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| Number | Title | Issue Date |
| 5352705 | Inhibitors of farnesyl protein transferase The present invention is directed to compounds which inhibit farnesyl-protein transferase (FTase) and the farnesylation of the oncogene protein Ras. The invention is further directed to chemotherapeutic compositions containing the compounds of this invent... | 10/04/1994 |
| 5326773 | Inhibitors of farnesyl-protein transferase The present invention is directed to compounds which inhibit farnesyl-protein transferase (FTase) and the farnesylation of the oncogene protein Ras. The invention is further directed to chemotherapeutic compositions containing the compounds of this invent... | 07/05/1994 |
| 5324726 | Benzodiazepine analogs Benzodiazepine analogs of the formula: ##STR1## wherein: R3 is ##STR2## --NH(CH2)2 --3 NHCOR7, ##STR3## or --X11 NR18 SO2 (CH2)q... | 06/28/1994 |
| 5314900 | Aryl thiopyrano[2,3,4-C,D]indoles as inhibitors of leukotriene biosynthesis Compounds having the formula I: ##STR1## are inhibitors of 5-lipoxygenase and inhibitors of leukotriene biosynthesis. These compounds are useful as anti-asthmatic, anti-allergic, anti-inflammatory, and cytoprotective agents. They are also useful in ... | 05/24/1994 |
| 5310884 | LTD4 receptor and photoaffinity probe The LTD4 receptor has been defined by radioligand binding studies as a member of the family of G-protein coupled receptors. A photoactivable azido derivative of LTD4 ([125 I]Azido-LTD4) has been synthesized for ... | 05/10/1994 |
| 5308852 | Heteroarylnaphthalenes as inhibitors of leukotriene biosynthesis Compounds having the formula I: ##STR1## are inhibitors of leukotriene biosynthesis. These compounds are useful as anti-asthmatic, anti-allergic, anti-inflammatory, and cytoprotective agents. They are also useful in treating angina, cerebral spasm, ... | 05/03/1994 |
| 5298655 | Farnesyl pyrophosphate analogs The present invention is directed to farnesyl pyrophosphate analogs which inhibit farnesyl-protein transferase (FTase) and the farnesylation of the oncogene protein Ras. The invention is further directed to chemotherapeutic compositions containing the com... | 03/29/1994 |
| 5292879 | Intermediates for preparing cationic-2-heteroaryl-phenyl-carbapenem antibacterial agents Carbapenem compounds of the formula ##STR1## are useful intermediates for preparing antibacterial agents.... | 03/08/1994 |
| 5290798 | (hetero-arylmethoxy)indoles as inhibitors of leukotriene biosynthesis Compounds having the formula I: ##STR1## are inhibitors of leukotriene biosynthesis. These compounds are useful as anti-asthmatic, anti-allergic, anti-inflammatory, and cytoprotective agents. They are also useful in treating diarrhea, hypertension, a... | 03/01/1994 |
| 5281720 | Pyranylphenyl hydroxyalkylnaphthoic acids as inhibitors of leukotriene biosynthesis Compounds having the formula I: ##STR1## are inhibitors of leukotriene biosynthesis. These compounds are useful as anti-asthmatic, anti-allergic, anti-inflammatory, and cytoprotective agents. They are also useful in treating angina, cerebral spasm, ... | 01/25/1994 |
| 5274096 | Hydrazine synthesis An improved synthesis is described for producing a quinolinylmethoxyphenyl hydrazine which is an intermediate in the preparation of quinolinylmethoxyindoles useful as inhibitors of leukotriene biosynthesis. The improved process eliminates two isolation st... | 12/28/1993 |
| 5266568 | Hydroxyalkylquinoline ether acids as leukotriene antagonists Compounds having the formula I: ##STR1## are leukotriene antagonists and inhibitors of leukotriene biosynthesis. These compounds are useful as anti-asthmatic, anti-allergic, anti-inflammatory, and cytoprotective agents. They are also useful in t... | 11/30/1993 |
| 5254682 | Cyclic renin inhibitors containing 3(S)-amino-4-cyclohexyl-2(R)-hydroxy-butanoic acid or 4-cyclo-hexyl-(2R, 3S)-dihydroxybutanoic acid or related analogs Compounds of the formula: ##STR1## are disclosed. These compounds inhibit the angiotensinogen-cleaving action of the natural proteolytic enzyme, renin, and are useful in treating, preventing or managing renin-associated hypertension, hyperaldosteroni... | 10/19/1993 |
| 5252585 | Fluorinated quinoline indoles as inhibitors of the biosynthesis of leukotrienes This invention relates to compounds having the formula I: ##STR1## wherein R1 is H, F or MeO, which are inhibitors of leukotriene biosynthesis. These compounds are useful as anti-asthmatic, anti-allergic, anti-inflammatory, and cytoprotect... | 10/12/1993 |
| 5245069 | Process for the preparation of bis(aryl)-phosphorohalidates This invention relates to a novel process for preparing bis(aryl)phosphorohalidates which are useful in the synthesis of various enol phosphates. The process of this invention provides a means of producing a high-yield, high-purity product without the nee... | 09/14/1993 |
| 5242680 | Thiol-reactive maleimido-based radiolabeling reagents Novel thiol-reactive maleimido-based radiolabeling reagents are disclosed which are useful for binding and receptor studies and assays. The reagents are also useful as diagnostic imaging agents, and as radiotherapeutic drugs.... | 09/07/1993 |
| 5238922 | Inhibitors of farnesyl protein transferase The present invention is directed to compounds which inhibit farnesyl-protein transferase (FTase) and the farnesylation of the oncogene protein Ras. The invention is further directed to chemotherapeutic compositions containing the compounds of this invent... | 08/24/1993 |
| 5223509 | ଲ-carbolines as cholecystokinin and gastrin antagonists This invention relates to certain ଲ-carbolines, which are antagonists of the functions of cholecystokinin (CCK) and gastrin, to pharmaceutical compositions comprising these compounds, and to the use of these compounds in the prevention and treatment... | 06/29/1993 |
| 5220018 | Cholecystokinin antagonists Benzodiazepine analogs of the formula: ##STR1## are disclosed which are antagonists of gastrin and cholecystokinin (CCK).... | 06/15/1993 |
| 5220017 | Cholecystokinin antagonists Benzodiazepine analogs of the formula: ##STR1## are disclosed which are antagonists of gastrin and cholecystokinin (CCK).... | 06/15/1993 |
| 5218115 | Cholecystokinin antagonists Benzodiazepine analogs of the formula: ##STR1## are disclosed which are antagonists of gastrin and cholecystokinin (CCK).... | 06/08/1993 |
| 5218114 | Cholecystokinin antagonists Benzodiazepine analogs of the formula: ##STR1## are disclosed which are antagonists of gastrin and cholecystokinin (CCK).... | 06/08/1993 |
| 5215989 | Nitrogen-containing heterocyclic compounds as class III antiarrhythmic agents Compounds of structural formula: ##STR1## wherein Ar is an aromatic ring, B is a cyclic moiety fused to Ar of 5-7 members, X and Y are bridging groups, Q is a nitrogen containing heterocycle, R2 and R3 are H, substituted or unsu... | 06/01/1993 |
| 5210082 | 2-benzazepines with 5- and 6-membered heterocyclic rings to treat pain and anxiety disorders Pharmaceutical compositions containing aromatic 2-benzazepines with fused 5- or 6-membered heterocyclic rings are disclosed which are useful in the treatment of panic disorder or anxiety disorder.... | 05/11/1993 |
| 5206240 | Nitrogen-containing spirocycles Spirocycles of general structural formula: ##STR1## are Class III antiarrhythmic agents.... | 04/27/1993 |
| 5206237 | Benzodiazepine analogs Pharmaceutical compositions containing benzodiazepines of the formula: ##STR1## are disclosed which are useful in the treatment of panic disorder or anxiety disorder.... | 04/27/1993 |
| 5194605 | Cyclic renin inhibitors containing 2-substituted (3S,4S)-4-amino-5-cyclohexyl-3-hydroxy pentanoic acid, 2-substituted (3S,4S)-5-cyclohexyl-3,4-di-hydroxy pentanoic acid or 2-substituted (4S,5S)-5-amino-6-cyclohexyl-4-hydroxyhexanoic acid or its analogs Compounds of the formula ##STR1## are disclosed. These compounds inhibit the angiotensinogen-cleaving action of the natural proteolytic enzyme, renin, are useful in treating, preventing or managing renin-associated hypertension, hyperaldosteronism, ... | 03/16/1993 |
| 5189050 | Fermentation analogs of Virginiamycin M1 to treat panic and anxiety disorder Pharmaceutical compositions containing Virginiamycin M1 having the Formula: ##STR1## and Virginiamycin M1 analogs having the Formulae I-IV: ##STR2## are disclosed which are useful in the treatment of panic disorder or ... | 02/23/1993 |
| 5185331 | Triazolobenzodiazepines Pharmaceutical compositions containing Triazolobenzodiazepines of the formula: ##STR1## are disclosed which are useful in the treatment of panic disorder or anxiety disorder.... | 02/09/1993 |
| 5177071 | 1,4-benzodiazepines with 6-membered heterocyclic rings to treat panic and anxiety disorder Pharmaceutical compositions containing 6-membered heterocyclic rings are disclosed which are useful in the treatment of panic disorder or anxiety disorder.... | 01/05/1993 |
| 5171860 | Diamino isothiazole-1-oxides and 1,1 dioxides as gastric secretion inhibitors This invention is directed to diamino isothiazole -1-oxides and -1,1-dioxides and related compounds as well as pharmaceutical compositions and methods useful in the treatment of gastric secretion in mammals.... | 12/15/1992 |
| 5166151 | 2-Benzazepines with 5- and 6-membered heterocyclic rings, compositions and medical methods of use thereof Aromatic 2-benzazepines with fused 5- or 6-membered heterocyclic rings which are antagonists of cholecystokinins and/or gastrin, and are useful in the treatment or prevention of CCK-related and/or gastrin-related disorders of the gastrointestinal, central... | 11/24/1992 |
