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"To place a man in a multi-stage rocket and project him into the controlling gravitational field of the moon where the passengers can make scientific observations, perhaps land alive, and then return to earth--all that constitutes a wild dream worthy of Jules Verne. I am bold enough to say that such a man-made voyage will never occur regardless of all future advances."
Lee deForest, American radio pioneer ; 1957
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| Number | Title | Issue Date |
| 5312821 | 2-heterocyclic-5-hydroxy-1,3-pyrimidines useful as antiinflammatory agents The present invention is novel compounds which are 2-heterocyclic-4,6-ditertiarybutyl-5-hydroxy-1,3-pyrimidines, where heterocyclic is selected from imidazole, thiazole, and oxazole, and pharmaceutically acceptable additional salts, bases, and base salts ... | 05/17/1994 |
| 5306822 | Arylmethylenyl derivatives of oxazolidinone The present invention is for selected novel compounds, as well as, pharmaceutical compositions and methods of use for known and the selected novel compounds both of the formula ##STR1## having activity useful for treating allergies and inflammation.... | 04/26/1994 |
| 5278317 | Optically pure R-enantiomer of alpha,alpha-dilower alkyl-pyrrolidine-3-methane amines Optically pure isomers of 7-[3-(1,1-dialkylmethyl-1-amino)-1-pyrrolidinyl]quinolones and naphthyridones as therapeutically active and safe antibacterial agents are described, as well as pharmaceutical compositions thereof, and a method of treating ba... | 01/11/1994 |
| 5273995 | [R-(R*R*)]-2-(4-fluorophenyl)-ଲ,δ-dihydroxy-5-( 1-methylethyl-3-phenyl-4-[(phenylamino) carbonyl]- 1H-pyrrole-1-heptanoic acid, its lactone form and salts thereof [R-(R*,R*)]-2-(4-fluorophenyl)-ଲ,δ-dihydroxy-5-((1-methylethyl)- 3-phenyl-4-[(phenylamino)-carbonyl]-1H-pyrrole-1-heptanoic acid or (2R-trans)-5-(4-fluorophenyl)-2-(1-methylethyl-N,4-diphenyl-1-[2-(tetrahyd ro-4-hydroxy-6-oxo-2H-pyran-2-yl)ethyl]-1H-... | 12/28/1993 |
| 5274002 | Trisubstituted phenyl analogs having activity for congestive heart failure Novel trisubstituted phenyl analogs are now found to have activity as for the treatment of congestive heart failure.... | 12/28/1993 |
| 5270319 | 5-hydroxy-2-pyrimidinylmethylene derivatives useful as antiinflammatory agents The present invention is novel compounds which are 5-hydroxy-2-pyrimidinylmethylene derivatives and pharmaceutically acceptable addition salts, bases, and base salts thereof, pharmaceutical compositions and methods of use therefor. The invention compounds... | 12/14/1993 |
| 5258528 | Individual stereoisomers of pyrrolidine methanamines substituted on the ring nitrogen by a 1-phenylethyl group Individual stereoisomers of 7-[3-(1-aminoalkyl)-1-pyrrolidinyl]-quinolones and naphthyridones are described, their therapeutic advantages as antibacterial agents, as well as a novel method for the preparation and isolation of such stereoisomers.... | 11/02/1993 |
| 5256662 | Quinolinecarboxylic acid antibacterial agents Novel 8-alkenyl, alkynyl, allenyl and cycloalkyl-quinolinecarboxylic acids are described as antibacterial agents as well as methods of manufacture including novel intermediates used in said manufacture.... | 10/26/1993 |
| 5250704 | Process for the manufacture of (S)-3-amino-1-substituted-pyrrolidines A novel process for preparing a stereospecific (S)-3-amino-1-substituted pyrrolidine used as a key intermediate in preparing quinolone and naphthyridone antibacterial agents where the 7-position is occupied with a sterospecific 3-aminopyrrolidine side cha... | 10/05/1993 |
| 5248682 | 2-substituted-4,6-di-tertiary-butyl-5-hydroxy-1,3-pyrimidines useful as antiinflammatory agents The present invention is novel compounds which are 2-substituted-4,6-di-tertiarybutyl-5-hydroxy-1,3-pyrimidines and pharmaceutically acceptable acid addition or base salts thereof, pharmaceutical compositions and methods of use therefor. The invention ... | 09/28/1993 |
| 5240929 | 2-heterocyclic-5-hydroxy-1,3-pyrimidines useful as antiinflammatory agents The present invention is novel compounds which are 2-heterocyclic-4,6-ditertiarybutyl-5-hydroxy-1,3-pyrimidines, where heterocyclic is selected from imidazole, thiazole, and oxazole, and pharmaceutically acceptable additional salts, bases, and base salts ... | 08/31/1993 |
| 5239082 | Sulfonamide tetrazole ACAT inhibitors Pharmaceutically useful compounds having ACAT inhibitory activity of the formula ##STR1## wherein R1 is phenyl, substituted phenyl, naphthyl, substituted naphthyl, a heteroaromatic group or a hydrocarbon group having from 1 to 18 carb... | 08/24/1993 |
| 5236926 | 9-substituted-8-halo or -8-hydroxy-9-deazaguanines as inhibitors or PNP for pharmaceutical compositions The present invention is novel 9-substituted-8-hydroxy or -8-halo-9 deazaguanines and pharmaceutical compositions and methods of use therefor. The derivatives are inhibitors of purine nucleoside phosphorylase selectively cytotoxic to T-cells but not to B-... | 08/17/1993 |
| 5232950 | Method for using ketamine for prevention or reduction of the effects of stroke in a subject having increased risk for stroke The present invention is a method of use for the prevention or reduction of the effects of stroke in a subject susceptible to or at risk of stroke with ketamine. The method also includes combination of ketamine and a benzodiazepine in the use.... | 08/03/1993 |
| 5221676 | 7-substituted quinolones and naphthyridones as antibacterial agents 7-Substituted quinolones and naphthyridones are described as antibacterial agents as well as a process for their manufacture, compositions therefor, wherein the 7-substituent is a pyrrolidine ring substituted at the 3-position by a substituted aromatic hy... | 06/22/1993 |
| 5220025 | 2-substituted amino-4, 6-di-tertiary-butyl-5-hydroxy-1, 3-pyrimidines as antiinflammatory agents The present invention is novel compounds which are 2-substituted amino-4,6-di-tertiarybutyl-5-hydroxy-1,3-pyrimidines and pharmaceutically acceptable acid addition or base salts thereof, pharmaceutical compositions and methods of use therefor. The inventi... | 06/15/1993 |
| 5218090 | EGF receptor truncates The present invention is for EGF receptor truncates which retain the activity of ligand binding for the EGF receptor. The specific truncates include LD1 D2 D3.Apa L encompassing amino acids Met-24 to Val505... | 06/08/1993 |
| 5215986 | 5-hydroxy-2-pyrimidinylmethylene oxaza heterocycles Novel 5, 6, or 7 membered oxaza heterocycles substituted at the 4-carbon by a 5-hydroxypyrimidinylmethylene group inhibitors of 5-lipoxygenase and/or cyclooxygenase and are thus useful in treating inflammatory diseases are described as well as pharmaceuti... | 06/01/1993 |
| 5212189 | Thiadiazole or oxadiazole analogs of fenamic acids containing substituted hydroxamate side chains as antiinflammatory agents The present invention is a novel compound which is a thiadiazole or oxadiazole analog of a fenamic acid having a substituted hydroxamate side chain and pharmaceutically acceptable acid addition or base salts thereof, pharmaceutical compositions and method... | 05/18/1993 |
| 5210204 | Biphenyl oxadiazoles and thiadiazoles as angiothesin II antagonists Heterocyclic methyl derivatives of biphenyl oxadiazoles and thiadiazoles are described, as well as methods for the preparation of said derivatives and pharmaceutical compositions of the same, which are useful as antagonists of the angiotensin II enzyme an... | 05/11/1993 |
| 5208253 | 3-alkyloxy-, aryloxy-, or arylalkyloxy-benzo(b) thiophene-2-carboxamides as inhibitors of cell adhesion 3-Alkyloxy-, aryloxy-, or arylalkyloxy-benzo[b]thiophene-2-carboxamides are described as agents which block leukocyte adherence to vascular endothelium and, as such, are effective therapeutic agents for treating inflammatory diseases. Certain of these com... | 05/04/1993 |
| 5208225 | Compositions containing fixed combinations Continuous administration of compositions containing a fixed quantity of synthetic estrogen in combination with a synthetic progestogenic agent are useful to relieve menopausal symptoms, to prevent osteoporosis and for other hormone-replacement treatments... | 05/04/1993 |
| 5198466 | Oxysulfonyl urea ACAT inhibitors Novel compounds of the formula ##STR1## wherein R is hydrogen, a straight or branched alkyl group having from 1 to 8 carbon atoms or benzyl; wherein each of R1 and R2 is hydrogen, an aralkyl group, a straight or branched hydroca... | 03/30/1993 |
| 5196431 | 2-substituted amino-4, 6-di-tertiary-buthyl-5-hydroxy-1, 3-pyrimidines as antiinflammatory agents The present invention is novel compounds which are 2-substituted amino-4,6-di-tertiarybutyl-5-hydroxy-1,3-pyrimidines and pharmaceutically acceptable acid addition or base salts thereof, pharmaceutical compositions and methods of use therefor. The inventi... | 03/23/1993 |
| 5192792 | Isatine derivatives, and their method of use A method of treatment of central nervous system disorders with compounds having the formula ##STR1## and isomers thereof wherein R1, R2, R4, R5, R6, and R7 and as defined in the specif... | 03/09/1993 |
| 5189058 | Iminodicarbonic, iminodicarbonodithioic, and thiocarbonylcarbamic acid esters useful as ACAT inhibitors The compounds of the present invention have the formula ##STR1## wherein each of X and Y is oxygen or sulfur, R is hydrogen or lower alkyl, and each of R1 and R2 is phenyl, substituted phenyl, naphthyl, substituted naphthyl, ara... | 02/23/1993 |
| 5187175 | 2-carbonyl substituted-5-hydroxy-1, 3-pyrimidines as antiinflammatory agents The present invention is novel compounds which are 2-carbonyl substituted-5-hydroxy-1,3-pyrimidines and pharmaceutically acceptable acid addition or base salts thereof, pharmaceutical compositions and methods of use therefor. The invention compounds are n... | 02/16/1993 |
| 5185358 | 3-heteroatom containing urea and thiourea ACAT inhibitors Compounds useful in treating hypercholesterolemia and atherosclerosis having the formula ##STR1## wherein X is oxygen or sulfur, Het is a monocyclic heterocyclic group having three hetero atoms selected from nitrogen, oxygen and sulfur, and R | 02/09/1993 |
| 5185349 | Substituted amide ACAT inhibitors lactone derivatives Novel lactone and lactam compounds which are useful to lower blood cholesterol levels in a patient, said compounds containing an arylcarboxamide or arylthiocarboxamide moiety.... | 02/09/1993 |
| 5177217 | Process for the manufacture of (S)-3-amino-1-substituted-pyrrolidines A novel process for preparing a stereospecific (S)-3-amino-1-substituted pyrrolidine used as a key intermediate in preparing quinolone and naphthyridone antibacterial agents where the 7-position is occupied with a sterospecific 3-amino-pyrrolidine side ch... | 01/05/1993 |
| 5175153 | Substituted alpha-amino acids having pharmaceutical activity The present invention is novel substituted -amino acids, pharmaceutical compositions, method of use, and preparations therefore having utility for treating disorders which benefit from blockade of aspartate and glutamate receptors.... | 12/29/1992 |
| 5175356 | Quinolinecarboxylic acid antibacterial agents Novel 8-alkenyl, alkynyl, allenyl and cycloalkyl-quinolinecarboxylic acids are described as antibacterial agents as well as methods of manufacture including novel intermediates used in said manufacture.... | 12/29/1992 |
| 5157128 | Certain optically active substituted ,-dialkyl-pyrrolidine-3-methamines useful as intermediates Optically pure isomers of 7-[3-(1,1-dialkylmethyl-1-amino)-1 -pyrrolidinyl[quinolones and naphthyridones as therapeutically active and safe antibacterial agents are described, as well as pharmaceutical compositions thereof, and a method of treating bacter... | 10/20/1992 |
| 5151355 | Process for the production of high purity thrombin A liquid thrombin preparation is prepared by reacting a unit of prothrombin with less than 5 units of thromboplastin in the presence of calcium, contacting the resultant thrombin with a phosphate buffer, and diluting and filtering the suspension. The filt... | 09/29/1992 |
| 5116834 | Quinolinecarboxylic acid antibacterial agents Novel 8-alkenyl, alkynyl, allenyl and cycloalkyl-quinolinecarboxylic acids are described as antibacterial agents as well as methods of manufacture including novel intermediates used in said manufacture.... | 05/26/1992 |
| 5114958 | 1,2,4-oxadiazole and 1,2,4-thiadiazole derivatives of fenamates as antiinflammatory agents 1,2,4-Oxadiazole and 1,2,4-thiadiazole derivatives of the fenamic acids, in which the fenamate residue is present at the 3-position of the 1,2,4-oxadiazole or 1,2,4-thiadiazole, pharmaceutically acceptable acid addition or base salts and methods of prepar... | 05/19/1992 |
| 5112868 | Hydroxamate derivatives of selected nonsteroidal antiinflammatory acyl residues having cyclooxygenase and 5-lipoxygenase inhibition The present invention is novel selected hydroxamic acid derivatives of acyl residues of selected NSAIDS, i.e. having 5-lipoxygenase and cyclooxygenase inhibiting properties, pharmaceutical compositions for treating conditions advantageously affected by th... | 05/12/1992 |
| 5112846 | N-hydroxyamide, N-hydroxythioamide, hydroxyurea, and N-hydroxythiourea derivatives of selected nsaids as antiinflammatory agents The present invention includes N-hydroxyamide, N-hydroxyurea, N-hydroxythioamide, and N-hydroxythiourea derivatives of fenamates, indomethacin, cicloprofen, oxepinac, and indoprofen as dual inhibitors or selective inhibitors of cyclooxygenase and 5-lipoxy... | 05/12/1992 |
| 5074426 | Dividable capsule A capsule which is dividable into accurate individual dosage units by the user is comprised of first and second capsule units, each being cylindrical about a longitudinal axis along the major part of its length. The capsule units are detachably joined in ... | 12/24/1991 |
| 5072001 | Certain optically active substituted 3-pyrraidine acetic acid derivatives useful as intermediates Optically pure isomers of 7-[3-(1,1-dialkylmethyl-1-amino)-1-pyrrolidinyl]quinolones and naphthyridones as therapeutically active and safe antibacterial agents are described, as well as pharmaceutical compositions thereof, and a method of treating ba... | 12/10/1991 |
