitor that can be used for treating diseases based on abnormal cell proliferation, and in particular cancer. The cell growth inhibitor contains an anti-glypican 3 antibody as an active ingredient. ... | 06/29/2010 |
| 7670256 | Automotive drive train and method for reducing chatter in the same The invention relates to a method for reducing chatter in automotive drive train which comprises an internal combustion engine as the drive and a clutch device. According to the method, a rotating component of the drive train is driven by means of the internal combu... | 03/02/2010 |
| 7428778 | Method and a system for inserting elements in the ground, a data recording medium for the method A method of inserting a preceding element and then a following element in the ground, along a calculated path, in order to construct a work, the method including: a step of determining an absolute positioning error of a preceding element relative to the nominal posi... | 09/30/2008 |
| 7332182 | Pharmaceutical formulation containing opioid agonist, opioid antagonist and irritant Disclosed in certain embodiments is an oral dosage form comprising: a therapeutically effective amount of an opioid analgesic; an opioid antagonist; and an irritant in an effective amount to impart an irritating sensation to an abuser upon ... | 02/19/2008 |
| 7268164 | Anti-epileptogenic agents Methods and compounds useful for the inhibition of convulsive disorders, including epilepsy, are disclosed. The methods and compounds of the invention inhibit or prevent ictogenesis and epileptogenesis. Methods for preparing the compounds of the invention are also d... | 09/11/2007 |
| 7259297 | Environmental stress-tolerant plants The present invention relates to an environmental stress-tolerant plant. The invention discloses a transgenic plant containing a gene in which a DNA encodes a protein consisting of the amino acid sequence as shown in SEQ ID NO: 4 with the deletion of amino acids fro... | 08/21/2007 |
| 7073096 | File path resolving debugger A method for debugging an application running on a target device includes running a debugging program on a host device. A global path substitution is specified, the global path substitution indicating a first file path according to a file path convention of the host... | 07/04/2006 |
| 7055108 | Directional focus manager A method for navigating a web page with directional keys is provided where the page is scanned for a next closest element along a predetermined search path in the direction of a selected arrow key. In this regard, the search path can be defined as a tunnel or a cone... | 05/30/2006 |
| 6743442 | Melt-extruded orally administrable opioid formulations Bioavailable sustained release oral opioid analgesic dosage forms, comprising a plurality of multiparticulates produced via melt extrusion techniques are disclosed. ... | 06/01/2004 |
| 6670528 | Environmental stress-tolerant plants According to the present invention, there is provided a transgenic plant transformed with a DNA coding for the Arabidopsis thaliana DREB1A transcription factor of SEQ ID NO: 2, that binds to a stress responsive element, and regulates the transcription of ... | 12/30/2003 |
| 6211367 | Methods of Synthesing Purine Compounds Having PDE Iv Inhibitory Activity The present invention comprises compounds having the general formula I: ##STR1## wherein: Y, is N or CH Z is selected from the group consisting of alkyl groups such as alkylene groups such as CH2, CH2 CH2, CH(CH3); a... | 04/03/2001 |
| 6166089 | Prodrugs with enhanced penetration into cells The invention relates to a pharmaceutically acceptable prodrug which is a covalent conjugate of a pharmacologically active compound and an intracellular transporting adjuvant, characterized by the presence of a covalent bond which is scission-sensitive to... | 12/26/2000 |
| 6130434 | Dissolution stage for an environmental scanning electron microscope A system is provided for imaging, in an ESE microscope or other variable pressure microscope, a single sample at various time intervals during dissolution of the sample in a liquid. The system includes a sample chamber having a sample well. The sample wel... | 10/10/2000 |
